共查询到20条相似文献,搜索用时 125 毫秒
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藏药独一味及制剂的药理及临床研究概述 总被引:6,自引:0,他引:6
马维宁 《中国民族医药杂志》2005,11(1):39-40
独一味是藏、蒙、纳西等民族的民间常用药材,具有止血、镇痛、活血化瘀、抗菌消炎、增强免疫力等作用。在距今1000多年的藏医学名著《四部医典》和《晶珠本草》中已有记载。藏医将其用于骨髓炎、关节黄水病、骨折、跌伤、枪伤等症的治疗。独一味现已被开发成胶囊、片、颗粒剂等成药,在临床上应用广泛,研究报道较多。 相似文献
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目的研究独一味Lamiophlomis rotata(Benth.)Kudo的化学成分。方法独一味的50%乙醇提取液采用硅胶、ODS、Sephadex LH-20进行分离纯化,根据理化性质及波谱数据鉴定所得化合物的结构。结果从中分离得到10个化合物,分别鉴定为去咖啡酰基类叶升麻苷(1)、markhamioside A(2)、gentioside(3)、6-O-乙酰山栀苷甲酯(4)、phloyoside I(5)、7,8-dehydropenstemoside(6)、phlorigidoside C(7)、β-胡萝卜苷(8)、咖啡酸(9)、棕榈酸(10)。结论化合物1~3首次从该植物中分离得到。 相似文献
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Maoxing Li Ruxue Zhang Zhengping Jia Jie Sheng Jianguo Qiu Juan Wang 《Phytotherapy research : PTR》2009,23(6):816-822
Lamiophlomis rotata (Benth.) Kudo (LR) is a traditional drug used by Chinese minorities such as Tibetans, Mongolians and Na Xi with the beneficial effects of hemostasis and alleviating pain. Flavonoids ingredients (P1), iridoid glycosides ingredients (P2) and maximus polarity components ingredients (P3) were isolated from the aqueous extract of LR (AELR) with polyamide and macroporous adsorptive resins chromatographic columns. The hemostatic activity of these ingredients was estimated by the changes in bleeding time (BT), clotting time (CT) and blood coagulation parameters in mice or rats. RP‐HPLC was used to analyze the chemical composition of P2. As a result, AELR and P2 significantly shortened BT, CT and thrombin time (TT), and increased fibrinogen (FIB), but P1 and P3 showed no hemostatic effect during the experiment. Moreover, P2 showed satisfactory hemostatic effect with dose‐effect relationship and low toxicity in mice. 8‐Dehydroxy shanzhiside, phloyoside II, shanzhiside methylester, loganin, and 8‐O‐acetylshanzhiside methylester were detected as the main iridoid glycosides in P2 by RP‐HPLC. Our results suggest that iridoid glycosides may be the hemostatic activity ingredients of L. rotata and are a potential hemostatic medicine. Copyright © 2009 John Wiley & Sons, Ltd. 相似文献
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Experimental study on the hemostatic activity of the Tibetan medicinal herb Lamiophlomis rotata 总被引:1,自引:0,他引:1
The blood hemostatic activity of the Tibetan medicinal herb Lamiophlomis rotata was evaluated in BALB/c mice and Wistar rats. L. rotata aqueous extract (LRAE) was given to mice at concentrations of 0.5, 1.0, 2.0 g/kg body weight and 0.75, 1.5, 3.0 g/kg to rats. The hemostatic activity of LRAE was estimated by changes in bleeding time (BT), prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT) and fibrinogen (FIB). At the same time hepatic function and blood fat indexes including AST, ALT, Alb, Chol and LDL-C were measured also. The results showed that an appropriate level of LRAE could shorten the BT and TT values and increase the Alb level paralleling that of FIB. However, the shortening of the PT was only possible by a high and long administration of LRAE, and no change in APTT was observed. On the other hand, LRAE showed some effects in improving the liver function and reducing blood lipids by decreasing the levels of AST, ALT, Chol and LDL-C. All these changes had a significant dose-effect and time-effect relationship. These results confirm the hemostatic and thromboplastic effects of L. rotata and these effects might be implemented by improving the synthetic function of the liver. 相似文献
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HPLC梯度洗脱法测定山栀苷甲酯、8-0-乙酰山栀苷甲 酯在独一味中含量 总被引:1,自引:0,他引:1
目的 建立独一味中山栀苷甲酯、8-O-乙酰山栀苷甲酯的HPLC检测方法.方法 色谱柱Dikma platisil C18( 250 mm×4.6 mm,5 μm),柱温35℃,以乙腈-水进行梯度洗脱,流速1.0 mL/min,检测波长235 nm.结果 山栀苷甲酯进样量在0.023 0~3.450 0 μg范围内呈良好... 相似文献
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独一味水提取物止血作用及其机理的初步研究 总被引:11,自引:0,他引:11
目的研究藏药独一味水提取物(HLRE)的止血、促凝血作用及其机理。方法小鼠灌胃给予HLRE高、中、低剂量,3天后测定止血时间(BT)和凝血时间(CT),同时进行血小板计数(PLC);大鼠不同剂量口服给药14d后,颈总动脉采血,测定凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)、纤维蛋白原(FIB)含量以及肝功能和血脂等指标。结果HLRE2g/kg剂量组与1g/kg剂量组与生理盐水组比,出血时间和凝血时间都显著缩短,但各给药组血小板计数无显著性差异。PT、APTT无差异;TT明显缩短;FIB、Alb(白蛋白)显著增加;转氨酶、血脂有降低趋势。结论HLRE具有较好的止血、促凝血作用,推测其可能是通过增加纤维蛋白原(FIB)的含量,缩短大鼠凝血酶时间(TT)来发挥上述作用的。 相似文献
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大孔吸附树脂分离纯化独一味总黄酮的研究 总被引:15,自引:0,他引:15
目的 研究大孔吸附树脂富集、纯化独一味总黄酮的工艺条件及参数。方法 以静态饱和吸附量、静态洗脱率、动态比上柱量、比吸附量、比洗脱量为考察指标,比较了8种大孔树脂分离、纯化独一味总黄酮的工艺。又以总黄酮收率和纯度为指标,对最佳树脂吸附工艺条件进行了筛选。结果 8种树脂中,LSA-10型树脂具有最佳的吸附及洗脱参数,其动态饱和吸附量达到100.6mg·g-1干树脂 ,3倍体积蒸馏水、3倍体积 50 %乙醇依次洗脱 ,总黄酮收率为85% ,纯度为 94.5%。结论 LSA-10型树脂综合性能较好,适于独一味总黄酮的分离纯化。 相似文献
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浙江产香茶菜属植物8个居群的RAPD分析 总被引:5,自引:1,他引:5
目的 从DNA分子水平上探讨香茶菜属植物种群变异特点。方法 从70个随机引物中筛选出10个具有较高多态性检测能力的引物。用这10个随机引物对浙江境内3种香茶菜的8个居群进行了RAPD分析,对得出的RAPD结果应用SPSSl0.0进行的聚类分析和应用CANOC03.10进行的除趋势对应分析。结果 共检测出144个位点,其中单态位点11个,占7.64%,多态位点133个,占92.36%。分析结果表明,浙江产香茶菜不同种、同一种的不同居群间存在明显的遗传分化,其中种间的差异要大于种内,大萼香茶菜Isodon macrocalyx居群间的差异要比香茶菜I.amethystoides居群的小。结论 香茶菜形态与化学成分的变异有一定的遗传学基础。 相似文献
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目的 研究藏药独一味种群结构及更新规律.方法 采用植物种群生态学研究方法,调查独一味密度、叶展距、重量、根茎芽数目,计算样方内独一味大小结构、根茎芽生长规律.结果 独一味种群能适应退化草场生态环境.单株独一味每年更新依靠根茎芽萌发,根茎芽数目与独一味植株大小呈正相关;独一味地上部分重量与地下部分重量呈正相关.独一味种群... 相似文献