掌侧LCP结合Kapandji技术治疗背侧不稳定桡骨远端关节内骨折初步报道

目的 探讨掌侧锁定加压钢板(locking compression plate,LCP)结合Kapandji技术治疗背侧不稳定桡骨远端关节内骨折的方法 及疗效.方法 背侧不稳定桡骨远端关节内骨折患者43例,男17例,女26例;年龄42～65岁,平均57岁.按AO/ASIF分型,C1型26例,C2型16例,C3型1例.采用掌侧LCP结合Kapandji技术进行治疗.在Stewart等改良的Sarmiento评分基础上再次进行改良,从掌倾角、尺偏角、桡骨短缩和关节面台阶方面对桡骨远端影像学进行评估;采用Gartland-Werley功能评分对腕关节功能进行评估.结果 所有患者均获得随访,随访时间16～47个月,平均27个月.掌倾角由术前-19.3°±11.2°改善至术后8.1°±3.2°,尺偏角由术前-13.6°±4.1°改善至术后18.0°±8.2°,桡骨短缩由术前(6.2±2.8)mm改善至术后(0.2±0.2)mm,关节面塌陷由术前(5.5±4.3)mm改善至术后(0.1±0.2)mm.在Stewart等改良的Sarmiento评分基础匕再次进行改良的评分,优34例,良9例;Gartland-Werley功能评分,优18例,良22例,可3例.结论 掌侧LCP结合Kapandji技术是治疗背侧不稳定桡骨远端关节内骨折的一种有效方法 ,可有效防止复位丢失、肌腱激惹等并发症,减少结构性植骨及行早期关节活动.     

新型锁定加压钢板治疗老年桡骨远端C型骨折

目的 探讨新型2.4 mm锁定加压钢板(LCP)治疗老年桡骨远端C型骨折的初期疗效.方法 回顾性分析2006年10月至2008年11月采用新型2.4 mm LCP治疗21例老年桡骨远端C型骨折患者,男7例,女14例;年龄71～85岁,平均76岁.骨折按AO分型:C1型6例,C2型13例,C3型2例,均为闭合性骨折.所有患者均经掌侧入路复位固定,术中不显露背侧组织,骨缺损严重行置入人工骨.结果 所有患者获平均10.6个月(8～27个月)随访.X线片示骨折全部一期愈合,平均愈合时间为8周.2例骨缺损严重者,术中植入人工骨.所有患者均无感染、骨不连、钢板松动、腕管综合征等并发症发生.术后功能康复时间4～36周,平均11周.腕关节活动度:背伸23°～84°,平均71.3°;掌屈33°～86°,平均72.0°;尺偏19°～29°,平均26.3°;桡偏12°～30°,平均19.9°;前臂旋前60°～87°,平均79.5°;旋后52°～80°,平均76.4°.与健侧对比,握力减弱3例,活动后疼痛3例.按改良的Mcbride腕关节功能评价标准:优14例,良5例,可2例,优良率为90.5%.结论 新型2.4 mm LCP治疗老年骨质疏松引起的桡骨远端C型骨折,内固定坚强,可以早期功能锻炼,疗效佳.     

桡骨远端C型骨折掌侧锁定钢板与外固定架的疗效比较

目的比较掌侧锁定钢板与外固定架治疗桡骨远端C型骨折的疗效。方法采用随机对照法,纳入2014年10月到2017年10月收治的桡骨远端C型骨折患者,随机分为两组,分别采用外固定架或者掌侧锁定钢板治疗。比较两组患者手术时间、术中出血量、骨折愈合时间、术后并发症发生率;比较末次随访时患者腕关节活动度、桡骨掌倾角、尺偏角;比较健、患侧握力比值和患侧腕关节Gartland-Werley评分。结果共纳入30例患者,其中外固定架组14例,掌侧锁定钢板组16例。两组患者术后均随访1年。结果显示,掌侧锁定钢板组手术时间长于外固定架组,术中出血量多于外固定架组,但末次随访时桡骨掌倾角、尺偏角恢复水平优于外固定架组(P<0.05);两组骨折愈合时间,末次随访时腕关节屈伸、旋转活动度,健、患侧握力比,患侧腕关节Gartland-Werley评分等,均未见明显统计学差异(P>0.05);两组患者均未发生术后并发症。结论对于桡骨远端C型骨折,外固定架治疗的手术风险小于掌侧锁定钢板,但会造成术后一定程度的复位丢失,然而这种复位丢失并不影响患者的腕关节功能恢复。     

切开复位掌侧锁定加压钢板内固定治疗桡骨远端C型骨折效果分析

目的 探讨切开复位掌侧锁定加压钢板(LCP)内固定治疗桡骨远端C型骨折的临床效果。方法 回顾性分析内乡菊潭医院骨科2019-01—2020-11收治的76例桡骨远端C型骨折患者的临床资料。分为闭合复位外固定支架组(外固定支架组,40例)和切开复位掌侧LCP内固定组(LCP内固定组,36例)。比较2组手术时间、术中失血量、术后骨折愈合时间。统计术后随访6个月期间的并发症发生率。末次随访,评价腕关节功能和测量尺偏角、掌倾角、桡骨高度。结果 外固定支架组的手术时间、术中失血量、住院时间、术后骨折愈合时间均优于LCP内固定组,差异有统计学意义(P<0.05)。2组患者术后6个月随访期间的并发症发生率差异无统计学意义(P>0.05)。末次随访时,LCP内固定组患者的尺偏角、掌倾角、桡骨高度改善效果及腕关节功能优良率均优于外固定支架组,差异有统计学意义(P<0.05)。结论 对桡骨远端C型骨折患者,闭合复位外固定支架和切开复位掌侧LCP内固定术均可获得满意效果,其中闭合复位外固定支架术的创伤小,患者术后恢复快;而切开复位掌侧LCP内固定术有利于恢复患者的腕关节功能。应根据患者的年...     

LCP钢板与外固定架治疗C型桡骨远端骨折的疗效比较

  目的 比较LCP钢板与外固定架治疗C型桡骨远端骨折的疗效。方法 回顾性分析2007年10月至2010年10月分别采用LCP钢板和外固定架治疗C型桡骨远端骨折的病例。其中LCP组38例,男13例,女25例;年龄23~65岁,平均45.1岁;按AO/OTA分型：C1型15例,C2型18例,C3型5例。外固定组26例,男12例,女14例;年龄25~60岁,平均47.1岁;按AO/OTA分型：C1型11例,C2型13例,C3型2例。比较两组术后影像学指标、功能指标,并采用Gartland-Werley功能评分标准对术后疗效进行评估。结果 所有患者均获得随访,随访时间LCP组12~36个月,平均23.8个月;外固定组12~44个月,平均31.2个月。X线片均显示两组骨折全部愈合。两组患者尺偏角、桡骨高度、腕关节背伸、掌屈、尺偏、桡偏、旋前、旋后及Gartland-Werley评分均无显著性差异。LCP组掌倾角11.71°±3.02°,外固定组掌倾角7.15°±2.98°,LCP组优于外固定组。LCP组伤口感染2例,正中神经损伤1例,固定松动1例;外固定组钉道感染3例,固定松动1例,腕关节僵硬2例。结论 两种固定方式治疗C型桡骨远端骨折均可达到较为满意的临床效果,LCP钢板术后影像学结果稍好,固定可靠。临床可根据患者具体情况选择治疗方式。     

锁定加压钢板联合外固定架与单纯锁定加压钢板治疗C型桡骨远端骨折的疗效比较

目的比较锁定加压钢板联合外固定架和单纯锁定加压钢板治疗C型桡骨远端骨折的疗效。方法手术治疗60例C型桡骨远端骨折患者,按治疗方法分为锁定加压钢板联合外固定架组(联合组,30例)和单纯锁定加压钢板组(LCP组,30例)。比较两组手术相关指标、影像学指标及腕关节活动度、疼痛VAS评分、Gartland-Werley评分。结果联合组手术时间较LCP组长,但差异无统计学意义(P0.05)。患者均获得随访,时间24~36个月。术后3 d、6周、24个月随访时,联合组掌倾角、尺偏角、桡骨高度的改善优于LCP组,差异均有统计学意义(P0.05)。术后24个月两组腕关节掌屈、背伸活动度比较差异均无统计学意义(P0.05)。联合组VAS评分及Gartland-Werley评分稍优于LCP组,但差异均无统计学意义(P0.05)。结论锁定加压钢板联合外固定架与单纯锁定加压钢板治疗C型桡骨远端骨折效果均良好,但在掌倾角、尺偏角、桡骨高度恢复方面前者优于后者。     

两种内固定方法治疗桡骨远端骨折的疗效比较研究

目的 对比斜T型锁定加压接骨板系统(locking compression plate,LCP)及AO普通T型板钉系统治疗桡骨远端骨折的疗效.方法 对1999年3月至2009年12月我科收治的313例桡骨远端骨折患者中获得完整随访资料的72例(73侧),采用Sarmiento改良的Gartland-Werley评分系统(GW评分)进行术后功能评分,并比较LCP(LCP组)及AO普通T型板钉系统(普通组)内固定术后两组腕关节的功能.结果 术后随访时间为3个月至6年,平均25.4个月.X线片显示骨折全部愈合.GW评分LCP组平均1.98分,普通组平均1.43分,两组差异无统计学意义(P>0.05);两组在患者满意度上差异也无统计学意义(P>0.05).结论 对于绝大部分复位失败的桡骨远端A型骨折、移位明显的B型骨折及C型骨折,应用AO普通T型板钉固定就可满足手术需要,而对于骨质疏松严重的粉碎性C型骨折,LCP的内固定效果更为可靠.     

锁定加压钢板内固定治疗桡骨远端C型骨折

[目的] 探讨锁定加压钢板(LCP)内固定治疗桡骨远端AO分型C型骨折的初期疗效.[方法] 总结从2004年1月-2007年1月应用锁定加压钢板(LCP)内固定治疗桡骨远端C型闭合性骨折37例.手术采用掌侧入路,复位后于掌侧置入LCP钢板,在C型臂X线机透视下检查桡骨长度,桡骨关节面,掌倾角,及尺偏角复位情况,满意后置入锁定螺钉,必要时可以在临时固定下,前臂旋前位显露桡骨背侧组织,对于严重骨缺损者应予植骨.术后第1 d开始被动活动腕关节,1周后主动活动,功能锻炼.[结果] 全部获得随访,平均11个月(8～21个月).X线片显示骨折全部Ⅰ期愈合,平均愈合时间为8周,所有病例均无感染、骨不连、钢板松动、腕管综合征、正中神经炎等并发症.按改良的Mcbride腕关节功能评价标准:优25例,良8例,可4例,优良率为89.18%.[结论] 坚强内固 定下早期进行腕关节功能锻炼是治疗粉碎及不稳定桡骨远端骨折的有效措施,使用锁定加压钢板(LCP)内固定治疗桡骨远端C型骨折具有复位满意,固定坚强,可早期进行功能锻炼,关节功能恢复优良等优点.     

合并尺骨茎突骨折对桡骨远端骨折钢板内固定术后功能恢复的影响

目的探讨合并尺骨茎突骨折对桡骨远端骨折钢板内固定术后功能恢复的影响。方法将38例桡骨远端骨折患者按是否合并尺骨茎突骨折分为A组(合并尺骨茎突骨折,19例)和B组(不合并尺骨茎突骨折,19例)。观察术后及末次随访时腕关节影像学参数(掌倾角、尺偏角、桡骨茎突高度)、腕关节活动范围及Gartland-Werley腕关节评分。结果患者均获得随访,时间10～18个月。术后及末次随访时两组掌倾角、尺偏角及桡骨茎突高度比较差异无统计学意义(P 0. 05)。末次随访时,两组腕关节屈伸及前臂旋转活动范围及Gartland-Werley腕关节评分比较差异均无统计学意义(P 0. 05)。结论合并尺骨茎突骨折对桡骨远端骨折钢板内固定术后功能康复无明显影响。     

植骨内固定与闭合复位支架外固定治疗桡骨远端C型骨折疗效比较

目的：比较植骨内固定与闭合复位支架外固定治疗桡骨远端C型骨折的临床疗效。方法对38例桡骨远端C型骨折患者分别采用植骨内固定(17例)与闭合复位支架外固定(21例)治疗。比较两组术后影像学指标,腕关节功能按Gartland-Werley功能评分标准进行评价。结果患者均获得随访,时间6~18个月。术后3个月掌倾角、桡骨高度内固定组均优于外固定组,差异均有统计学意义( P<0．05)。末次随访腕关节背伸、掌屈、旋前、旋后及 Gartland-Werley 功能评分内固定组均优于外固定组,差异均有统计学意义( P <0．05)。腕关节功能评估：内固定组优6例,良9例,可2例,优良率15/17;外固定组优4例,良10例,可5例,差2例,优良率14/21;两组差异有统计学意义(P<0．05)。结论植骨内固定治疗桡骨远端C型骨折能达到理想复位,能有效防止骨折复位丢失和再移位,临床疗效优于闭合复位支架外固定。     

Vasopressor hormone response following mesenteric traction during major abdominal surgery

Background : We investigated the vasopressor hormone response following mesenteric traction (MT) with hypotension due to prostacyclin (PGI₂) release in patients undergoing abdominal surgery with a combined general and epidural anesthesia. Methods : In a prospective, randomized, placebo-controlled study we administered 400 mg ibuprofen (i.v.) in 42 patients scheduled for abdominal surgery. General anesthesia was combined with epidural anesthesia (T4-L1). Before as well as 5, 15, 30, 45, and 90 min after MT we recorded plasma osmolality, hemodynamics and measured 6-keto-PGFlα (stabile metabolite of PGI₂), TXB₂ (stabile metabolite of thromboxane A₂) active renin, and arginine vasopressin (AVP) plasma concentrations by radioimmunoassay. Catecholamine levels were assessed by high-pressure liquid chromatography (HPLC) with electrochemical detection. Results : Following MT, arterial hypotension occurred along with a substantial PGI₂ release. This was completely abolished by ibuprofen administration. Although plasma levels of 6-keto-PGF_1α (1133 (708) vs. 60 (3) ng/L, median (median absolute deviation), P=0.0001, placebo vs. ibuprofen) remained significantly elevated, blood pressure was restored within 30 min after MT in the placebo group. At the same point in time plasma concentrations of TXB² (164 (87) vs. 58 (1) ng/L, P=0.0001), epinephrine (46 (33) vs. 14 (6) ng/L, P=0.001), AVP (41 ± (18) vs. 12 (7) ng/L, P=0.0004), and active renin (27 (12) vs. 12 (4) ng/L, P = 0.001) were significantly higher in placebo-treated patients. Conclusion : Under combined general and epidural anesthesia arterial hypotension following MT due to endogenous PGI₂ release is associated with enhanced release of AVP, active renin, epinephrine and thromboxane A₂, presumably contributing to hemodynamic stability within 30 min after MT.     

A Teaspoon Pump for Pumping Blood with High Hydraulic Efficiency and Low Hemolysis Potential

Abstract: Virtually all blood pumps contain some kind of rubbing, sliding, closely moving machinery surfaces that are exposed to the blood being pumped. These valves, internal bearings, magnetic bearing position sensors, and shaft seals cause most of the problems with blood pumps. The original teaspoon pump design prevented the rubbing, sliding machinery surfaces from contacting the blood. However, the hydraulic efficiency was low because the blood was able to "slip around" the rotating impeller so that the blood itself never rotated fast enough to develop adequate pressure. An improved teaspoon blood pump has been designed and tested and has shown acceptable hydraulic performance and low hemolysis potential. The new pump uses a nonrotating "swinging" hose as the pump impeller. The fluid enters the pump through the center of the swinging hose; therefore, there can be no fluid slip between the revolving blood and the revolving impeller. The new pump uses an impeller that is comparable to a flexible garden hose. If the free end of the hose were swung around in a circle like half of a jump rope, the fluid inside the hose would rotate and develop pressure even though the hose impeller itself did not "rotate"; therefore, no rotating shaft seal or internal bearings are required.     

A comparison of the inhibitory effects of four volatile anaesthetics on the metabolism of chlorzoxazone, a substrate for CYP2E1, in rabbits

Background: Halothane inhibits in vitro and in vivo activity of cytochrome P-450 (CYP) 2E1. There are several fluorinated volatile anaesthetics besides halothane, and most of them are defluorinated by CYP2E1. It is unclear whether other fluorinated anaesthetics inhibit the in vivo activity of CYP2E1.
Methods: We compared the inhibitory effects of therapeutic concentrations of four inhalational anaesthetics, halothane, enflurane, isoflurane, and sevoflurane, on chlorzoxazone metabolism in rabbits receiving artificial ventilation.
Results: All four inhalational anaesthetics decreased arterial blood pressure and increased plasma chlorzoxazone concentration. However, no significant differences in the plasma chlorzoxazone concentration were found between the four anaesthetics. The estimated chlorzoxazone clearance increased after beginning inhalation with all four agents, but no significant difference in clearance was noted between agents.
Conclusions: At therapeutic concentrations, the in vivo inhibitory effect on chlorzoxazone metabolism was similar for all four inhalational anaesthetics examined, even though their chemical characteristics and extent of hepatic metabolism differ considerably.     

Microspheres Based Detoxification System: A New Method in Convective Blood Purification

Abstract: A variety of protein-bound or hydrophobic substances, accumulating as a result of pathologic conditions such as exogenous or endogenous intoxications, are removed poorly by conventional detoxification methods because of low accessibility (hemodialysis), insufficient adsorption capabilities (hemosorption), low efficiency (peritoneal dialysis), or economic limitations (high-volume plasmapheresis). Combining advantages of existing methods with microspheric technology, a module-based system was designed. Major operating parameters of the latter can be modified to allow for adjustment to individual clinical situations. An extracorporeal blood circuit including a plasmafilter is combined with a secondary high-velocity plasma circuit driven by a centrifugal pump. Different microspheric adsorbers can be combined in one circuit or applied in sequence. Thus, a prolonged treatment can be tailored using specially designed selective adsorber materials. Comparing this system with existing methods (high-flux hemodialysis, molecular adsorbent recycling system), results from our in vitro studies and animal experiments demonstrate the superior efficiency of substance removal.     

Tissue perfusion in relation to cardiac output during continuous positive-pressure ventilation and administration of propranolol or verapamil

Background : Our objective was to determine whether administration of propranolol or verapamil modifies the hemodynamic adaptation to continuous positive-pressure ventilation (CPPV), in particular the regional distribution of cardiac output (CO).
Methods : General hemodynamics and regional blood flows assessed by microsphere technique (15 (μm) were recorded in 16 anesthetized pigs during spontaneous breathing (SB) and CPPV with 8 cm H₂O end-expiratory pressure (CPPV8) before and after intravenous administration of propranolol (0.3 mg · kg⁻¹ followed by 0.15 mg · kg⁻¹ · h⁻¹, n=8) or verapamil (0.1 mg · kg⁻¹ followed by 0.3 mg · kg⁻¹ · h⁻¹, n=8).
Results : CPPV8 depressed CO by 25% without shifts in its relative distribution with the exception of a noteworthy increase in adrenal perfusion. Propranolol increased arterial blood pressure, and due to a fall in heart rate, CO dropped by 25%. The kidneys and, to a lesser extent, the splanchic region and central nervous system received increased fractions of the remaining CO at the expense of skeletal muscle flow. Similar patterns were seen during SB and CPPV8 such that the combination of propranolol and CPPV8 depressed CO by 50%. The circulatory effects of verapamil were less evident but myocardial perfusion tended to increase.
Conclusions : The combination of propranolol or verapamil with CPPV does not result in any specific hemodynamic interaction in anesthetized pigs, except that the combined effect of propranolol and CPPV may severely reduce CO.     

Volatile anaesthetics reduce adhesion of blood platelets under low-flow conditions in the coronary system of isolated guinea pig hearts

Background : Inhibitory effects of volatile anaesthetics on platelet aggregation have been demonstrated in several studies. However, the influence of volatile anaesthetics on intracoronary platelet adhesion has not been elucidated so far.
Methods : Isolated hearts of guinea pigs were perfused with buffer in the absence or presence of volatile anaesthetics (0.5 and 1 MAC) at constant coronary flow rates of 5 ml/min for 25 min, then 1 ml/min for 30 min and again 5 ml/min for 10 min. Before, during and after low-flow perfusion, a bolus of human platelets was applied into the coronary system. To simulate thrombogenic conditions, 0.3 U/ml human thrombin was infused during low-flow perfusion and reperfusion. The number of platelets sequestered to the endothelium was calculated from the difference between coronary in- and output of platelets. The myocardial production of lactate and consumption of pyruvate and coronary perfusion pressure were also determined.
Results : At a flow rate of 5 ml/min only about 3% of the applied platelets did not emerge from the coronary system, in any group. In contrast, 13.1±1.2% (mean±SEM) of infused platelets became adherent in low-flow perfusion in the control group without anaesthetic. The adherence was reduced with each 1 MAC isoflurane (to 6.2±1.2%), sevoflurane (to 4.4±0.9%) or halothane (to 3.2±1.5%) (each P <0.05 vs. control). Volatile anaesthetic, 0.5 MAC, did not inhibit platelet adhesion to a statistically significant extent in any case. Perfusion pressure and metabolic parameters were not statistically different between the control and the hearts exposed to anaesthetics.
Conclusion : Volatile anaesthetics in a concentration of 1 MAC can reduce the adhesion of platelets in the coronary system under reduced flow conditions. This action does not arise from vasodilation or inhibition of ischaemic stress.     

Bariatric Surgery in Some "Central and East-European (former Eastern bloc)"Countries - Current Status and Prediction for the Next Millennium

Background: Obesity is increasing globallly, including in the formerly "Eastern Bloc" countries. Methods: A survey was made of obesity and bariatric surgery. Results: In the 8 East and Central European countries studied, with total population 300 million, roughly 43% of the population was overweight (BMI 25-30), 23% obese (BMI > 30), with about 15 million people morbidly obese (BMI > 40). From 0-10 morbidly obese individuals/100,000/year undergo bariatric surgery. Conclusion: Most countries were found to provide inadequate treatment for obesity.The majority of the morbidly obese are not treated effectively. However, health-care awareness of obesity and bariatric surgeons are slowly increasing.     

Synergistic interaction between the effects of propofol and midazolam with fentanyl on phrenic nerve activity in rabbits

Background: It has been shown that the depressive effects of both propofol and midazolam on consciousness are synergistic with opioids, but the nature of their interactions on other physiological systems, e. g. respiration, has not been fully investigated. The present study examined the effect of propofol and midazolam alone and in combination with fentanyl on phrenic nerve activity (PNA) and whether such interactions are additive or synergistic. Methods: PNA was recorded in 27 anaesthetised and artificially ventilated rabbits. In three groups, propofol, fentanyl and midazolam were administered intravenously in incremental doses to construct dose-response curves for the depressant effects of each one on PNA. In another two groups, the effect of pretreatment with either fentanyl 1 μg · kg^?1 i. v. or midazolam 0.05 mg · kg^?1 i. v. on the effects of propofol and fentanyl respectively on PNA were studied. Results: Propofol and fentanyl caused a dose-dependent depression of PNA with complete abolition at the highest total doses of 16 mg · kg^?1 i. v. and 32 μg · kg^?1 i. v., respectively. In contrast, midazolam in incremental doses to a total of 0.8 mg · kg^?1 reduced mean PNA by 63%, but approximately 12% of PNA remained at a total dose as high as 6.4 mg · kg^?1. The mean ED₅₀s, calculated from dose-response curves, were 5.4 mg · kg^?1, 3.9 μg · kg^?1 and 0.4 mg · kg^?1 for propofol, fentanyl and midazolam, respectively. Initial doses of either fentanyl 1 μg · kg^?1 i. v. or midazolam 0.05 mg · kg^?1 i. v. acted synergistically with subsequent doses of either propofol or fentanyl to abolish PNA at total doses of 8 mg · kg^?1 and 8 μg · kg^?1, respectively. Conclusion: Fentanyl has a synergistic interaction with both propofol and midazolam on PNA and hence potentially on respiration.     

Influence of dopexamine hydrochloride on haemodynamics and regulators of circulation in patients undergoing major abdominal surgery

Background: Catecholaminergic support is often used to improve haemodynamics in patients undergoing major abdominal surgery. Dopexamine is a synthetic vasoactive catecholamine with beneficial microcirculatory properties. Methods: The influence of perioperative administration of dopexamine on cardiorespiratory data and important regulators of macro- and microcirculation were studied in 30 patients undergoing Whipple pancreaticduodenectomy. The patients received randomized and blinded either 2 μg · kg^?1 · min^?1 of dopexamine (n=15) or placebo (n=15, control group). The infusion was started after induction of anaesthesia and continued until the morning of the first postoperative day. Endothelin-1 (ET-1), vasopressin, atrial natriuretic peptide (ANP), and catecholamine plasma levels were measured from arterial blood samples. Measurements were carried out after induction of anaesthesia, 2 h after onset of surgery, at the end of surgery, 2 h after surgery, and on the morning of the first postoperative day. Results: Cardiac index (CI) increased significantly in the dopexamine group (from 2.61±0.41 to 4.57±0.78 1 · min^?1 · m^?2) and remained elevated until the morning of the first postoperative day. Oxygen delivery index (DO₂I) and oxygen consumption index (VO₂I) were also significantly increased in the dopexamine group (DO₂I: from 416±91 to 717±110 ml/m² · m²; VO₂I: from 98±25 to 157±22 ml/m² · m²), being significantly higher than in the control group. pHi remained stable only in the dopexamine patients, indicating adequate splanchnic perfusion. Vasopressive regulators of circulation increased significantly only in the untreated control patients (vasopressin: from 4.37±1.1 to 35.9±12.1 pg/ml; ET-1: from 2.88±0.91 to 6.91±1.20 pg/ml). Conclusion: Patients undergoing major abdominal surgery may profit from prophylactic perioperative administration of dopexamine hydrochloride in the form of improved haemodynamics and oxygenation as well as beneficial influence on important regulators of organ blood flow.