Benign fibrous histiocytoma of bone: a case report

Benign fibrous histiocytoma (BFH) occurs commonly in soft tissues with very few cases of BFH of bone on record. We report a case of BFH of tibia in fifty year old male who presented with supracondylar fracture femur due to trivial fall and a brief review of literature.     

Malignant fibrous histiocytoma of bone

Summary Malignant fibrous histiocytoma (MFH) of bone is a well-defined tumor by light microscopy but no agreement has been achieved concerning its histogenesis. We present the light and electron microscopic findings of four cases of MFH of bone. In case 1 multiple bone tumors were observed and in case 4 the tumor developed after irradiation. It was our aim to document the cytological variability and to arrange the findings in a histogenetic concept of primary intraosseous MFH. We observed some undifferentiated cells but mainly histiocyte- and fibroblast-like cells including intermediate forms, and several types of giant cells. We should emphasize the fact that there were also some large cells with a light microscopic resemblance to rhabdomyoblasts and with electron microscopic characteristics of myoblastic differentiation. From the ultrastructural point of view, therefore, MFHs seem to derive from a primitive mesenchymal stem cell rather than from the ordinary histiocyte. It is suggested that osteosarcoma and MFH of bone may have a common progenitor cell but it is important to make a clear clinico-pathological distinction between the tumors because of differing biological behavior.     

Benign fibrous histiocytoma of the renal capsule.

The first case of benign fibrous histiocytoma of the renal capsule is reported in a male aged 44 years. The tumor had its point of origin in the renal capsule. Histologically, the tumor was composed of intersecting fascicles of fibroblastic cells forming a loose crisscross or "storiform" pattern. Electron microscopic studies of tumor cells revealed intermediate filaments and membrane-bound collagen fibers which continued to extracellular collagen bundles. This deep seated fibrous histiocytoma had a more prominent storiform pattern and fewer secondary elements such as xanthoma cells than cutaneous ones.     

Malignant fibrous histiocytoma of bone.

Existence of an entity called malignant fibrous histiocytoma of bone was emphasized, based on two of our own cases experienced recently and on previous reports related to this tumor. Histologically the tumor resembles markedly the malignant fibrous histiocytoma originating in the soft part. In addition, an attempt was made to clarify its biological behavior, histological subclassification and criteria to be malignant and differential diagnoses from several other bone diseases which sometimes mimic this malignant bone tumor.     

Benign multilocular cystic nephroma (author's transl)]

A case of benign multilocular cystic nephroma in a 12 month old male infant is reported. The patho-anatomical features of this rare renal lesion are demonstrated. Its possible histogenesis and relationship to nephroblastoma are discussed.     

Paraneoplastic hypoglycemia due to malignant histiocytoma (Doege-Potter syndrome) (author's transl)]

A case report is given on a male patient who was 52 years old when he died. 9 years ago a nephrectomy was performed because of a densely-packed mesenchymal tumor of the adipose tissue of the pelvis renalis. 7 years after the surgical intervention he suffered from several hypoglycemic crises. An operation was performed, and 2 large tumor nodes were removed from the greater omentum. A retroperitoneal relapse was inoperable. Nevertheless, the disorder of the carbohydrate metabolism disappeared after the operation. At the autopsy, one year later, a large retroperitoneal tumor with metastases in the lymph nodes was found. The neoplastic growth was classified as a malignant histiocytoma, and the hyperglycemia was taken as a paraneoplastic syndrome (Doege-Potter).     

Benign fibrous histiocytoma of the small intestine in a cow

A well circumscribed, firm nodule was found protruding from the duodenal wall of an adult cow at routine meat inspection. On the basis of morphological and immunophenotypic features, a diagnosis of benign fibrous histiocytoma (BFH) was established. Malignant fibrous histiocytoma has been reported previously in the cow, albeit rarely, but to the best of our knowledge this is the first recorded case of bovine intestinal BFH.     

Malignant fibrous histiocytoma (MFH) in axilla

Palpable axilla mass in woman is relatively rare. Almost all palpable lumps in axilla are axillarys accessory breasts without mass lesion. All diseases develop in breast can also develop in axillarys accessory breasts and other soft tissue mass can occur in axilla. Malignant fibrous histiocytoma (MFH) is the most common malignant soft tissue tumor, but axillarys MFH is extremely rare. We report our experience with a 75-year-old woman with MFH in axilla, treated with wide excision.     

Ultrastructural features of malignant fibrous histiocytoma of bone.

Five cases of malignant fibrous histiocytoma originating in the femur and tibia, sometimes with local recurrences, are reported. Histological and clinical characteristics of this lesion were similar to those in soft tissues with the same disease. The present histiocytomas were observed by electron microscopy and shown to consist of 5 types of neoplastic cells which were regarded as undifferentiated cells, histiocyte-like cells, which were predominating, fibroblast-like cells, multinucleated giant cells and xanthomatous cells. These findings led us to confirm the existence of malignant fibrous histiocytoma originating in bone as well as in soft tissues.     

Malignant fibrous histiocytoma of bone: an ultrastructural study

An ultrastructural study of a case of malignant fibrous histiocytoma of bone in a 16-year-old skeletally mature female is presented. There were multiple metastatic bone lesions and a marked hypercalcemia. The cell population was similar to that found in soft tissue malignant fibrous histiocytoma lesions and comprised undifferentiated cells, fibroblastlike cells, histiocytes, and multinucleated giant cells. Occasional myofibroblasts and transitional cells with histiocytic and fibroblastic components were seen. The histiocytes were characterized by prominent Golgi bodies. Although there were many fibroblastlike cells, the rough endoplasmic reticulum was rarely as extensive or as well organized as in normal fibroblasts. The giant cells did not have the ultrastructural characteristics of osteoclasts, i.e., the clear zones and ruffled borders. Zonula adherens (belt desmosome) junctions were seen, but in general, intercellular junctions were poorly developed as to length and extent.     

Benign fibrous histiocytoma of the skin metastasizing to the inguinal lymph node

Benign fibrous histiocytoma (FH, dermatofibroma) is a common skin lesion but its metastasizing variant is extremely rare and only a few cases have been reported to date. The usual sites of metastases include locoregional lymph nodes and lung. In the majority of cases, the clinical course is indolent. At present, there are no reliable clinical or histological features of the primary tumour that could predict the risk of locoregional or distant metastases. Authors describe a case of metastasizing FH and briefly review available data.     

Low frequency vibration on human hollow bone (author's transl)

With the aid of a stable fixation and a hammer system was removed the bone in vibrations which was registered. The vibrations have relations to the regions of the bone and have a practical connexion to the knowledge of the fracturation of the bone.     

Benign fibrous histiocytoma presenting as anal canal polyp: first case report

Nonepithelial and nonmelanocytic anal neoplasms are uncommon. The majority are mesenchymal tumors, most of which are malignant sarcomas, particularly leiomyosarcomas and gastrointestinal stromal tumors. Benign mesenchymal anal neoplasms are even rarer. The most common reported cases were anal leiomyomas, granular cell tumors, fibroadenomas, and xanthogranulomas. Benign fibrous histiocytomas (BFHs) or dermatofibromas are common mesenchymal cutaneous tumors that occur in different sites and at any age. Review of the literature did not show previous reports of BFH arising in the anal canal region. We report the first case of a solitary BFH, an unexpected occurrence of a common tumor type presenting as a polyp in an unusual site such as the anus. This rare occurrence can present diagnostic challenges for the surgeons and pathologists. Clinically, it can be confused with the usual anal tags, fibroepithelial polyps, or hemorrhoids. Benign fibrous histiocytoma is a neoplasm with a potential of local recurrence and, therefore, carries certain clinical implications for the patients' management and follow-up when compared with the common nonneoplastic causes of anal polyps such as the anal tags of anal fissures, hemorrhoids, or fibroepithelial papilla. Histologically, it should be differentiated from other histiocytic lesions. This can be resolved by the application of certain histologic features with the appropriate immunohistochemical markers taken within the correct clinical context.     

Histobiopsy of bone marrow (author's transl)]

The histobiopsy of the bone marrow is more and more included in clinicohaematological diagnostics. It has better diagnostic possibilities than the cytology of smears (aspiration biopsy). The specimen is taken from the iliac crest by puncture or the milling method. The sample can be considered representative of the whole bone marrow with regard to the normal quantity and quality. The pathologist ordinarily per forms the processing and assessment of the specimens in a desirably constructive cooperation with the clinical haematologist. The paper presents a condensed review of the histological technics and the recording of features in bone marrow sections, the indications for bone marrow histobiopsy, the results (2769 cases of literature and 496 own cases), and the clinical significance of human bone marrow histobiopsy.