清热解毒汤联合布洛芬混悬液治疗急性支气管炎伴高热患儿的效果

目的：探讨清热解毒汤联合布洛芬混悬液治疗急性支气管炎伴高热患儿的效果。方法：选取86例急性支气管炎伴高热患儿为研究对象,按随机数字表法将患儿分为对照组和观察组,各43例。对照组采用布洛芬混悬液治疗,观察组在对照组基础上加用清热解毒汤治疗,比较两组临床疗效,治疗前后血清炎性指标[血清降钙素原（PCT）、C反应蛋白（CRP）、淀粉样蛋白A(SAA)]水平、临床症状积分,以及不良反应发生率。结果：观察组治疗总有效率为93.02%(40/43),高于对照组的76.74%(33/43),差异有统计学意义（P<0.05）;观察组治疗后临床症状积分及血清PCT、CRP、SAA水平均低于对照组,差异有统计学意义（P<0.05）;两组不良反应发生率比较,差异无统计学意义（P<0.05）。结论：清热解毒汤联合布洛芬混悬液治疗急性支气管炎伴高热患儿效果确切,能降低血清炎性指标水平和临床症状积分,提高治疗总有效率,效果优于单用西药治疗。     

布洛芬两种剂型治疗儿童发热的疗效与安全性对比分析

目的：比较布洛芬两种剂型治疗儿童发热的疗效与安全性。方法选取116例发热儿童作为研究对象,随机均分为对照组和观察组（n=58）。对照组采用布洛芬混悬液治疗,观察组则采用布洛芬缓释混悬液治疗。分析2组患儿在治疗过程中的不良反应情况,并评定患儿治疗效果。结果治疗后,对照组治疗总有效率为94.83%,观察组治疗总有效率也为94.83%,2组治疗效果比较差异无统计学意义。治疗期间,对照组患儿不良反应率为13.79%,观察组患儿不良反应率为3.45%,2组患儿的不良反应情况比较差异具有统计学意义（P<0.05）。对照组用药量为6 mg/（kg·次）布洛芬混悬液显著高于观察组的用药量3 mg/（kg·次）布洛芬缓释混悬液,且两种药品市场价格差别不大。结论布洛芬缓释混悬液和布洛芬混悬液治疗儿童发热均具有良好的临床效果,但是布洛芬缓释混悬液治疗的安全性更高,费用较低,值得临床推广应用。     

布洛芬混悬液治疗小儿上呼吸道感染90例疗效分析

目的:探讨布洛芬混悬液治疗小儿上呼吸道感染的临床效果。方法:对门诊患儿用布洛芬混悬液治疗小儿上呼吸道感染90例,与服速效感冒冲剂的患儿进行比较分析。结果:治疗组总有效率97.8%,对照组总有效率82.2%,两组疗效比较差异有统计学意义。结论:布洛芬混悬液可代替退热针剂,作用持久,服用方便,值得临床推广使用。     

匹多莫德口服液治疗小儿反复呼吸道感染58例临床观察

目的 探讨匹多莫德口服液治疗小儿反复呼吸道感染的疗效.方法 选取110例反复呼吸道感染患儿随机分为两组,治疗组58例,对照组52例,比较两组的疗效.结果 治疗组的有效率明显高于对照组,总有效率为93.1%,对照组总有效率为65.5%.两组总有效率比较(P<0.01)差异有统计学意义.结论 匹多莫德口服液对小儿反复呼吸道感染有较好疗效且依从性好,可降低儿童反复呼吸道感染的发生率.     

思密达保留灌肠治疗婴幼儿急性轮状病毒性肠炎疗效与方法

目的:为评价思密达保留灌肠治疗婴幼儿急性轮状病毒性肠炎效果。方法:将177例急性轮状病毒性肠炎患儿,随机分为对照组(87)例,在常规综合治疗基础上,对照组给予思密达口服,观察组采用思密达保留灌肠。结果:对照组总有效率为78.16%,观察组97.78%,两组差异有统计学意义(χ2=16.28,P<0.01):两组治疗显效病例症状改善及消失时间比较,差异有统计学意义(P<0.01)。结论:思密达保留灌肠治疗婴幼儿急性轮状病毒性肠炎与口服相比能缩短病程、安全、疗效显著。     

布洛芬不同给药途径治疗小儿发热的疗效观察

目的观察布洛芬栓、布洛芬混悬液不同给药途径对发热患儿的降温效果,为发热患儿合理给药方式提供参考。方法对311例体温大于38.5℃的急性呼吸道感染患儿随机分为布洛芬栓塞肛组、布洛芬混悬液口服组、布洛芬混悬液灌肠组。观察其降温效果并对比分析。结果 3组总有效率、显效率比较,差异无统计学意义(P>0.05)。结论可根据患儿具体情况选择合适的退热途径。布洛芬栓塞肛降温退热疗效好,治疗小儿发热效果满意,且给药方便,无不良反应值得,临床推广。     

布洛芬混悬液与对乙酰氨基酚在小儿高热治疗中的临床疗效观察

目的:观察分析布洛芬混悬液与对乙酰氨基酚在小儿高热治疗中的临床疗效。方法:选择2015年10月至2016年10月在我院诊治的100例高热患儿作为本次研究对象,按照不同的治疗方法随机将其分成对照组和实验组,每组50例;对照组患儿予以对乙酰氨基酚进行治疗,实验组患儿予以布洛芬混悬液进行治疗;对比分析两组患者的服药后的不良反应发生情况以及治疗疗效。结果:实验组患儿的不良反应发生率为8.00%明显低于对照组的20.00%(P0.05);实验组患儿的治疗总有效率为94.00%显著高于对照组患儿的80.00%(P0.05);以上内容组间差异显著,均具有统计学意义。结论:采用布洛芬混悬液治疗小儿高热比对乙酰氨基酚的治疗效果更佳,不良反应发生率更低,安全性更高,加速患儿康复进程。     

尼美舒利对儿童急性呼吸道感染伴高热的退热疗效观察

目的探讨尼美舒利在儿童急性呼吸道感染伴高热的退热疗效。方法选择2个月至13岁患急性呼吸道感染伴高热的儿童120例,随机分成尼美舒利治疗组、布洛芬治疗组和安乃近治疗组。观察治疗后1及4h的体温变化,并对治疗的依从性和不良反应进行评估。结果尼美舒利在治疗后1及4h的体温下降和总有效率均优于布洛芬和安乃近,治疗满意度好,口感明显优于布洛芬。三者不良反应均较小。结论尼美舒利退热高效、安全,口感好,值得在儿童急性呼吸道感染伴高热时推广应用。     

微波治疗仪在小儿下呼吸道感染及顽固性腹泻治疗中的应用

目的:观察微波治疗仪在小儿下呼吸道感染及顽固性腹泻治疗中的应用效果。方法:选取收治的小儿下呼吸道感染及顽固性腹泻患儿99例,按照数字随机法随机分成观察组和对照组,对照组采取常规治疗,观察组在对照组基础上,加用微波治疗仪治疗,比较两组治疗效果。结果:观察A组下呼吸道感染患儿总有效率95.24%,对照A组下呼吸道感染患儿总有效率76.47%,观察A组总有效率高于对照A组,差异有统计学意义(P<0.05)。观察B组顽固性腹泻患儿总有效率92.31%,对照B组顽固性腹泻患儿总有效率70.00%,观察B组总有效率高于对照B组,差异有统计学意义(P<0.05)。结论:微波治疗仪在小儿下呼吸道感染及顽固性腹泻治疗中效果显著,可提高疗效,临床价值较高。     

一清胶囊在小儿急性呼吸系统感染中的应用

目的对白云区医院儿科门诊呼吸道感染患儿,应用“一清胶囊”治疗的疗效分析。方法对2006年3月至2006年7月本院儿科门诊就诊的212例患儿,采用随机对照原则进行分组,分为治疗组与对照组。治疗组与对照组的比例为1:1。治疗组:门诊常用抗生素加一清胶囊,3岁以下婴幼儿每次0.5粒,>3岁每次1粒,>7岁每次可服2粒,均为每日3次,3天为一疗程。对照组:抗生素加病毒唑,必要时加解热药。结果两组有效率比较,χ2=32.60,P<0.01,两组疗效比较,治疗组有效率为100%,而对照组有效率为75.50%,经统计学处理P<0.01,两组有效率差异有统计学意义。治疗组疗效优于对照组。结论一清胶囊对治疗呼吸道感染疗效确切,医疗同道们不妨一试。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.     

Scientific principles and rigorous processes should be followed in developing clinical guidelines for therapeutic interventions of integrative medicine

A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care（~＇4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.