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Magdarina D Agtini Rooswanti Soeharno Murad Lesmana Narain H Punjabi Cyrus Simanjuntak Ferry Wangsasaputra Dazwir Nurdin Sri Pandam Pulungsih Ainur Rofiq Hari Santoso H Pujarwoto Agus Sjahrurachman Pratiwi Sudarmono Lorenz von Seidlein Jacqueline L Deen Mohammad Ali Hyejon Lee Deok Ryun Kim Oakpil Han Jin Kyung Park Agus Suwandono Ingerani Buhari A Oyofo James R Campbell H James Beecham Andrew L Corwin John D Clemens 《BMC infectious diseases》2005,5(1):1-11
Background
In preparation of vaccines trials to estimate protection against shigellosis and cholera we conducted a two-year community-based surveillance study in an impoverished area of North Jakarta which provided updated information on the disease burden in the area.Methods
We conducted a two-year community-based surveillance study from August 2001 to July 2003 in an impoverished area of North Jakarta to assess the burden of diarrhoea, shigellosis, and cholera. At participating health care providers, a case report form was completed and stool sample collected from cases presenting with diarrhoea.Results
Infants had the highest incidences of diarrhoea (759/1 000/year) and cholera (4/1 000/year). Diarrhea incidence was significantly higher in boys under 5 years (387/1 000/year) than girls under 5 years (309/1 000/year; p < 0.001). Children aged 1 to 2 years had the highest incidence of shigellosis (32/1 000/year). Shigella flexneri was the most common Shigella species isolated and 73% to 95% of these isolates were resistant to ampicillin, trimethoprim-sulfamethoxazole, chloramphenicol and tetracycline but remain susceptible to nalidixic acid, ciprofloxacin, and ceftriaxone. We found an overall incidence of cholera of 0.5/1 000/year. Cholera was most common in children, with the highest incidence at 4/1 000/year in those less than 1 year of age. Of the 154 V. cholerae O1 isolates, 89 (58%) were of the El Tor Ogawa serotype and 65 (42%) were El Tor Inaba. Thirty-four percent of patients with cholera were intravenously rehydrated and 22% required hospitalization. V. parahaemolyticus infections were detected sporadically but increased from July 2002 onwards.Conclusion
Diarrhoea causes a heavy public health burden in Jakarta particularly in young children. The impact of shigellosis is exacerbated by the threat of antimicrobial resistance, whereas that of cholera is aggravated by its severe manifestations. 相似文献2.
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Susceptibility of Neisseria gonorrhoeae isolates from Jakarta, Indonesia, to antibiotics 总被引:1,自引:0,他引:1
R C Rockhill B Leksana U Wijaya D Martosudarmo W Soekanto W Widajatno 《The Southeast Asian journal of tropical medicine and public health》1982,13(1):96-99
The minimum inhibitory concentration (MIC) of penicillin, tetracycline and spectinomycin was determined for 6 beta-lactamase (PPNG) and 73 non beta-lactamase producing Neisseria gonorrhoeae isolates from Jakarta, Indonesia. All PPNG were resistant to greater than or equal to 128 micrograms/ml penicillin. Forty-six percent of the non-PPNG strains were inhibited by less than or equal to 1.0 microgram/ml of penicillin and 97% by less than or equal to 4 micrograms/ml. Most of the PPNG and non-PPNG isolates (90%) were inhibited by less than or equal to 4 micrograms/ml tetracycline and less than or equal to 16 micrograms/ml spectinomycin. Two non-PPNG strains were resistant to 64 micrograms/ml of tetracycline, 8 micrograms/ml penicillin and 32 micrograms/ml spectinomycin. The non-PPNG strains generally were more resistant to penicillin and tetracycline compared to strains tested from other parts of the world in previously reported studies. 相似文献
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Arvin Pramudita Siti Rosidah Novi Yudia Jeffri Simatupang Wulan Pingkan Sigit Rita Novariani Priscilia Myriarda Bambang Budi Siswanto 《Global Heart》2022,17(1)
Background:Although there have been several studies investigating prognostic factors for mortality in COVID-19, there have been lack of studies in low- and middle-income countries, including Indonesia. To date, the country has the highest mortality rate among Asian countries.Objective:We sought to identify the prognostic factors of mortality in hospitalized patients with COVID-19 in Jakarta.Methods:In this retrospective cohort study, we included all adult inpatients (≥18 years old) with confirmed COVID-19 from Koja General Hospital (North Jakarta, Indonesia) who had been hospitalized between March 20th and July 31st, 2020. Demographic, clinical, laboratory, and radiology data were extracted from the medical records and compared between survivors and non-survivors. Univariate and multivariate logistic regression analysis were used to explore the prognostic factors associated with in-hospital death.Results:Two hundred forty-three patients were included in the study, of whom 32 died. Comorbid of hypertension (OR 3.59; 95% CI 1.12–11.48; p = 0.031), obesity (OR 6.34; 95% CI 1.68–23.98; p = 0.007), immediate need of HFNC and/or IMV (OR 64.93; 95% CI 11.08–380.61; p < 0.001), abnormal RDW (OR 3.68; 95% CI 1.09–12.34; p = 0.035), ALC < 1,000/µL (OR 3.51; 95% CI 1.08–11.44; p = 0.038), D-dimer > 500 ng/mL (OR 9.36; 95% CI 1.53–57.12; p = 0.015) on admission, as well as chloroquine treatment (OR 3.61; 95% CI 1.09–11.99; p = 0.036) were associated with greater risk of overall mortality in COVID-19 patients. The likelihood of mortality increased with increasing number of prognostic factors.Conclusion:The potential prognostic factors of hypertension, obesity, immediate need of HFNC and/or IMV, abnormal RDW, ALC < 1,000/µL, D-dimer > 500 ng/mL, and chloroquine treatment could help clinicians to identify COVID-19 patients with poor prognosis at an early stage. 相似文献
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Objective: To assess the extent of existing published evidence on cholera and to characterize the epidemiologic data of cholera in Nepal.Methods: We conducted a literature scoping review by summarizing published literature reporting on cholera in Nepal from January 1946 to March 2019 in online databases: MEDLINE, Embase, Cochrane, and Global Health. Additionally, we reviewed national surveillance data on clinically diagnosed and laboratory confirmed cholera reported by the Ministry of Health and Population. Results: Most of the published studies were conducted predominantly in Kathmandu Valley during the rainy season; however, outbreaks have been reported in other parts of Nepal including Terai, Hilly and Mountain regions. Our literature review exhibited that all age groups were affected by cholera, but particularly children and young adults were at-risk age groups in Nepal. Vibrio cholerae serogroup O1, biotype El Tor, serotype Ogawa has been predominantly isolated with an emergence of resistant strains since 1996. Two mass vaccination campaigns using oral cholera vaccines were conducted: Rautahat district in 2014 and Banke district in 2017. Conclusions: Capacity building for a nation wide systematic cholera surveillance with rapid and reliable diagnosis is needed to better estimate the burden of cholera and identify geographically at-risk areas associated with the disease in Nepal. It is essential for developing an adequate policy on oral cholera vaccine introduction and effective water, sanitation and hygiene interventions. 相似文献
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Bukitwetan P Suryawidjaja JE Salim OCh Hidayat A Herwana E Lesmana M 《The Southeast Asian journal of tropical medicine and public health》2007,38(6):1088-1094
A study was conducted during January 2003 through August 2005, at two community health centers in south Jakarta, Indonesia, to detect nontyphoidal Salmonella infections in children with diarrhea. A total of 814 rectal swab samples were collected, of which 56 (6.9%) were positive for Salmonella. Among the serovars detected, Salmonella enterica serovar Typhimurium was found most frequently in 32.1% of all Salmonella isolates. Antimicrobial susceptibility testing using eight antibiotics showed 5.6% to 66.7% of Salmonella serovars resistant to ampicillin, trimethoprim-sulfamethoxazole, chloramphenicol, tetracycline, and nalidixic acid. However, all serovars were susceptible to norfloxacin, ciprofloxacin, and ceftriaxone. 相似文献
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H Witjaksono Z Benci? S Hendro W E DeWitt S Soediono B Winardi 《The Southeast Asian journal of tropical medicine and public health》1979,10(1):100-105
As the seventh pandemic of cholera is caused by V. cholerae biotype El Tor, the former criteria for endemicity of cholera need to be reconsidered as regards their applicability in areas that are infected with cholera. As the mortality rate of cholera nowadays can be reduced to a very low level due to modern methods of treatment, it is suggested that the infection rates of cholera should be taken into consideration as criteria of cholera endemicity, i.e. 1. Five years persistence of cholera cases in a given area. 2. Five percent infection rate among family contacts of cholera cases. 3. Minimum infection rate of 1% in a vicinity where cholera cases occur. It was also found that in such an endemic area it is very difficult to eliminate V. cholerae infection from a locality, even when all family contacts are treated with the full dose of tetracycline. 相似文献
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Objective: To describe the clinical manifestation of patient with severe dengue, to identify the serotypes and genotypes of dengue viruses(DENV) which concurrently infecting the patient, and to explore the possible relationship of severe dengue with the concurrent infection of DENV. Methods: Dengue diagnosis was performed using NS1 antigen detection and Ig G/Ig M ELISA. Standard clinical and laboratory examinations were performed to obtain the clinical and hematological data. DENV concurrent infections were detected and confirmed using RT-PCR and DENV Envelope gene sequencing. Phylogenetic analyses were performed to determine the genotypes of the viruses. Results: The patient was classified as having severe dengue characterized by severe plasma leakage, hemorrhage, and organ damage involving lung, liver, and kidney. Concurrent infection of DENV serotype 2 and 3 was observed. The infecting DENV-2 virus was grouped into Cosmopolitan genotype while DENV-3 virus was classified into Genotype Ⅰ. Both viruses were closely related to isolates that were endemic in Jakarta. Viremia measurement was conducted and revealed a significantly higher virus titer of DENV-3 compared to DENV-2. Conclusions: The occurrence of multi-serotype DENV infections was presented in a patient with severe clinical manifestation in Indonesia. The hyperendemicity of dengue in Indonesia may contribute to the DENV concurrent infections cases and may underlie the severity of the disease. 相似文献
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High rates of sexually transmitted diseases among male transvestites in Jakarta, Indonesia 总被引:2,自引:0,他引:2
Joesoef MR Gultom M Irana ID Lewis JS Moran JS Muhaimin T Ryan CA 《International journal of STD & AIDS》2003,14(9):609-613
Many male transvestites (waria) in Jakarta, Indonesia engage in unprotected receptive anal and oral intercourse with homosexual and bisexual men for pay. Although this behaviour clearly puts them at risk of sexually transmitted diseases (STDs), including HIV infection, little is known about the prevalence of STD among them. To learn the STD prevalence and its risk factors, we conducted an STD prevalence survey among waria in North Jakarta, Indonesia. From August to December 1999 we offered screening for rectal and pharyngeal infections with Neisseria gonorrhoeae (Ng), Chlamydia trachomatis (Ct) by DNA probe (GenProbe PACE 2) and for Treponema pallidum (Tp) by non-treponemal and treponemal serological tests. Of 296 participants (median age 28 years), 93% reported having been paid for sex. A total of 96% reported having had oral sex (median five times/week) and/or anal sex (median three times/week) in the last week. Ng was found in the rectum of 12.8% and the pharynx of 4.2%; Ct was found in 3.8% and 2.4%, respectively. A total of 43.6% had reactive non-treponemal and treponemal tests. Of the 129 with positive treponemal tests, 42.6% had non-treponemal test titres greater than 1:8. In the logistic regression model, waria who were younger (< or =25 years old) had a significantly 3.5 times risk of Ng and/or Ct infections than older waria (>25 years old). Because only 12% of waria stated that they consistently used condoms during any sex act, it is important to warn them that STD/HIV transmission can occur with either anal or oral sex and that the risk of either anal or oral transmission can be reduced by condom use. In addition, high rates of asymptomatic syphilis and rectal gonorrhoea warrant a periodic screening and treatment for these infections in this population. Because waria have the highest rates of HIV and their clients consist of homosexual and bisexual men, successful prevention efforts in waria could help curb the spread of the epidemic. 相似文献
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D T Dennis T R Hadi R J Brown S Sukaeri B Leksana R Cholid 《The Southeast Asian journal of tropical medicine and public health》1981,12(4):574-580
Rickettsia tsutsugamushi was isolated from L. (L.) arenicola chiggers and three species of rats in an area of scrub and sedge along the Bay of Jakarta. This is the only finding in Indonesia of a cycle of the agent of scrub typhus associated with L. (L.) arenicola. A serologic survey of nearly 300 persons living in two kampungs near the site at which rickettsiae were recovered revealed one individual with antibodies to R. tsutsugamushi. Murine typhus, with a seropositivity rate of 6.5%, may be endemic at low levels. 相似文献
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H Maheudin F Partono P Idris K N Idris 《The Southeast Asian journal of tropical medicine and public health》1977,8(2):173-178
A blood and clinical survey for bancroftian filariasis was made in the Kepu District of Central Jakarta in June 1976. About 90% of 614 inhabitants in the survey area was examined. The microfilarial rate was 4.5%; 5.8% in males and 3.3% in females. Most of the carriers were asymptomatic. The microfilarial density was low. There were 15 persons (2.7%) with signs and symptoms of filariasis; 11 males and 4 females. The total filariasis infection rate was 6.7%. The percentage of infected persons increased with years of residency. Persons living in poorly built houses had approximately 9 times higher microfilarial rate and 5 times higher disease rate than those living in modern houses. 相似文献
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Cholera is a substantial health burden on the developing world and is endemic in Africa, Asia, South America, and Central America. The exact scale of the problem is uncertain because of limitations in existing surveillance systems, differences in reporting procedures, and failure to report cholera to WHO; official figures are likely to greatly underestimate the true prevalence of the disease. We have identified, through extensive literature searches, additional outbreaks of cholera to those reported to WHO, many of which originated from the Indian subcontinent and southeast Asia. Such underestimation of cholera can have important implications for decisions on provision of health interventions for indigenous populations, and on risk assessments for travellers. Furthermore, until recently, it has not been possible to implement public-health interventions in low-income countries to eliminate disease, and the prevention of cholera in travellers has been limited to restrictive guidelines. However, a vaccine against cholera is now available that has proven efficacy and tolerability in mass vaccination campaigns in low-income countries, and among travellers. 相似文献
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S W Joseph D W Eggena H Danusantoso H O Tanzil A Chatim 《The Southeast Asian journal of tropical medicine and public health》1976,7(4):513-517
Sputum specimens from more than 1000 Indonesian tuberculosis suspects were examined by bacteriologic culture, and by bright field and fluorescence microscopy. Two hundred twenty had positive Mycobacterium tuberculosis cultures and of these 68% were positive by fluorescence microscopy. Agreement between culture, both negative and positive, and fluorescence microscopy was 87%. Sensitivity to antituberculous drugs was performed in 209 isolates. Significant resistance to isoniazid, para-amino salicylic acid, and streptomycin was found i.e. 65 (31%), 19 (19%), 54 (26%), respectively. Fluorescence microscopy was a useful method for rapid microscopic confirmation of tuberculosis and was especially valuable in detecting difficult-to-culture organisms. 相似文献
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Vollaard AM Ali S Smet J van Asten H Widjaja S Visser LG Surjadi C van Dissel JT 《The Southeast Asian journal of tropical medicine and public health》2005,36(6):1552-1561
We assessed the water supply, water quality and human waste disposal and their association with diarrheal illness in Jatinegara, East-Jakarta, where part of the area has been involved in the Kampung Improvement Program (KIP). Three hundred seventy-eight households, randomly selected in the study area, were visited and questioned about water source, sanitation and diarrheal illness during the previous 3 months. Microbiological quality of drinking water was assessed. The water sources were boreholes (243; 64%), the water mains (77; 20%), bottled water (45; 12%), and vendors or dug wells (243; 4%). Fecal coliforms were isolated in 56% of the samples [median 23 (IQR 6-240) /100 ml in the contaminated samples]. Only 2 (3%) of the water mains' samples contained >100 fecal coliforms/100 ml, compared to 57 (24%) groundwater samples. Most residents used private toilets with drainage into on-site septic tanks, yet in over one quarter of households human excreta was disposed of into rivers or gutters. KIP areas lagged behind in environmental hygiene. Diarrheal episodes, reported in one third of the households, were significantly associated with water contaminated with >100 fecal coliforms/100 ml [OR 2.4 (95% CI: 1.4-4.2)], but no association with water source or environmental contamination was found. Significantly, all individuals reported boiling water before consumption. 相似文献
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Oyofo BA Subekti DS Svennerholm AM Machpud NN Tjaniadi P Komalarini TS Setiawan B Campbell JR Corwin AL Lesmana M 《The American journal of tropical medicine and hygiene》2001,65(2):120-124
Infection caused by enterotoxigenic Escherichia coli (ETEC) poses a serious health problem among children and adults in developing countries. Colonization of the small intestinal mucosa by ETEC strains is mediated by antigenically specific fimbriae, also known as colonization factor antigens (CFA). The significance of this study arises from reports that active and passive immunization with ETEC strains harboring CFAs has previously been shown to induce protective immunity against diarrhea in animal models. The aim of this study was to determine toxin-associated CFAs of ETEC isolated from a diarrheal disease case-control study in Jakarta, Indonesia. Thirteen hundred and twenty-three diarrheic and control patients with lactose-fermenting colonies were screened by ganglioside GM1-enzyme-linked immunosorbent assay (GM1-ELISA) for heat-labile (LT) and heat-stable (ST) toxins. Two hundred and forty-six (19%) ETEC isolates identified by GM1-ELISA for the LT/ST toxins were screened for CFAs by Dot blot assay using monoclonal antibodies against CFA/I, II, and IV and against the putative colonization antigens (PCF) PCFO159, PCFO166, CS7, and CS17. Of the 246 ETEC isolates, 177 (72%) elaborated ST, 56 (23%) produced LT, while 13 (5%) elicited both the ST and LT toxins. CFA testing of the 246 ETEC isolates showed that 21 (8%) expressed CFA/I, 3 (1%) exhibited CFA/II, 14 (6%) elaborated CFA/IV, while 7 (3%) expressed PCFO159 and PCFO159 plus CS5. No CFAs or PCFs could be associated with 201 (82%) of the ETEC strains. This report documents the types of CFAs associated with ETEC strains in Jakarta, Indonesia. These data may help current research efforts on the development of CFA-based vaccines for humans against ETEC and provide additional information for future ETEC vaccine trials in Southeast Asia. 相似文献
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Christian Schaetti Ahmed M Khatib Said M Ali Raymond Hutubessy Claire-Lise Chaignat Mitchell G Weiss 《BMC infectious diseases》2010,10(1):339