早期糖尿病视网膜病变与视觉诱发电位相关研究

目的分析图形视觉诱发电位(P-VEP)与早期糖尿病视网膜病变(DR)之间的关系,研究P-VEP对早期DR的诊断作用。方法对30例(60只眼)正常人和80例(160只眼)糖尿病患者进行P-VEP检测。结果DR患者眼底尚未出现改变时,P-VEP的LP100、AP100差异有统计学意义,但与DR进展无明显相关性。结论 P-VEP的相关参数能够在眼底尚未出现明显病变之前预测DR的发生,但与DR的发展无显著相关性,在DR的早期诊断有一定的临床应用价值。     

甲状腺相关眼病图形视觉诱发电位的研究

目的了解图形视觉诱发电位(P-VEP)在甲状腺相关眼病视神经病变(DON)早期诊断中的应用价值.方法随机选取39例甲状腺相关眼病(TAO)和30例正常对照进行P-VEP检查.结果P-VEP的改变主要为P1振幅(PA)的降低(P＜0.05).结论P-VEP比较敏感地反映TAO视神经功能的变化,可作为DON早期诊断的敏感指标.     

糖尿病视网膜病变前期视网膜电图和视觉诱发电位分析

目的:分析糖尿病视网膜病变(diabetic retinopathy,DR)前期闪光视网膜电图(flash electroretinogram,FERG)和图形视觉诱发电位(pattern visual potential,PVEP)各参数的变化,寻找DR前期的诊断指标。方法:采用国际标准法对20例(40眼)正常人进行闪光视网膜电图(FERG)和图形视觉诱发电位(PVEP)检测,对20例(40眼)糖尿病(diabetes mellitus,DM)进行眼底荧光血管造影(fluorescence fundus angiography,FFA)、FERG和PVEP检测。结果:DM患者FERG、PVEP与对照组之间有差异,表现为Rod-R a,b波幅值、Max-R a,b波幅值、Cone-R a波幅值显著降低(P<0.01);Cone-R b波幅值,OPs总幅值、P100波幅值降低(P<0.05);P100波潜伏值的延迟(P<0.01)。结论:DM组在眼底尚无病变前,其FERG,PVEP已出现异常,因此FERG,PVEP是DR前期诊断的重要指标。     

视觉诱发电位在糖尿病视网膜病变诊断中的应用

目的:探讨图形视觉诱发电位(P-VEP)与糖尿病视网膜病变(diabetic retinopathy,DR)的关系。方法:对正常对照者及糖尿病患者分别测P-VEP潜伏期LN75、LP100、LN145及波幅AN75、AP100、AN145。结果:糖尿病患者视网膜尚未出现病变时,P-VEP的潜伏期已明显延迟,随着糖尿病视网膜病变程度的进一步发展,P-VEP潜伏期进一步延迟,但未达显著性差异。DR及各期波幅下降不显著。P-VEP的潜伏期及波幅与视力无关,糖尿病病程早期潜伏期已明显延长,P-VEP波幅与病程无关。结论:糖尿病早期P-VEP潜伏期即有明显延长,P-VEP潜伏期比波幅具更好的临床使用价值。     

图像反转视觉诱发电位和闪光视觉诱发电位的相互关系之探讨

图像反转视觉诱发电位(以下简称P-VEP)和闪光视觉诱发电位(以下简称F-VEP)是视觉诱发电位(以下简称VEP)的两种基本形式。由于它们所采用的刺激方式不同,因此     

视觉诱发电位监测二硫化碳毒性视网膜病变

目的　探索使用图形视觉诱发电位 (VEP P)早期诊断二硫化碳 (CS2 )中毒性视网膜病变的可能性。方法　选择不同程度接触CS2 5年以上者 1 1 6人 (2 32眼 ) ,并以非接触者 32人 (64眼 )作对照组 ,检测P VEP,并根据接触的不同方式及浓度分组研究。比较各组VEP PP1 0 0 波波幅及潜伏时、潜时值差、波幅差值及A/L值。结果　每日长时间接触CS2 的中、低浓度组的VEP PP1 0 0 波波幅 (8.37±3 .2 0 ) μV及 (7.95± 3.34) μV ,较非接触组的 (9.64± 3.2 5) μV明显下降 (P <0 .0 5;P <0 .0 1 ) ,其A/L值降低。结论　VEP P有助于CS2 中毒性视网膜病变及视神经病变的早期诊断     

不同时期糖尿病视网膜病变患者视网膜电图、视觉诱发电位的变化分析

目的观察不同时期糖尿病视网膜病变患者(DR)视网膜电图、视觉诱发电位的变化。为预防DR的发生及病情监测提供依据。方法对不同时期糖尿病DR共37例(74只眼)进行分组,第一组:眼底正常组20只眼,第二组:非增生期糖尿病视网膜病变30只眼,增殖期糖尿病视网膜病变24只眼为第三组,正常人10例(20只眼)设为对照组,进行ERG、振荡电位OPs和VEP检测并记录。结果OPs:三个组的振幅总和(Σ0)和对照组比较均有明显差异(P<0.05)。ERG:第一组和对照组比较,a波、b波的峰值期延长,有明显差异(P<0.05);第二组与第三组分别与对照组比较,a波、b波的峰值期延长及波幅降低有明显差异(P<0.05);并且第二组与第三组间比较,a波、b波的峰值期延长及波幅降低也有明显差异(P<0.05),全视网膜光凝治疗前后a、b波峰值期时间延长,差异有显著意义(P<0.05)。VEP:第二组及第三组P_(100)波潜伏期延长,与对照组比较有显著意义(P<0. 05)。结论OPs是目前诊断早期DR较敏感的指标,ERG a、b波峰值期的延长和振幅的变化可成为监测DR发展的指标,DR后VEP的改变主要是潜伏期的延长。     

前部缺血性视神经病变的图形视觉诱发电位改变

前部缺血性视神经病变 ( anterior ischemic opticneuropathy,AION)是以视力急性下降 ,视盘缺血水肿 ,视野水平盲或象限盲为临床特征的眼底病。多发生在中老年人 ,常伴有高血压、动脉硬化、糖尿病、颈动脉疾病等血管性疾患 [1 ] 。为了进一步了解该病的临床特点 ,我们对 31例 AION患者的 37只患眼进行了图形视觉诱发电位 ( pattern visual evokedpotential,P- VEP)检测 ,现将结果报告如下。1　对象和方法2 0 0 1年 1月～ 2 0 0 2年 6月我院住院的 AION患者 31例 ,其中男 12例 ,女 19例 ;右眼 16例 ,左眼 9例 ,双眼 6例 ,共 37只患眼…     

The North Jutland County Diabetic Retinopathy Study (NCDRS)

Purpose: This study set out to map the associations between retinal lesions, visual acuity (VA) and the presence of clinically significant macular oedema (CSMO) in diabetes subjects. Methods: This cross‐sectional study comprised 656 type 1 and 328 type 2 diabetes subjects undergoing retinopathy screening in the County of North Jutland, Denmark. Numbers of specific retinal lesions were quantified from retinal photographic recordings. Associations between CSMO, number of specific retinal lesions and VA were established. The percentages of eyes with CSMO ascribed to retinal lesions were calculated. Results: The presence of CSMO, number of specific retinal lesions and VA were all significantly associated. The parameter with the highest statistical association with CSMO measured by Spearman’s correlation coefficient was hard exudates (type 1: 0.524; type 2: 0.715), followed by microaneurysms (type 1: 0.298; type 2: 0.508), retinal haemorrhages (type 1: 0.227; type 2: 0.595), cottonwool spots (type 1: 0.207; type 2: 0.259) and VA (type 1: ? 0.137; type 2: ? 0,175). Conclusions: All retinal lesions are significantly associated with CSMO and together can predict for up to 42.3% (in type 1 diabetes) and 64.3% (in type 2 diabetes) of CSMO cases.     

外伤性视神经挫伤患者的图形视觉诱发电位分析

目的:探讨图形视觉诱发电位(PVEP)在眼外伤性视神经挫伤中的应用价值。方法:对49例临床诊断为外伤性视神经挫伤的单眼患者进行PVEP测定,并与自体健侧眼进行对照。结果:挫伤眼与自体健侧眼比较,P100波幅差异有极显著意义(P<0.01)、P100峰潜时与正常值比较有明显差异(P<0.01)。结论:PVEP对视神经挫伤的诊断有一定的临床价值。     

单眼先天性白内障患者的VEP观察

目的 对单眼先天性白内障患者伴随的弱视进行VEP研究，旨在了解视觉诱发电位在先天性白内障患者中的表现并探讨其在诊断及估计预后方面的价值。方法 对26例先天性单眼白内障患者进行术前和术后VEP检查、分析。结果 先天性白内障儿童患眼FVEP的振幅和潜伏时较正常眼无明显改变，而PVEP的振幅降低，潜伏时延长；闪光视觉诱发电位N2和P2的潜伏时治疗后无明显改变；图形视觉诱发电位P1oo的振幅在术后一年升高，潜伏时无明显改变。结论 PVEP可以发现先天性白内障患者中存在的弱视。并且对弱视程度的判断和治疗有一定的指导意义；而FVEP对弱视的诊断和治疗无明显意义。     

Multifocal Visual Evoked Potential (mfVEP) and Pattern-Reversal Visual Evoked Potential Changes in Patients with Visual Pathway Disorders: A Case Series

The purpose of this study was to evaluate multifocal visual evoked potential (mfVEP) and pattern-reversal visual evoked potential (PVEP) changes in patients with pathology at various levels of the visual pathway determined by other methods. Six patients with different visual pathway disorders, including vascular ischaemic events and compressive optic neuropathy, were reviewed. All patients were tested with both mfVEP and full-field and half-field PVEPs. Results were assessed in relation to other diagnostic tests such as magnetic resonance imaging, Humphrey visual field test, and optical coherence topography. The cases in this study demonstrate a potential higher sensitivity of mfVEP compared with conventional PVEPs in detecting lesions affecting the peripheral field, horizontal hemifields, and lesions of the post-chiasmal pathway. The limitation of the PVEP in this setting is probably due to phase cancellation and overrepresentation of the macular region. mfVEP provides a more accurate assessment of visual defects when compared with conventional PVEP. The independent assessment of different areas of the visual field improves the detection and localization of lesions and provides an objective topographical map that can be used in clinical practice as an adjunct to other diagnostic tests and to assess disease progression.     

Multifocal Visual Evoked Potential (mfVEP) and Pattern-Reversal Visual Evoked Potential Changes in Patients with Visual Pathway Disorders: A Case Series

Abstract

The purpose of this study was to evaluate multifocal visual evoked potential (mfVEP) and pattern-reversal visual evoked potential (PVEP) changes in patients with pathology at various levels of the visual pathway determined by other methods. Six patients with different visual pathway disorders, including vascular ischaemic events and compressive optic neuropathy, were reviewed. All patients were tested with both mfVEP and full-field and half-field PVEPs. Results were assessed in relation to other diagnostic tests such as magnetic resonance imaging, Humphrey visual field test, and optical coherence topography. The cases in this study demonstrate a potential higher sensitivity of mfVEP compared with conventional PVEPs in detecting lesions affecting the peripheral field, horizontal hemifields, and lesions of the post-chiasmal pathway. The limitation of the PVEP in this setting is probably due to phase cancellation and overrepresentation of the macular region. mfVEP provides a more accurate assessment of visual defects when compared with conventional PVEP. The independent assessment of different areas of the visual field improves the detection and localization of lesions and provides an objective topographical map that can be used in clinical practice as an adjunct to other diagnostic tests and to assess disease progression.     

Visual Field Abnormalities in Early-Stage Diabetic Retinopathy Assessed by Chromatic Perimetry

PurposeThe purpose of this study was to define the nature and extent of sensitivity loss using chromatic perimetry in diabetics who have mild or no retinopathy.MethodsThirty-four individuals with type II diabetes mellitus who have mild nonproliferative diabetic retinopathy (MDR; N = 17) or no diabetic retinopathy (NDR; N = 17) and 15 visually normal, non-diabetic controls participated. Sensitivity was assessed along the horizontal visual field meridian using an Octopus 900 perimeter. Measurements were performed under light- and dark-adapted conditions using long-wavelength (red) and short-wavelength (blue) Goldmann III targets. Cumulative defect curves (CDCs) were constructed to determine whether field sensitivity loss was diffuse or localized.ResultsSensitivity was reduced significantly under light-adapted conditions for both stimulus colors for the NDR (mean defect ± SEM = −2.1 dB ± 0.6) and MDR (mean defect ± SEM = −4.0 dB ± 0.7) groups. Sensitivity was also reduced under dark-adapted conditions for both stimulus colors for the NDR (mean defect ± SEM = −1.9 dB ± 0.7) and MDR (mean defect ± SEM = −4.5 ± 1.0 dB) groups. For both diabetic groups, field loss tended to be diffuse under light-adapted conditions (up to 6.9 dB loss) and localized under dark-adapted conditions (up to 15.4 dB loss).ConclusionsVisual field sensitivity losses suggest neural abnormalities in early stage diabetic eye disease and the pattern of the sensitivity losses differed depending on the adaptation conditions. Chromatic perimetry may be useful for subtyping individuals who have mild or no diabetic retinopathy and for better understanding their neural dysfunction.     

视网膜振荡电位和视觉诱发电位检测在糖尿病视网膜病变前期诊断中应用

目的:观察尚未发生眼底病变的糖尿病确诊患者在不同病程时期视网膜振荡电位(OPs)和视觉诱发电位(VEP)的变化情况。方法:采用国际标准法对35例70眼正常人进行OPs和VEP的检测,对94例188眼未发生眼底病变糖尿病确诊患者按病程长短分为3组,分别进行OPs和VEP的检测。结果:各实验组与对照组相比表现为OPs幅值的降低和VEP峰值降低,潜时值延长,P<0.01,有显著统计学差异。各实验组之间相比表现为病程越长OPs幅值越低和VEP峰值越低,潜时值越长,P<0.01,有显著统计学差异。结论:糖尿病患者在眼底尚无病变前,其OPs和VEP已经出现异常,并且随着糖尿病病程的延长,各项指标的变化更加明显。因此,采用OPs和VEP的联合检测可以为糖尿病视网膜病的早期诊断提供依据。