颈椎前路手术并发脑脊液漏的防治

[目的]探讨颈椎前路手术减压并发脑脊液漏的原因及防治措施。[方法]回顾分析本院2000年5月～2007年8月行颈椎前路手术624例，发生脑脊液漏19例。采用术中明胶海绵、筋膜片封堵，配合术后头低脚高位，细盐袋适度加压，保持切口干燥及腰椎蛛网膜下腔持续引流等方法治疗。[结果]12例经采用术中填塞封堵明胶海绵的方法，切口Ⅰ期愈合。5例术中填塞封堵明胶海绵，术后抬高床尾，颈部适度加压，对症处理，7～10d切口愈合。2例采用腰椎蛛网膜下腔持续引流，术后2周切口愈合。[结论]颈椎前路手术并发脑脊液漏，采用明胶海绵、筋膜片填塞封堵，紧密缝合切口，抬高床尾，颈前适度均匀加压，腰椎蛛网膜下腔持续引流等方法，是行之有效的非手术治疗措施。     

颈椎手术并发脑脊液漏的处理

目的 探讨颈椎手术并发脑脊液漏（CSFL）的处理方法及其疗效。方法 对11例颈椎手术并发CSFL的患者,后路手术采用自体筋膜修补2例,前路手术采用自体筋膜明胶海绵堵塞9例,手术后仍存在CSFL患者采取去枕头高足低位、延长脱水剂应用时间、行腰穿蛛网膜下腔引流。结果 2例后路手术CSFL患者修补成功。9例前路行硬膜堵塞患者4例仍有CSFL,行腰穿蛛网膜下腔引流,切口引流或漏出0—3d停止．切口在引流后7d拆线均愈合。结论 CSFL术中采用修补或堵塞硬膜破口术后采用头高足低位、延长脱水剂应用时间可减少手术后CSFL的发生;术后持续腰穿蛛网膜下腔引流,能有效终止切口内CSFL,有利于切口愈合,避免感染发生。     

胸腰椎爆裂性骨折前路术中硬膜损伤及脑脊液漏的处理

[目的]探讨胸腰椎爆裂性骨折前路手术中硬脊膜损伤及脑脊液漏的处理及其疗效。[方法]1999~2009年532例胸腰椎爆裂性骨折前路减压手术中出现硬膜损伤及脑脊液漏23例,为术中减压损伤硬膜、骨折块刺破硬膜或骨折移位致硬膜严重撕裂伤所致。硬膜缺损面积(0.6~3.0)cm×(0.8~2.5)cm。采用皮下筋膜和明胶海绵或阔筋膜和医用耳脑胶封堵填塞法处理。术后取低枕平卧位,常规应用甲强龙、甘露醇及抗生素4~6 d。术后24~48 h拔除引流管。[结果]经术中采用皮下筋膜和明胶海绵或阔筋膜和耳脑胶封堵填塞法和术后辅助处理后,21例治愈,切口Ⅰ期愈合;另2例术后存在脑脊液漏者,分别在术后8、15 d治愈。术后随访3~52个月(平均23个月)。全部病例无切口感染及脑脊液囊肿形成,效果良好。[结论]对胸腰椎爆裂性骨折前路减压术中发生CSFL者采用皮下筋膜和明胶海绵或阔筋膜和医用耳脑胶封堵填塞法处理是行之有效的措施,疗效满意。     

颈椎前路手术并发脑脊液漏的原因分析和治疗体会

目的分析颈椎前路手术并发脑脊液漏的原因,并针对原因提出预防和治疗方法。方法回顾性分析自2013-01—2015-09颈椎前路手术并发脑脊液漏5例。对于3例硬脊膜破损面积0.5 cm2者,硬脊膜破口处平铺明胶海绵,将卷实的柱状明胶海绵填塞在植入的髂骨或钛笼两侧。对于2例破损面积≥0.5 cm2者,可先用腰背筋膜或人工硬脊膜补片覆盖于破损处,再用明胶海绵填塞压实。结果 5例在术中发现硬脊膜破裂脑脊液漏,用明胶海绵填塞封堵。3例术后无明显脑脊液漏,切口愈合良好。1例术后仍有少量脑脊液漏(100 ml/d),术后处理5 d后拔出引流管,缝合引流口,切口愈合。1例经积极处理后脑脊液每日引流量持续不减少(300 ml/d),予以腰椎蛛网膜下腔穿刺持续引流,12 d后愈合。本组经平均15(5~28)个月随访,术后无神经压迫症状,功能恢复良好,无脑脊液囊肿形成,未发现明显后遗症。结论经术前预防、术中明胶海绵封堵和术后引流等积极处理,颈椎前路手术并发的脑脊液漏多能被控制,取得满意的手术效果。     

脊柱前路手术并发硬膜损伤的原因与治疗

目的探讨脊柱前路手术并发硬膜损伤的原因及其治疗手段。方法总结12例脊柱前路手术并发硬膜损伤的临床资料,初步探讨硬膜损伤的发生原因及术中、术后处理措施。结果病理性因素导致的硬膜损伤9例,占总数的75%,而医源性损伤3例,占25%。术中采用明胶海绵覆盖硬膜破口9例,明胶海绵覆盖后再用纤维蛋白胶封闭3例;术后发生脑脊液漏3例,经过相应处理均得到治愈。结论慢性脊柱病变导致的硬膜病理性改变、爆裂性骨折片对硬膜的直接损伤及术中医源性损伤是脊柱前路手术并发硬膜损伤的主要原因,术中采用明胶海绵覆盖或结合纤维蛋白胶封闭是治疗硬膜损伤的有效手段。     

颈前路减压并发脑脊液漏的处理

目的探讨颈前路减压并发脑脊液漏(CSFL)的处理及其疗效。方法1997年10月～2002年10月共行颈椎前路减压手术1052例,颈椎病926例,颈椎后纵韧带骨化症(OPLL)126例。术中共发生CSFL11例,其中9例为颈椎后纵韧带骨化症切除骨化块后引起,2例为重度脊髓型颈椎病切除椎体后方骨赘所致。硬脊膜缺损面积为(0.6～2.0)cm×(1.0～1.5)cm。采用皮下筋膜和明胶海绵的封堵填塞法处理。术后取低枕平卧位,常规应用地塞米松、速尿及抗生素,并补充白蛋白或血浆3～5d。术后24h拔除引流条。其中3例术后仍存在CSFL(均为OPLL行颈前路切除骨化块者),采用明胶海绵填塞、缝合封闭和对症处理等方法治疗。结果经术中采用封堵填塞法和术后辅助处理后,8例治愈,切口Ⅰ期愈合;另3例术后存在CSFL者,分别在术后5、14、17d治愈。术后随访10～62个月(平均26个月)。全部病例无切口感染及脑脊液囊肿形成。术后神经功能恢复良好。结论对颈前路减压术中发生CSFL者采用封堵填塞法处理,对术后存在CSFL者行常规保守治疗、明胶海绵填塞和缝合封闭是行之有效的措施,疗效满意。     

颈前路后纵韧带骨化切除术并发脑脊液漏的处理及疗效分析

目的:探讨颈椎后纵韧带骨化症(ossification of posterior longitudinal ligament,OPLL)患者经颈椎前路手术并发脑脊液漏的处理方法及临床疗效。方法:2008年1月~2012年1月,采用颈前路后纵韧带骨化切除术治疗颈椎OPLL患者126例,男89例,女37例;年龄46～72岁,平均61岁;病程3d～7年,平均4.2年。骨化物在矢状面上范围涉及1～3个椎体。术中发现11例患者合并硬脊膜骨化,其中7例术中发生硬脊膜破损(4例为硬脊膜撕裂,3例形成硬脊膜缺损);115例未合并硬脊膜骨化患者中,4例发生硬脊膜撕裂。术中均采用明胶海绵覆盖及生物蛋白胶封堵,术后采用常压引流、卧床休息、预防感染及营养支持等方法综合处理,观察患者脑脊液漏情况及转归。结果:11例术中硬脊膜破损的患者术后均发生脑脊液漏,脑脊液漏发生率为8.7%(11/126),其中合并硬脊膜骨化患者术后脑脊液漏发生率为63.6%(7/11),未合并硬脊膜骨化患者术后脑脊液漏发生率为0.03%(4/115),两组比较差异有统计学意义(P<0.001)。经综合处理后,3例于术后3～5d内痊愈;8例患者切口愈合拔管后形成间隙性脑脊液囊肿,经反复穿刺抽吸、颈部环形加压包扎治疗,均于术后14～30d内痊愈,其中1例合并颅内感染,经腰大池置管持续引流加鞘内注射抗生素治疗痊愈。11例患者均获随访,随访时间为1～36个月,平均12.8个月,无神经症状加重及持续性头痛等后遗症发生,术后平均神经功能改善率为51.2%。结论:颈椎OPLL患者行颈前路手术术中易发生硬脊膜损伤,术中一期修复极为困难,术后脑脊液漏发生率高,应采取综合措施处理,以获痊愈。     

颈椎手术并发脑脊液漏的治疗

目的探讨颈椎手术并发脑脊液漏(CSFL)的治疗方法。方法对颈椎手术215例中并发CSFL12例,术中采用硬膜破损缝合、筋膜片修补、明胶海绵压迫,配合术后引流管口缝合,保持切口干燥及腰椎蛛网膜下腔持续引流等方法治疗。结果8例术后未见明显脑脊液被引流出,切口一期愈合。4例于术后5、6d拔除引流管后仍持续有较多脑脊液渗出,其中2例采用腰椎蛛网膜下腔持续引流,于7d和14d后切口愈合;1例采用缝合法治愈;1例缝合后切口处出现大小2cm×2cm波动性包块,3周后消失。结论颈椎手术并发CSFL根据硬脊膜损伤不同给予相应的修复是首选方法,术后控制引流量、并发症能有效防治术后脑脊液漏的发生。     

颈前路手术并发脑脊液漏的原因及处理

目的探讨颈前路手术并发脑脊液漏(CSFL)的原因及处理方法。方法2006年4月~2009年4月我治疗组共行颈前路手术728例,术后发生CSFL6例,其中3例为颈椎后纵韧带骨化症患者,1例为多节段颈椎病患者,1例为外伤后颈椎脱位患者,1例为颈椎后纵韧带骨化合并硬膜囊骨化患者。6例患者均于术中发现脑脊液漏。除1例后纵韧带骨化合并硬膜囊骨化患者在切除后纵韧带骨化块后发现硬膜有一处约3×2mm左右缺损外,余患者均未发现明显硬脊膜缺损。1例正中部位硬膜囊破损患者术中行硬膜囊修补术,其余5例无法修补硬脊膜患者采用自体筋膜和明胶海绵、生物蛋白胶填塞处理。全部病例术后采用头高脚低卧位,常规使用抗生素、补足液体及应用白蛋白并加强伤口换药,保持伤口清洁干燥。结果经上述处置后,全部6例患者在术后5~17d脑脊液漏完全治愈,未并发椎管内及颅内感染、脊髓及神经根症状、脑脊液囊肿形成。术后患者神经功能恢复良好。JOA评分提高4~6分(平均4.8分)。结论对颈前路手术发生CSFL的患者术中尽量修补破损的硬脊膜,并采用自体筋膜填塞,术后采用头高脚低位并重视补液及加强换药,可以有效治疗脑脊液漏。该方法操作简单易行,无严重并发症发生,是值得应用的治疗措施。     

颈椎前路手术并发脑脊液漏的处理

目的 探讨颈前路手术中脑脊液漏并发症的防治措施.方法 通过回顾性的方法 对2000-01-2009-08所发生6例颈椎前路手术后脑脊液漏患者的临床资料进行分析总结.结果 术中采用硬脊膜破损口缝合或修补和明胶海绵封堵填塞法处理,术后采用俯卧头低腰高体位,引流管拔除时管口皮肤全层缝合,或经腰椎蛛网膜下腔持续引流及对症处理,...     

老年腰椎椎管狭窄症患者术中硬膜囊撕裂位置及术中术后处理对策

目的探讨老年腰椎椎管狭窄症患者手术发生硬膜囊撕裂的解剖学机制,比较撕裂位置及术中、术后处理对策。方法回顾性分析2012年01月~2014年01月本院行腰椎后路手术的216例〉70岁老年患者,记录患者一般资料、病程时间、术前诊断、手术方式和节段、术中硬膜囊撕裂的位置、术后脑脊液漏情况和处理方法以及并发症等。结果共计151例患者入选,其中男89例,女62例,年龄70~93岁,平均78.12岁。术中发生硬膜囊撕裂共计34例,术后出现脑脊液漏23例,硬膜囊撕裂位置发生率硬膜囊后外侧〉根袖〉硬膜囊外侧〉硬膜囊腹侧。术中采取硬膜囊缝合修补、明胶海绵压迫、生物蛋白胶粘合等处理,术后常规给予预防感染、神经根脱水、补液等治疗,均于术后3~10 d拔管,3~4周切口愈合,全部患者未出现严重并发症。结论 〉70岁老年腰椎椎管狭窄症患者术中硬膜囊撕裂及术后脑脊液漏的发生率高于整体人群,且多位于硬膜囊后外侧及根袖,术中及时发现并仔细缝合或修补破损的硬膜、术后间断夹闭引流管、延长拔管时间能获得良好的效果。     

Effect of fibrin glue on the prevention of persistent cerebral spinal fluid leakage after incidental durotomy during lumbar spinal surgery

Approximately one million spinal surgeries are performed in the United States each year. The risk of an incidental durotomy (ID) and resultant persistent cerebrospinal fluid (CSF) leakage is a significant concern for surgeons, as this complication has been associated with increased length of hospitalization, worse neurological outcome, and the development of CSF fistulae. Augmentation of standard dural suture repair with the application of fibrin glue has been suggested to reduce the frequency of these complications. This study examined unintended durotomies during lumbar spine surgery in a large surgical patient cohort and the impact of fibrin glue usage as part of the ID repair on the incidence of persistent CSF leakage. A retrospective analysis of 4,835 surgical procedures of the lumbar spine from a single institution over a 10-year period was performed to determine the rate of ID. The 90-day clinical course of these patients was evaluated. Clinical examination, B-2 transferrin assay, and radiographic imaging were utilized to determine the number of persistent CSF leaks after repair with or without fibrin glue. Five hundred forty-seven patients (11.3%) experienced a durotomy during surgery. Of this cohort, fibrin glue was used in the dural repair in 278 patients (50.8%). Logistic models evaluating age, sex, redo surgery, and the use of fibrin glue revealed that prior lumbar spinal surgery was the only univariate predictor of persistent CSF leak, conferring a 2.8-fold increase in risk. A persistent CSF leak, defined as continued drainage of CSF from the operative incision within 90 days of the surgery that required an intervention greater than simple bed rest or over-sewing of the wound, was noted in a total of 64 patients (11.7%). This persistent CSF leak rate was significantly higher (P < 0.001) in patients with prior lumbar surgery (21%) versus those undergoing their first spine surgery (9%). There was no statistical difference in persistent CSF leak between those cases in which fibrin glue was used at the time of surgery and those in which fibrin glue was not used. There were no complications associated with the use of fibrin glue. A history of prior surgery significantly increases the incidence of durotomy during elective lumbar spine surgery. In patients who experienced a durotomy during lumbar spine surgery, the use of fibrin glue for dural repair did not significantly decrease the incidence of a persistent CSF leak.     

颈椎严重后纵韧带骨化症前路手术脑脊液漏的预防和处理

 目的 探讨前路手术治疗颈椎严重后纵韧带骨化症过程中,预防和处理脑脊液漏(cerebrospinal fluid leakage,CSFL)的经验。方法 回顾性分析2008年1月至2011年5月行前路手术治疗的47例颈椎严重后纵韧带骨化症(骨化厚度 >5 mm,椎管狭窄率 >50%)患者资料,其中15例患者术中出现硬膜缺损,男11例,女4例;年龄40～68岁,平均55.6岁。术前认真分析CT影像,行针对性的减压准备;术中应用直接切除、间接漂浮等技巧减少硬膜损伤,采用缝线修补、肌肉覆盖等方法处理硬膜缺损;术后给予卧床、引流等措施治疗CSFL。结果 术后15例患者均获得随访,随访时间为12～18个月,平均14.8个月。10例患者伤口愈合,术后未发生CSFL;5例患者确诊出现CSFL,其中4例经加压包扎、引流等治疗4～6 d后脑脊液漏出停止;1例形成脑脊液囊肿,经反复穿刺后3周内囊肿消失。所有患者伤口均完全愈合,无一例发生椎管内及颅内感染、气道阻塞等并发症,且无一例行二次修补或转流手术,术后神经功能恢复良好。结论 颈前路手术治疗严重后纵韧带骨化过程中,术前分析CT片并行充分减压准备,术中避免硬膜损伤及有效修补缺损,术后给予卧床、引流等措施能有效预防和处理CSFL。     

腰大池置管引流治疗颈椎前路手术后并发脑脊液漏

目的探讨腰大池置管引流治疗颈椎前路手术后并发脑脊液漏的临床疗效及安全性。方法回顾性分析2011年6月—2016年12月颈椎前路手术后并发脑脊液漏并接受腰大池置管引流治疗的17例患者(观察组)的临床资料,以同时期因外伤致硬膜破损脑脊液漏并接受腰椎穿刺引流术治疗的21例患者作为对照组,以治愈率、引流时间、24 h引流量、头痛持续时间以及治疗期间头晕、恶心、呕吐发生例数评价治疗脑脊液漏的疗效;以并发症发生和随访期恢复情况评价其安全性。结果所有患者均随访12个月,2组患者脑脊液漏均治愈。观察组脑脊液24 h引流量明显高于对照组,头痛持续时间、引流时间均短于对照组,差异均有统计学意义(P 0.05);观察组治疗期间头晕、恶心、呕吐发生例数显著低于对照组,差异具有统计学意义(P 0.05)。所有病例均未发生颅内感染等严重并发症。观察组伤口愈合良好,随访期内无再发脑脊液漏、脑脊液囊肿形成;对照组治疗期内并发高热1例,经抗感染治疗后痊愈,随访期内1例患者脑脊液漏复发。结论腰大池置管引流治疗颈椎前路手术后并发脑脊液漏疗效确切,具有治疗时间短、并发症少、患者痛苦小的优点,值得临床推广应用。     

Anterior cervical micro-dural repair of cerebrospinal fluid fistula after surgery for ossification of the posterior longitudinal ligament. Technical note

BACKGROUND: Cerebrospinal fluid (CSF) fistulas may occur during anterior cervical surgery performed for the resection of ossification of the posterior longitudinal ligament (OPLL), as OPLL occasionally erodes to and through the dura. These fistulas have been variously managed with gelfoam, dural substitutes sutured in place, fibrin glue, lumbar drains, and lumboperitoneal shunts. However, more adequate dural repair is now feasible with the 1.4-mm microdural titanium stapler. METHODS: A 59-year-old female with OPLL and moderate to severe myelopathy (Nurick Grade IV) had a C3-C7 anterior corpectomy with fusion using Orion plates followed by a C3-T1 posterior wiring and fusion with halo application. During the anterior approach, a 5-mm CSF fistula at C4-C5 was directly repaired under the operating microscope using a 1.4-mm microdural stapler, bovine pericardial graft, and fibrin glue. Immediately postoperatively, a lumboperitoneal shunt was also placed. RESULTS: Postoperatively, her myelopathy improved to a mild to moderate level (Nurick Grade II). Her acute left deltoid plegia resolved within 3 months. CONCLUSIONS: The 1.4-mm microdural stapler makes "watertight" closure of anterior cervical CSF fistulas more feasible.     

可吸收止血流体明胶在钩椎关节切除术中的应用

目的探讨可吸收止血流体明胶(Surgiflo~(TM))应用于钩椎关节切除术中的有效性和安全性。方法 2017年1月—2019年5月海军军医大学附属长征医院采用钩椎关节切除术治疗神经根型颈椎病患者126例,术中使用可吸收止血流体明胶止血61例(Surgiflo组),采用明胶海绵止血65例(明胶海绵组)。记录2组术中止血时间、术中出血量、术后1 d和2 d引流量、术后1 d和末次随访日本骨科学会(JOA)评分,以及术后有无过敏、感染等并发症,综合评价2组治疗效果。结果 Surgiflo组术中止血时间、术中出血量、术后1 d和2 d引流量、术后1 d JOA评分均优于明胶海绵组,差异有统计学意义(P 0.05);2组末次随访JOA评分差异无统计学意义(P 0.05)。Surgiflo组和明胶海绵组术后伤口感染发生率分别为0和1.5%(1/65)。结论可吸收止血流体明胶是一种安全、有效的止血剂,在钩椎关节切除手术中可减少术中止血时间、术中出血量、术后引流量,且围手术期症状缓解迅速,不增加伤口感染的风险。     

Sellar repair with resorbable polyglactin acid sheet and fibrin glue in endoscopic endonasal transsphenoidal surgery

BACKGROUND: Cerebrospinal fluid leakage after transsphenoidal surgery represents a serious problem. Various methods to prevent postoperative CSF leakage are available, but immediate and tight dural closure is still difficult. The efficacy of a novel sellar repair was described. METHODS: The sellar repair using absorbable PGA sheet and fibrin glue was applied to 18 consecutive patients with sellar tumors that include 13 pituitary adenomas, 2 craniopharyngiomas, 2 Rathke's cleft cysts, and 1 meningioma within 135 patients who were treated with endoscopic endonasal transsphenoidal approach. The reaction speed and strength between PGA sheets and fibrin glue were examined in vitro. RESULTS: Polyglactin acid sheets were adhered to the rabbit skin with fibrin glue within 3 minutes and withstood a pressure of more than 220 mm Hg. Postoperative CSF leakage of the patients was not observed in any patients, and excellent adhesion of the PGA sheets to surrounding mucosa was estimated by endoscopic observation after the surgery. CONCLUSIONS: Repair of the sellar floor with PGA sheet and fibrin glue is a safe and effective method to prevent postoperative CSF leakage, which decreases the necessity for lumbar drainage after the operation.     

Dural substitute with polyglycolic acid mesh and fibrin glue for dural repair: technical note and preliminary results

Background An ideal dural substitute that enables watertight closure, has sufficient strength, and can be absorbed without remnant materials that induce inflammation, adhesion, and infection is not available. The purpose of this study was to evaluate the efficacy of a bioabsorbable polyglycolic acid (PGA) mesh and fibrin glue as a substitute for dural repair. Methods Altogether, 10 patients with noted dural tears during extradural spinal surgery and 20 patients who underwent durotomy for intradural spinal surgery were included in this study. In a series of 20 consecutive cases, dural closure was performed by suture and fibrin glue. In the subsequent 10 consecutive patients, dural closure was performed by suture and fibrin glue with the use of absorbable PGA mesh. The medical records and magnetic resonance imaging (MRI) of the surgical site were retrospectively reviewed to evaluate the presence of a cerebrospinal fluid (CSF) fistula or leakage after the surgery. Results A CSF fistula occurred in five patients who underwent dural repair with fibrin glue alone, and postoperative MRI showed CSF leakage in two patients with incidental dural tears after laminectomy for ossification of ligamentum flavum. No CSF fistula was present in patients who underwent dural repair using PGA mesh and fibrin glue, and no adverse effects or complications were encountered postoperatively. Follow-up MRI revealed no evidence of CSF leakage around the reconstructed dura mater. Conclusions The use of PGA mesh and fibrin glue for the repair of dura mater is a useful method of preventing CSF leakage in spinal surgery.     

应用明胶海绵野三明治冶法在硬脊膜缝合后预防脑脊液漏的作用

 目的 探讨明胶海绵“三明治”法(医用胶+明胶海绵+医用胶)在加强硬脊膜后方裂口缝合预防脑脊液漏的作用。方法 回顾性分析2007年2月至2011年6月收治的54例椎管内硬脊膜下肿瘤患者资料,根据修复硬脊膜的方法将患者分成两组。常规修复组23例,男16例,女7例;年龄24～69 岁,平均(45.2±7.2)岁;“三明治”组31例,男19例,女12例;年龄22～67 岁,平均(44.2±6.4)岁。患者在切除椎管内硬脊膜下的肿瘤后,常规修复组采用连续锁边缝合硬脊膜后覆盖大小合适的明胶海绵;“三明治”组在连续锁边缝合硬脊膜后,加用医用胶喷涂缝合口及周缘硬脊膜,而后覆盖大小合适的明胶海绵,最后再次在明胶海绵表面及周缘喷涂医用胶。结果 与常规修复组比较,“三明治”组术后当天、第1天、第2天、第3天引流量均明显下降。常规修复组在引流管拔除后7～10 d仍有3例出现切口积液,经穿刺抽液、沙袋加压、俯卧体位等治疗后切口愈合。两组患者均获随访,随访时间12~63个月,平均26.5个月。常规组3个月后有5例伤口发生深部积液;“三明治”组未见明显异常。结论 应用“三明治”法修复硬脊膜背部损伤裂口可明显提高缝合修复效果,有效减少术后引流量,降低脑脊液漏发生率。