软组织损伤及药理学治疗的现代概念

软组织损伤及药理学治疗的现代概念赵惠民１软组织损伤的现代概念［１，２］人体软组织是由骨胳肌、筋膜、韧带、关节囊、骨膜、脂肪组织等运动系统软组织构成。软组织损伤包括急性损伤（Ａｃｕｔｅｔｒａｕｍａ）和慢性损伤（Ｃｈｒｏｎｉｃｓｔｒａｉｎ）。急性损伤常由...     

针刺运动疗法治疗急性腰部软组织损伤

方法 介绍采用针刺运动疗法治疗急性腰部软组织损伤300例，结果 痊愈286例，显效10例，有效3例，无效1例，总有效率99．67％。提示；该疗法治疗急性腰部软组织损伤疗效较佳，主要与3个因素有关，远道经络辩证取穴，运动针感、针运热感。     

速效止痛粉治疗急性软组织损伤

速效止痛粉治疗急性软组织损伤山东省泰安市中医院（２７１０００）蔺军田，李军自１９８９年至１９９２年运用自拟速效止痛粉治疗急性软组织损伤２００例，取得了较好的临床疗效，现总结如下。临床资料本组２００例均为急性闭合性损伤，男１２９例，女７１例；年龄８～７...     

奇正消痛贴膏治疗新兵军事训练急性闭合性软组织损伤临床观察

目的 观察奇正消痛贴膏治疗急性软组织损伤的临床疗效.方法 采用随机对照方法,将382例急性软组织损伤的新兵分为治疗组(200例)和对照组(182例),分别给予奇正消痛贴膏和麝香解痛膏治疗,评价其疗效和安全性.结果 治疗组显效率(87.5%)显著高于对照组(63.2%)(P<0.05).结论 奇正消痛贴膏治疗急性软组织损伤起效快,安全有效,使用方便,值得推广.     

手针、手象针治疗软组织损伤

手针、手象针治疗软组织损伤广东省韶关市中医院（５１２０２６）卢梅生笔者对软组织损伤中的部分病例采用手针、手象针治疗，每可取得较好的疗效，现报告如下。临床资料本组４８例中，男３１例，女１７例；年龄最大６５岁、最小１５岁；病程最长３年、最短半小时；急性损...     

急性软组织损伤的血流图分析及中药的影响 附155例报道

急性软组织损伤系局部无菌性炎症,临床上以损伤局部组织肿胀,疼痛、青紫为特点。长期临床实践证明,运用中药治疗,疗效显著。然而,对于软组织损伤患者,目前的生化检查多呈正常反应值,难以表达损伤局部病理变化,亦不利于从临床上观察及探讨中药治疗软组织损伤的疗效机理。为此,我们根据软组织损伤局部“淤血”的病理特点,从1986年迄今观察了155例下肢急性软组织损伤患者的肢体血流图变化,希冀阐明软组织损伤与局部血液循环障碍的关系。在此基础上,运用中华全国中医学会骨伤科学会付主任委员,名老中医李同生教授治疗跌打损伤的经验方一盘珠汤①治疗,并进行治疗前后肢体血流图的动态观察。现报道如下。     

封管注射法排除输液时空气故障的效果观察

目的探讨乙醇加止痛消炎膏外敷治疗急性软组织损伤的效果，减少由于处置不当而导致的病情加重或长期慢性水肿疼痛现象发生。方法将230例急性软组织损伤患者随机分为观察组（126例）和对照组（104例），分别采用乙醇加止痛消炎膏调和外敷局部、止痛消炎膏直接外敷局部。结果观察组总有效率为95．2％，对照组为84．6％，两组比较，差异有显著性意义（P〈0．01）；观察组换药次数显著少于对照组（P〈0．05）。结论乙醇加止痛消炎膏调和外敷治疗浅部软组织损伤疗效好，可减少换药次数，有助于软组织恢复。     

软伤灵活血膏治疗急慢性软组织损伤100例

我院采用自制活血膏药治疗各种急慢性软组织损伤，疗效较好，现报告如下。临床资料100例中男73例，女27例；年龄5～86岁。急性软组织损伤66例（上肢21例，下肢23例，腰部急性损伤22例）。慢性软组织损伤34例（左肩关节损伤3例，右肩关节损伤7例，双肩关节损伤1例，腰部损伤23例）。治疗方法1．方剂组成及制法：老陈醋2000ml，乳香309，没药309，红花509，三七粉309，皂＄1）509，见肿消309，当归309，血竭209，自然铜209，冰片209。先将以上药物分别加工过100目筛后。备用。再将老陈醋2000ml放于搪瓷缸内于文火上煎熬至300ml左右待温度降至1…     

洋金花伤膏治疗急性闭合性软组织损伤

目的 观察洋金花伤膏治疗急性闭合性软组织的疗效和安全性。方法 急性闭俣笥软组织损伤患者４０５例,治疗组（即洋金花伤膏组）３０４例,对照组（即麝香追风膏组）１０１例,按照中药新药指导原则,采用双盲、随机对照的方法进行观察。结果 治疗组总效率９６．４％,两组有显著差异,治疗组疗效明显优于对照组。结论洋金花伤膏是治疗急性闭合性软组织损伤的外用佳药。     

三五灵擦剂治疗软组织损伤疗效分析

软组织损伤是外科常见病,就诊率甚高,据初步统计,就诊率占外科就诊总数的45%左右,尤以急性软组织损伤为多。随着交通运输业、建筑业及其它工业的发展,受伤率将逐年上升。但目前治疗软组织损伤的外用药物品种较少,且有的价格较高,有的疗效欠佳。针对上述情况,我们经过反复研究与实践,研制出一种以治疗软组织损伤为主的三五灵擦剂。     

Use of pervomur for irrigation of purulent cavities

Experimentally it has been shown that diluted Pervomur (1:3) may be used for the intraoperation washing of the pleural cavity. The use of the diluted drug during the operations for acute purulent diseases of the lungs and pleura made it possible to prevent postoperative pleural empyemas and suppluration of soft tissue wounds in most patients.     

Salvage of partial facial soft tissue avulsions with medicinal leeches

BACKGROUND: Medicinal leeches have been demonstrated to be extremely useful and safe in the salvage of venous outflow compromised tissue, particularly in digit replants and various forms of flaps. OBJECTIVE: To demonstrate the utility of medicinal leeches in the salvage of venous outflow-compromised traumatic soft tissue avulsions in key facial structures. METHODS: A retrospective review of 4 cases involving the external ear, nose, lip, and scalp in which apparent venous outflow compromise was present. Medicinal leeches were applied acutely in each of these 4 cases, salvaging each of the partially avulsed soft tissue segments. RESULTS: Complete or near complete salvage of each soft tissue segment after using medicinal leeches. CONCLUSIONS: Although it is unusual for a partial soft tissue avulsion of the face to require medicinal leech therapy, situations may occur in which there is adequate arterial inflow but inadequate venous outflow. In such cases, medicinal leeches may play a very important role in salvaging the soft tissue segment. This is particularly important in vital structures such as the ear, nose, lip, and eyelid in which acute or secondary reconstruction is complex. EBM RATING: C.     

术中即时扩张在急诊皮肤软组织缺损修复中的应用

目的:探索术中即时扩张技术在急诊皮肤软组织缺损修复中应用的可行性。方法:笔者对86例急诊皮肤软组织缺损(缺损面积在3cm×4cm～12cm×8cm)的患者,采取该技术进行术中即时扩张,一期修复皮肤软组织缺损。结果:本组86例患者,应用该技术均一次性达到了修复目的,术后随访6个月～3年,所有患者局部皮肤色泽及厚薄与周围正常皮肤一致,瘢痕不明显。结论:术中即时扩张技术可以运用于皮肤软组织缺损的修复。它是一种简单、安全而行之有效的治疗方法,可以运用于临床,尤其在基层医院。     

Conversion of open tibial IIIb to IIIa fractures using intentional temporary deformation and the Taylor Spatial Frame

The closure of small-to-moderate-sized soft tissue defects in open tibial fractures can be successfully achieved with acute bony shortening. In some instances, it may be possible to close soft tissue envelope defects by preserving length and intentionally creating a deformity of the limb. As the soft tissue is now able to close, this manoeuvre converts an open IIIb to IIIa fracture. This obviates the need for soft tissue reconstructive procedures such as flaps and grafts, which have the potential to cause donor-site morbidity and may fail. In this article, the authors demonstrate the technique for treating anterior medial soft tissue defects by deforming the bone at the fracture site, permitting temporary malalignment and closure of the wound. After healing of the envelope, the malalignment is gradually corrected with the use of the Taylor Spatial Frame. We present two such cases and discuss the technical indications and challenges of managing such cases.     

奇正消痛贴膏对兔耳软组织损伤影响的活体观察

目的：观察奇正消痛贴膏对活体兔耳软组织微循环的影响,为临床应用提供基础资料。方法：新西兰大白兔10只,制作兔耳软组织损伤模型,在第1、2、3周分为3组,每组10只兔耳,空白给药组和实验组兔耳外敷奇正消痛贴膏提取液,模型组外用生理盐水。采用显微放大、数字采集系统,红外测温仪及测厚仪等对用药后0、0.5、3、5h的兔耳软组织局部微循环血流速度、温度的变化进行观察,同时观察第1～5天的兔耳局部肿胀程度。结果：空白给药组3h的血流速度加快,5h恢复正常。模型组3、5h的速度持续加快。与模型组比较,实验组5h血流速度明显慢,兔耳损伤部位肿胀程度于3、4、5h明显缩小。结论：奇正消痛贴的应用能明显减轻损伤急性期微循环血流速度的加快,防止进一步水肿及出血。在慢性期,能够有效地减小兔耳损伤部位肿胀程度,与急性期比较,明显发挥消肿作用。     

复方生肌膏促进肛裂术后创面愈合的临床观察

为观察复方生肌膏在促进肛裂术后创面愈合及减少术后并发症的作用,将肛裂术后患者92例分为治疗组49例和对照组43例,治疗组在术后使用复方生肌膏外敷治疗,对照组术后使用马应龙麝香痔疮膏外敷治疗。结果显示,治疗组在减轻疼痛、促进创面愈合、缩短愈合时间等方面的疗效均明显优于对照组（P〈0．05或P〈0．01）。结果表明,复方生肌膏具有促进肛裂术后创面愈合,缓解疼痛的作用。     

Pentoxifylline effects on acute and late complications after radiotherapy in rabbit

Soft tissue damages after radiotherapy are an uncommon but serious complication. Late damage after radiation is the principal dose-limiting factor in radiation therapy today and is dependent on vascular pathology as a result of radiation. Pentoxifylline is a methylxanthine derivative that produces dose-related improvement in blood flow, lower blood viscosity, improved erythrocyte flexibility, and increased tissue oxygen levels. An agent that increases blood flow and tissue oxygen content may contribute to enhanced healing of soft tissue pathology. Sixteen adult New Zealand rabbits were separated into 2 groups and inspected for 30 weeks after radiation. We noted acute and chronic reactions and pathologic changes in different regions of the head and neck of rabbits. The prophylactic administration of pentoxifylline in the postirradiation period can reduce late soft tissue pathology, but it does not affect acute radiation reactions.     

Regression of prostatic cancer metastasis by high doses of diethylstilbestrol diphosphate

Diethylstilbestrol diphosphate (DES-P) has shown effective symptomatic relief in patients with metastatic carcinoma of the prostate. Although there is little known about its role in soft tissue metastasis, our experience in 3 patients with advanced carcinoma of the prostate infiltrating the trigone and ureterovesical junction revealed significant improvement of hydronephrosis. All patients failed to respond to conventional doses of stilbestrol. Diethylstilbestrol diphosphate is recommended in the treatment of advanced carcinoma of the prostate with soft tissue metastasis. It is safe and effective, and the tumor responses outweigh the side effects of the drug. The mechanism of action of this compound is discussed.     

Erythropoietin,a novel repurposed drug: An innovative treatment for wound healing in patients with diabetes mellitus

Developing a new drug is expensive: the cost of going from bench to bedside is about $US1 billion. Therefore, the repurposing of an approved drug is potentially rewarding because it expands the drug's existing therapeutic profile and preempts additional development costs. As the safety profile of a repurposed drug is already well known, any new investigations could then focus on its efficacy and other therapeutic benefits. Recombinant erythropoietin (EPO) is a potential candidate for repurposing because the results of numerous studies have shown that systemic and topical EPO is therapeutically beneficial when it is administered to healthy and diabetic animals with acute and chronic skin wounds and burns. Moreover, the molecular mechanisms of EPO's actions have been elucidated: EPO acts on those nonhematopoietic cells which are involved in the innate immune response where it promotes cellular proliferation and differentiation, exerts its cytoprotective actions, and inhibits apoptosis. In this review, the mechanism of EPO's action in skin wound healing is reviewed, and its potential for treating acute and chronic skin wounds and stimulating tissue regeneration in diabetic patients is discussed.     

Local application of VEGF compensates callus deficiency after acute soft tissue trauma—results using a limb‐shortening distraction procedure in rabbit tibia

Acute soft tissue trauma influences callus formation and fracture healing. Several studies showed a relationship between angiogenesis and bone formation during distraction osteogenesis. The purpose of this study was to investigate the influence of controlled release of vascular endothelial growth factor (VEGF) on callus formation in a limb‐shortening distraction procedure after acute compartment syndrome. Acute soft tissue trauma with critical increased compartment pressure was generated in 22 rabbits, and the limb was shortened simulating fracture site debridement. In the test group (n = 11), a VEGF‐coated collagen matrix was locally applied around the fracture, while no collagen was applied in the control group (n = 11). Following 10 days in limb shortening, a gradual distraction of 0.5 mm/12 h was performed using an external fixation device and followed up for 40 days. Osseous consolidation occurred in all animals. Average callus diameter (1.54 ± 0.8 vs. 1.27 ± 0.14 mm) and torsional strength (72% vs. 46% of normal) were significantly higher in the test versus the control group. Blood vessel formation increased with a significantly higher number of vessels (6.3 vs. 3.81/mm²) and larger cross‐sectional area (>40 µm, 90.5% vs. 86%) in the test versus control group. The results showed that locally applied VEGF stimulates fracture healing after acute soft tissue trauma and might be an option for fracture treatment in cases with severe soft tissue damage. © 2011 Orthopaedic Research Society Published by Wiley Periodicals, Inc. J Orthop Res 29: 1093–1098, 2011