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1.
目的 采用不同浓度异丙肾上腺素对兔肾脏进行灌注,监测其对兔肾盂压力和生命体征的影响,以探索最佳灌注浓度。方法 将60只新西兰雄性大白兔采用随机抽签方法分成A、B、C、D四组,每组15只,其中A组、B组、C组为实验组,D组为对照组,实验组分别使用浓度为1.0、0.9、0.8μg/mL的异丙肾上腺素溶液进行肾盂灌注,D组使用生理盐水进行肾盂灌注。记录灌注0、4、8、16、25 min时各组大白兔的肾盂压、平均动脉压、心率及血药浓度。结果 3只大白兔因麻醉过深死亡,在A组、B组及D组各1只,得出57只有效实验数据。4组大白兔肾盂灌注后,肾盂压均升高,实验组与对照组比较,差异有统计学意义(P<0.05);A、B、C三组灌注至4 min后各组肾盂压力开始下降,D组灌注后肾盂压持续升高,在4、8、16、25 min时4组肾盂压力差异有统计学意义(P<0.05);在16、25 min时,A、B、C三组间差异有统计学意义(P<0.05)。实验组大白兔肾盂灌注4 min时,平均动脉压、心率、血药浓度数值均高于对照组,差异均有统计学意义(P<0.05)。结论 异丙肾上腺素作为灌注液...  相似文献   

2.
【目的】探讨静息心率对伴有正常射血分数的心力衰竭患者死亡率的预测作用。【方法】选择685例心力衰竭患者,进行超声心动图及生化检查。按入院时静息心率分为4组,A组心率<60次/min,B组心率60~70次/min,C组心率71~90次/min,D组心率>90次/min。分析各组患者在1年内的死亡率。【结果】1年内A组全因死亡率为10%,B组为18%,C组为20%,D组为35%(P<0.0001)。【结论】随着静息心率的增加,伴有正常射血分数的心力衰竭患者全因死亡率增加,因此静息心率可能是心血管疾病的一项独立危险因素。  相似文献   

3.
目的:探讨右美托咪定多模式给药在胸科麻醉中的应用效果。方法:选取84例胸科手术患者为研究对象,依据随机分配原则分为A组、B组、C组、D组四组,A组选用右美托咪定和罗哌卡因,B组选用右美托咪定和右美托咪定复合罗哌卡因,C组选用氯化钠和罗哌卡因,D组选用氯化钠和右美托咪定复合罗哌卡因,对比四组麻醉情况。结果:与T_0比价,A组、B组两组在T_1阶段平均动脉压、心率数值降低,C组、D组两组在T_2阶段时,平均动脉压、心率数值升高;C组、D组两组在T_2、T_3阶段时,平均动脉压、心率数值高于A组、B组两组数值,差异有统计学意义(P<0.05)。结论:右美托咪定多模式给药在胸科麻醉中的应用效果显著,值得应用。  相似文献   

4.
王栋 《中国医药导报》2011,8(28):184-185
目的:分析不同心率的急性心肌梗死患者对心功能的影响及特点。方法:将286例急性心肌梗死患者按入院时心率快慢分为4组,A组79例,心率〈70次/min;B组56例,心率70~79次/min;C组74例,心率80~89次/min;D组77例,心率≥90次/min,对比分析4组患者入院前后的临床特点。结果:随着心率的增加,心功能逐渐减退,发病至入院时间越来越长;溶栓率减少,而未通率增加,则死亡率增加。患者发病至入院的时间逐渐延长,收缩压、舒张压、脉压及白细胞计数均逐渐增加,B、C、D组与A组比较,差异均有统计学意义(均P〈0.05或P〈0.01)。结论:入院时心率快的急性心肌梗死患者多发病时间长,心功能差,预后差。  相似文献   

5.
目的探讨瑞芬太尼抑制重度子痫前期剖宫产术患者气管插管反应的有效剂量及对新生儿的影响。方法将100例重度子痫前期剖宫产患者用随机数字表法分为五组,A组瑞芬太尼剂量为0.25μg/kg,B组为0.50μg/kg,C组0.75μg/kg,D组1.00μg/kg,E组1.25μg/kg。进行血气分析、新生儿阿氏评分、收缩压和心率观察,统计有效率,分析半数有效剂量和有效剂量。结果五组血气分析结果及新生儿阿氏评分比较,差异无统计学意义(P均0.05);插管前各组收缩压、心率均较基础值低,差异有统计学意义(P0.05);插管后D组、E组收缩压、心率较基础值低,A组、B组较基础值高,差异有统计学意义(P0.05);分娩时各组收缩压、心率均低于基础值。插管后A组、B组、C组收缩压、心率及胎儿娩出时A组、B组、C组、D组收缩压、心率均高于E组,差异有统计学意义(P0.05)。A、B、C、D、E各组有效率分别为15.00%、45.00%、65.00%、75.00%、90.00%(P=0.0000);ED50为0.64μg/kg(95%CI 0.52~0.74),ED95为1.32μg/kg(95%CI 1.08~1.70μg/kg)。结论瑞芬太尼能有效抑制子痫前期剖宫产气管插管反应,应提前准备复苏设备以及时处理使用后新生儿短暂呼吸抑制。  相似文献   

6.
多普勒超声对正常人二尖瓣口及肺静脉血流频谱的分析   总被引:1,自引:0,他引:1  
目的利用多普勒超声观察正常人二尖瓣口及肺静脉血流频谱的变化,旨在探讨其影响因素及其间的相互关系.方法108例正常的健康人,平均年龄43 1±15.7岁.脉冲多普勒记录二尖瓣口血流频谱(MIF)及肺静脉血流频谱(PVF)参数.结果(1)MIF参数A、Ai、AF随年龄增长而升高,E、Ei、E/A随年龄增长而降低;PVF参数S、Si、S/D及SF随年龄增长而升高,D、Di随年龄的增长而降低.(2)在一定心率范围内,随着心率加快,MIF参数EI与PVF参数DI降低,SF增高.(3)MIF参数E、Ei、E/A、AF、APVF参数D、Di、S/D、SF、AR均有较好的相关性.结论正常人MIF和PVF的多普勒超声表现会受年龄、心率等些因素的影响,但其相互之间有着本质的联系.  相似文献   

7.
不同诱导量顺式阿曲库铵的肌松作用及安全性观察   总被引:1,自引:0,他引:1  
目的观察不同剂量顺式阿曲库铵的肌松作用及不良反应情况,寻找适宜的麻醉诱导剂量。方法将100例ASAI~II级手术患者随机分为A组、B组、C组及D组,各25例;分别静注顺式阿曲库铵0.1mg/kg(A组),0.15mg/kg(B组),0.2mg/kg(C组)和阿曲库铵0.5mg/kg(D组)诱导,观察血压、心率、全身皮肤情况和四个成串刺激(TOF)的变化。结果四组气管插管条件评估分级比较差异无统计学意义。与A组相比,B组、C组及D组肌松作用起效块,时间长(<0.05)。B组、C组及D组起效时间比较差异无统计学意义。D组1例患者出现皮肤潮红,心率加快,血压下降,需静注麻黄碱升压。结论在临床麻醉诱导时,顺式阿曲库铵的适宜剂量为0.15mg/kg(3倍ED95)。  相似文献   

8.
目的探讨盐酸戊乙奎醚在小儿全身麻醉(全麻)后肌松拮抗中的优势及安全性。方法将年龄5~7岁患儿80例,性别不限,随机分为A、B、C、D 4组。在全麻结束后,4个成串刺激(TOF)恢复75%时:A组患儿给予阿托品15μg/kg、新斯的明40μg/kg;B组患儿给予盐酸戊乙奎醚20μg/kg;C组患儿给予新斯的明40μg/kg;D组患儿给予盐酸戊乙奎醚20μg/kg、新斯的明40μg/kg。观察患儿心率,心率变异指数(HRI),体温,收缩压(SBP),拔管时间。结果 A组患儿心率明显增加,HRI增加,呼吸浅快,体温升高,烦躁;B组患儿心率增加不明显,呼吸恢复慢,拔管时间延长;C组患儿心率明显减慢,需用阿托品提高心率;D组患儿心率稍减慢,HRI小,呼吸恢复快而平稳,体温正常,患儿安静,与A组比较拔管时间无显著差异。结论盐酸戊乙奎醚复合新斯的明在小儿全麻后残余肌松拮抗中应用是安全有效的,且具有镇静的优势。  相似文献   

9.
杨海燕  王春  陈晓琳 《西部医学》2015,(3):392-394,397
目的调查β-受体阻滞剂在老老年慢性稳定型冠心病患者中的应用情况。方法选取老年科80岁以上慢性稳定型冠心病住院患者180例,根据患者病情分为A、B、C、D 4组:A组无慢性心衰及Ⅱ型糖尿病史;B组合并有慢性心衰病史,无Ⅱ型糖尿病史;C组无慢性心衰病史,有Ⅱ型糖尿病史;D组合并有慢性心衰及Ⅱ型糖尿病史。调查其一般临床资料及β-受体阻滞剂临床使用率、目标心率达标率及安全性。结果β-受体阻滞剂应用率为82.2%(148例);在应用倍他乐克的143例患者中,应用平片者占21.7%,剂量为6.25~200mg/d[(35.54±16.87)mg/d],其中25~50mg/d者占87.1%;应用缓释片者占78.3%,剂量为11.875~190mg/d[(43.67±20.54)mg/d],其中23.75~47.5mg/d者占85.7%;B、C、D组患者的剂量明显低于A组,差异有统计学意义(P<0.05或P<0.01);143例患者目标心率达标率为39.2%,明显副作用发生率为9.1%;B、C、D组患者的目标心率达标率明显低于A组,差异有统计学意义(均P<0.05)。结论β-受体阻滞剂在老老年慢性稳定型冠心病患者中临床安全性较高,目标心率达标率低。  相似文献   

10.
目的:探讨心率对急性心肌梗死患者近期和远期预后的影响。方法:将我院的1228例急性心肌梗死患者,根据患者出院时的静息心率水平分为4组(A组:心率<60次/min,共312例;B组:心率为60~80次/min,共287例;C组:心率为80~100次/min,共345例;D组:心率>100次/min,共284例)并进行定期回访调查。了解各组患者3个月内,1年内,2年内的再梗死情况、发生心力衰竭再入院情况和猝死情况,并进行比较。结果:3个月内,1年内,2年内各组发生再梗死的患者例数情况均为D组>C组>B组>A组(P?0.05)。3个月内各组发生因心力衰竭而再次入院的患者例数情况D组>C组>B组>A组(P<0.05),1年内和2年内各组发生因心力衰竭而再次入院的患者例数情况均为D组>C组>B组>A组(P?0.05)。3个月内,1年内,2年内各组发生猝死患者例数情况均为D组>C组>B组>A组(P?0.05)。结论:心率过快的急性心肌梗死患者发生再梗死,心力衰竭,猝死的机率均较大,应引起临床医生的广泛重视。医生应严格控制患者的心率水平,以达到理想的预后效果,提高患者的生活质量。  相似文献   

11.
Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P < 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (>0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P <0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P < 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.  相似文献   

12.
Objective: To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods: SD rats served as both donors and recipients. 4℃ sodium lactate Ringer's was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava (IVC) inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results: Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion: This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.  相似文献   

13.
Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P< 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P< 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.  相似文献   

14.
目的:评价使用安心颗粒对急诊经皮冠状动脉介入术(PPCI)术后生活质量的影响.方法:将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组(术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次)和对照组(仅接受基础药物治疗).所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表(MIDAS)、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果:入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异(P>0.05);出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低(P<0.05);组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低(P<0.05).两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血(P>0.05).两组发生轻度血小板减少症的患者数比较无差异(P>0.05).结论:PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.  相似文献   

15.
Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P<0.01);the MAP decreased(P<0.01)and the HR increased drastically(P<0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.  相似文献   

16.
Objective:To investigate the gene expression of osteoprotegerin(OPG) and osteoclast differentiation factor(ODF) in the bone tissue of patients with hip fracture due to osteoporosis. Methods:OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers(over 50 years old) with hip fracture(Observer Group) and 30 cases of hip facture sufferers with no osteoporosis(Control group) were analyzed with the Semi-Quantitative RT-PCR method. Results:The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion:Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.  相似文献   

17.
Objective:To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas(SPTP). Methods:Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin(HE) staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results:Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin(9/9 cases), AAT(9/9 cases), NSE(9/9 cases), ACT(7/9 cases), CK20(2/9 cases), CgA(1/9 cases), S-100(3/gcases), PR(4/gcases), Syn(3/9 cases) and CD56(5/9cases), negative in CEA and ER. Conclusion:SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.  相似文献   

18.
A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care(~'4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.  相似文献   

19.
Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.  相似文献   

20.
Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.  相似文献   

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