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Altered pulmonary gas transfer capacity and capillary blood volume in pediatric Crohn's disease 下载免费PDF全文
Marie Verstraete MD Marie‐Luce Choukroun MD PhD Valerie Siao‐Him Fa MD Michael Fayon MD PhD Laurent Rebouissoux MD Raphael Enaud MD Thierry Lamireau MD PhD 《Pediatric pulmonology》2017,52(8):1051-1056
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Prognostic and pathophysiological marker for patients with chronic thromboembolic pulmonary hypertension: Usefulness of diffusing capacity for carbon monoxide at diagnosis 下载免费PDF全文
Rika Suda Nobuhiro Tanabe Keiichi Ishida Fumiaki Kato Takashi Urushibara Ayumi Sekine Rintaro Nishimura Takayuki Jujo Toshihiko Sugiura Ayako Shigeta Seiichiro Sakao Koichiro Tatsumi 《Respirology (Carlton, Vic.)》2017,22(1):179-186
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Qiang Zheng Ingrid A. Cox Lucy Leigh Barbara de Graaff Fay H. Johnston Tamera J. Corte Luke D. Knibbs Petr Otahal Vidya Navaratnam Julie A. Campbell Ian Glaspole Yuben Moodley Peter Hopkins John A. Mackintosh Hasnat Ahmad E. Haydn Walters Andrew J. Palmer 《Respirology (Carlton, Vic.)》2023,28(10):916-924
Background and Objective
Little is known about the association between ambient air pollution and idiopathic pulmonary fibrosis (IPF) in areas with lower levels of exposure. We aimed to investigate the impact of air pollution on lung function and rapid progression of IPF in Australia.Methods
Participants were recruited from the Australian IPF Registry (n = 570). The impact of air pollution on changes in lung function was assessed using linear mixed models and Cox regression was used to investigate the association with rapid progression.Results
Median (25th–75th percentiles) annual fine particulate matter (<2.5 μm, PM2.5) and nitrogen dioxide (NO2) were 6.8 (5.7, 7.9) μg/m3 and 6.7 (4.9, 8.2) ppb, respectively. Compared to living more than 100 m from a major road, living within 100 m was associated with a 1.3% predicted/year (95% confidence interval [CI] −2.4 to −0.3) faster annual decline in diffusing capacity of the lungs for carbon monoxide (DLco). Each interquartile range (IQR) of 2.2 μg/m3 increase in PM2.5 was associated with a 0.9% predicted/year (95% CI −1.6 to −0.3) faster annual decline in DLco, while there was no association observed with NO2. There was also no association between air pollution and rapid progression of IPF.Conclusion
Living near a major road and increased PM2.5 were both associated with an increased rate of annual decline in DLco. This study adds to the evidence supporting the negative effects of air pollution on lung function decline in people with IPF living at low-level concentrations of exposure. 相似文献6.
Comparison of sitting and supine forced vital capacity in collagen VI‐related dystrophy and laminin α2‐related dystrophy 下载免费PDF全文
Katherine G. Meilleur PhD Melody M. Linton BS Joseph Fontana MD Anne Rutkowski MD Jeffrey Elliott MA Mark Barton RT Peter McGraw RT Angela Kokkinis BSN Sandra Donkervoort MS Meganne Leach MSN Minal Jain DSc Jahannaz Dastgir DO James Collins MD Rhonda Szczesniak PhD Kelly Yang PhD Hemant Sawnani MD Carsten G. Bönnemann MD 《Pediatric pulmonology》2017,52(4):524-532
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Prevalence of airflow obstruction and reduced forced vital capacity in an Aboriginal Australian population: The cross‐sectional BOLD study 下载免费PDF全文
Nathania A.J.B. Cooksley David Atkinson Guy B. Marks Brett G. Toelle David Reeve David P. Johns Michael J. Abramson Deborah L. Burton Alan L. James Richard Wood‐Baker E. Haydn Walters A. Sonia Buist Graeme P. Maguire 《Respirology (Carlton, Vic.)》2015,20(5):766-774
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BACKGROUND: The measurement of single-breath diffusing capacity (Dlco(SB)) assumes that diffusing capacity per liter of alveolar volume (Dlco/VA) determined in a 750-mL gas sample represents the diffusing capacity (Dlco) of the entire lung. Fast-responding gas analyzers provide the opportunity to verify this assumption because of the possibility to measure CO and CH(4) fractions continuously throughout the entire expiration. Continuous gas sampling provides more information per measurement, but this information cannot be expressed in the traditional parameters. Our goals were to find new parameters to express the extra information of the continuous gas sampling, and to compare these new parameters with the traditional parameters. METHODS: We compared a new method to determine Dlco with the traditional method in 62 healthy volunteers and 26 COPD patients. Traditionally, Dlco(SB) is determined by multiplying Dlco/VA with alveolar volume, both calculated from gas concentrations in a 750-mL gas sample. The new method calculates total-breath Dlco (Dlco(TB)) by integration of Dlco/VA against exhaled volume. RESULTS: In healthy volunteers, Dlco/VA shows a slight upward slope during exhalation, while in COPD patients Dlco/VA shows a horizontal line. Total-breath total lung capacity (TLC) is larger than single-breath TLC both in healthy volunteers and in COPD patients, leading to a Dlco(TB) that is significantly larger than Dlco(SB) in both groups (p < 0.001). CONCLUSION: The assumption that a 750-mL gas sample represents the entire lung seems to be correct for Dlco/VA but not for the CH(4) fraction in case of ventilation inhomogeneity. 相似文献
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Treatment of hyperglycaemia in newly diagnosed diabetic patients is associated with a reduction in oxidative stress and improvement in β‐cell function 下载免费PDF全文
Jhankar D. Acharya Amol J. Pande Suyog M. Joshi Chittaranjan S. Yajnik Saroj S. Ghaskadbi 《Diabetes/metabolism research and reviews》2014,30(7):590-598