在老年晚期肺癌患者中应用循证护理对其生活质量与焦虑抑郁的影响探究

目的探究老年晚期肺癌患者接受循证护理对其焦虑抑郁、生活质量的影响。方法将老年晚期肺癌患者以计算机随机化法分组,其中对照组实施常规护理干预,实验组则实施循证护理干预,分析2组老年晚期肺癌患者护理干预的结果。结果实验组干预后的生活质量评分均高于对照组(P0.05);实验组干预后的焦虑、抑郁评分低于对照组,P0.05;2组治疗效果相比,无统计学意义(P0.05)。结论老年晚期肺癌患者接受询证护理干预,能够有效改善患者的焦虑、抑郁心理,提高患者的生活质量。     

心理护理干预对宫颈癌患者心理状况的影响

目的:探讨心理护理干预对宫颈癌患者心理状况的影响。方法:选择治疗的宫颈癌患者共60例,随机分为观察组和对照组。对照组患者给予常规的护理干预措施,观察组患者在对照组护理干预基础上实施心理护理干预。评定两组焦虑抑郁心理情绪。结果:观察组干预前的焦虑评分和抑郁评分分别和对照组干预前比较,差异无统计学意义(P>0.05);观察组干预后的焦虑和抑郁评分分别和本组干预前的焦虑和抑郁评分比较,差异有统计学意义(P<0.05);对照组干预后的焦虑和抑郁评分分别和本组干预前的焦虑和抑郁评分比较,差异有统计学意义(P<0.05);观察组干预后的焦虑和抑郁评分分别和对照组干预后的焦虑和抑郁评分比较,差异有统计学意义(P<0.05)。结论:心理护理干预能够显著改善宫颈癌患者心理状况,减轻不良心理情绪对疾病的影响,护理效果显著。     

护理干预对乳腺癌术后放射治疗患者焦虑和抑郁心理的影响

目的探讨护理干预对乳腺癌术后放射治疗患者的焦虑和抑郁心理的影响.方法针对160例乳腺癌术后放射治疗患者,随机分为实验组和对照组各80人.实验组实施护理干预,对照组按常规护理.比较两组的焦虑和抑郁程度,及调查患者的满意度.结果实验组和对照组护理前SAS评分、SDS评分无显著性差异(P>0.05),而护理后两组SAS评分、SDS评分有显著性差异(P<0.05).实验组和对照组对护理服务的满意度分别为95.0%和68.3%,两者具有显著性差异(P<0.05).结论护理干预对乳腺癌术后放疗患者有积极影响,可明显减轻患者的焦虑和抑郁心理.     

心理护理干预对手术患者的影响

目的：分析心理护理干预对手术患者的影响。方法：选取我院120例手术患者为研究对象,将其随机分为观察组与对照组,对照组实施手术室常规护理干预,观察组在此基础上加用心理护理干预,比较2组患者的焦虑、抑郁评分。结果：护理前,观察组与对照组焦虑、抑郁评分比较,无明显差异（P>0.05）,有统计学意义;护理后,观察组焦虑、抑郁评分均优于对照组（P<0.05）,差异有统计学意义。结论：心理护理干预可有效缓解手术患者心理焦虑、抑郁程度,值得在临床上推广。     

心理护理对大肠癌化疗患者焦虑及抑郁情绪的影响

目的:探讨心理护理对大肠癌化疗患者焦虑及抑郁情绪的影响。方法:选取本院收治的大肠癌化疗患者53例,随机分为实验组与对照组。实验组在常规护理的基础上加用心理护理干预,对照组只进行常规的护理。两组分别于第1天和第36天进行量表评分。比较实验组与对照组患者焦虑、抑郁减轻是否有差别。资料采用t检验。结果:心理护理干预后,实验组焦虑及抑郁评分明显降低,两组患者心理护理前、后焦虑、抑郁评分差值比较差异有显著性。结论:心理护理干预对大肠癌化疗患者焦虑及抑郁情绪有明显缓解作用。     

探讨积极的院前心理护理干预对冠心病患者预后的影响

目的分析探讨积极的院前心理护理干预对冠心病患者预后的影响。方法我院在2017年1月至2018年12月,对被诊断为冠心病的120例患者的临床资料进行分析,使用随机分组法,分为对照组与观察组各60例,对照组患者进行常规护理,观察组采取常规护理并实施心理护理干预,分析两组患者的情绪。结果两组患者在干预前焦虑与抑郁评分相比较,差异无统计学意义(P0.05),通过护理干预后,观察组患者的焦虑评分与抑郁评分明显低于对照组,差异具有统计学意义(P0.05);观察组患者生活质量评分明显高于对照组,差异具有统计学意义(P0.05)。结论采取积极的院前心理护理干预,能有效改善冠心病患者的焦虑与抑郁程度,提高生活质量,具有临床推广意义。     

心理干预对肺癌术后化疗抑郁患者 HAMD 评分的影响

目的：探索心理干预对肺癌术后化疗抑郁患者 HAMD评分的影响。方法将68例肺癌术后化疗抑郁患者随机分为两组,给予对照组34例患者常规护理,给予观察组34例患者心理干预,治疗2个月后两组患者进行疗效及抑郁评分（HAMD）比较。结果接受心理干预后,观察组患者的焦虑抑郁发生率明显低于对照组,严重程度减弱,其差异具有统计学意义（ P ＜0．01）。结论肺癌术后化疗患者在进行心理干预后能有效减轻肺癌患者抑郁程度,促进患者康复,明显提高了患者的生活质量。     

心理护理及健康教育对老年肺癌患者生存质量的影响

目的 探讨老年肺癌患者实施心理护理及健康教育对其生存质量的影响。方法 选择2009年12月至2013年7月期间在我院接受诊治的肺癌患者86例;按照随机数字表法将其随机分为对照组与观察组各43例;对照组实施常规干预措施,观察组在对照组基础上实施心理护理及健康教育。对比分析两组患者的生存质量及焦虑、抑郁评分情况。结果 两组干预前生存质量评分比较,差异均无统计学意义（P〉0.05）;观察组干预后生存质量评分均显著高于对照组,差异均具有统计学意义（P〈0.05）;且两组干预后生存质量评分均显著高于干预前,差异均具有统计学意义（P〈0.05）;两组干预前焦虑与抑郁评分比较差异均无统计学意义（P〉0.05）;观察组干预后焦虑与抑郁评分显著低于对照组,其差异均有统计学意义（P〈0.05）;两组各组间干预后焦虑[（64.92±6.81）分]与抑郁评分[（64.04±6.72）分]显著低于各组间干预前焦虑[（60.42±4.92）分]与抑郁评分[（59.75±5.03）分],差异有统计学意义（P〈0.05）。结论 老年肺癌患者在常规干预措施基础上实施心理护理及健康教育可显著改善患者的生存质量,减轻抑郁及焦虑不良情绪,具有重要临床意义。     

循证护理对冠心病患者心理及生活方式的影响

目的观察循证护理对冠心病患者心理及生活方式的影响.方法选择86例冠心病患者,随机分为对照组和实验组各43人,对照组进行常规护理,实验组从心理、生活方式方面进行循证护理,比较两组患者生活方式转变情况及焦虑、抑郁评分情况.结果实验组吸烟、饮酒、体质量超标和缺乏运动等不良生活方式明显改善,焦虑、抑郁情绪评分明显降低P<0.05,差异有统计学意义.结论循证护理能有效改善患者不良生活方式及焦虑、抑郁情绪.     

综合护理干预对非小细胞肺癌化疗患者生活质量、焦虑及抑郁的影响

目的:探讨综合护理干预对非小细胞肺癌化疗患者生活质量、焦虑及抑郁的影响。方法:选取符合标准的120例非小细胞肺癌化疗患者作为研究对象,根据运用不同的护理方法,随机分为试验组和对照组,两组患者各60例。对照组给予内科常规护理措施,试验组在对照组的基础上,再针对性给予综合护理干预,最后观察两组护理措施对患者疗效、生活质量、焦虑及抑郁的影响。结果:试验组在治疗有效率、焦虑、抑郁、生活质量以及整体健康状况均明显优于对照组,差异有统计学意义(P<0.05)。结论:综合护理干预可明显提高患者的治疗效果、生活质量,并且可减轻患者焦虑及抑郁的症状。在临床上值得进一步探究。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.     

Scientific principles and rigorous processes should be followed in developing clinical guidelines for therapeutic interventions of integrative medicine

A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care（~＇4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.