共查询到20条相似文献,搜索用时 15 毫秒
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It is known that patients with rheumatoid arthritis (RA) have an increased risk for non-Hodgkin’s lymphomas in comparison
with the general population. Although increased risk of lymphoma is attributed to the disease activity, the drugs used in
the therapy of RA may also cause increased risk of malignancy. Herein, we report on an RA patient who developed non-Hodgkin’s
lymphoma after methotrexate therapy and review the literature about it. A 74-year-old man with RA had been treated with low-dose
methotrexate and subsequently developed anaplastic large cell lymphoma of the T-cell phenotype. Anaplastic large cell lymphoma
has been reported rarely in rheumatoid arthritis. 相似文献
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Anaplastic large cell lymphoma in a patient with MAGIC syndrome: a case and review of the literature
Chen Zhe Zhang Shangzhu Wang Li Fei Yunyun Shen Min Wu Huanwen Liu Jinjing Zheng Wenjie 《Clinical rheumatology》2021,40(5):2075-2082
Clinical Rheumatology - Mouth and genital ulcer with inflamed cartilage syndrome (MAGIC syndrome) is a rare autoinflammatory disorder with unknown etiology. Except for the common clinical... 相似文献
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Anti TNF-alpha drugs seem to be the new frontier of Rheumatoid Arthritis (RA) therapy. The association infliximab methotrexate has been approved for the treatment of RA not responding to the classic therapy, but the short clinical experience in using antiTNF-alpha molecules brings to segnalation of new risks or adverse events. We describe a case of a patient, treated for many years with classic RA therapy, which developed a refractory anemia after treatment with association infliximab-methotrexate. 相似文献
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Kisacik B Akdogan A Maras Y Kalyoncu U Karadag O Kilickap S Calguneri M 《Rheumatology international》2008,28(9):909-911
Anaplastic large-cell lymphoma (ALCL) is a rare T-cell lymphoma and typically is seen in children and young adults. Primary bone infiltration of ALCL is exceedingly rare. Herein we report ALCL of bone in a pregnant admitted with symmetric polyarthritis. Magnetic resonance imaging of the pelvis revealed soft tissue component of that destructive mass lesion on the right iliac crest after delivery. Excisional biopsy from the destructive mass showed anaplastic large cell lymphoma (CD 30 was positive and ALK negative). The patient was treated with combination chemotherapy consisting of cyclophosphamide, doxorubicin, vincristine and prednisolone (CHOP) every 4 weeks. After the third cycle of chemotherapy, a marked improvement of her arthritis and right iliac pain was noted. 相似文献
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Triantafillidis JK Cheracakis P Sklavaina M Apostolopoulou K 《Scandinavian journal of gastroenterology》2002,37(7):863-865
Pyoderma gangrenosum is an extraintestinal manifestation of inflammatory bowel disease requiring meticulous medical and/or surgical treatment. We describe a 46-year-old patient who developed harsh pyoderma gangrenosum during a severe flare-up of the underlying Crohn disease of the terminal ileum. The patient responded favorably to treatment with infliximab-the chimeric antibody against tumor necrosis factor-alpha. The drug was administered intravenously at a dose 5 mg/kg/BW at baseline and weeks 2 and 6. Abdominal signs and symptoms as well as the skin lesions improved markedly before the second infusion. The patient is presently on infliximab maintenance regimen at a dose of 5 mg/kg/BW being administered as a 3 dose loading regimen at 0, 2 and 6 weeks with a treatment-free interval of 10 weeks until the next loading dose. The skin lesions remained in remission. Infliximab is a promising therapeutic modality for patients with Crohn disease and pyoderma gangrenosum. 相似文献
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