KUS股骨近端锁定钢板治疗老年患者股骨粗隆间骨折38例

目的观察应用KUS股骨近端锁定钢板治疗老年股骨粗隆间骨折的疗效。方法对38例老年股骨粗隆间骨折患者施行KUS股骨近端锁定钢板固定治疗,术后随访观察疗效。结果38例患者均获得随访,均达骨性愈合,术后髋关节恢复良好,临床疗效优18例,良17例,中3例,优良率为92．1％。结论KUS股骨近端锁定钢板治疗老年股骨粗隆间骨折,操作简单,固定可靠,疗效满意,有利于骨折的愈合,并发症少,是治疗老年股骨粗隆间骨折的较好选择。     

股骨近端解剖锁定钢板治疗19例老年股骨粗隆间骨折

目的探讨应用股骨近端解剖锁定钢板治疗老年粗隆间骨折的疗效。方法对19例老年股骨粗隆间骨折患者行股骨近端解剖锁定钢板固定治疗的术中观察及术后随访。结果采用股骨近端解剖锁定钢板治疗19例老年股骨粗隆间骨折,术中操作简单,术后固定可靠。结论老年粗隆间骨折常合并骨质疏松,应用股骨近端解剖锁定钢板内固定治疗此类疾病,疗效可靠,有利于骨折愈合,并能减少老年患者的并发症,具有良好的临床应用价值。     

改良股骨近端锁定钢板治疗老年股骨粗隆间骨折25例

目的探讨改良股骨近端锁定钢板治疗老年股骨粗隆间骨折的临床疗效。方法对25例老年股骨粗隆间骨折,均采用闭合改良股骨近端锁定钢板内固定治疗。结果随访时间10~24个月,骨折均愈合。髋关节功能良好。结论采用闭合复位改良股骨近端锁定钢板内固定治疗老年股骨粗隆间骨折可获得良好的临床疗效。     

锁定钢板在老年患者股骨粗隆间骨折中的应用

目的：探讨锁定钢板在老年患者股骨粗隆间骨折中的应用的优越性。方法：将需要手术的12例股骨粗隆间骨折的老年患者采用锁定钢板做内固定材料。结果：经过随访,12例患者均获得满意的手术效果,髋关节活动功能基本正常。结论：老年患者股骨粗隆间骨折需要牢固固定及早期功能锻炼,锁定钢板是治疗老年患者股骨粗隆间骨折的理想内固定物。     

近端锁定钢板治疗伴骨质疏松或骨量减少的老年股骨粗隆间骨折37例疗效观察

目的探讨股骨近端锁定钢板在治疗伴有骨质疏松或骨量减少老年股骨粗隆间骨折中的有效性。方法回顾性分析2007年3月至2009年5月该院采用股骨近端锁定钢板治疗股骨粗隆间骨折伴有骨质疏松或骨量减少的老年患者37例的临床资料。结果骨折疗效评价,优21例(56.8%),良9例(24.3%),可6例,死亡1例,优良率为81.1%。骨折愈合时间9～16周。结论锁定钢板治疗伴有骨质疏松或骨量减少的老年股骨粗隆间骨折安全有效。     

老年粗隆间骨折患者应用锁定钢板治疗疗效分析

目的：探讨锁定钢板在老年患者股骨粗隆间骨折患者临床治疗中的应用效果。方法：2012年1月-2013年3月期间我院骨科收治的60例老年股骨粗隆间骨折患者作为本组研究的观察对象,均行股骨近端锁定钢板固定治疗,术后随访6周,并对患者进行Harris髋关节功能评分以评价治疗效果。结果：本组老年人粗隆间骨折患者经股骨近端解剖锁定钢板内固定手术治疗后,手术时间、术中出血量、住院时间等情况非常理想,髋关节功能恢复优良率为95％。结论：在老年粗隆间骨折患者的治疗中应用股骨近端解剖锁定钢板内固定手术,具有操作简便,并发症少,愈合效果好等优势,疗效确切,值得在临床中推广普及。     

股骨粗隆间骨折的治疗选择

目的分析股骨近端锁定钢板和螺旋刀片式股骨近端髓内钉(PFNA)治疗股骨粗隆间骨折的疗效。方法对32例股骨粗隆间骨折患者行手术治疗,其中近端锁定钢板治疗22例,PFNA治疗10例。观察2组临床疗效及并发症。结果 32例均获得随访,股骨近端锁定钢板固定,优16例,良5例,差1例;PFNA固定,优8例,良2例,差0例。结论股骨近端锁定钢板具有操作简单、创伤小、适应证广、固定牢靠、并发症少的优点,是治疗股骨粗隆间骨折的有效方法;PFNA为髓内固定系统,符合微创理论及生物力学固定原则,是治疗不稳定粗隆间骨折特别是伴骨质疏松老年患者的理想材料。     

股骨近端锁定钢板治疗老年股骨粗隆间骨折26例

目的总结股骨近端锁定钢板治疗老年股骨粗隆间骨折的临床疗效。方法 26例老年股骨粗隆间骨折,采用切开复位股骨近端锁定钢板固定。结果术后随访1-2年,骨折愈合佳,患髋功能恢复良好,无行走痛,基本生活能够自理,从事一般家务劳动。结论采用股骨近端锁定钢板治疗老年股骨粗隆间骨折,痛苦小,效果可靠,无拔钉及脱板现象,且手术操作简便,值得基层医院推广应用。     

股骨近端锁定钢板治疗老年股骨粗隆间骨折的临床体会

目的 探讨采用股骨近端锁定钢板治疗老年股骨粗隆间骨折的优势.方法 回顾性分析2009年4月至2011年9月采用股骨近端锁定钢板治疗股骨粗隆间骨折45例的临床效果.结果 临床随访10～ 29个月,平均18个月,所有病例均获骨性愈合.根据Harris评分标准,优良率为93.3％.结论 采用股骨近端锁定钢板治疗老年股骨粗隆间骨折不需暴露骨折断端,通过牵引与手法整复可获满意复位,手术操作简单、创伤小、出血少、固定牢靠,可早期进行不负重下患肢功能锻炼,骨折愈合好.     

锁定钢板联合抗骨质疏松药物治疗老年股骨粗隆间骨折

目的 探讨锁定钢板内固定联合抗骨质疏松药物治疗老年性股骨粗隆间骨折的疗效.方法 2008年1月～2010年2月共收治42例老年性股骨粗隆间骨折患者,应用股骨近端锁定钢板内固定治疗,术后使用抗骨质疏松药物.结果 经6～24个月,平均12个月的随访,42例患者均获得愈合.无骨不连、髋内翻、短缩畸形,有1例螺钉松动,但无钢板断裂,无感染等并发症发生.根据Matta髋关节评分,优29例,良10例,可3例,优良率92.9%.BMD术后12个月T值≤-1.5SD,骨质疏松程度减轻.结论 锁定钢板内固定治疗老年股骨粗隆间骨折具有损伤小、固定可靠、骨折愈合率高等特点,术后联合使用抗骨质疏松药物,可提高骨强度、减轻骨质疏松程度,在老年股骨粗隆间骨折的治疗中有良好的效果.     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.     

Scientific principles and rigorous processes should be followed in developing clinical guidelines for therapeutic interventions of integrative medicine

A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care（~＇4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.