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1.
Jim Wang James Kollias Margaret Boult Wendy Babidge Helen N. Zorbas David Roder Guy Maddern 《The breast journal》2010,16(1):60-65
Abstract: Although treatment recommendations have been advocated for all women with early breast cancer regardless of age, it is generally accepted that different treatments are preferred based on the age of the patient. The aim of this study was to assess the pattern of breast cancer surgery after adjusting for other major prognostic factors in relation to patient age. Data on cancer characteristics and surgical procedures in 31,298 patients with early breast cancer reported to the National Breast Cancer Audit between 1999 and 2006 were used for the study. There was a close association between age and surgical treatment pattern after adjusting for other prognostic factors, including tumor size, histologic grade, number of tumors, lymph node positivity, lymphovascular invasion (LVI), and extensive intraduct component. Breast Conserving Surgery (BCS) was highest among women aged ≤40 years (OR = 1.140; 95% CI: 1.004–1.293) compared to women aged 51–70 years (reference group). BCS was lowest in women aged >70 years (OR = 0.498, 95% CI: 0.455–0.545). Significantly more women aged ≤50 years underwent more than one operation for breast conservation (20.4–24.8%) compared with women aged >50 years (11.4–17.0%). Women aged >70 years were more likely to receive no surgical treatment, 3.5% versus 1.0–1.3% in all other age groups (≤40, 41–50 51–70 years). There is an association between patient age and the type of breast cancer surgery for women in Australia and New Zealand. Women age ≤40 years are more likely to undergo BCS despite having adverse histologic features and have more than one procedure to achieve breast conservation. Older women (>70 years) more commonly undergo mastectomy and are more likely to receive no surgical treatment. 相似文献
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Disparities in the Local Management of Breast Cancer in the US according to Health Insurance Status 下载免费PDF全文
Thomas M. Churilla MD Brian Egleston PhD Richard Bleicher MD Yanqun Dong MD PhD Joshua Meyer MD Penny Anderson MD 《The breast journal》2017,23(2):169-176
Although standard practice guidelines for breast cancer are clear, the interplay between insurance and practice patterns for the US is poorly defined. This study was performed to test for associations between patient insurance status and presentation of breast cancer as well as local therapy patterns in the US, via a large national dataset. We queried the NCI Surveillance, Epidemiology, and End Results data base for breast cancer cases diagnosed from 2007 to 2011 in women aged 18–64 with nonmetastatic ductal/lobular cancers, treated surgically. We tested for associations between insurance status (insured/Medicaid/uninsured) and choice of surgical procedure (mastectomy/breast conserving surgery [BCS]), omission of radiotherapy (RT) following BCS, and administration of post‐mastectomy radiation (PMRT). There were 129,565 patients with localized breast cancer analyzed. The health insurance classification included insured (84.5%), Medicaid (11.5%), uninsured (2.1%) and unknown (1.9%). Medicaid or uninsured status was associated with large, node positive tumors, black race, and low income. The BCS rate varied by insurance status: insured (52.2%), uninsured (47.7%), and Medicaid (45.2%), p < 0.001. In multivariable analysis, Medicaid insurance remained significantly associated with receipt of mastectomy (OR [95% CI] = 1.07 [1.03–1.11]), while RT was more frequently omitted after BCS in both Medicaid (OR [95% CI] = 1.14 [1.07–1.21]) and uninsured (OR [95% CI] = 1.29 [1.14–1.47]) patients. Insurance status was associated with significant variations in breast cancer care in the US. Although patient choice cannot be determined from this dataset, departure from standard of care is associated with specific types of insurance coverage. Further investigation into the reasons for these departures is strongly suggested. 相似文献
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The Role of Preoperative Magnetic Resonance Imaging in the Assessment and Surgical Treatment of Interval and Screen‐Detected Breast Cancer in Older Women 下载免费PDF全文
Martha E. Goodrich MS Julie Weiss MS Tracy Onega PhD Steve L. Balch MBA Diana S. M. Buist PhD Karla Kerlikowske MD Louise M. Henderson PhD Rebecca A. Hubbard PhD the Breast Cancer Surveillance Consortium 《The breast journal》2016,22(6):616-622
We describe the relationship between preoperative magnetic resonance imaging (MRI) and the utilization of additional imaging, biopsy, and primary surgical treatment for subgroups of women with interval versus screen‐detected breast cancer. We determined the proportion of women receiving additional breast imaging or biopsy and type of primary surgical treatment, stratified by use of preoperative MRI, separately for both groups. Using Breast Cancer Surveillance Consortium (BCSC) data, we identified a cohort of women age 66 and older with an interval or screen‐detected breast cancer diagnosis between 2005 and 2010. Using logistic regression, we explored associations between primary surgical treatment type and preoperative MRI use for interval and screen‐detected cancers. There were 204 women with an interval cancer and 1,254 with a screen‐detected cancer. The interval cancer group was more likely to receive preoperative MRI (21% versus 13%). In both groups, women receiving MRI were more likely to receive additional imaging and/or biopsy. Receipt of MRI was not associated with increased odds of mastectomy (OR = 0.99, 95% CI: 0.67–1.50), while interval cancer diagnosis was associated with significantly higher odds of mastectomy (OR = 1.64, 95% CI: 1.11–2.42). Older women with interval cancer were more likely than women with a screen‐detected cancer to have preoperative MRI, however, those with an interval cancer had 64% higher odds of mastectomy regardless of receipt of MRI. Given women with interval cancer are reported to have a worse prognosis, more research is needed to understand effectiveness of imaging modalities and treatment consequences within this group. 相似文献
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Juin Liu MD Xi-Shan Hao MD Yong Yu MD Zhi-Yi Fang MD Jun-Tian Liu MD Yun Niu MD Ian S. Fentiman MD DSc 《The breast journal》2009,15(3):296-298
Abstract: Between July 1989 and December 2002, 172 women with Stage I/II breast cancer were treated by breast conservation therapy (BCT). All underwent quadrantectomy and axillary node clearance. Minimum follow-up was 5 years and 79 (52%) were followed for >10 years. At 5 years, local relapse-free and overall survival rates were 98.3% and 98.3%. The 10-year rates were 95% and 94%, respectively. The 10-year local recurrence rate was higher in patients with involved margins (33.3% versus 2.7%, p = 0.0272). Furthermore 10-year death rates in margin positive patients were higher (18.2% versus 2.5%, p = 0.0486). Excellent or good cosmetic results were achieved in 54%. BCT is a reasonable option for early stage breast cancer in Chinese women but margin status is the most important determinant of local recurrence. Negative margins are required for optimal local control and minimization of distant metastasis. 相似文献
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Riccardo Masetti MD Alba Di Leone MD Gianluca Franceschini MD Stefano Magno MD Daniela Terribile MD Maria Cristina Fabbri MD Federica Chiesa MD 《The breast journal》2006,12(S2):S174-S180
Abstract: Conservative surgery has become a well-established alternative to mastectomy in the treatment of breast cancer. However, in case of larger lesions or small-size breasts, the removal of adequate volumes of breast tissue to achieve tumor-free margins and reduce the risk of local relapse may compromise the cosmetic outcome, causing unpleasant results. In order to address this issue, new surgical techniques, so-called oncoplastic techniques, have been introduced in recent years to optimize the efficacy of conservative surgery both in terms of local control and cosmetic results. This article discusses the indications, advantages, and limitations of these techniques and their results in terms of local recurrence and overall survival. 相似文献
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Frances C. Wright MD FRCSC Cagla Eskicioglu MD Joan Glazier MRT CBI Roberta Jong MD FRCPC Petrina Causer MD FRCPC May Lynn Quan MD FRCSC 《The breast journal》2008,14(6):556-561
Abstract: Breast magnetic resonance imaging (MRI) may provide a more accurate assessment of synchronous contralateral breast cancer in select cohorts of patients. The utility of this imaging technique for detecting synchronous contralateral breast cancers in patients with locally advanced breast cancer (LABC) has not previously been described. We report our experience in assessing contralateral disease in a cohort of women with LABC who had clinical assessment, mammography, ultrasound, and MRI prior to neo‐adjuvant therapy. Patients, who presented with LABC, stage IIB (T3N0), stage III A/B, were identified from a prospectively kept data base at a single tertiary care centre between November 2001 and August 2005. Charts were retrospectively reviewed and demographic, imaging and pathologic variables were abstracted. One hundred and one female patients with LABC were identified (median age 49). One hundred of 101 patients presented with a clinically obvious LABC. Three patients had LABC that was not visualized mammographically but was detected on ultrasound and MRI. Seventeen of 101 patients (17%) had contralateral imaging findings that required biopsy for diagnosis. Of the contralateral biopsies, 41% (7/17) were malignant. These malignant lesions were identified clinically in 4/7 patients, on 7/7 ultrasounds, 7/7 mammograms, and 5/5 MRI. Overall, 7% (7/101) patients had malignant synchronous contralateral disease. In our LABC patient cohort, 7% of patients presented with malignant contralateral disease. The incidence of contralateral disease in women with LABC is comparable with patients who present with early stage breast cancer. No single screening technique, ultrasound, mammogram or MRI, appeared to be superior for identifying contralateral synchronous malignancy. 相似文献
7.
Runhua Shi MD PhD Glenn Mills MD Jerry McLarty PhD Gary Burton MD Zhenzhen Shi Jonathan Glass MD 《The breast journal》2013,19(6):664-667
Breast cancer survival is affected both by endogenous factors and exogenous factors such as socioeconomic status. This study explored the relationship between insurance status and overall survival of 987 female breast cancer patients in a population served by a public hospital. All patients were offered the same level of care regardless of ability to pay. Of the 987 breast cancer patients investigated, 54.6% were African‐American. 54.1% of patients were insured (commercial insurance or Medicare), 27.1% with Medicaid, and 18.8% who were uninsured. Overall median survival was 15.5 years and was not statistically significant between Caucasian and African‐American women. Median survival times were 15.8, 11.3, and 8.2 years for insured, Medicaid, and uninsured groups, respectively. Uninsured patients had worse overall survival rates compared with insured patients (p < 0.05). Adjusting for other factors (e.g., stage, age, race, body mass index, and income), insurance was a significant factor affecting survival with hazard ratios of 2.24 and 3.22 for Medicaid and uninsured patients, respectively, compared with insured patients. Even in a public hospital, after adjusting for potential risk factors, insurance status still proved to be an important factor in the survival of breast cancer patients. Further research is necessary to identify causal factors related to the survival disparities associated with insurance status. 相似文献
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Quality-of-Life Measurement in Women with Breast Cancer 总被引:1,自引:0,他引:1
Richard P. McQuellon Ph.D. Gretchen Kimmick M.D. Gail J. Hurt R.N. M.A. Ed. 《The breast journal》1997,3(4):178-186
Abstract: The health-related quality of life (QOL) of breast cancer patients has been the focus of study for many years. However, it is only recently that the quality-of-life construct has been precisely defined and measured with validated, reliable instruments. The measurement of health-related quality of life and the application of this data in clinical practice has been facilitated by the publication of several QOL instruments widely used in clinical trials. Knowledge of available instruments and a growing database on quality of life following treatment for breast cancer allows clinicians and patients to better collaborate to improve patient functioning following treatment. The task for practitioners is to translate current QOL data into useful information for patients. 相似文献
9.
Abstract: The American Cancer Society has recommended monthly breast self-examinations (BSEs) to aid in the early detection of breast cancer. Compliance with BSE recommendations has been shown to be decreased in certain ethnic groups. This investigation evaluates relevant variables involved in BSE compliance in an urban breast cancer screening center. A survey over a 1-year period (June 1996–June 1997) was given to all patients on their initial visit to the Breast Health Center at Tulane University Medical Center. Demographic and socioeconomic factors associated with the compliance of BSE were explored. The overall rate of BSE was relatively high at 80%. There was no difference between ethnic groups in rates of BSE (Caucasians 21% versus African Americans 20%). Statistically significant variables associated with BSE noncompliance were high school education (did not complete high school 16% versus completed high school 33%; p < 0.0004), employment status (employed 16% versus unemployed 31%; p < 0.0004), and marital status (married 15% versus single/divorced 22%; p < 0.05). While the majority of women in our study practiced BSE and ethnicity did not predict BSE, several socioeconomic factors were predictive of BSE compliance. Efforts to increase community outreach to lower socioeconomic patients as well as efforts to ensure proficient BSE techniques by patients may help detect early breast cancer. 相似文献
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李平 《中国现代手术学杂志》2011,15(2):107-110
目的总结早期老年乳腺癌保乳治疗的临床疗效。方法保乳手术治疗23例早期老年乳腺癌患者,其中Ⅰ期7例,ⅡA期12例,ⅡB期4例,术中切除距肿块边缘2 cm以上乳腺,术后予放疗、化疗及激素治疗。结果随访3.5(2~5)年,未见复发及远处转移。采用Harris提出的四等分类法为美容评定标准,佳4例(17.4%),良16例(69.6%),一般2例(8.7%),差1例(4.3%),总优良率87.0%。结论保乳治疗早期老年乳腺癌具有机体创伤小、组织器官破坏少、美容效果好和保存功能的优点,在严格掌握手术适应证的前提下,并不增加复发及远处转移的风险。 相似文献
12.
C. Diaconu V. Gavrilovici D. Ghenghe Cr. Dragomir Laurette Cozma Ligia Ciornea 《Acta chirurgica Belgica》2013,113(6):589-592
Purpose: To assess the value of aggressive loco-regional surgery in desperate situations with locally advanced breast cancer .Methods: In this study there were considered 31 patients with locally advanced breast cancer who underwent surgery in a 5-year period. 10 of them received 3 cycles of chemotherapy and radiotherapy before surgical intervention; the rest of the 21 patients had systemic or local contra-indications for neo-adjuvant therapy. We describe clinical aspects and technical difficulties. Surgical intervention focused on tumour removal and lymph node dissection. Skin defect was covered with flaps according to the Mortimer-Show technique. Postoperatively, the outcome was influenced in a favourable way by the use of Detralex, a micronised flavonoid; all but 2 patients received chemotherapy and locoregional radiotherapy.Results: 25 patients survived free of disease; from 6 patients who suffered recurrence, 2 are still living and 4 have died. Conclusions: In some forms of locally advanced breast cancer, aggressive surgery offers improvement in the quality of life and increases survival. 相似文献
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Kuerer HM Hwang ES Anthony JP Dudley RA Crawford B Aubry WM Esserman LJ 《Annals of surgical oncology》2000,7(5):325-332
Background: The efficacy of prophylactic mastectomy and oophorectomy in reducing breast and ovarian carcinoma has recently been reported in high-risk women. Because cost has become central to medical decision-making, this study was designed to evaluate currently existing coverage policies for these procedures.Methods: A confidential detailed cross-sectional nationwide survey of 481 edical directors from the American Association of Health Plans, Medicare, and Medicaid was conducted.Results: Of the 150 respondents, 65% (n 5 97) had 100,000 or more enrolled members and 35% (n 5 53) had fewer than 100,000 enrolled members. Only 44% of private plans have specific policies for coverage of prophylactic mastectomy for a strong family history of breast cancer and 38% of plans for a BRCA mutation. Only 20% of total responding plans had a policy for coverage of prophylactic oophorectomy under any clinical circumstance. Governmental carriers were significantly less likely to have any policy for prophylactic surgery (range, 2%–12%) compared with nongovernmental plans (range, 24%–44%; P,.001). No significant regional differences for coverage policies were identified (P.05).Conclusions: Significant variations currently exist for health insurance coverage of prophylactic mastectomy and oophorectomy. As genetic testing becomes widespread, more uniform policies should be established to enable appropriate high-risk candidates equal access and coverage for these procedures. 相似文献
15.
▪ Abstract: The study aim was to compare breast cancer treatment and survival between older and younger women treated at the University of Texas M. D. Anderson Cancer Center over a 30-year period, 1958–1987. Data were obtained from the Medical Informatics Tumor Registry and were examined by 15-year time periods. Treatments were stratified by no surgery, surgery alone, or surgery and additional treatment. Mantel–Haenszel chi-square statistics and actuarial life tables were used for comparisons. Among 3,382 women treated for breast cancer, treatment differed by age groups (p < 0.01). The most consistent finding by disease stage was that older women were less likely to receive treatment in addition to surgery compared to younger women (p < 0.01–0.05). Among women with local or regional involvement who received surgery and additional treatment, 5-year survival was similar regardless of age group. However, among women with distant disease who received surgery and additional treatment, 5-year survival differed significantly by age group (p = 0.03); women in the 65- to 74-year age group experienced the best survival. In this hospital population, older women with breast cancer who received surgery and additional treatment experienced similar, sometimes better, 5-year survival compared with younger women, which suggests that older women, in some cases, may benefit from combined modality treatment for breast cancer. ▪ 相似文献
16.
Few studies have examined the relationship of insurance status with the presentation and treatment of breast cancer. Using a state cancer registry, we compared tumor presentation and surgical treatments at presentation by insurance status (private insurance, Medicare, Medicaid, or uninsured). Student's t-test, Chi-square test, and ANOVA were used for comparison. P-values reflect a comparison to insured patients. From 1996 to 2005, there were 6876 cases of invasive breast cancer with either private (n = 3975), Medicare (n = 2592), Medicaid (n = 193), or no insurance (n = 116). The median age (years) at presentation was 55 for private, 76 for Medicare, 54 for Medicaid and 54 for uninsured. The mean and median tumor size (mm) were 18.5 and 15 for private; 20.9 and 15 for Medicare; 24.2 and 18 for Medicaid; and 29.5 and 17 for uninsured, respectively; (p < 0.001 for all). Fewer women with Medicare and Medicaid presented with node negative breast cancers: private, 73.4% node negative; Medicare, 79.5% (p < 0.001); Medicaid, 60.9% (p < 0.001); and uninsured, 58% (p = 0.005). Significantly more uninsured women had no surgical treatment of their breast cancer: 15.5% versus 4.3% for private (p < 0.001). Among women with non-metastatic T1/T2 tumors, 71.5% with private insurance underwent breast-conserving surgery (BCS), compared with 64.2% of Medicare (p < 0.001), 65% of Medicaid (p = 0.097), and 65.4% of uninsured (p = 0.234). The rate of reconstruction following mastectomy was higher for private insurance (36.6%), compared with Medicare (3.8%, p < 0.0001), Medicaid (26.1%, p = 0.31), and uninsured (5.0%, p = 0.0038). The presentation of breast cancer in women with no insurance and Medicaid is significantly worse than those with private insurance. Of concern are the lower proportions of BCS and reconstruction among patients who are uninsured or have Medicaid. Reduction of disparities in breast cancer presentation and treatment may be possible by increasing enrollment of uninsured, program-eligible women in a state-supported screening and treatment program. 相似文献
17.
Abstract: Modified radical mastectomy and lumpectomy axillary node dissection with postoperative radiation therapy are both good surgical options for the treatment of early stage breast cancer. A number of parameters should be considered when evaluating a breast cancer patient for mastectomy versus breast conservation therapy. These parameters include size of the lesion and its biological characteristics as well as patient age and preference. Progress in breast cancer screening and treatment, including BRCA-1 testing and sentinel node biopsy, may also affect these decisions. 相似文献
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Sharon L Brennan Margaret J Henry Anita E Wluka Geoffrey C Nicholson Mark A Kotowicz Joanne W Williams Julie A Pasco 《Journal of bone and mineral research》2009,24(5):809-815
With few exceptions, an inverse relationship exists between social disadvantage and disease. However, there are conflicting data for the relationship between socioeconomic status (SES) and BMD. The aim of this study was to assess the association between SES and lifestyle exposures in relation to BMD. In a cross‐sectional study conducted using 1494 randomly selected population‐based adult women, we assessed the association between SES and lifestyle exposures in relation to BMD. BMD was measured at multiple anatomical sites by DXA. SES was determined by cross‐referencing residential addresses with Australian Bureau of Statistics 1996 census data for the study region and categorized in quintiles. Lifestyle variables were collected by self‐report. Regression models used to assess the relationship between SES and BMD were adjusted for age, height, weight, dietary calcium, smoking, alcohol consumption, physical activity, hormone therapy, and calcium/vitamin D supplements. Unadjusted BMD differed across SES quintiles (p < 0.05). At each skeletal site and SES index, a consistent peak in adjusted BMD was observed in the mid‐quintiles. Differences in adjusted BMD were observed between SES quintiles 1 and 4 (3–7%) and between quintiles 5 and 4 (2–7%). At the spine, the maximum difference was observed (7.5%). In a subset of women, serum 25(OH)D explained a proportion of the association between SES and BMD (difference remained up to 4.2%). Observed differences in BMD across SES quintiles, consistent across both SES indices, suggest that low BMD may be evident for both the most disadvantaged and most advantaged. 相似文献
20.
Lynne Wittenberg MPH Maya Yutsis PhD Sharee Taylor BS Janine Giese‐Davis PhD Caroline Bliss‐Isberg PhD Path Star JD David Spiegel MD 《The breast journal》2010,16(5):481-489
Abstract: We conducted a nonrandomized study matching 42 women newly diagnosed with breast cancer (sojourners) with 39 trained breast cancer survivors (navigators) who provided one‐on‐one peer counseling for 3–6 months. Because little is known about how marital status might impact participants in such an intervention, we tested whether being married/partnered buffered navigators and sojourners from distress at baseline and over time. We examined baseline and slopes over time for change in depression and trauma symptoms, and emotional well‐being. We were particularly concerned that being matched with a newly diagnosed breast cancer patient might trigger a re‐experiencing of trauma symptoms for the navigator, so we examined a re‐experiencing subscale. All participants completed baseline, 3‐, 6‐, and 12‐month assessments. Our hypotheses were tested in separate Analyses of Variance (married versus not) for the 39 sojourners and 34 navigators who provided baseline assessments, and the 29 sojourners and 24 navigators who were matched and provided at least one follow‐up. We found no significant baseline associations for navigators or sojourners. Being single/not married was associated with increasing depression symptoms over time in both navigators and sojourners compared with being married/partnered. By 12 months, these increases crossed above the clinical cut‐off for significant depression symptoms. Single status did not predict increasing trauma symptoms over time. However, being single/not married predicted a significant increase in navigators’ re‐experiencing of trauma symptoms. Over time, married sojourners increased significantly in emotional well‐being, whereas single/not married navigators did not differ from married navigators. In addition to providing ongoing training and emotional support to navigators, our findings indicate the importance of providing additional support for women who are not married or partnered. 相似文献