Effect of rewarming in oxygenation and respiratory condition after neonatal exposure to moderate therapeutic hypothermia

BackgroundTo assess changes in clinical condition and oxygenation in neonates after rewarming following moderate therapeutic hypothermia (MTH) for neonatal encephalopathy.MethodsRetrospective study of 28 neonates receiving MTH in a tertiary neonatal intensive care unit in Israel. We compared pre-and 24 h post-rewarming arterial oxygen saturation (SaO₂) as measured by the blood gases analyzer, pulse-oximetry saturation (SpO₂), and cardio-respiratory condition.ResultsThe SpO₂ declined from 96.9% (±2.9) before rewarming to 95.2% (±2.6) after rewarming (p < 0.001). Twelve neonates (42.9%) had clinical respiratory impairment (needing higher respiratory support or had new onset desaturations). In 16 neonates (57.1%) with no change in respiratory support after rewarming, SpO₂ decreased from 98.3 ± 1.9% to 95.6 ± 3.0% (p < 0.001) and SaO₂ decreased from 97.1 ± 1.7% to 96.0 ± 2.3% (p = 0.002). The mean SpO₂ decrease was greater than mean SaO₂ decrease (2.63 ± 1.8 and 1.1 ± 1.3 respectively, p = 0.021).ConclusionNeonates who underwent MTH showed reduction in oxygenation after rewarming either by decreasing SpO₂ or increasing FiO₂ requirements. The SpO₂ decline was larger than the SaO₂ decline. We suggest careful monitoring of neonates after rewarming.