共查询到20条相似文献,搜索用时 15 毫秒
1.
The authors have investigated the aging changes of the human AV node, AV bundle, and bundle branches considering the influences of various disorders of individuals upon these conduction tissues. These conduction tissues began to develop gradually from the infant stage and the development was completed by young adult stage. Aging changes of the conduction tissues were fat infiltration, fibrosis and elastosis, disappearance of muscle fiber, and general atrophy of the conduction tissues. They were thought to occur not only by aging but also by the influences of various disorders particularly of long-standing chronic diseases. Changes of the conduction tissues seem to be related with thickening and luminal narrowing of the AV nodal artery and superior ventricular septal arteries. Marked elastosis or atrophy was noted in the cases suffering from some long-standing disorder regardless of the sort of disorders. In the cases which were diagnosed as complete heart block clinically, destruction of the conduction tissues was extremely severe including those of the SA node. 相似文献
2.
The cardiac conduction systems including sinoatrial (SA) node, atrioventricular (AV) node, atrioventricular(His) bundle, and peripheral conduction system (left and right bundle branch, and Purkinje fiber) of 23 patients with Duchenne progressive musculr dystrophy(DMD) were studied with light microscope. Infiltration of fat tissue and mild fibrosis were occasional findings in SA and AV nodes. Degeneration of the conduction muscle fiber was hardly noted in SA node, AV node, and His bundle. Only the peripheral conduction system (Purkinje fiber) showed significant degenerations such as eosinophilic, necrotic and vacuolar changes with fibrosis. These necrobiotic changes resembled hyaline and vacuolar skeletal and cardiac muscular degenerations in DMD and were assumed to have occurred on the basis of the structural and constitutional characteristics of the peripheral conduction fiber as a striated muscle fiber. The vascular changes and amyloid deposit suggesting precocious aging in the conduction systems were not observed. 相似文献
3.
The development of the atrioventricular (AV) node and bundle in the ferret heart was examined at the light microscopic level. The AV node develops from two primordia which were first observed in the posterior wall of the common atrium during the stage when the single heart tube convolutes. During septation of the heart, the AV nodal primordia eventually fuse and come to lie at the base of the interatrial septum. The right AV nodal primordium is located below the attachment of the right venous valve to the interatrial septum. The left AV nodal primordium maintains a position anterior to the prospective ostium of the coronary sinus. At 16 days of gestation, large pale cells were seen in the dorsal AV canal. By 21 days of gestation these AV canal cells have been replaced by AV bundle cells. At this time the bundle is continuous with both nodal primordia. At birth the AV bundle is continuous mainly with the component of the AV node that is derived from the right AV node primordium. The anulus fibrosus begins to undergo the greatest developmental change after the AV node and bundle attain their final position in the AV junction. However, the anulus does not completely separate the atria from the ventricles during the later stages of development nor at birth, so that accessory AV pathways are present in the newborn ferret heart. Both the AV node and the AV bundle also demonstrated continuity with the myocardial cells of the interventricular septum in the neonatal heart. During development there was no evidence that rings of specialized tissues at the junctions of the cardiac chambers give rise to any component of the cardiac conduction system. 相似文献
4.
Thomas A. Marino 《Developmental dynamics》1979,154(3):365-391
The cells of the atrioventricular (AV) junction in the ferret heart were examined using light microscopy, a wax-model reconstruction and quantitative electron microscopy to determine their organization and characteristics. A series of subdivisions of the specialized tissues of the AV junction was apparent at both the light and electron microscopic levels. A transitional zone was observed interposed between the atrial muscle cells and the AV node. The AV node consisted of a coronary sinus portion, a superficial portion and a deep portion. The AV bundle had a segment above the anulus fibrosus, a segment which penetrated the right fibrous trigone, a non-branching segment below the anulus fibrosus and a branched segment. At the ultrastructural level the AV junctional conduction tissues had fewer irregularly oriented myofibrils than did working atrial myocardial cells. T-tubules, present in atrial muscle cells, were not observed in the modified muscle cells of the AV node and bundle. Conventional intercalated discs also were not observed between the cells of the AV node or the AV bundle. Atrial myocardial cells had the highest percentage of the plasma membrane occupied by desmosomes, fasciae adherentes and gap junctions. The AV bundle cells had the highest percentage of appositional surface membrane and a relatively large fraction of plasma membrane occupied by gap junctions. Cells of the superficial portion of the AV node had the smallest percentage of the plasma membrane composed of gap junctions, desmosomes or fasciae adherentes, as well as the smallest fraction of the cell membrane apposed to adjacent cells. The stereological data indicate that the most useful distinguishing characteristic between atrial muscle cells and conduction cells was that a smaller percentage of the conduction cell sarcoplasm was occupied by mitochondria and myofibrils. The most useful characteristics that could be used to differentiate between the regions of the AV junctional conduction tissues were the amounts and types of surface membrane specializations in the respective cell types. 相似文献
5.
The microscopic anatomy of the atrioventricular node, bundle of His, both bundle branches and surrounding fibrous cardiac skeleton was studied in 40 large breed dogs of various ages. In the AV conduction system of all dogs over five years of age there was an increase of fibrous connective tissue, an infiltration of adipose tissue, loss of conduction fibers and focal fibrosis extending from the central fibrous body. Fibrosis was seen in the summit of the interventricular septum posterior to the AV node in dogs of all ages. Chondroid metaplasia was consistently observed in the central fibrous body and the root of the aorta in large breed dogs, including ten Doberman Pinschers of all ages. This metaplasia varied from a few chondroblasts and chondrocytes to mature chondrocytes with mineralization. Bone formation was seen in eight dogs. These changes appeared in close approximation to the cardiac conduction system above the bundle of His. No degenerative changes were seen in the AV bundle. Approximately one-half of the large breed dogs five years of age and older had thickened medial and intima proliferation in the small coronary arterioles supplying the AV node. The results of this study suggest that the presence of cartilage and bone in the central fibrous body is a normal occurrence in large breed dogs at all ages. 相似文献
6.
George E. Sandusky Kirklyn M. Kerr Charles C. Capen 《Anatomical record (Hoboken, N.J. : 2007)》1979,193(4):883-901
The microscopic anatomy of the atrioventricular node, bundle of His, both bundle branches and surrounding fibrous cardiac skeleton was studied in 40 large breed dogs of various ages. In the AV conduction system of all dogs over five years of age there was an increase of fibrous connective tissue, an infiltration of adipose tissue, loss of conduction fibers and focal fibrosis extending from the central fibrous body. Fibrosis was seen in the summit of the interventricular septum posterior to the AV node in dogs of all ages. Chondroid metaplasia was consistently observed in the central fibrous body and the root of the aorta in large breed dogs, including ten Doberman Pinschers of all ages. This metaplasia varied from a few chondroblasts and chondrocytes to mature chondrocytes with mineralization. Bone formation was seen in eight dogs. These changes appeared in close approximation to the cardiac conduction system above the bundle of His. No degenerative changes were seen in the AV bundle. Approximately one-half of the large breed dogs five years of age and older had thickened medial and intima proliferation in the small coronary arterioles supplying the AV node. The results of this study suggest that the presence of cartilage and bone in the central fibrous body is a normal occurrence in large breed dogs at all ages. 相似文献
7.
D K Racker 《The Anatomical record》1999,256(1):49-63
There is little detailed knowledge of the architecture of the AV junction region, the cytoarchitecture of the AV node or of its atrial connections. In the present study, the gross anatomy and topography of intracardiac structures in 21 adult canine hearts were photographically compared in whole and dissected hearts and tissue blocks and serial histologic sections made in three orthogonal planes. There are seven major new findings: 1) A coronary sinus fossa exists at the crux of the heart. It separates the right medial atrial wall (MAW) superoposterior region from the left atrium, its floor is the coronary sinus, and it carries the medial atrionodal bundle and proximal AV bundle on its right wall. 2) The posterior MAW forms two isolated bridges of myocardium as it surrounds the coronary sinus ostium, is isolated from the sinus venarum with crista terminalis and interatrial septum-by the floor of the inferior vena cava, and the narrow bridges link the posterior atrial wall to the mid MAW. 3) The tendon of Todaro has both epicardial and endocardial exposures, terminates in the superoposterior MAW and its medial aspect is adjacent sequentially to the medial atrionodal bundle and proximal AV bundle. 4) Only ordinary myocardium contacts the anulus fibrosus. 5) The ventricular septum's shoulder is humped shape posteriorly, is completely overlaid by anular myocardium and the medial leaflet and is joined by struts of papillary muscle. 6) The membranous septum joins the anterior ventricular septum to the crista supraventricularis, forms part of the posterior noncoronary and right aortic valve sinus walls and encases the right bundle branch. 7) The specialized conduction tissues, the superior, medial and lateral atrionodal bundles, the proximal AV bundle, AV node, distal AV bundle and right bundle branch are subjacent to MAW epicardium outside the right atrium, share regular intracardiac relationships with topographic landmarks and the medial atrionodal bundle, terminal superior atrionodal bundle, the proximal AV bundle and AV node are aligned to the medial leg of Koch's triangle. Thus, atrial myocardium of the AV junction region is that of the MAW. The floor of the inferior vena cava forms a natural barrier to impulse transmission along the full extent of the posterior MAW. The specialized tissues are outside of the MAW. Anatomic landmarks form reliable topographic landmarks for the specialized AV junction region tissues. A knowledge of the association of the specialized conduction tissues with specific regions of the MAW is useful in localizing the tissues and along with the coronary sinus fossa provides several extracardiac approaches. 相似文献
8.
Kaneshige T Machida N Yamamoto S Nakao S Yamane Y 《Journal of comparative pathology》2007,136(2-3):120-126
The cardiac conduction system was examined histologically in four canine cases of endocardiosis of the mitral valve (MV) with complete atrioventricular (AV) block. In all cases, moderate to severe reduction of the conduction fibres due to fibrous or fibro-fatty replacement was observed in the penetrating and branching portions of the AV bundle. In addition, degenerative and fibrotic lesions were commonly seen at the upper portions of the left and right bundle branches. These changes in the AV conduction system were associated with marked degeneration and fibrosis of the base of the central fibrous body and the upper part of the ventricular septum. The degenerative and sclerotic changes of the AV junctional region, affecting the AV bundle and bundle branches, were qualitatively similar to those in age-matched control dogs, but were more severe. It is possible that the pathological process occurred as a result of ageing and may have been exaggerated or accelerated by the abnormal mechanical forces created by excessive motion of the prolapsed MV and the long-term haemodynamic stresses of mitral regurgitation, resulting in interruption of the AV conduction system to produce complete AV block. Conduction abnormalities represent a possible complication in some canine cases of MV endocardiosis. 相似文献
9.
Darlene K. Racker 《Anatomical record (Hoboken, N.J. : 2007)》1999,256(1):49-63
There is little detailed knowledge of the architecture of the AV junction region, the cytoarchitecture of the AV node or of its atrial connections. In the present study, the gross anatomy and topography of intracardiac structures in 21 adult canine hearts were photographically compared in whole and dissected hearts and tissue blocks and serial histologic sections made in three orthogonal planes. There are seven major new findings: 1) A coronary sinus fossa exists at the crux of the heart. It separates the right medial atrial wall (MAW) superoposterior region from the left atrium, its floor is the coronary sinus, and it carries the medial atrionodal bundle and proximal AV bundle on its right wall. 2) The posterior MAW forms two isolated bridges of myocardium as it surrounds the coronary sinus ostium, is isolated from the sinus venarum with crista terminalis and interatrial septum—by the floor of the inferior vena cava, and the narrow bridges link the posterior atrial wall to the mid MAW. 3) The tendon of Todaro has both epicardial and endocardial exposures, terminates in the superoposterior MAW and its medial aspect is adjacent sequentially to the medial atrionodal bundle and proximal AV bundle. 4) Only ordinary myocardium contacts the anulus fibrosus. 5) The ventricular septum's shoulder is humped shape posteriorly, is completely overlaid by anular myocardium and the medial leaflet and is joined by struts of papillary muscle. 6) The membranous septum joins the anterior ventricular septum to the crista supraventricularis, forms part of the posterior noncoronary and right aortic valve sinus walls and encases the right bundle branch. 7) The specialized conduction tissues, the superior, medial and lateral atrionodal bundles, the proximal AV bundle, AV node, distal AV bundle and right bundle branch are subjacent to MAW epicardium outside the right atrium, share regular intracardiac relationships with topographic landmarks and the medial atrionodal bundle, terminal superior atrionodal bundle, the proximal AV bundle and AV node are aligned to the medial leg of Koch's triangle. Thus, atrial myocardium of the AV junction region is that of the MAW. The floor of the inferior vena cava forms a natural barrier to impulse transmission along the full extent of the posterior MAW. The specialized tissues are outside of the MAW. Anatomic landmarks form reliable topographic landmarks for the specialized AV junction region tissues. A knowledge of the association of the specialized conduction tissues with specific regions of the MAW is useful in localizing the tissues and along with the coronary sinus fossa provides several extracardiac approaches. Anat Rec 256:49–63, 1999. © 1999 Wiley‐Liss, Inc. 相似文献
10.
Morphology and electrophysiology of the mammalian atrioventricular node 总被引:12,自引:0,他引:12
The AV node of those mammalian species in which it has been thoroughly investigated (rabbit, ferret, and humans) consists of various cell types: transitional cells, midnodal (or typical nodal cells), lower nodal cells, and cells of the AV bundle. There are at least two inputs to the AV node, a posterior one via the crista terminalis and an anterior one via the interatrial septum, where atrial fibers gradually merge with transitional cells. The role of a possible third input from the left atrium has not been investigated. Since the transition from atrial fibers to nodal fibers is gradual, it is very difficult to define the "beginning" of the AV node, and gross measurements of AV nodal length may be misleading. Histologically, the "end" of the AV node is equally difficult to define. At the site where macroscopically the AV node ends, at the point where the AV bundle penetrates into the membranous septum, typical nodal cells intermingle with His bundle cells. A conspicuous feature, found in all species studied, is the paucity of junctional complexes, most marked in the midnodal area. The functional counterpart of this is an increased coupling resistance between nodal cells. An electrophysiological classification of the AV nodal area, based on transmembrane action potential characteristics during various imposed atrial rhythms (rapid pacing, trains of premature impulses), into AN (including ANCO and ANL), N, and NH zones has been described by various authors for the rabbit heart. In those studies in which activation patterns, transmembrane potential characteristics, and histology have been compared, a good correlation has been found between AN and transitional cells, N cells and the area where transitional cells and cells of the beginning of the AV bundle merge with midnodal cells, and NH cells and cells of the AV bundle. Dead-end pathways correspond to the posterior extension of the bundle of lower nodal cells and to anterior overlay fibers. During propagation of a normal sinus beat, activation of the AN zone accounts for at least 25% of conduction time from atrium to His bundle, the small N zone being the main source of AV nodal delay. Cycle length-dependent conduction delay is localized in the N zone. Conduction block of premature atrial impulses can occur both in the N zone and in the AN zone, depending on the degree of prematurity. Several factors determining AV nodal conduction delay have been identified.(ABSTRACT TRUNCATED AT 400 WORDS) 相似文献
11.
Michio Tanaka Shutaro Satake Yutaka Kawahara Masaya Sugiura Kenzo Hirao Kazushi Tanaka Tokuhiro Kawara Akihiro Masuda Toshio Nishikawa Takeshi Kasajima 《Pathology international》1991,41(7):487-498
Radiofrequency catheter ablation of the atrioventricular (AV) node or bundle of His was performed in 12 adult mongrel dogs. The aim was to create chronic incomplete AV block (first- and second-degree AV block) and to examine the histopathology of the ablated lesions. However, the late electrophysiological results (2 4 weeks follow up) were various: normal in 2 dogs, mild PR prolongation (< 50%) in 2 dogs, first-degree AV block (PR prolongation a 50%) in 2 dogs, second degree AV block in 2 dogs, complete AV block in 4 dogs. The maximally ablated area (%) of the atrioventricular conduction system in serial histologic sections from dogs with these conditions was 69%, 75%, 89.5%, 95% and 99.5%, respectively. The number of intact conduction cells at the maximally ablated site varied from 6 to 30 in the four cases of incomplete AV block. The mean ablated volume (%) of either the AV node or penetrating His bundle correlated roughly with the degree of AV block. The ablated lesions were well demarcated and almost replaced by dense fibrous tissue at 4 weeks. Interruption (3 dogs) or thinning (1 dog) of the endocardial elastic lamellae was detected, in association with endocardial thickening (mean 913 μm). Endocardial thrombi were found in 3 dogs (2 fresh, 1 organized). We conclude that radiofrequency catheter ablation does not cause severe complicated lesions. Several possible conditions for creating chronic incomplete AV block are discussed. Acta Pathol Jpn 41: 487–498, 1991. 相似文献
12.
There have been advances in electrophysiology which have necessitated a more thorough semi-quantitative analysis of the entire conduction system to yield data useful for correlation purposes. Thus an attempt is made to modify and expand our previous method of studying the conduction system pathologically. This method thus includes the study of the sinoatrial (SA) node and its approaches, the atrial preferential pathways, the approaches to the atrioventricular (AV) node, the AV node, the penetrating and branching portions of the AV bundle, the bundle branches, the peripheral Purkinje nets, and the remainder of the atrial and ventricular myocardium. The SA node and its approaches are studied in a longitudinal manner. This gives a better insight into the pathologic changes than does a study in the transverse direction. The approaches to the AV node, bundle and bundle branches are studied in an oblique manner, rather than horizontally apicalward, or from the posterior to the anterior septal region. The horizontal manner does not give sufficient sampling of the AV node and bundle unless complete serial sections are made. Sectioning from the posterior to the anterior septal wall makes difficult an evaluation of the right bundle branch. In conduction system correlation with Wolff-Parkinson-White and Lown-Ganong-Levine syndromes complete serial sectioning of both AV rims is advisable. Where complete serial sectioning is impossible in large adult hearts, retaining every fifth section may be permissable. In the study of congenitally abnormal hearts, it is advisable to embed the entire heart as a unit. If that is impossible because of the size of the heart, then very careful judicious planning of the fashioning of the blocks is necessary, so that displaced SA nodes, and anterior AV nodes and bundles are not overlooked. 相似文献
13.
M Tanaka S Satake Y Kawahara M Sugiura K Hirao K Tanaka T Kawara A Masuda T Nishikawa T Kasajima 《Acta pathologica japonica》1991,41(7):487-498
Radiofrequency catheter ablation of the atrioventricular (AV) node or bundle of His was performed in 12 adult mongrel dogs. The aim was to create chronic incomplete AV block (first- and second-degree AV block) and to examine the histopathology of the ablated lesions. However, the late electrophysiological results (2-4 weeks follow-up) were various: normal in 2 dogs, mild PR prolongation (less than 50%) in 2 dogs, first-degree AV block (PR prolongation greater than or equal to 50%) in 2 dogs, second-degree AV block in 2 dogs, complete AV block in 4 dogs. The maximally ablated area (%) of the atrioventricular conduction system in serial histologic sections from dogs with these conditions was 69%, 75%, 89.5%, 95% and 99.5%, respectively. The number of intact conduction cells at the maximally ablated site varied from 6 to 30 in the four cases of incomplete AV block. The mean ablated volume (%) of either the AV node or penetrating His bundle correlated roughly with the degree of AV block. The ablated lesions were well demarcated and almost replaced by dense fibrous tissue at 4 weeks. Interruption (3 dogs) or thinning (1 dog) of the endocardial elastic lamellae was detected, in association with endocardial thickening (mean 913 microns). Endocardial thrombi were found in 3 dogs (2 fresh, 1 organized). We conclude that radiofrequency catheter ablation does not cause severe complicated lesions. Several possible conditions for creating chronic incomplete AV block are discussed. 相似文献
14.
Raymond C. Truex Thomas A. Marino Deborah R. Marino 《Anatomical record (Hoboken, N.J. : 2007)》1978,192(3):337-350
This light microscopic study of the cardiac junctional tissues was based on 27 human embryos, fetuses and postnatal hearts. Evidence was presented that superficial and deep portions of the postnatal AV node were derived from two cellular primordia in the posterior wall of the common atrium at the 6-mm stage. The small right primordia was associated with the right venous valve and gave rise to the loosely organized superficial AV node that extended posteriorly to the coronary sinus ostium. A larger left primordia formed the more compact deep subdivision of the AV node located against the anulus fibrosus. In most postnatal hearts the two subdivisions are partially or completely fused to form the adult AV node. Failure of the nodal primordia to fuse during cardiogenesis may result in two separate nodal cell aggregates above the anulus. The present observations provide a rational explanation for the two AV nodal masses described in the literature and an additional specimen that is illustrated in this communication. An AV bundle was first identified in a 13-mm embryo and appeared to be derived from large clear cells of the posterior AV canal. At 25 mm the bundle formed a broad band across the top of the IV septum and continued into both ventricles. At this stage multiple cell strands penetrated the endocardial cushion to connect the AV bundle to the two nodal primordia. Failure of normal fusion between the AV node primordia and AV bundle can result in a variety of junctional anomalies including congenital heart block. 相似文献
15.
In this study the structure of the atrioventricular (AV) node and bundle in the newborn ferret heart was examined by light and electron microscopy. At the light microscopic level the AV node could be subdivided into deep and superficial portions. Electron microscopy revealed that both superficial and deep AV nodal cells were characterized by a paucity of myofibrils, desmosomes, fasciae adherentes and gap junctions. Deep AV nodal cells, however, had more surface specializations than did superficial AV nodal cells. In both subdivisions the constituent cells were ellipsoid with tapering end-processes. In contrast to the nodal cells, the newborn AV bundle cells were round to ovoid. The AV bundle cells were organized into large fascicles, and there was a high frequency of anastomosing intercommunication between fascicles. These bundle cells had few myofibrils and a high incidence of apposed plasma membrane. The present morphological findings support the concept that there are significant postnatal morphological changes that occur in the region of the AV junction. These results are also consistent with findings in other species that AV nodal conduction time is similar in newborns and adults, while conduction through the AV bundle increases with age. 相似文献
16.
Ying Lu Thomas N. James Shoji Yamamoto Fumio Terasaki 《Anatomical record (Hoboken, N.J. : 2007)》1993,236(3):493-510
Twenty-three chicken hearts were used to study the cardiac conduction system by light and electron microscopy. In addition to a sinus node, atrioventricular node (AVN), His bundle, left and right bundle branches (LBB, RBB), the chicken also has an AV Purkinje ring and a special middle bundle branch (MBB). The sinus node lies near the base of the lower portion of the right sinoatrial valve. The AV node is just above the tricuspid valve and anterior to the coronary sinus. The His bundle descends from the anterior and inferior margin of the AV node into the interventricular septum, then dividing into right, left and middle branches some distance below the septal crest. The middle bundle branch turns posteriorly toward the root of the aorta. The AV Purkinje ring originates from the proximal AV node and then encircles the right AV orifice, joining the MBB to form a figure-of-eight loop. The chicken conduction system contains four types of myocytes: (1) The P cell is small and rounded, with a relatively large nucleus and sparse myofibrils. (2) The transitional cell is slender and full of myofibrils. (3) The Purkinje-like cell resembles the typical Purkinje cell, but is smaller and darker. (4) The Purkinje cell is found in the His bundle, its branches, and the periarterial and subendocardial Purkinje network. © 1993 Wiley-Liss, Inc. 相似文献
17.
Kaneshige T Machida N Nakao S Doiguchi O Katsuda S Yamane Y 《Journal of comparative pathology》2007,137(2-3):146-150
A histological investigation of the atrioventricular (AV) conduction system was performed in two young adult dogs with complete AV block. In both cases, infiltration of lymphocytes and plasma cells into the AV node and loss and disappearance of the conduction fibres were observed. Such inflammatory lesions of the AV conduction system were associated with complete AV block. The aetiology of these changes and the cause of its location at the AV node were not elucidated. 相似文献
18.
The cardiac conduction system was examined histologically in 13 feline cases of hypertrophic cardiomyopathy (HCM) with complete atrioventricular (AV) block. Marked degeneration and fibrous replacement of the AV conduction system were consistently observed in the combined regions of the branching portion of the AV bundle and the upper portion of the left bundle branch. These changes were associated with extensive fibrosis of the central fibrous body and endocardial and myocardial fibrosis in the upper border of the ventricular septum. Chondrometaplastic lesions or osseous lesions, or both, present in the base of the central fibrous body, compressed the underlying penetrating or branching (or both) portions of the AV bundle, causing apparent reduction of the conduction fibres. The pathological process and the nature and predilection sites of the lesions resembled those associated with ageing in human patients with complete AV block. It is possible that the pathological process in the cats was fundamentally related to the normal ageing phenomenon and may have been exacerbated by mechanical forces created by the cardiac hypertrophy associated with HCM. 相似文献
19.
W W Tse 《The American journal of physiology》1975,229(1):34-37
Effects of epinephrine on the automaticity of canine AV nodal fibers were studied on spontaneously beating AV node-His bundle preparations. Transmembrane potentials of single fibers of the AV node or His bundle were recorded with microelectrode techniques. Action potentials of most AV nodal fibers were characterized by steep phase-4 depolarization and smooth transition from phases 4 to 0. Epinephrine (0.1-0.2 mug/ml) increased the spontaneous rate of the AV nodal fibers. The slope of phase 4 depolarization was increased and the threshold shifted to a more negative level. These changes probably accounted for the increase in the automaticity of the node. Also, in the presence of epinephrine, the pacemaker of the preparation was consistently located at the AV node had a higher degree of automaticity than the His bundle. The findings of the present experiment, therefore, further support the view that the AV node is automatic. 相似文献
20.
Christos E. Nerantzis Gerasimos Gavrielatos Nikolaos Kalogrias Loukas K. Pappas Konstantinos P. Letsas Nikolaos G. Karakoukis Philippos N. Koutsaftis 《Cardiovascular pathology》2009,18(6):346-351
BackgroundThere is a controversy in the literature concerning the origin, course, and distribution of the atrioventricular (AV) node artery.MethodsPostmortem coronary angiography, dissection, and microscopic examination were performed in 100 human hearts specimens, providing anatomical, histological, and postmortem angiographic features of the AV node artery.ResultsTwo anatomical types of AV node artery, depending on its length (long–short), were found. “Long-length” (LL) AV node artery supplied with blood almost all the AV conducting tissue in 72 cases. It consisted of a horizontal and descending part ending in two branches. “Short-length” (SL) AV node artery had only a horizontal part, perfusing exclusively the AV node and several times the nonpenetrating main bundle of His. In 67 of 100 cases, the AV arteries were arising from the right coronary artery, distal to the posterior descending (PD) artery. The AV node artery never originated from the PD artery. In 54 of 100 cases, it passed under the coronary sinus (CS) and in the remaining 46 it passed underneath the right atrium endocardium.ConclusionsThe above-described postmortem coronary angiographic findings are essential for interventional cardiologists and cardiac surgeons. Damage to the LL or SL type of AV node artery may cause severe or limited AV conduction abnormalities, respectively. Furthermore, the course of AV node artery under the CS makes it susceptible to injuries provoked by diagnostic or therapeutic procedures involving the CS area. 相似文献