多巴酚丁胺负荷试验~（99m）Tc－MIBI心肌断层显像的临床应用

为了评价多巴酚丁胺负荷试验９９ｍＴｃ－ＭＩＢＩ心肌单光子发射型计算机断层（ＳＰＥＣＴ）显像检测冠心病的准确性，对比了２１例（２２例次）临床确诊或可疑冠心病患者的多巴酚丁胺负荷试验９９ｍＴｃ－ＭＩＢＩ心肌ＳＰＥＣＴ显像与冠状动脉造影的结果。有明显冠状动脉狭窄的１２例患者，１１例多巴酚丁胺９９ｍＴｃ－ＭＩＢＩ心肌ＳＰＥＣＴ异常；冠状动脉造影正常的７例患者，其中６例心肌ＳＰＥＣＴ正常。多巴酚丁胺９９ｍＴｃ－ＭＩＢＩ心肌ＳＰＥＣＴ检测冠心病的灵敏度为９２％（１１／１２），特异性为８６％（６／７）。初步表明，多巴酚丁胺药物负荷试验９９ｍＴｃ－ＭＩＢＩ心肌ＳＰＥＣＴ显像是安全的，对于检测冠状动脉病变有较高的灵敏度和特异性，具有较好的临床应用前景。     

冠状动脉造影与~（99m）Tc－MIBI心肌灌注断层显像诊断冠心病对比分析

为比较冠状动脉造影和９９ｍＴｃ－ＭＩＢＩ心肌灌注断层显像在诊断冠心病中的作用。１１６例患者均行冠状动造影和９９ｍＴｃ－ＭＩＢＩ心肌灌注断层显像。最终诊断：冠心病９１例，其他心脏病１５例，无器质性心脏病者１０例。９１例冠心病中，有９０例核素心肌显像呈阳性，１０例无器质性心脏病患者９例核素心肌显像呈阴性。提示：对于诊断冠心病，心肌灌注单光子发射计算机断层显像（ＳＰＥＣＴ）的敏感性和特异性分别为９９％和９０％。冠状动脉造影与心肌ＳＰＥＣＴ均阳性者，冠心病确诊无疑；均阴性者，可予排除；单纯冠状动脉造影阳性或ＳＰＥＣＴ阳性者，临床上需细心诊断     

~（99m）Tc－MIBI心肌断层显像硝酸异山梨酯试验对心肌存活的评价

采用９９ｍ锝─甲氧基异丁基腈异（９９ｍＴｃ－ＭＩＢＩ）结合硝酸异山梨酯静脉滴注，对２９例心肌梗塞患者进行心肌断层显像。所有患者均进行静态心肌断层显像，然后静脉给予硝酸异山梨酯，达到标准后给予９９ｍＴｃ－ＭＩＢＩ，１．５ｈ后以与静态显像相同的条件采集和处理。结果显示，静态心肌显像有３８．３％的节段呈现为灌注异常区，给予硝酸异山梨酯后有３９％的节段心肌灌注得到改善。结果表明，硝酸异山梨酯静脉输入能明显改善９９ｍＴｃ－ＭＩＢＩ对心肌梗塞患者心肌存活的探测效果。     

99mTc-MIBI 心肌灌注断层显像诊断病毒性心肌炎的初步观察

为了探讨Ｔｃ－９９ｍ－甲氧基异丁基异腈（９９ｍＴｃ－ＭＩＢＩ）心肌灌注断层显像在病毒性心肌炎诊断中的应用价值，对１３０例病毒性心肌炎患者及３５例对照组行９９ｍＴｃ－ＭＩＢＩ单光子发射断层（ＳＰＥＣＴ）心肌灌注显像，分析重建后的断层图像，按是否有花斑样改变和灶性放射性稀疏，将患者再分为阳性和阴性两组，分析两组的年龄及性别构成，计算并比较阳性组、阴性组及对照组的心／肝计数比及心腔／心肌计数比。结果发现:３５例对照组心肌灌注显像正常，７１例患者出现阳性结果，阳性率为５４．６％，阳性组患者年龄轻、男性多、心／肝比及心腔／心肌计数比明显低于阴性组及对照组。结果提示９９ｍＴｃ－ＭＩＢＩ心肌灌注断层显像有助于病毒性心肌炎的诊断。     

冠状动脉造影与^99mTc—MIBI心肌灌注断层显像诊断冠心病对比分析

为比较冠状动脉造影和＾９９ｍＴｃ－ＭＩＢＩ心肌灌注断层显像在诊断冠心病中的作用。１１６例患者均行太动造影和＾９９ｍ－Ｔｃ－ＭＩＢＩ心肌灌注断层显像。最终诊断；冠心病９１例，其他心脏病１５例，无器质性心脏者１０例。９０例冠心病中，有９０例核素心肌显像呈阳性，１０例无器质性现患者９例核素心肌显像呈阴性。     

多巴酚丁胺负荷试验^99mTc—MIBI心肌断层显像的临床应用

为了评价多巴酚丁胺负荷试验＾９９ｍ－Ｔｃ－ＭＩＢＩ心肌单光子发射型计算机断层显像检测冠心病的准确性，对比了２１例临床确诊或可疑冠心病患者的多巴酚丁胺负荷试验＾９９ｍＴｃ－ＭＩＢＩ心肌ＳＰＥＣＴ显像与冠状动脉造影的结果。     

多巴酚丁胺与潘生丁^99mTc—MIBI心肌显像诊断冠心病价值的比较

为比较多巴酚丁胺（Ｄｏｂｕ－ＥＣＴ）和潘生丁（Ｄｉｐｙ－ＥＣＴ）＾９９ｍＴｃ－ＭＩＢＩ心肌显像诊断冠心病的价值，以冠状动脉造影为标准，对２１０例拟诊与确诊冠心病患者行药物负荷＾９９ｍＴｃ－ＭＩＢＩ心肌显像，其中Ｄｏｂｕ－ＥＣＴ１００例，Ｄｉｐｙ－ＥＣＴ１１０例。诊断冠心病的敏感性，特异性，阳性预测值和阴性预测值，Ｄｏｂｕ－ＥＣＴ和Ｄｉｐｙ－ＥＣＴ（分别为９３．３％对９５．５％，８０％对８９．２％，     

Isoket介入^99mTc—MIBI心肌显像法检测犬心肌存活力

目的通过动物实验探讨二硝酸异山梨醇酯（Ｉｓｏｋｅｔ）介入９９ｍＴｃ－ＭＩＢＩ显像在心肌存活力估测中的价值。方法用结扎左冠状动脉前降支的方法制成９只犬心肌梗死模型，随机分为三组（Ⅰ、Ⅱ、Ⅲ组）分别于冠状动脉结扎１．５ｈ、３．０ｈ、６．０ｈ再灌注。对９只犬心肌梗死再灌注模型进行静息９９ｍＴｃ－ＭＩＢＩ、Ｉｓｏｋｅｔ介入９９ｍＴｃ－ＭＩＢＩ心肌断层显像。结果３组犬在静息心肌显像中的１９、２３、２５个放射性分布异常节段各有１０个节段出现放射性填充，分别占５２．６％、４３．３％、４０．０％，Ｉｓｏｋｅｔ介入后，三组犬的放射分布得分亦降低。结论Ｉｓｏｋｅｔ能明显提高９９ｍＴｃ－ＭＩＢＩ对心肌存活力的估计，Ｉｓｏｋｅｔ介入９９ｍＴｃ－ＭＩＢＩ显像是评估心肌存活力的实用方法。     

~(99m)Tc-MIBI心肌显像心肌活力评估及在冠脉成形术中的应用研究

目的　探讨有效提高常规静息９９ｍＴｃ－甲基异丁基异腈（ＭＩＢＩ）心肌显像检测存活心肌的方法,评价该方法在血管成形术中评估存活心肌的价值。方法分别对２０例、３０例和１０例冠心病病人血管成型术前和术后进行,（１）静息－含服硝酸甘油介入,（２）静息－门控,（３）静息－延迟（４ｈ）９９ｍＴｃ－ＭＩＢＩ心肌显像。结果 ３种方法评估存活心肌阳性预测值分别为９５．９％、６８．５％和８４．１％;阴性预测值分别为６８．２％、９０．１％和９０．０％;预测准确率分别为８２．５％、７７．３％和８７．２％。结论（１）～（３）种显像方法有效地提高了常规静息９９ｍＴｃ－ＭＩＢＩ心肌显像为血管成形术适应证的选择和临床评估其疗效提供了客观依据。     

^99mTc—MIBI心肌平面显像和断层显像对冠心病诊断价值的比…

对３０例临床为冠心病、心绞痛患得的＾９９ｍＴｃ－ＭＩＢＩ心肌平面与断层显像进行了对比研究，所有的人均做了冠状动脉造影检查，结果提示，平面显像与断层显像的特异性一致为９１．７％，灵敏度分别为８７．５％与９５．８％，主要是平面显像对三支病变的检出率低下断层。     

99mTc-MIBI心肌灌注断层显像与心电图对冠心病的诊断价值

目的评估^99mTc—MIBI心肌灌注断层显像与心电图（ECG）在冠心病（CAD）诊断的价值。方法对28例冠心病和可疑冠心病患者进行心电图检查和^99mTc—MIBI心肌灌注断层显像（同时采用半定量方法分析患者左心室心肌血流灌注情况），其中13例患者行冠状动脉造影术（CAG）。结果心肌灌注断层显像与ECG阳性率分别为42．9％、53．6％，两者阳性率间差异无显著性意义（P〉0．05）。ECG诊断冠心病的敏感性为3／3，特异性为3／10，阳性预测值为3／10，阴性预测值为3／3，准确度为6／13。心肌灌注显像诊断冠心病的敏感性为3／3，特异性为8／10，阳性预测值为3／5，阴性预测值为8／8，准确度为11／13。心肌灌注断层显像和ECG与CAG阳性率间差异均无显著性意义（P〉0．05）。结论^99mTc—MIBI心肌灌注层显像与心电图是安全、无创伤、方便及费用低的检查方法，临床联合应用对冠心病的诊断、治疗和预后判断有重要的价值。     

腺苷负荷试验心肌灌注显像在老年人冠心病中的临床应用

目的 评价腺苷负荷试验心肌灌注显像在诊断老年人冠心病的准确性及临床应用的特点.方法 63例临床疑诊冠心病或已诊断但病情不稳定需介入治疗老年患者,住院后分别行腺苷负荷试验心肌灌注显像和冠状动脉(冠动)造影检查.腺苷负荷试验心肌灌注采用单光子发射断层显像图像采集系统,腺苷以140μg·kg-1·min-1静脉注射,用药时间6 min,注射过程中全程监测心电图、血压及患者的症状.于注射腺苷3 min末,静脉注射核素显像剂99cm Tc-MIBI 925 MBq,1.5 h后行心肌灌注断层显像,若显像异常,次日行静息心肌显像.冠脉造影按常规程序,在腺苷负荷试验心,肌灌注显像前后1周内进行.结果 63例中,53例冠脉造影阳性,10例阴性,而腺苷负荷试验心肌灌注显像51例阳性,7例阴性.腺苷负荷试验心肌灌注显像诊断老年人冠心病的总体敏感性为96.2%,特异性为70.0%,阳性预测值94.4%,阴性预测值77.8%,准确性为92.1%.53例冠脉造影显示,冠脉狭窄病变中,单支病变29例,二支14例,三支10例;累及左前降支(LAD)44支,左回旋支(LCX)18支,右冠脉(RCA)25支.腺苷负荷试验心肌灌注显像判断血管病变以LAD敏感性最高,达到95.5%;RCA次之,为84.0%;LCX最差,仅为55.6%;但特异性可达100%.监测过程中,32例(50.0%)患者发生胸闷、胸痛、头晕、头痛等不良反应,无严重事件发生.结论 腺苷负荷心肌灌注显像诊断老年人冠心病的敏感性、特异性高,尤其对探查和定位严重的冠脉病变准确性更高;腺苷负荷试验过程中副作用小,且因检查无创,因此在老年人冠心病的临床诊断应用中具有重要的价值.     

99mTc－MIBI心肌灌注平面显像潘生丁试验在冠心病诊断中的价值

为了进一步证实９９ｍＴｃ－ＭＩＢＩ心肌灌注显像潘生丁试验对冠心病诊断的价值，我们采用国产ｒ照相机及计算机系统对４２例有胸痛症状的住院病人进行了９９ｍＴｃ－ＭＩＢＩ心肌灌注平面显像潘生丁试验和冠状动脉造影检查的对比研究。以冠状动脉造影结果分组，４２例受试者中２７例冠脉管腔有≥５０％的狭窄，男性２５例，女性２例，平均年龄５３．７０±８．５７岁。另外１５例冠脉造影正常，男性８例，女性７例，平均年龄５２．７３±１０．１０岁，作为正常对照组。潘生丁负荷为：０．７ｍｇ／ｋｇ×４ｍｉｎｉｖ，ＧＺＡ－１型ｒ照相机及计算机对心肌灌注显像图进行采集，平滑及灰阶开窗处理，由两名有经验的医师读片。结果表明：９９ｍＴｃ－ＭＩＢＩ心肌灌注平面显像对冠心病诊断的灵敏度为９６．３０％（２６／２７）；特异性为８０．００％（１２／１５）；对识别冠脉单支、双支、三支病变的灵敏度分别为１００％（１６／ｌ６）、８０．００％（４／５）和１００％（６／６）；全组共有４４支血管出现有意义的狭窄（≥５０％），心肌显像图上有３３支血管相应供血区出现放射性稀疏缺损，即检出病变血管的灵敏度为７５．００％（３３／４４）。对ＬＡＤ、ＬＣＸ、ＲＣＡ病变的检出率分别为９?     

腺苷负荷心肌灌注显像141例临床分析

目的:腺苷负荷心肌灌注显像(MPI)与冠状动脉造影(CAG)2种检查方法的结果对比分析。方法:对141例患者分别行腺苷负荷MPI及CAG检查,并使用校正的TIMI血流分级(CTFC)方法评价冠状动脉血流速度。对2种方法的检查结果进行比较分析。结果:腺苷负荷MPI阳性的99例患者中,经CAG检查确诊冠心病者52例,冠状动脉慢血流(CSF)者37例,冠状动脉正常者10例。腺苷负荷MPI对冠心病诊断的灵敏度和特异度为92.9%和44.7%;对CSF诊断的灵敏度和特异度为82.2%和75.0%。结论:腺苷负荷MPI阳性者中一部分为冠心病患者,一部分为CSF者,对于腺苷负荷MPI异常的患者需进一步行CAG检查以明确病情。     

腺苷负荷心肌灌注显像在冠心病诊断中的应用

目的:评价腺苷负荷心肌灌注显像试验对冠心病的诊断价值。方法:60例住院患者均行腺苷负荷心肌灌注显像和冠状动脉造影(CAG),腺苷以0.14mg/(kg.min)的速度外周静脉输入,第3分钟时,静脉注射放射性核素99mTc-MIBI740MBq,1.5h后进行心肌断层显像,若异常,次日行静息心肌显像,分析腺苷负荷试验心肌核素显像对于冠心病诊断的敏感性、特异性及其特点。结果:CAG阳性42例中,心肌核素显像阳性37例(敏感性88%)。18例CAG无明显狭窄,其中13例心肌核素显像阴性(特异性为72%)。前降支病变36例,心肌核素前壁区域低灌注20例,回旋支病变22例,侧壁区域低灌注14例,右冠脉病变28例,下壁区域低灌注27例,右冠脉病变较前降支或回旋支病变的心肌核素显像阳性率高(P0.05)。在应用过程中,腺苷未出现明显不良反应。结论:腺苷负荷试验心肌核素灌注显像对于冠心病诊断的敏感性、特异性较高,对诊断冠心病具有重要意义。     

100例~(99m)Tc-MIBI心肌灌注断层显像与冠状动脉造影的对比

本文报道100例~(99m)Tc-甲氧异丁异腈(MIBI)心肌灌注断层显像(SPECT)与冠状动脉造影对比的结果。~(99m)Tc-MIBI心肌SPECT对冠心病诊断敏感性为96%,特异性为83%,如排除心肌梗塞病例,对单纯心绞痛患者诊断的阳性率为88%,对左前降支的诊断阳性串为86%,左回旋支为69%,右冠状动脉86%,总的阳性预测值96%。阴性预测值84%。此外,对6例左冠状动脉主干病变,分析了核素显像特点。总之,~(99m)Tc-MIBI心肌SPECT对冠心病的诊断有较大价值。     

Identification of hemodynamically significant coronary artery stenoses by dipyridamole-magnetic resonance imaging and99mTc-methoxyisobutyl-isonitrile-SPECT

Magnetic resonance imaging (MRI) has been used in conjunction with dipyridamole induced wall motion abnormalities for the noninvasive detection of coronary artery disease (CAD). To assess the clinical usefulness of dipyridamole-MRI for the localization of CAD and to evaluate the relation between dipyridamole induced wall motion abnormalities and myocardial perfusion 33 patients with severe CAD (>70% diameter reduction) underwent MRI at rest and after dipyridamole infusion (0.75 mg dipyridamole/kg over a period of 10 minutes). All patients performed exercise stress testing and 20 patients of the study group additionally had rest and exercise stress^99mTc-methoxyisobutyl-isonitrile-SPECT (MIBI-SPECT). Two patients (6%) could not be evaluated due to severe motion artifacts during dipyridamole MRI.Segmental wall motion and perfusion of corresponding short axis planes were related to the major coronary arteries using a standardized segmental coronary artery perfusion pattern. Detection of wall motion abnormalities or perfusion defects by 2 blinded observers in consensus was the criterion for grading a segment normal or pathologic. For localization of CAD, segmental gradings were related to the presumed coronary artery territories.Stress-ECG was pathologic in 19/31 patients yielding a sensitivity of 61% and dipyridamole induced angina was present in 68% (21/31) of patients. Dipyridamole-MRI detected coronary artery disease with a sensitivity of 84% (26/31 patients) and all patients with new wall motion abnormalities also had dipyridamole induced angina. For the subgroup of 20 patients with MIBI-SPECT images, CAD was detected by both MIBI-SPECT and Dipyridamole-MRI in 90% (18/20) of patients. Dipyridamole-MRI and MIBI-SPECT gradings agreed in 55/60 (92%) coronary artery perfusion territories. There were no significant differences with respect to the sensitivities of Dipyridamole-MRI/MIBI-SPECT for the localization of individual coronary artery stenoses yielding 81%/78% for left anterior descending, 80%/80% for left circumflex and 92%/89% for right coronary artery stenoses. However, specificity of Dipyridamole-MRI (89%) for the detection of RCA stenoses was slightly better than for MIBI-SPECT (80%).Dipyridamole-MRI induced regional wall motion abnormalities proved to be a highly sensitive parameter for the non-invasive localization of CAD. The similarity of dipyridamole-MRI and MIBI-SPECT results suggests a close agreement between functional and perfusion parameters in the assessment of hemodynamically significant coronary artery stenoses. The clinical utility of this MRI stress test is still limited by high cost and long imaging times which may, however, be overcome by the development of new shorter imaging sequences.Abbreviations CAD coronary artery disease - MRI magnetic resonance imaging - MIBI-SPECT 99mTc-methoxyisobutyl-isonitrile-SPECT     

Acute beta-blockade reduces the extent and severity of myocardial perfusion defects with dipyridamole Tc-99m sestamibi SPECT imaging

OBJECTIVES: The goal of this study was to examine the effect of acute beta-blockade on dipyridamole Tc-99m sestamibi myocardial perfusion imaging (DMPI). BACKGROUND: Studies suggest that antianginal drugs may reduce the presence and severity of myocardial perfusion defects with dipyridamole stress. However, there are no data regarding specific drugs. METHODS: Patients with catheterization-proven coronary artery disease (CAD) were enrolled in this prospective, double-blind, placebo-controlled study and randomly assigned to DMPI after placebo, low-dose metoprolol (up to 10 mg), and high-dose metoprolol (up to 20 mg). Patients underwent one Tc-99m sestamibi study at rest on a separate day. The interval between DMPI studies was 相似文献   

硝酸甘油介入99 mTc-MIBI心肌断层显像对存活心肌的评价

为评价硝酸甘油（NTG）介入99m锝-甲氧基异丁基异脯（99mTc－MIBI）心肌显像估测存活心肌的价值，对24例心肌梗死病人不同日行两种方案的99mTc－MIBI心肌显像：一种在静息状态进行，另一种在舌下含服NTG0．6mg后进行。8例经皮腔内冠状动脉成形术（PTCA）的病人术后2～4周随访了99mTc－MIBI静息显像。结果显示，99mTc－MIBI静息显像有118个心肌节段摄取正常，98个摄取异常（16个节段摄取减低，82个摄取严重减低），在98个摄取异常的节段中，NTG介入99mTc－MIBI显像有39个（39．80％）节段摄取增加。8例行PTCA的病人，NTG介入99mTC－MIBI显像证实为可逆性缺损的心肌节没有84．21％在PTCA后心肌灌注改善（存活心肌），而为NTG介入99mTc－MIBI显像证实为不可逆性缺损的心肌节段有88．24％在PTCA后心肌灌注无改善。NTG介入99mTc－MIBI显像预测存活心肌的准确性为86．11％。表明，NTG介入99mTc－MIBI心肌显像可提高缺血但存活心肌的检出率。     

Comparison of stress/rest myocardial perfusion tomography, dipyridamole and dobutamine stress echocardiography for the detection of coronary disease in hypertensive patients with chest pain and positive exercise test.

OBJECTIVES: Although different noninvasive tests have been proposed for detecting coronary artery disease (CAD) in patients with hypertension and chest pain symptoms, the relative performance of the available techniques has not been systematically assessed. BACKGROUND: Patients with hypertension frequently complain of chest pain and exhibit ischemic-like ST segment changes on the exercise electrocardiogram (ECG). However, the specificity of such changes for predicting significant CAD is very low, because these patients often exhibit a normal coronary angiogram. METHODS: In 101 patients with hypertension, chest pain and positive exercise ECG, we performed stress/rest myocardial single photon emission computed tomography with 99mTc-MIBI, dipyridamole and dobutamine stress echocardiography and coronary angiography. All patients had normal global ventricular function and 57 had left ventricular hypertrophy. All were kept on ACE inhibitors during the study period. RESULTS: No patients had significant side effects during perfusion scintigraphy. Dose-limiting side effects were observed in five patients with dipyridamole and in seven patients with dobutamine. Only 56% of study patients exhibited significant CAD. Sensitivity, specificity, accuracy, positive and negative predictive values were, respectively, 98%, 36%, 71%, 67% and 94% for perfusion scintigraphy, 61%, 91%, 74%, 90% and 64% for dipyridamole and 88%, 80%, 84%, 85% and 83% for dobutamine stress echocardiography. CONCLUSIONS: This study shows that stress echo in patients with hypertension yields a satisfactory diagnostic accuracy for identifying significant epicardial CAD. Our results indicate that dobutamine might be superior to dipyridamole. The low specificity of myocardial scintigraphy probably relates to the fact that this method traces perfusion abnormalities, not necessarily caused by epicardial CAD, possibly due to microvascular disease and not causing obvious wall motion abnormalities.