光动力治疗后的湿性年龄相关性黄斑变性患者的生存质量研究

目的评价光动力治疗（PDT）后的湿性年龄相关性黄斑变性（AMD）患者的生存质量。方法46例典型为主型的AMD患者采用PDT，并随访1年。对治疗前后AMD患者的最佳矫正视力、生存质量进行统计分析。结果治疗1年后，71．0％的患者视力下降小于3行。治疗后，调查量表中有部分视功能有显著改变。结论PDT能有效阻止湿性AMD所致的视力严重下降。     

年龄相关性黄斑变性的治疗现状

老年黄斑变性（age2related macular degenerati称AMD或ARMD）又称年龄相关性黄斑变性,常伴有进行性视力损害,严重影响老年人的生存质量,是全世界第三位不可逆性和西方国家老年人首位的致盲眼病,其在亚洲发病率亦呈逐渐增多的趋势。     

年龄性相关性黄斑变性的中医辨证治疗

年龄相关性黄斑变性（age-relatedmaculardegeneration，AMD）是全球性老年人致盲的主要眼病，尤以渗出型AMD致盲率高。且发病率随着年龄增长而增加，中医辨证治疗本病具有明显优势，本病贵在早期发现，早期治疗，预后较好。     

中医药治疗年龄相关性黄斑变性的优势（中）

很多患者对年龄相关性黄斑变性（AMD）的发生和发展以及如何治疗有很多疑问．希望更多地了解有关AMD的知识。其实．这对于AMD早期干预和及时治疗都是十分有利的。     

GPR143在年龄相关性黄斑变性中的研究进展

年龄相关性黄斑变性(AMD)是目前世界上不可逆致盲的主要原因之一,AMD在白种入中最常见,其发病风险随年龄增长而增加.AMD发生有种族、遗传易感性和色素生成等相关影响因素,其中最主要的缺陷发生在视网膜色素上皮(RPE)细胞上.RPE具有吸收散射光、循环吞噬脱落光感受器外节盘膜、支持视网膜间物质运输活动等多种功能,对视觉...     

年龄相关性黄斑变性的临床治疗及疗效评估

目的:分析年龄相关性黄斑变性的临床治疗方法以及疗效评估.方法:在2013年7月-2016年5月期间到院进行诊断治疗的年龄相关性黄斑变性患者中抽选66例,征得患者和其家属同意后,等分为对照组和实验组,各组病例数有33例,两组患者均以口服的方式使用维生素E胶丸和维生素C,实验组在此基础上加用舒肝明目丸予以进一步的治疗,对比分析两组患者治疗效果.结果:实验组治疗总有效率(90.9%)和对照组比较明显要高,组间数据对比有统计学意义,P<0.05.结论:在年龄相关性黄斑变性的临床治疗中使用中医,可提高疗效,有使用价值与推广价值.     

中医药治疗年龄相关性黄斑变性的优势（上）

年龄相关性黄斑变性（aged—related macular degeneration,AMD）为眼科难治性眼底病,是导致50岁以上人群低视力和致盲的首要病因。在我国随着人口老龄化．年龄相关性黄斑变性的发病率也逐年上升。据统计,我国75岁以上人群的发病率已高达15．15％。目前,美国超过175万人患此病,     

曲安奈德玻璃体腔注射治疗年龄相关性黄斑变性

目的：观察玻璃体眼内注射曲安奈德（TA）在年龄相关性黄斑变性中的疗效。方法：确诊为年龄相关性黄斑变性的患者30例45眼,给予眼内注射TA注射液4mg（0.1ml）。术后1、3、6个月定期随访,观察患者术后视力变化及新生血管膜大小改变,并对药物本身相关的潜在并发症进行监测。结果：11例患者（单眼患者5例,双眼患者6例）17眼完成术后6个月的随访,视力〈0.1者4眼,0.1～0.5者11眼,〉0.5者2眼。36眼术后视力有所提高,15眼视力达0.5以上。术后6个月的随访,17眼的新生血管膜面积明显缩小,但与术后3个月的随访相比,无明显变化。结论：曲安奈德眼内注射治疗AMD是安全有效的,并且在术后三个月时效果最佳。     

老年性黄斑变性：年龄越大，危险越高

一个人如果没有一个好的视力，生活质量就无从谈起。老年性黄斑变性就是一种对视力产生严重影响的疾病。 老年性黄斑变性又称为年龄相关性黄斑变性，简称AMD，是一种慢性进行性眼病，是与年龄相关的疾病。     

光动力疗法治疗渗出型老年性黄斑变性的效果分析与研究

目的观察渗出型老年性黄斑变性实施光动力疗法治疗的效果。方法选择2013年2月—2015年1月收治的渗出型老年性黄斑变性患者76例,随机分为激光组和光动力组,每组38例。激光组采用激光治疗,光动力组实施光动力疗法治疗。比较两组患者治疗总有效率、并发症发生率、2年复发率、干预前后患者黄斑脉络膜新生血管渗漏面积、黄斑脉络膜新生血管复合体厚度、矫正视力。计量资料比较采用t检验;计数资料比较采用χ2检验,P0.05为差异有统计学意义。结果光动力组渗出型老年性黄斑变性治疗总有效率高于激光组,差异有统计学意义(P0.05);光动力组并发症发生率、2年复发率低于激光组,差异有统计学意义(P0.05);干预前两组黄斑脉络膜新生血管渗漏面积、黄斑脉络膜新生血管复合体厚度、矫正视力相近,差异无统计学意义(P0.05);干预后光动力组黄斑脉络膜新生血管渗漏面积、黄斑脉络膜新生血管复合体厚度、矫正视力[(22.25±0.61)μm2、(236.21±20.51)μm、(4.78±0.32)]优于激光组[(26.14±0.62)μm2、(263.92±20.25)μm、(3.98±0.69)],差异有统计学意义(均P0.05)。结论渗出型老年性黄斑变性实施光动力疗法治疗的效果确切,可有效降低患者黄斑脉络膜新生血管渗漏面积、黄斑脉络膜新生血管复合体厚度,矫正视力,减少并发症,降低复发率。     

Biomarkers of oxidative stress in patients with wet age related macular degeneration

Objective

The aim of this study was to analyze biomarkers of oxidative stress in patients with wet age related macular degeneration (AMD).

Participants and Measurements

Case-control study that includes 163 patients with wet AMD (age group of 55–82 years with the mean age of 71 years and 170 age-matched healthy controls in the age group of 55–78 years with the mean age of 71 years. The following parameters were determined: reduced and oxidized Glutathione (GSH/GSSH), protein carbonyl groups, total antioxidant activity in plasma and the activity of endogenous antioxidant enzymes, such as, gluthatione peroxidase, gluthatione reductase and superoxide dismutase.

Results

We observed total antioxidant activity higher in control group (CG) compared with patients with wet AMD (7.1 ± 1.2 μM Trolox vs 5.8 ± 1.1 μM Trolox). Values of superoxide dismutase activity (SOD), gluthatione reductase (GR) and gluthatione peroxidase (GPx) are higher in control group than in patients with wet AMD. According to the GSH/GSSH results, average values were higher in the CG than in patients with wet AMD and data were not significantly different.. Values of protein carbonyl groups were higher in patients with wet AMD than in CG and significant differences were found.

Conclusions

The finding of the present study suggests that the patients with wet AMD are an altered metabolic state of oxidation-reduction and that it is convenient to give therapeutic interventions with antioxidants. We have demonstrated that systematic oxidative stress, measured by different biomarkers is closely associated with the wet AMD.     

Determinants of health related quality of life and health state utility in patients with age related macular degeneration: the association of contrast sensitivity and visual acuity

Background There has been increasing interest in the use of measures of health related quality of life (HRQoL) and health state utility values in Age Related Macular Degeneration (ARMD). Visual acuity has been found to be an important determinant of such measures in previous studies. More recently, another measure of visual impairment, contrast sensitivity has received considerable attention. We designed a study to examine whether the contribution of contrast sensitivity in explaining HRQoL and health utilities over and above that of visual acuity. Methods 209 patients with unilateral or bilateral ARMD were recruited into a cross-sectional study of patients from a large teaching hospital. Patients underwent visual tests (near and distant visual acuity, contrast sensitivity) and completed a vision function questionnaire, the VF-14, HUI3, and time trade-off. Results Using multivariate regression analysis, the study revealed that contrast sensitivity remained a statistically significant predictor of all outcome measures even when visual acuity was included. This result was supported by the correlation coefficients between measures. Conclusions The measurement of contrast sensitivity appears to be better related to a person’s HRQoL and health utility. Future studies should consider incorporating contrast sensitivity in addition to visual acuity. Studies, in particular economic evaluations, may underestimate the effect of treatment unless contrast sensitivity is considered.     

补充维生素D对光动力疗法治疗食管癌患者生命质量的影响

目的 探讨补充维生素D(VitD)对光动力疗法(PDT)治疗食管癌患者负性情绪及生命质量的影响。方法 150例食管癌患者按随机数字表法分为对照组和干预组。两组患者均接受PDT治疗,干预组在治疗前1周开始接受800 IU维生素D3口服,持续时间6个月。采用酶联免疫吸附测定法(ELISA)测定血清VitD水平、焦虑自评量表(SAS)和心境状态量表(POMS)评测心境状态、生活质量表(QOL)评测生活质量。结果 治疗后,干预组生活质量提高率和焦虑明显缓解率(81.1%、85.1%)显著高于对照组(52.1%、56.1%),差异有统计学意义(分别〖XC小五号.EPS;P〗＝13.247,P＝0.001,〖XC小五号.EPS;P〗＝14.904,P＝0.001))。治疗前,2组患者POMS、QOL评分、VitD水平比较,差异均无统计学意义(P＞0.05);治疗后,干预组POMS的紧张-焦虑、忧郁-沮丧、疲惫-惰性维度、活力-好动评分以及QOL评分均优于对照组、VitD水平高于对照组(P＜0.05)。结论 补充VitD有助于降低接受PDT治疗食管癌患者的负性情绪、提高患者生命质量。     

结直肠癌患者生命质量及其影响因素研究

目的评价结直肠癌患者的生命质量和社会支持,并探讨其相关的影响因素。方法采用欧洲癌症研究与治疗组织（EORTC）QLQ-C303.0生命质量问卷（中文版）和社会支持评价量表（SSRS）对103例结直肠癌术后患者进行调查。结果结直肠癌患者社会支持的总体状况较好。生命质量得分的多元线性回归分析结果表明,术后症状数目多是影响结直肠癌患者生命质量的不利因素,而高文化程度、好的社会支持、性格外向是影响结直肠癌患者生命质量的有利因素。结论加强术后护理,减少结直肠癌患者术后合并症状,增加结直肠癌患者的社会支持以及开展术后心理督导有利于改善结直肠癌患者的生命质量。     

Photodynamic therapy in age-related macular degeneration

INTRODUCTION: Exudative form of age-related macular degeneration is the leading cause of legal blindness in elderly. PURPOSE: The purpose of this study is to report 3.5 years experience with photodynamic therapy in this disorder. PATIENTS AND METHODS: Patient files of all patients underwent photodynamic therapy with verteporfin in Department of Ophthalmology, Semmelweis University, Budapest in a 3.5 years period were reviewed. Changes in visual acuity were considered as main outcome variable compared to natural history data. RESULTS: From April, 2000 to September 2003, 302 patients were treated using photodynamic therapy with verteporfin for exudative form of age-related macular degeneration. The mean change of visual acuity were 2.6 and 2,7 lines at 12 and 24 months, respectively, while according to the natural history data 4.2 and 4.5 could have been expected. After 2 years, 83% of the patients had visual acuity better than or equal to 20/200 (this is the level of legal blindness), while only 33% was expected according to natural history data. Visual acuity of 20/80 or better (practical ambulatory vision) was found in 39% of the treated eyes (12% in natural history data). There was no severe adverse event. CONCLUSIONS: Photodynamic therapy was found to reduce the risk of severe visual loss. The authors' results confirm the data from the international trials. To achieve good results, good patient compliance and continuous access to the treatment are indispensible.