白塞氏病并发外阴溃疡1例

1 病例报告 患者,29岁,已婚,孕5产1,因外阴肿痛伴溃疡3 月,于2003年5月3日入院.患者有反复发作口腔溃疡病史.5年前因右侧会阴体部溃疡在当地医院治愈.否认糖尿病、结核病史.3 月前无明显诱因出现外阴肿痛,会阴体及大阴唇多处溃疡,疼痛难忍,在当地反复治疗(具体不详)无效.     

早期前体T细胞急性淋巴细胞白血病1例报告

1 病例资料 患者男,39岁,因"反复发作2个月余"于2018年9月10日就诊于浙江省立同德医院.2018年7月因低热(37.8 ℃)伴疲倦嗜睡、右侧后背部疼痛,影响睡眠曾就诊于当地医院,查血常规示血小板计数降低(66×109/L),其余无特殊;超声检查示右侧颈部淋巴结肿大,未治疗.     

下肢静脉血栓形成并发肺栓塞猝死二例报告

1 病例摘要例1:患者男,38岁.因反复发作右侧胸部撕裂样疼痛伴左下肢胀半年,于1986年3月1日入院.患者于1985年6月因右侧中耳胆脂瘤作手术,术后恢复佳.同年9月某夜,突然发生右侧胸部撕裂样疼痛伴呼吸困难.胸片示右侧肺底部炎症.半个月后,左侧下肢肿胀、发冷、发绀及小腿疼痛.诊断为"左下肢静脉血栓形成",给予抗炎,扩血管治疗.同年11月9日再次突然胸部撕裂样疼痛发作,伴痰中带血,色鲜红,X线示     

全科医生对一例白塞氏病患者的处理

病例回顾 患者,男,39岁,以“反复口腔溃疡5年”为主诉来诊。患者5年前无明显诱因出现反复发作性口腔溃疡,疼痛、多发,多见于颊黏膜、舌缘、软腭、咽部等部位,可自愈,但反复发作。患者曾经用过西瓜霜喷剂、口腔贴膜等对症治疗,曾就诊于外院,考虑为口腔溃疡并已除外口腔癌（依靠症状,未做病理）。2011年曾出现双侧膝关节疼痛。     

WONCA Online电子病例介绍——血管性水肿

病例简介:患者,女,25岁,因眼部水肿(见图1)反复发作1年就诊.患者无过敏史,水肿处无瘙痒,但有中度疼痛.余体格检查无异常.     

骨癌误诊腰椎间盘突出症1例

重视全面检查,减少并发症,现将腰椎间盘突出手术后并发骨癌1例报告如下. 病历资料 患者,女,65岁,农民.因"腰腿痛2年,加重伴右下肢麻木疼痛1年"入院.患者于2年前无明显诱因出现腰部疼痛不适伴右下肢轻微麻木,未做进一步检查及治疗,其后症状反复发作,于入院前1年自觉腰痛及右下肢麻木疼痛加重伴活动功能受限.于当地医院就诊,诊断为"坐骨神经痛",给予"万通筋骨片,氨酚待因片"等药物(具体不详)治疗后,症状无明显缓解.     

外伤后阴囊横纹肌肉瘤1例

患者男,15岁,于10月前外伤导致右侧阴囊疼痛不适,右侧阴囊逐渐长大,伴坠胀不适,无排尿障碍,无明显尿频、尿急、尿痛及血尿。因＂阴囊持续长大、影响活动＂于2011年4月到我院就诊。查体：右侧阴囊明显肿大,如排球大小（图1）,     

发热、皮疹、溃疡、关节肿痛

患者××,男性,38岁,农民.因反复发作口腔溃疡半年余,发热、面部皮疹、关节肿痛6天,于1994年5月6日来我所就诊.患者于半年前开始反复发作口腔溃疡,半月前因双下肢静脉曲张,轻度水     

膈肌子宫内膜异位症合并自发性气胸1例报告

<正>1病历摘要患者女,37岁,已婚,因反复发作性右侧气胸5年,胸痛加重半年入院。5年前于月经期突发右侧胸痛,伴胸闷、气短,无明显呼吸困难,就诊当地医院经检查后诊断为"右侧气胸",给予胸腔闭式引流、抗炎及对症治疗,病情好转出院。此后每于     

姐妹同患贝赫切特综合征合并骶髂关节炎二例

例 1 患者女 ,2 4岁。因反复口腔溃疡、外阴溃疡伴结节性红斑 10年于 2 0 0 1年 3月 5日来我院就诊。患者自 10年前开始出现口腔痛性溃疡 ,每年反复发作多于 3次 ,同时伴发外阴溃疡。其后出现双下肢结节性红斑 ,有疼痛感 ,不痒。病程中有双骶髂部及臀部疼痛 ,偶有足跟痛。不伴发热 ,光过敏 ,无腹泻。无双手关节及腕关节疼痛 ,无眼科疾患。父母无类似疾病。体格检查 :体温 36 9℃ ,一般情况好 ,脸面部皮肤未见痤疮样皮疹。全身浅表淋巴结不肿大。双眼无充血 ,视力正常。舌面及颊粘膜各见一溃疡 ,触痛。双下肢见暗红色色素沉着。双骶髂关节压…     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.