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目的 研究老鹳草提取物对Lewis结肠癌瘤株转染的C57BL/6小鼠黏附分子PS2和c-myc表达的影响,探讨其抗转移机制. 方法将36只荷瘤模型小鼠随机分成空白对照组、老鹳草提取物组和羟喜树碱组各12只. 空白对照组:腹腔内注射0.9%氯化钠溶液10 mL8226;kg-1;老鹳草提取物组:腹腔内注老鹳草提取物12 mg8226;kg-1; 羟喜树碱组:腹腔内注羟基喜树碱2.5 mg8226;kg-1,各组均每周腹腔注射1次,连续3周,观察移植瘤体生长情况,免疫荧光法检测瘤体内PS2和c-myc表达. 结果 与空白对照组比较,老鹳草提取物和羟喜树碱组都可使移植瘤体的体积缩小,差异有统计学意义(P<0.01),但老鹳草提取物组比羟喜树碱组效果更明显,差异有统计学意义(P<0.01). 与空白对照组比较,老鹳草提取物组和羟基喜树碱组移植瘤体的PS2、c-myc表达均降低,但老鹳草提取物组效果更明显,差异有统计学意义( P<0.01). 结论 老鹳草提取物抗Lewis结肠癌转移机制可能与降低PS2和c-myc的表达有关. 相似文献
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目的 研究老鹳草巴布剂治疗类风湿性关节炎的药效作用。方法 将30只雌性SD大鼠随机分为对照组、模型组、空白制剂组、伤湿止痛膏(阳性药)组、老鹳草巴布剂(含没食子酸3.40 mg·g-1)组,每组6只。除对照组外,其余各组构建佐剂性关节炎大鼠模型:于每只大鼠右后足足趾皮内注射弗氏完全佐剂0.1 mL致炎,对照组大鼠相同部位注射同等体积生理盐水,第7天再次注射加强免疫。对照组及模型组不做干预,阳性药组、老鹳草巴布剂组、空白制剂组分别连续21 d于大鼠右后大腿关节处贴敷伤湿止痛膏、老鹳草巴布剂、空白巴布剂。观察大鼠体质量及足趾肿胀度的变化;采用酶联免疫吸附(ELISA)法测定不同组别大鼠血清中肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、血管内皮生长因子A(VEGF-A)及白细胞介素-17(IL-17)水平;HE染色观察各组大鼠膝关节滑膜病理变化。结果 对照组大鼠健康状态良好,毛发顺滑有光泽;模型组大鼠较对照组可见活动、饮食减少,毛发略微发黄,足趾肿胀,关节呈急性炎症表现,表面皮肤发红发亮充血,活动受限,但无死亡;老鹳草巴布剂组、伤湿止痛膏组大鼠状态有所改善。HE染色结果表明,对照组大鼠关节结构正常;模型组、空白制剂组大鼠膝关节可见滑膜细胞增生、炎性细胞浸润并伴有血管翳生成,软骨被侵蚀;与模型组比较,老鹳草巴布剂组与伤湿止痛膏组大鼠踝关节病变情况不同程度得到改善。与模型组比较,老鹳草巴布剂组和伤湿止痛膏组大鼠足肿胀度显著降低(P<0.05),血清IL-6、TNF-α、VEGF-A、IL-17水平明显降低(P<0.05)。结论 老鹳草巴布剂抗类风湿性关节炎的作用良好。 相似文献
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本文报道我国北方使用的来源于菊科植物的中药败酱草的生药形态组织学的研究结果,它们是:苣荬菜Sonchus arvensis L.S.、苦苣菜oleraceus L.圆耳苦苣菜S.asper (L.)Hill.紫花山莴苣Lactuca tatarica(L.)C.A.Mey.、中华苦荬菜Ixeris ccinensis(Thunb.)Nakai、抱茎苦荬菜I.sonchifolia Hance和苦荬菜I.denticulata(Houtt.)Stebb..文中附有生药组织图7幅以及上述生药的性状检索表和显微特征检索表. 相似文献
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全国范围的商品调查和产地的标本采集与原植物鉴定研究表明,目前使用的中药龙胆来源于龙胆科龙胆属的九种植物,即东北龙胆Gentiana manshurica Kitag.建德龙胆G.manshurica Kitag.ssp.jiandeensis J.P.Luo et Z.C.Lou(ssp.nov.),龙胆G.scabra Bunge,三花龙胆G.triflora Pall.,坚龙胆G.rigescens Franch.,头花龙胆G.cephalantha Franch.,亚木龙胆G.suffrutescens J.P.Luo et Z.C.Lou(sp.nov.),德钦龙胆G.atuntsiensis W.W.Sm.和红花龙胆G.rhodantha Franch.。研究和比较了上述九种植物叶的组织构造特征,编写了原植物形状分种检索表和叶的显微特征分种检索表。 相似文献
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中药石斛鉴定研究——Ⅰ.石斛原植物和药材调查 总被引:2,自引:0,他引:2
本文通过对商品“石斛”主产区广西、贵州、四川、云南等省区原植物和药材调查,确定了商品石斛原植物有21个种,其中以粉花石斛Dendrobium loddigesii Rolfe、铁皮石斛Dendrobium candidum Wall. ex Lindl.、重唇石斛Dendrobium hercoglossum Rchb. f.、束花石斛Dendrobium chrysanthum Wall. ex Lindl.、流苏石斛Dendrobium fimbriatum Hook.、钩状石斛Dendrobium aduncum Wall.ex Lindl.和罗河石斛Dendrobium lohohense Tang et Wang等产量较大,使用最广;作了原植物检索表和药材检索表,对原植物产地和生境作了记载,提供药材鉴别和采集加工方法,并附药材照片。 相似文献
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商品黄芪的地区用药及其易混品的形态与显微鉴别 总被引:1,自引:1,他引:0
黄芪的地区用药及易混品共5种,即:梭果黄芪Astragalus ernesti Comb.,淡紫花膜荚黄芪A.membranaceus (Fisch.) Bunge f.purpurinus (Y.C.Ho)Y.C.Ho,乌拉特黄芪A.hoantchy Franch.,甘青黄芪A.tanguticus Batalin和马衔山黄芪A.mahoschanicus Hand.-Mazz.等,对其生药形态和组织特征进行了比较研究,并编写了生药性状和组织特征检索表。 相似文献
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国产麻黄的形态组织学研究——Ⅰ.北方主产的七种麻黄 总被引:3,自引:0,他引:3
据文献记载和作者的调查,我国产麻黄属(Ephedra)植物共有13种3变种1变型。本文报道我国北方生产的7种麻黄生药形态组织学比较研究结果。7种麻黄是:草麻黄Ephedra sinica Stapf、木贼麻黄E.equisetina Bunge、中麻黄E.intermedia Schrenk ex Mey.、膜果麻黄E.przewalskii Stapf,单子麻黄E.monosperma Gmel.ex Mey.、雌雄麻黄E.fedtschenkoae Pauls和细子麻黄E.reaeliana Florin。文中附有生药性状与组织构造特征比较表及生药组织图。 相似文献
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花椒及其同类品的形态组织学研究 总被引:4,自引:0,他引:4
据文献记载和作者实际调查,我国各地花椒属(Zanthoxylum L.)植物果实作药用者计约18种。本文先报道其中8种果皮的形态组织学研究结果:花椒Zanthoxylum bungeanum Maxim.青椒Z.schinifolium Sieb.et Zucc.,竹叶椒Z.armatum DC.,野花椒Z.simulans Hance,勒(木党)Z.avicennae(Lam.)DC.,椿叶花椒Z.ailanthoides Sieb.et Zucc.,朵椒Z.molle Rehd.及两面针Z.nitidum(Roxb.)DC.。本文附形态组织图并分别列有生药性状及显微特征检索表。 相似文献
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本文报道我国西南产麻黄——丽江麻黄Ephedra likiangensis Florin、匍枝丽江麻黄E.likiangensis f.mairei(Florin)C.Y.Cheng、藏麻黄E.saxatilis Royle ex Florin、山岭麻黄E.gerardiana Wall、垫状山岭麻黄E.gerardiana Var.congesta C.Y.Cheng、矮麻黄E.minuta Florin和异株矮麻黄E.minuta var.dioeca C.Y.Cheng,以及形态组织特征较特殊的宁夏产斑子麻黄E.lepidosperma C.Y.Cheng、新疆产窄膜麻黄E.lomatolepis Schrenk,西藏产西藏中麻黄E.intermedia var.tibetica Stapf的生药形态组织学研究结果。并根据对国产麻黄的生药形态组织学的系统研究结果,分别编写了各种国产麻黄(包括13种3变种1变型)的生药性状和生药显微特征检索表。 相似文献
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一、绪言福寿草是我国东北产的一种药用植物,全草及地下部分皆可供药用,其名称并不见于我国古代文献的记载,它曾被 Maximovicz 用一个不完整的标本描写为 Adonis appen-nina 植物的一个变种 A.appennina var.dahurica Maxim.;其后由 Regel 及 Radd 两氏重新加以区分,始定名为 A.amurensis Regel et Radd.,其种名“Amurensis”即指其原发现地苏联远东临接我国黑龙江省的阿穆尔(Amur)州之意.此后 Hooker 及等 相似文献
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The aerial parts of Scopolia lurida contain large quantities of tropane alkaloids and are a possible source of hyoscyamine and hyoscine. The leaves and stems are very similar to those of Atropa belladonna but they can be distinguished by certain microscopical characters; these include the presence of branched covering trichomes on the leaves and stems of Scopolia lurida and the absence of idioblasts containing microsphenoidal crystals of calcium oxalate from the leaf lamina. 相似文献
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Chemical characteristics for different parts of Panax notoginseng using pressurized liquid extraction and HPLC-ELSD 总被引:1,自引:0,他引:1
J.B. Wan F.Q. Yang S.P. Li Y.T. Wang X.M. Cui 《Journal of pharmaceutical and biomedical analysis》2006,41(5):1596
The chemical characteristics for different parts of Panax notoginseng, including root, fibre root, rhizome, stem, leaf, flower and seed, were determined using high performance liquid chromatography-evaporative light scattering detection (HPLC-ELSD) and pressurized liquid extraction (PLE). Eight major saponins, namely notoginsenoside R1, ginsenosides Rg1, Re, Rb1, Rc, Rb2, Rb3 and Rd were also quantitatively compared among the different parts of P. notoginseng. The chromatograms showed that there was significant difference between underground (root, fibre root, rhizome) and aerial (leaf and flower) parts from P. notoginseng, though the similarities of entire chromatographic patterns among tested samples from underground (0.965 ± 0.029, n = 12) and aerial parts (0.987 ± 0.014, n = 5) were similar, respectively. Especially, no saponin was detected in the seed of P. notoginseng. Hierarchical clustering analysis based on eight investigated saponins or the ratios of contents for ginsenoside Rg1/Rb1 and ginsenoside Rb3/Rb1 showed that the samples from different parts of P. notoginseng were divided into three main clusters. One cluster was underground parts, which contained rich protopanaxatriol and protopanaxadiol types saponins. The leaf and flower were in the same cluster, which contained protopanaxadiol type saponins only. Especially, ginsenoside Rc, Rb2 and Rb3, rare in the underground parts, were rich in aerial parts of P. notoginseng. The stem of P. notoginseng was another cluster. Based on the cluster analysis, the chemical characteristics for different parts of P. notoginseng were revealed. They are composite cluster (underground parts), protopanaxadiol cluster (aerial parts) and interim (stem) cluster, which was the one between the two typical clusters, respectively. The result shows that chemical characteristics of underground parts and aerial parts from P. notoginseng are obviously different, which is helpful for pharmacological evaluation and quality control of P. notoginseng. 相似文献
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目的:优选老鹳草颗粒荆的最佳辅料制备颗粒荆。方法:提取老鹳草总鞣质并浓缩至浸膏,与不同辅料混合制成颗粒剂,以吸水值为测定指标,用作图法考察。结果:乳糖的吸水值最小。结论:选择乳糖作为老鹳草颗粒的辅料较好。 相似文献
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目的:研究牻牛儿苗药材的质量控制方法。方法:采用HPLC法建立牻牛儿苗药材的HPLC指纹图谱,收集不同产地的23批样品进行测定,并使用聚类分析和主成分分析对指纹图谱进行模式识别研究。结果:根据主成分分析和聚类分析结果,筛选14批样品建立指纹图谱共有模式。结论:该方法可用于牻牛儿苗质量控制及综合评价。 相似文献
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《Pharmaceutical biology》2013,51(7):519-520
A quantitative determination of α-tocopherol in Globularia alypum L. was established by high-performance liquid chromatography (HPLC)-UV method. The investigations were carried out to evaluate the α -tocopherol content of the extracts from the air-dried aerial parts and the leaves of the plant. The calibration curve was used to calculate the content of the α-tocopherol, which was estimated as 0.002% and 0.0007% on the dried weight of the leaves and the aerial parts of G. alypum. 相似文献