红皮病型银屑病患者的护理

目的总结红皮病型银屑病患者的护理经验。方法对22例红皮病型银屑病患者的治疗效果和护理措施进行回顾性分析。结果 22例红皮病型银屑病患者通过正规治疗及实施有效的护理,22例患者痊愈出院,无1例出现并发症。结论有效的护理措施对提高红皮病型银屑病患者的治疗效果具有积极的意义。     

红皮病型银屑病76例诱发因素分析

银屑病是一种常见且易复发的慢性炎症性皮肤病，病程较长。尤以侵犯青壮年为多发，对患者的身体健康和精神影响较大。红皮病型银屑病是一种较少见的严重的慢性疾病，为了尽可能预防红皮病型银屑病的发生，采取有效的健康教育对策。对我院76例红皮病型银屑病的诱发因素进行调查分析，现报道如下。     

复方甘草酸苷联合阿维A胶囊治疗红皮病型银屑病疗效观察

目的:探讨复方甘草酸苷联合阿维A胶囊治疗红皮病型银屑病疗效。方法:选取80例红皮病型银屑病患者随机分组,对照组常规治疗,观察组患者则在此基础上口服阿维A胶囊,对比两组患者治疗前后银屑病皮损面积和严重程度。结果:观察组患者治疗4周、8周后PASI评分名低于对照组,差异具有统计学意义(P0.05)。结论:阿维A胶囊联合复方甘草酸苷治疗红皮病型银屑病不仅具有很好的疗效。     

老年红皮型银屑病护理

红皮型银屑病是累及全身大部分皮肤的一种严重类型银屑病,由于本病病情严重,治疗困难,因此老年患者对该病治疗更是缺乏信心。我院采用中药水疗与药物封包等自然疗法、心理护理、健康教育等护理方法,对自2012.9-2013.12收治的120例老年红皮型银屑病患者,治疗效果,基本痊愈率达33.3%,显效率达66.7%。     

引发重症银屑病的罪魁祸首

银屑病俗称“牛皮癣”,临床上分为寻常型、红皮病型、脓疱型、关节病型。其中红皮病型、脓疱型、关节病型银屑病发病率不足1％,统称为重症银屑病。重症银屑病对机体健康有明显的影响,尤其是严重的泛发型脓疱银屑病和红皮病型银屑病可危及生命,关节病型银屑病可致残疾,给患者带来巨大的痛苦。那么,引起重症银屑病的罪魁祸首究竟有哪些呢?     

红皮病型银屑病应用窄谱UVB与阿维A治疗的疗效观察

目的:探讨应用窄谱UVB联合阿维A治疗红皮病型银屑病患者的临床效果.方法:将120例红皮病型银屑病患者分成观察组和对照组,每组60例.对照组患者仅采用阿维A进行治疗,观察组患者采用阿维A联合窄谱UVB进行治疗,对比分析两组患者的临床治疗效果.结果:治疗周期结束后观察组患者的临床治疗总有效率为93.3%,明显高于对照组患者的78.4%,组间比较差异显著(P0.05).结论:应用窄谱UVB联合阿维A治疗红皮病型银屑病,临床效果显著,安全性高,具有良好的临床应用价值.     

芳香维甲酸乙酯治疗32例银屑病临床分析

目的观察分析芳香维甲酸乙酯治疗银屑病临床疗效。方法治疗组芳香维甲酸乙酯口服:寻常型银屑病0.03mg/d;脓疱型及红皮病型银屑病0.03～0.06mg/d,病情控制后逐渐减量、停药。疗程3～6个月。对照组阿维A酸胶囊口服。依据银屑病皮损面积和严重度评分(PASI)变化判定疗效并计算有效率。结果治疗组寻常型21例,治疗4周时有效率66.67%;治疗8周时有效率85.71%;对照组寻常型13例,治疗4周时有效率46.15%;治疗8周时有效率53.85%。两组其余患者为脓疱型及红皮病型,治疗8周时有效率均为100.00%。治疗过程中有不同程度的唇炎、黏膜干燥、血清甘油三酯升高等,停药后均可恢复。结论芳香维甲酸乙酯对寻常型、脓疱型及红皮病型银屑病均有较好疗效,其中对寻常型银屑病疗效显著优于阿维A酸。     

芳香维甲酸乙酯治疗32例银屑病临床分析

目的 观察分析芳香维甲酸乙酯治疗银屑病临床疗效。方法 治疗组芳香维甲酸乙酯口服：寻常型银屑病0．03mg／d；脓疱型及红皮病型银屑病0．03—0．06mg／d，病情控制后逐渐减量、停药。疗程3-6个月。对照组阿维A酸胶囊口服。依据银屑病皮损面积和严重度评分（PASI）变化判定疗效并计算有效率。结果 治疗组寻常型21例，治疗4周时有效率66．67％；治疗8周时有效率85．71％；对照组寻常型13例，治疗4周时有效率46．15％；治疗8周时有效率53．85％。两组其余患者为脓疱型及红皮病型，治疗8周时有效率均为100．00％。治疗过程中有不同程度的唇炎、黏膜干燥、血清甘油三酯升高等，停药后均可恢复。结论 芳香维甲酸乙酯对寻常型、脓疱型及红皮病型银屑病均有较好疗效，其中对寻常型银屑病疗效显著优于阿维A酸。     

引发重症银屑病的罪魁祸首

银屑病俗称“牛皮癣”，临床上分为寻常型、红皮病型、脓疱型、关节病型。其中红皮病型、脓疱型、关节病型银屑病发病率不足1％，统称为重症银屑病。重症银屑病对机体健康有明显的影响，尤其是严重的泛发型脓疱银屑病和红皮病型银屑病可危及生命，关节病型银屑病可致残疾，给患带来巨大的痛苦。那么，引起重症银屑病的罪魁祸首究竟有哪些呢？     

药源性急性汞中毒诱发红皮病型银屑病一例报告

寻常型银屑病,由于药源性急性汞中毒而诱发转变为红皮病型银屑病较为少见,现将我们遇到一例报告如下。病例介绍患者,邵某,男,30岁,住院号100159。于1991年5月2日,开始用含汞中药(偏方)配制成香型,     

银屑病住院患者合并败血症分析

目的分析银屑病住院患者合并败血症的临床特点,做到早期诊断和治疗。方法回顾性分析2006年1月-2008年12月,在医院皮肤科住院714例银屑病患者中合并败血症的临床资料。结果 714例患者中,发生败血症7例,发生率为0.98%,其中5例为红皮病型银屑病患者,占红皮病型银屑病患者的6.85%;2例为脓疱型银屑病患者,占脓疱型银屑病患者的2.41%;从临床送检的各类标本中,共检出金黄色葡萄球菌12株,其中甲氧西林敏感金黄色葡萄球菌6株,耐甲氧西林金黄色葡萄球菌2株;凝固酶阴性葡萄球菌1株,为耐甲氧西林凝固酶阴性葡萄球菌;败血症治愈6例,治愈率85.71%。结论严重型银屑病患者合并败血症并非罕见,应引起临床皮肤科和感染科医师的重视;应监测血培养,进行脓疱的细菌培养和药物敏感性试验,首先给予经验治疗,根据药物敏感性结果再调整抗菌药物的使用,耐甲氧西林金黄色葡萄球菌感染首选万古霉素。     

Pustular psoriasis in childhood in 15 cases

Psoriasis is a common, chronic and recurrent, inflammatory disease of the skin. Children were affected in 30% of cases. Severe form can be observed: pustular psoriasis (PP), psoriatic arthropathy and erythrodermic psoriasis. There were 15 children with PP, with an age range of 1-15.5 years, (mean age 7.56 years). Psoriasis constituted 5% of the total dermatological disorders in children. The severe forms of psoriasis were rare in children Annular PP was the most common form of PP in children. Juvenile PP had generally better prognostic than in adults, but the evolution is characterized by recurrences.     

Cost-Effectiveness of Extracorporeal Photopheresis for the Treatment of Patients With Erythrodermic (Stage T4, M0) Cutaneous T-Cell Lymphoma in the Australian Setting

ObjectivesCutaneous T-cell lymphoma (CTCL) is a rare and incurable disease, and patients currently experience a lack of treatment options in Australia. This analysis evaluated the cost-effectiveness of extracorporeal photopheresis (ECP) compared with standard of care therapy for the treatment of patients with erythrodermic (stage T₄, M₀) CTCL, who are refractory to previous systemic treatment.MethodsA Markov model was developed from the perspective of the Australian government. Health states were treatment specific and transition probabilities were modeled from time-to-next-treatment data from a published Australian observational study of ECP and comparator treatments. Quality of life utility values were based on psoriasis as a proxy for CTCL, which was validated by consultation with local clinicians. The time horizon for the model was 5 years. The ECP treatment regimen was compared with a weighted treatment comparator based on results of a treatment survey and Australian prescribing data.ResultsECP as a second-line treatment option for CTCL was less costly and more effective than other treatment strategies. ECP had an average cost saving of $37 592 and incremental quality-adjusted life-year gained of 0.20 to 0.21, attributed to patients being able to better tolerate ECP thus avoiding subsequent treatment with high-cost alternatives.ConclusionsThis is the first published cost-utility analysis of ECP for CTCL. This analysis demonstrates that ECP is a cost-effective option for the treatment of patients with erythrodermic CTCL in Australia.     

Dermatologische Probleme bei Kindern mit Adipositas

While the impact of obesity on diabetes, cardiovascular disease and carcinoma development has been studied extensively, only little attention has been paid to its influence on the skin. Obesity alters the skin barrier, can induce skin manifestations, and worsens existing skin diseases like psoriasis. Cutaneous manifestations of obesity may be pseudoacanthosis nigricans, fibroma pendulans (skin tags, fibroepithelial polyps) and striae distensae. Obesity is also associated with hyperandrogenism in women and girls, promoting acne vulgaris, hirsutism, and androgenetic alopecia. In addition, there is a pathogenic association between obesity and psoriasis: the release of pro-inflammatory factors from fat tissue results in the worsening of psoriasis; an association between the severity of psoriasis and the body mass index has been shown. Obesity promotes skin infections like erysipelas and intertrigo.     

银屑病患者全血和皮肤谷胱甘肽过氧化物酶活力关系的研究

探讨了谷胱甘肽过氧化物酶（ＧＳＨ－Ｐｘ）与银屑病发病之间的关系。采用二巯基二硝基苯甲酸显色法，研究正常健康人和银屑病患者全血及皮肤ＧＳＨ－Ｐｘ活力的变化，结果表明，与正常健康人比较，银屑病患者全血和皮肤ＧＳＨ－Ｐｘ活力均明显降低（Ｐ＜０．００１，Ｐ＜０．０５），提示：ＧＳＨ－Ｐｘ活力的降低，特别是皮肤中ＧＳＨ－Ｐｘ活力的降低，可能是银屑病的重要原因之一。     

Life-threatening dermatoses

In the present review an overview from a special angle of dermatologic practice is provided: dermatologic diseases that represent immediate danger for the patients' life. Diseases were included in this circle on the basis of their importance in general medical practice. This selection includes diseases from dermatologic oncology, pustular and erythrodermic forms of psoriasis, bacterial, allergic conditions, and STDs. Severe burns, autoimmune bullous skin diseases and classic immunologic conditions are also covered. Beside the general approach, novel therapeutic possibilities are discussed in significant details.     

银屑病患者血浆内皮素-1检测及其临床意义

目的　探讨血浆内皮素 - 1在银屑病进行期和静止期水平的变化及其与银屑病发病机制的关系。方法　用放射免疫分析法检测 6 9例寻常型银屑病患者血浆中内皮素 - 1的水平 ,其中进行期 4 1例 ,静止期 2 8例 ,并与 2 2例健康者进行对照。结果　银屑病患者血浆内皮素 - 1高于正常对照组 (P <0 .0 5 ) ,且进行期银屑病患者血浆内皮素 - 1高于正常对照组 (P <0 .0 5 ) ,也高于静止期银屑病患者 (P <0 .0 5 )。结论　血浆内皮素 - 1水平异常可能与银屑病的发病有一定关系     

The prevalence of obesity is increased in patients with late compared with early onset psoriasis

PurposeWe compared the clinical and epidemiologic characteristics of early and late onset psoriasis with an emphasis on potential differences in the comorbidities associated with each subtype.MethodsAn observational, multicenter study was performed, and associations between the age at the time of diagnosis and binary comorbidity outcomes were evaluated using multiple logistic regression analysis adjusted for age and other relevant confounders.ResultsAn increased prevalence of positive family history, psoriatic arthritis, and depression was observed in patients with early onset psoriasis. On the other hand, late onset psoriasis was more frequently associated with obesity and elevated waist circumference compared with early onset form. Elderly psoriatic patients (at the age of 75 years) with late onset psoriasis are at an especially high risk for obesity compared with individuals at the same age with an early onset disease.ConclusionsThe increased frequency of psoriasis in the family of early onset patients may suggest that manifestation of psoriasis at younger age is driven by strong genetic influence. However, such a remarkable association of abdominal obesity with late onset psoriasis may suggest that obesity can be one of the acquired factors that may predispose for the development of psoriasis in the elderly.     

银屑病危险因素研究

目的探讨有家族史与无家族史银屑病患者的发病年龄、病情程度、发病季节及发病诱因等的关系.方法采用问卷调查形式对220例有家族史和547例无家族史银屑病患者以及647名正常对照进行调查,用EPIinfo软件对资料进行分析.结果①220例有家族史银屑病患者中,一级亲属和二级亲属的患病率分别为16.98%、2.70%.而对照的一级亲属和二级亲属的患病率分别为0.59%、0.19%.②有家族史银屑病患者中,女性平均年龄、平均发病年龄较男性早,统计学分析差异有显著性(t=1.7150,P＜0.05).有家族史男性发病年龄较无家族史男性要早,而女性患者中则差异无显著性(t=0.7392,P＞0.05).③发病诱因、病情程度及发病季节在有家族史和无家族史间无统计学意义,但环境因素无论对有家族史还是对无家族史银屑病患者,在统计学上差异均有显著性(χ2=0.23,P＜0.05).结论除平均年龄、平均发病年龄在有家族史和无家族史银屑病患者中存在统计学上显著差异外,发病诱因、病情程度及发病季节等则无统计学意义.说明遗传因素在有家族史患者中起着重要作用,同时也进一步论证了银屑病是一个多因素遗传病.     

银屑病与白细胞介素-17和白细胞介素-10表达水平的相关研究

目的 探讨银屑病与白细胞介素（IL）-17、IL-10表达的相关性.方法 采用酶联免疫吸附试验法检测32例银屑病患者（银屑病组）和30例健康体检者（对照组）血清IL-17和IL-10水平,并进行相关性分析.结果 银屑病组血清IL-17水平高于对照组[（57.59±11.99） ng/L比（33.27 ±6.49） ng/L],IL-10水平低于对照组[（25.38 ±4.32） ng/L比（32.01±5.54）n g/L],差异均有统计学意义（￡=9.84,5.27,P＜0.01）.银屑病患者血清IL-17与IL-10呈负相关（r=-0.70,P＜0.01）.结论 银屑病发病可能与IL-17、IL-10水平的失衡存在一定关联.