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1.
本文比较60例肝硬化患者和20例正常人血清锌、铜改变,并探讨其临床意义。 相似文献
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<正> 本文对在我院连续献血5年以上的135名献血者,做了血清铁(Fe~(3+))、铜(Cu~(2+))和锌(Zn~(2+))等3种元素的调查,并对照调查了同地区初次献血者30名,作为该地区人血清铁、铜和锌的正常对照值。现报告如下。 相似文献
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由于临床营养学对临床实践产生了积极的影响 ,人体微量元素日益受到重视 [1]。许多学者认为 ,不仅在一些疾病的预防和治疗中不能忽视微量元素的变化 ,而且测定微量元素可能为疾病的诊断提供帮助[1 ,2]。本文对80例健康体检者、100例缓解期肺心病患者和130例急性加重期肺心病患者血清微量元素 (锌、铜、镁、铁、钙 )的含量进行测定 ,并总结分析。资料与方法一、一般资料100例缓解期肺心病患者均为门诊病人 ,年龄50~72岁 (平均60岁 ) ,其中男性61例 ,女性39例 ,无其他系统慢性疾病史及金属职业接触史。130例… 相似文献
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血清中银测定对诊断肝豆状核变性具有特异性意义,肝合成铜蓝蛋白,铜蓝蛋白减少或缺乏,引起铜降低。在血清中雌激素浓度增高时和急性心肌梗死、各种淋巴瘤、甲状腺机能亢进、肝硬变、胆汁性肝硬变,类风湿性关节炎及烟酸缺乏症引起的糙皮症,血清铜含量都可能升高。锌是人体必需的十四种微量元素之一。人体血清中锌的代谢功能主要表现在含锌酶。此类酶超过七十种。如碱性磷酸酶、RNA与DNA聚合酶等。它在生长、性成熟、伤口愈合、味觉及嗅觉的产生、免疫反应等方面,都起着重要作用[1]。血清铁的测定,是临床血液系统疾病及某些疾病鉴别… 相似文献
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作者应用原子吸收光谱法测定了急性脑卒中患者血清中的铜锌镁的浓度及铜锌比值与正常对照组相比,结果表明:急性脑卒中患者无论是脑出血或脑梗塞均表现为血清铜升高,锌镁降低,铜锌比值升高(P<0.001);而脑梗塞与脑出血组相比,脑出血组血清铜升高较脑梗塞组更为明显(P<0.01),因而铜锌比值也有升高(P<0.01),但锌镁均无明显改变,其结果有助于二者的鉴别诊断。 相似文献
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测定50例食管癌患者手术前后血清铜、锌、铁含量和铜/锌比值,与31例正常人比较,并对手术前后的测定结果进行对比分析。发现食管癌血清铜含量和铜/锌比值显著升高,血清锌、铁含量显著下降(r<0.01);术后3周血清铜含量和铜/锌比值明显降低而锌、铁含量明显升高(P<0.01);根治性切除者术后可恢复到正常水平(P<0.05),姑息性切除者恢复困难;术后有癌复发转移时其参数可再度升高或降低。 相似文献
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胃癌患者手术前后血清锌铜铁钙的变化中山医科大学附属第一医院中心实验室张惠贤,俞纯山,于毅力,徐栋梁人体微量元素及常量元素在人类的生命活动、生理功能及新陈代谢等多方面起重要重用,与肿瘤的发生发展有密切的关系。胃癌是消化道最多见的癌肿,在各类肿瘤中死亡率... 相似文献
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目的探讨小儿呼吸系统感染与体内血清锌、铜及铜/锌值的关系。方法采用比色法测定了110例呼吸系统感染疾病和30例健康儿童血清锌、铜含量及铜/锌值。结果70例反复呼吸系统感染患儿与对照组相比,血清锌明显降低(P〈0.05),血清铜明显高于对照组。40例急性呼吸系统感染组患儿血清锌、铜与对照组相比,差异无统计学意义(P〉0.05),但两组与对照组相比,铜/锌值均高于对照组。结论适当补锌,有助于小儿呼吸系统疾病的预防和治疗,铜/锌值可作为早期诊断、治疗呼吸系统疾病的参考指标之一。 相似文献
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Although hemochromatosis and pathological situations due to chronic iron overload have been extensively described, there is
little information about the influence of iron on other trace elements in the cell. The aim of this study was to investigate
changes in the concentration of zinc, manganese, and copper in the liver, spleen, and brain of rats after iron overload. Iron
overload in Wistar rats was achieved by iron-supplemented diet or by intraperitoneal or intravenous injection of polymaltose
iron. Iron, zinc, manganese, and copper were determined by atomic absorption spectrophotometry. Iron overload in rats, regardless
of the route of its application, resulted in an increase not only of iron but also of zinc and manganese in the liver and
the spleen, whereas the content of these metals in the brain did not change. The copper content of the liver, spleen, and
brain remained the same after iron overload. The increase of zinc and manganese in the liver and spleen following iron overload
was probably a result not only of increased intestinal absorption but also of increased uptake from the cell. This is also
supported by the fact that no increase in the zinc and manganese concentrations occurred in the brain since, despite iron
overload, the iron content remained constant. 相似文献
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Objectives: The aim of the study was to investigate whether alterations in antioxidative enzyme activities are dependent on their cofactor concentrations in tobacco smokers. Design and methods: Plasma selenium, copper, zinc and iron concentrations, and the activities of related erythrocyte antioxidative enzymes copper-zinc superoxide dismutase (Cu-Zn SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) were measured in tobacco smokers and compared with those of nonsmokers. Plasma thiocyanate levels were measured as an index of smoking status. Results: While plasma copper concentration and erythrocyte Cu-Zn SOD activity were significantly higher, plasma selenium concentration and erythrocyte GSH-Px activities were significantly lower in tobacco smokers than in nonsmokers. There was no significant difference in plasma iron and zinc concentrations or erythrocyte CAT activity between the two groups. There were significant positive correlations between erythrocyte GSH-Px and plasma selenium levels, between Cu-Zn SOD and copper levels, and between CAT and iron levels, and a negative correlation between plasma thiocyanate and selenium content in tobacco smokers. Conclusions: These findings suggest that antioxidative enzyme activities change depending on their cofactor concentrations in tobacco smokers. 相似文献
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目的了解待产妇血清蛋白电泳图谱的改变。方法采用英国Helena Spife2000蛋白电泳仪测定90例待产妇(实验组)、30例育龄非孕健康女性(对照组)的血清蛋白电泳。同时在美国Beckman Array360上采用散射比浊法测定30例实验组和20例对照组的血清铜蓝蛋白(CER)、转铁蛋白(TRF)、补体C3(C3)、C反应蛋白(CRP)、免疫球蛋白G(IgG)、免疫球蛋白A(IgA)、免疫球蛋白M(Ig M)、α1-酸性糖蛋白(AAG)、α1-抗胰蛋白酶(AAT)、触珠蛋白(HPT)。结果实验组白蛋白百分比[(47.88±5.1)%]较对照组[(54.24±4.2)%]低(P<0.01),α1、α2、β球蛋白百分比较对照组显著增高,分别是α1球蛋白实验组[(6.87±1.78)%]、对照组[(3.96±0.67)%](P<0.01);α2球蛋白实验组[(10.70±2.25)%]、对照组[8.66±2.49)%](P<0.01);β球蛋白实验组[(16.21±3.05)%]、对照组[(11.86±1.90)%](P<0.01);而γ球蛋白百分比[(18.33±3.91)%]与对照组[(21.27±4.86)%]相比则明显降低(P<0.01)。实验组C3、TRF、CRP、CER、AAT较对照组显著增高(P<0.01),IgG较对照组显著降低(P<0.01),Ig M、IgA、HPT、AAG与对照组相比无显著性差异(P>0.05)。结论待产妇血清蛋白电泳谱的改变主要表现在白蛋白、γ球蛋白降低,而α1、α2、β球蛋白比例增加。α1球蛋白的增加与AAT、CER的增加有关,α2、β球蛋白比例增加与CRP、TRF、C3增高有关,而γ球蛋白降低与IgG降低有较大相关性。 相似文献
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目的:通过在不同孕期对妊娠妇女的血清叶酸、维生素B12和血清铁蛋白进行联合检测,为临床上治疗妊娠贫血提供有效依据。方法:对2013年4月~2013年11月期间,在我院待产的1067例妊娠妇女定为观察组,选取107例非妊娠妇女为对照组进行对比试验,分别进行血清叶酸、维生素B12和血清铁蛋白的含量分析,采用化学发光法检测对比两者间含量的差别。结果:随着孕期的增加,血清叶酸、维生素B。和血清铁蛋白的含量呈降低趋势,早孕期妇女的维生素B12与对照组相比无明显差异(P〉0.05),血清叶酸和血清铁蛋白较对照组低,且差异有统计学意义(P〈0.05);中、晚孕期妇女血清叶酸、维生素B12和血清铁蛋白的含量均低于对照组,差异有统计学意义(P〈0.05)。结论:对不同妊娠期的妇女进行血清叶酸、维生素B12和血清铁蛋白的含量检测,可对妊娠妇女的贫血原因进行准确分析,达到对妊娠妇女的贫血症状进行有效预防和治疗的目的,对胎儿的正常发育也有一定的临床意义。 相似文献
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The authors studied the changes in serum zinc concentration and distribution during the 15 days following acute myocardial infarction in 21 patients. The method is based on ultrafiltration and electrothermal atomic absorption spectrometry. It is rapid and needs only 2.5 ml of serum. Serum and erythrocyte copper and zinc, serum zinc-binding ligands and serum enzyme activities were also determined. Serum zinc ( P < 0.00001) and exchangeable zinc (mainly albumin-bound zinc, P = 0.01) declined within the first 3 days and then returned gradually to reference ranges. Exchangeable zinc was correlated with transthyretin ( P = 0.00001) and total serum zinc ( P < 0.00001). Exchangeable zinc accounted for virtually all of the differences in total serum zinc concentration after myocardial infarction. This result could be related to an increase of zinc uptake by tissues. Therefore, studies are needed to evaluate whether zinc supplementation in the early stages of acute myocardial infarction might improve prognosis. 相似文献
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目的 探讨1~10岁厌食症患儿和正常小儿血清瘦素与甲状腺激素、锌、铁含量、体重指数(BMI)的关系及其在厌食症发病过程中的作用。方法 用放射免疫方法检测54例厌食症患儿和46名正常小儿血清瘦素、甲状腺激素含量;同时用原子吸收法和亚铁嗪比色法测定血清锌、铁的含量,2组均测量身高和体重计算BMI。结果 厌食症组患儿血清瘦素、甲状腺激素、锌、铁含量显著低于正常小儿组水平(P<0.05和P<0.01);血清瘦素水平与血清锌、甲状腺激素含量呈正相关(Zn:r=0.46,P<0.01;T3:r=0.49,P<0.05;T4:r=0.56,P<0.05),与血清铁含量无相关性(Fe:r=0.14,P>0.05),与BMI无明显线性关系(男:r=0.12,P>0.05;女:r=0.26,P>0.05)。结论 瘦素、甲状腺激素和锌在厌食症发病机制中均发挥一定作用,共同影响厌食症患儿的食欲。 相似文献
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BackgroundIron deficiency anaemia is the most common nutritional deficiency disorder in the world. Iron deficiency is a potential complication in repeated apheresis donation. The present study was aimed to evaluate serum iron stores in regular plateletpheresis donors. Materials and methodsA total of 60 donors were included in this study, which included 30 regular plateletpheresis donors as cases and controls were 30 first time donors. The donor samples were collected before donation for complete hemogram, transfusion transmissible infections screening and serum iron, total iron binding capacity, percentage saturation of transferrin and serum ferritin. ResultsOut of 60 donors, more than half of the donors (56.6 %) had serum ferritin less than 30 ng/mL. Out of these 34 donors, 25 were from the case group and 9 donors in the control group. The median serum ferritin level in cases and controls was 11.86 ng/mL (Interquartile range 4.18–17.34 ng/mL) and 37.92 ng/mL (Interquartile range 27.87–86.20 ng/mL) respectively (p < 0.001). The mean serum iron in cases and controls was 71.23 ± 31.32 μg/dL and 93.53 ± 33.53 μg/dL respectively (p = 0.016). The mean percentage saturation in cases and controls was 20.09 ± 9.31 % and 26.26 ± 9.03 % respectively (p = 0.012). A significant decline in mean serum ferritin with increase in number of annual donations and decrease in donation interval was observed. DiscussionRegular plateletpheresis donation may lead to depletion of iron stores and subclinical iron deficiency. Donors with high platelet count are more likely to exhibit iron deficiency. Periodic serum ferritin estimation in donors participating in regular plateletpheresis donation is warranted. 相似文献
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目的 探讨微量元素锌、铜元素与体外受精-胚胎移植(IVF-ET)临床结局的关系.方法 回顾性分析43例IVF-ET治疗周期的临床资料以及绒毛膜促性腺激素(hCG)注射日血清和取卵日卵泡液内锌、铜元素含量.结果 应用Pearson相关分析显示,在43例治疗周期中卵泡液内铜浓度与获卵数、受精数和卵裂数呈正相关关系(r值分别为0.392、0.327和0.321,P值分别为0.0094、0.0325和0.0361).临床妊娠组与未妊娠组相比,卵泡液内锌、铜元素浓度差异均无统计学意义(P均>0.05);hCG注射日血清雌二醇差异有统计学意义[(4513.65±2538.3) ng/L与(6495.29±3402.8)ng/L,t=2.177,P=0.0353];hCG注射日血清锌含量差异有统计学意义[(98.60±18.08) μmol/L与(87.89±10.61) μmol/L,t =2.153,P=0.0372].结论 微量元素锌、铜在IVF-ET过程中可能发挥着重要作用. 相似文献
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Cu,Zn-superoxide dismutase is an endogenous scavanger of superoxide radicals (O(2)(*-)) which also induce the synthesis of this enzyme. Ceruloplasmin is an antioxidant and acute-phase reactant. Changes in the synthesis of both enzymes are related to the metabolism of copper and zinc. Concentrations of copper and zinc were previously found to be increased in the serum and arterial wall of atherosclerotic subjects. The aim of this study was to investigate the Cu,Zn-superoxide dismutase activity in erythrocytes and ceruloplasmin activity in serum, and to measure serum concentrations of copper, zinc, and malonyldialdehyde in patients with moderate and critical chronic ischemia of the lower limbs. A group of 26 patients with chronic arterial occlusion of the lower limbs was divided into two groups depending on the degree of ischemia: moderate and critical. Cu,Zn-superoxide dismutase activity in erythrocytes was measured using the RANSOD kit, the serum ceruloplasmin oxidase activity was determined with o-dianisidine as a substrate. Copper and zinc concentrations in serum were determined by atomic absorption spectrometry. There was an increase in the ceruloplasmin activity and serum copper concentration in critical ischemia (194.4+/-51.94 U/l and 23.5+/-4.2 micromol/l, respectively) compared with moderate ischemia (139.1+/-34.9 U/l and 18.5+/-2.0 micromol/l, respectively). The Cu,Zn-superoxide dismutase activity in erythrocytes was higher in moderate ischemia (2,657+/-1,564 U/g hemoglobin) than in controls (1,205+/- 353 U/g hemoglobin), but not different from critical ischemia. There was a negative correlation for Cu,Zn-superoxide dismutase and ceruloplasmin (r=-0.60, P=0.05) in critical ischemia. 相似文献
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