Une des causes d'erreur des méthodes d'analgésimétrie en expérimentation animale

Ohne Zusammenfassung     

Etude des hernandiacées

The alkaloidal content of the leaves and stem barks of H. peltata has been studied; eleven alkaloids and three lignans are isolated from the leaves, eleven alkaloids from the stem barks. Thirteen different alkaloids are identified by means of the spectral analysis; twelve are aporphines and nor-aporphines.     

Plantes médicinales populaires des marchés de Dakar (Sénégal)

Abstract

In Senegal about six hundred species are used in traditional medicine. Some of these plants are sold by herbalists in Dakar markets and in the suburbs. This study shows that only forty species are commonly used for various indications in popular traditional medicine in this area.     

Validation et contrôle des procédés de stérilisation non-standards

With the upcoming abundance of sterilization techniques applied to various pharmaceutical product types, it has appeared useful to the committee to compile general guidelines for the proper mastery of this critical step of many pharmaceutical processes. Derived from the experience gained with conventional and more recent sterilization proccesses, this reports offers guidance for the definition of product sterility and the validation and control of the safety, reliability efficiency and proper operation of the non-standard sterilization processes.     

Le diagnostic rapide des mécanismes de résistance aux antibiotiques

Rapid tests using immunologic, biochemical or molecular biology techniques have been introduced for routine diagnosis in the laboratories of microbiology. The development of rapid tests for the detection of antimicrobial resistance mechanisms is justified in patients with high mortality risk when the antimicrobial therapy is unadapted. Rapid tests for detection of beta-lactamase and methicillin-resistance in staphylococci are available for routine use. The development of new molecular techniques for identification coupled with the detection of resistance genes should allow to widely expand the number of resistance mechanisms screened for.     

Étude psychométrique des effets de la thioridazine sur des sujets normaux

Summary As regards motor-functions, we have noticed in normal subjects a real drop of the speed of tapping and an increase of the amplitude of the mistakes at mirror-drawing under the influence of thioridazine.As for personality we have noticed an increase of psychical tension at mirror-drawing and to the rating-scale and the notes depression and introversion at M.M.P.I.If we compare these results with those found on patients we come to think that the changes of personality brought by the drug are reactions secondary to a direct pharmacological reaction of thioridazine to the elementary level of impulses, vigilance or of psychomotion. A psychological conflict is necessary for the sedative effect of thioridazine to make good. In the case of a steady and level-headed subject the drug acts as a threat bringing negative reactions, an increase of anxiety. Yet the effects remain discrete at the quantity the drug is administered.