MSCT、超声心动图与MRI评价左心功能的比较研究

目的以磁共振成像(MRI)为对照标准,应用64层螺旋CT(MSCT),定量评价左心功能,探讨MSCT和MRI心功能评价指标的相关性及MSCT在冠心病左心功能评价中的应用价值;比较同组病例的超声心动图和心脏MRI的左心功能指标,探讨两种方法心功能指标的相关性。资料与方法临床拟诊冠心病的患者32例(均自愿参加),均行心脏MSCT、MRI和超声心动图检查。结果MSCT和MRI两种方法的心功能指标差异无统计学意义,舒张末期容积(EDV)、收缩末期容积(ESV)、每搏输出量(SV)、左室射血分数(EF)、心肌质量(MM)相关性高(r值=0.78~0.92);超声心动图和MRI两种方法的心功能指标差异亦无统计学意义,EDV和SV相关性高(r值分别为0.63和0.69);ESV和EF值相关性中等或低(r值分别为0.41和0.34)。EDV、ESV均值:MSCT>MRI>超声心动图;SV均值:MSCT>MRI和超声心动图;EF均值:超声心动图>MRI>MSCT。结论MSCT在左心功能定量评价方面准确、可靠,一次MSCT冠状动脉造影检查可以同时评估冠状动脉狭窄情况和左心室功能。超声心动图也具有重要的临床应用价值,但是MSCT用于定量评价左心功能较超声心动图更准确。     

双源CT不同R-R间期间隔法在定量评估左心功能中的对比研究

目的 探讨双源CT(dual-source CT,DSCT)不同R-R间期间隔重组在测定评估左心功能时有无差异性.资料与方法 对正常组(24名)和冠心病患者组(26例)行DSCT冠状动脉造影,分别以2%、5%及10%R-R间期间隔重组,并测定各间期左室舒张末期容积(EDV)、收缩末期容积(ESV)、每搏输出量(SV)、左室射血分数(EF).对测得的数据行单因素方差分析.结果 以2%、5%及10%R-R间期间隔重组测定左心功能时,各参数间差异无显著统计学意义.结论 以2%、5%及10%R.R间期间隔重组测定左心功能各指标之间的相关性高,临床可以应用10%R-R间期间隔重组测定左心功能,相对方便、快捷、精确.     

320排CT与二维超声心动图评价冠心病左心功能的初步比较研究

目的探讨320排CT和二维超声心动图对冠心病心功能评价的相关性及320排CT在冠心病左心室功能评价中的价值。资料与方法搜集2009年9月至12月间行320排CT冠状动脉造影检查和二维超声心动图的冠心病患者45例,其中男29例,女16例,平均年龄(64±9)岁。利用冠状动脉CT血管造影(CTA)的原始数据进行多期相重建,在专用心功能分析软件(Vitrea FX)中进行左心功能分析,利用Simpson法计算出左心功能指标:舒张末期容积(EDV)、收缩末期容积(ESV)、每搏输出量(SV)和射血分数(EF)。结果 320排CT与二维超声心动图两种方法的冠心病心功能指标差异无统计学意义(P>0.05),两种方法的冠心病心功能指标:EDV、ESV、SV和EF相关性高,相关系数分别为0.867、0.791、0.723和0.674。结论 320排CT在冠心病左心功能定量评价方面结果准确、可靠,与二维超声心动图测得的心功能指标差异无统计学意义,两种方法各指标间相关性高。320排CT心功能分析与冠状动脉造影检查协议相同,收缩末期和舒张末期图像可以通过回顾性心电门控冠状动脉CTA数据获得,心功能分析包含于冠状动脉检查中,患者无需...     

320排CT在评价左心功能中的研究

目的研究320排CT在评价患者左心功能中的应用。方法采用320排CT评价86例原发性高血压患者左心功能,包括左心室舒张末期容积(end-diastolic volume,EDV)、收缩末期容积(end-systolic volume,ESV)、每搏输出量(stroke volume,SV)和射血分数(ejection fraction,EF),与超声心动图测定的相关指标进行比较。结果 320排CT测定的左心功能各项指标与超声心动图存在较高的相关性(r=0.76~0.90),两者无统计学差异(P0.05)。结论 320排CT在评价左心功能方面准确、可靠,与超声心动图所得各项指标相关性高,还可以同时进行冠脉病变诊断,具有较高的临床应用价值。     

双源CT对无症状糖尿病患者冠状动脉病变及左心功能的研究

目的 :利用双源CT冠状动脉造影(DSCTA)探讨无症状糖尿病患者冠状动脉改变,并通过对比超声心动图,探讨DSCT在评价左心功能中的可行性。方法:选取行DSCTA检查患者80例(无症状糖尿病组40例,非糖尿病组40例),对比分析2组冠状动脉粥样硬化分支数目及钙化积分,以及DSCT与超声心动图所测左心室舒张末期容积(EDV)、收缩末期容积(ESV)及射血分数(EF)值。结果:无症状糖尿病组2支、3支病变数及钙化例数均多于非糖尿病组,而单支病变数少于非糖尿病组(均P0.05)。DSCT所测无症状糖尿病组的EDV及ESV值大于非糖尿病组,而EF值小于非糖尿病组(均P0.05)。DSCT所测左心功能各项指标(EDV、ESV、EF)与超声心动图所测数值相关性高,差异均无统计学意义(均P 0.05)。结论:无症状糖尿病患者较非糖尿病患者易发生广泛的冠状动脉粥样硬化,且心功能出现一定程度降低;DSCT能早期发现无症状糖尿病的冠状动脉及左心功能改变,可用于糖尿病患者冠状动脉硬化性心脏病的早期筛查。     

双源CT左心室功能分析与超声对比研究

目的 探讨双源CT(DSCT)检查与超声心动图检查在左心室功能评估中的相关性及一致性.方法 选择60例3 d内同时做DSCT冠状动脉造影和超声心动图检查的患者资料,2种检查各测量指标用配对样本t检验及 Blant-Altman分析.结果 2种方法各测量指标均存在显著正相关关系(P＜0.05).除了射血分数(EF)2种检查方法无显著差异(P＞0.05)外,其余各测量指标均存在显著差异(P＜0.05).DSCT左心室舒张末期容积(EDV)、收缩末期容积(ESV)、每搏输出量(SV)值均高于超声心动图检查, 心肌质量(MM)低于超声心动图检查.2种检查方法EF值一致性界限为-19.99%～24.91%,具有较好的一致性.结论 DSCT左室心功能分析与超声检查结果具有较好的相关性及一致性.DSCT在急性心肌梗死预测及左心室功能评估方面具有很大临床应用意义.     

实时三维超声心动图在评估心梗患者左心功能的应用价值

目的:本研究以磁共振成像(MRI)检查结果为标准,应用实时三维超声心动图(real time 3-dimensional echocardiography,RT-3DE),定量评价左心室收缩功能,并比较同组病例的二维超声心动(two-dimensionalechocardiograp hy,2D)的心功能指标,探讨实时三维超声心动图在心梗患者心功能评价中的应用价值.方法:临床诊断心梗患者33例,均行心脏MRI、二维超声心动图、实时三维超声心动图.结果:RT-3DE和MRI两种方法的心功能指标差异无统计学意义,收缩末期容积(ESV)、舒张末期容积(EDV)、每搏输出量(SV)、左室射血分数(EF)相关性高(r=0.81～0.87);2D和MRI两种方法测量的心功能指标差异没有统计学意义,EDV、SV相关性较高(r值分别为0.61、0.67);ESV和EF值相关性中等或较低(r值分别为0.41和0.33).结论:RT-3DE能够准确、可靠的定量评价左心功能,用于定量评价心梗患者左心室收缩功能较2D更准确.     

双源CT评价冠状动脉狭窄与左心室功能的临床应用价值

目的 探讨双源CT(dual-source computed tomography,DSCT) 冠状动脉造影评价冠状动脉狭窄程度与左心功能的相关性.方法 收集行DSCT冠状动脉造影检查冠心病患者87例及30例健康体检者,测量冠状动脉狭窄程度、左室舒张末期容积(EDV)、左室收缩末期容积(ESV)、每搏输出量(SV)、射血分数(EF)、心肌质量(MM),并与超声心动图(ECHO)、冠状动脉造影(CAG)作对照分析.结果 ①DSCT与CAG诊断冠状动脉狭窄无显著性差异(P>0.05).②DSCT和ECHO测量EDV、ESV、SV、EF相关性好,DSCT测得值稍大于ECHO,但各指标均无显著性差异(P＞0.05).③ESV、EF、SV 轻度狭窄组与重度狭窄组、中度狭窄与重度狭窄组间存在显著性差异(P<0.05),轻度狭窄组与中度狭窄组间无显著性差异(P>0.05);EDV、MM在轻度、中度、重度狭窄组间存在显著性差异(P<0.05);各指标在正常组和轻度狭窄组间无显著性差异(P>0.05).结论 DSCT冠状动脉造影一站式评估冠状动脉狭窄及心功能具有准确性高、可重复定量测量优势.根据冠状动脉狭窄程度可以初步评估心功能改变,当中度狭窄时,EDV、MM即出现显著改变,当重度狭窄时,各指标均出现显著改变,对心脏病变诊断、治疗监测等具有重要的临床应用价值.     

256层iCT评价正常升主动脉弹性与左心功能的相关性

目的 利用256层iCT探讨正常升主动脉弹性与左心功能的相关性.方法 收集行256层iCT冠状动脉CT血管成像(CTA)且冠状动脉正常,同时行超声检查无升主动脉粥样硬化的志愿者105例,分别按年龄分成3组、按性别分成2组,CT测量左室功能的诸参数:收缩末期容积(ESV)、舒张末期容积(EDV)、每搏输出量(SV)、射血分数(EF)、心输出量(CO)、心肌质量(MM);CT、超声2种方法测量冠状窦上方15 mm处升主动脉的最大及最小横断面积,计算主动脉弹性,评价升主动脉弹性与左心功能的相关性.结果 Bland-Altman图显示CT和超声测得升主动脉弹性值一致性良好(ICC=0.988,P<0.05);不同年龄组正常升主动脉弹性与EDV、ESV、SV、EF均有正相关关系,与MM有负相关关系,与CO没有相关性;与年龄呈负相关(r=-0.546,P<0.05).结论 正常升主动脉弹性与左心功能有一定的相关性,256层iCT能够准确测量升主动脉壁弹性并判断其与左心功能的关系,为临床评估心血管疾病的危险性提供了一定依据值.     

双源CT与超声心动图定量评价冠心病左心功能的比较研究

目的:以超声心动图为对照标准,探讨双源CT定量评价左心功能的可行性和准确性及其优势。方法:选取2011年1月～6月冠心病患者58例,其中合并II型糖尿病患者29例。全部病例于3天内行心脏双源CT及超声心动图检查。比较双源CT与超声心动图所测得的左心功能各参数。结果:双源CT和超声心动图所测左心功能各指标EDV、ESV、SV、EF相关性高(r=0.702～0.898),差异无统计学意义(P>0.05)。两种方法所测冠心病合并II型糖尿病组左心功能指标EDV、ESV值均较非糖尿病组测值高,EF值较低,差异均有统计学意义(P<0.05)。结论:两种方法评价左心功能相关性好,双源CT是一种评价左心功能准确可行的方法,一次冠状动脉造影所获得的数据,不但可评价左心功能,还可评价冠脉狭窄情况,无需额外增加对比剂和辐射剂量。     

Assessment of global left ventricular function: comparison of cardiac multidetector-row computed tomography with angiocardiography

OBJECTIVE: Evaluation of left ventricular function using electrocardiogram (ECG)-gated multidetector row CT (MDCT) by using 3 different volumetric assessment methods in comparison to assessment of the left ventricular function by invasive ventriculography. METHODS: Thirty patients with suspected or known coronary artery disease underwent MDCT coronary angiography with retrospective ECG cardiac gating. Raw data were reconstructed at the end-diastolic and end-systolic periods of the heart cycle. To calculate the volumes of the left ventricle, 3 methods were applied: The 3-dimensional data set (3D), the geometric hemisphere cylinder (HC), and the geometric biplane ellipsoid (BE) methods. End-diastolic volumes (EDV), end-systolic volumes (ESV), the stroke volumes (SV), and ejection fractions (EF) were calculated. The left ventricular volumetric data from the 3 methods were compared with measurements from left ventriculography (LVG). RESULTS: The best results were obtained using the 3D method; EDV (r = 0.73), ESV (r = 0.88), and EF (r = 0.76) correlated well with the LVG data. The EDV volumes did not differ significantly between LVG and the 3D method (P = 0.24); however, ESV, SV, and EF differed significantly. The ESV were significantly overestimated (P < 0.01), leading to an underestimation of the SV (P < 0.01) and the EF (P < 0.01). The HC method resulted in the greatest overestimation of the volumes. The EDV and the ESV were 31.8 +/- 37.6% and 136.4 +/- 92.9% higher than the EDV and ESV volumes obtained by LVG. Bland-Altman analysis showed systematic overestimation of the ESV using the HC method. CONCLUSION: MDCT with retrospective cardiac ECG gating allows the calculation of left ventricular volumes to estimate systolic function. The 3D method had the highest correlation with LVG. However, the overestimation of the ESV is significant, which led to an underestimation of the SV and the EF.     

双源CT和超声心动图评价左心功能的对比研究

目的：探讨双源CT评价左心功能的临床价值。方法：研究对象包括临床拟诊冠心病患者22例。分别采用双源CT和超声心动图测量左心功能。结果：双源CT冠脉造影检查21／22例获得满意图像。22例舒张末期位于90％R—R间期,20／22例收缩末期位于40％R－R间期。双源CT所测射血分数和超声心动图测量结果明显相关（r=0．72）。结论：双源CT冠脉造影检查测量左心功能准确可靠,有望为冠心病患者左心功能评价提供一项新方法。     

室间隔缺损封堵术后左心功能的超声评价

目的应用超声心动图评价Amplatzer封堵器治疗室间隔缺损(VSD)患者于封堵术前后左心功能的变化。方法观察28例VSD患者封堵术前、术后1个月和术后6个月左室舒张末期内径(EDD)、舒张末期容积(EDV)、收缩末期容积()ESV、每搏输出量()SV、射血分数()和短轴缩短率()大小及变化。结果封堵术后1个月较术前差异具有显著性意义,EDDEFFS(P<0.05),EDV(P<0.001)ESV(P<0.05)SV(P<0.001)EF,FS无明显变化;封堵术后6个月,6项指标均恢复正常,较,,,术前差异具有显著性意义(P<0.001)。结论超声引导下VSD封堵术能够有效的改善VSD患者的左心功能。     

M型、二维、实时三维超声心动图评价冠心病左室收缩功能的对比研究

目的:探讨M型超声心动图(MME)、二维超声心动图(2DE)、实时三维超声心动图(RT-3DE)在定量评价冠心病患者左室收缩功能(LVSF)的应用价值。方法:分别采用MME、2DE、RT-3DE测量34例冠心病患者左室舒张末期容积(LVEDV)、收缩末期容积(LVESV)、每搏量(SV)和射血分数(EF),并在三种方法间进行比较。结果:MME和2DE两种方法测定的LVEDV、LVESV、SV大于RT-3DE测值,而EF小于RT-3DE测值,MME和2DE两种方法与RT-3DE各测值之间差异均有统计学意义(P0.05)。MME、2DE两种方法间差异无统计学意义(P0.05)。结论:RT-3DE能准确评价冠心病患者LVSF状况;MME和2DE高估LVEDV、LVESV、SV,低估EF。     

Quantitative and qualitative assessment of left ventricular volume with ECG-gated multislice spiral CT: value of different image reconstruction algorithms in comparison to MRI

PURPOSE: To assess the value of different image reconstruction algorithms for assessment of the left ventricular function using retrospectively ECG-gated multislice spiral computed tomography (MSCT) of the heart. MATERIAL AND METHODS: MSCT and cine magnetic resonance (MR) imaging of the heart were performed in 15 patients. For MSCT, standard and multisegmental image reconstruction with improved temporal resolution were used. Standardized multiplanar reformats in the short axis and long axis views were reconstructed from MSCT data. End-systolic (ESV) and end-diastolic volume (EDV), stroke volume (SV), ejection fraction (EF) and myocardial mass (MM) were calculated. Left ventricular wall motion was assessed qualitatively. RESULTS: MSCT was in acceptable agreement with MR imaging for quantification of the ventricular function. According to the Bland-Altman approach the mean differences for the left ventricular volumes (ESV, EDV, SV) ranged from -9.6 ml to 3.1 ml with standard image reconstruction and from -0.6 ml to 1.9 ml utilizing multisegmental image reconstruction with limits of agreement ranging from -26.6 ml to 12.5 ml and -15.6 ml to 15.0 ml, respectively. Applying the multisegmental image reconstruction algorithm, a significantly improved agreement with the MR data was found for EDV, SV and EF. For wall motion analysis, standard image reconstruction showed a significant difference to MR imaging with a correspondence in 83.75% of the 240 assessed segments, while multisegmental image reconstruction agreed with MR imaging in 92.5% of the segments. CONCLUSION: Multisegmental image reconstruction improves the quantitative assessment of left ventricular function when compared to standard image reconstruction. Multisegmental image reconstruction allows qualitative wall motion analysis.     

Assessment of cardiac function and left ventricular regional wall motion by 99mTc multigated cardiac blood-pool emission computed tomography]

Forty-three patients underwent the analysis of left and right ventricular (LV and RV) volumes, and LV regional wall motion by multigated cardiac blood pool single photon emission computed tomography (SPECT) with 99mTc. To calculate the cardiac volume correctly, the optimal cutoff level in relation to background level was first obtained by a phantom study. Left ventricular end-diastolic, end-systolic volume (EDV and ESV) and ejection fraction (EF) calculated thus with SPECT were correlated well with the data obtained with left ventriculography (LVG) and magnetic resonance imaging (MRI), especially using horizontal long axial image. RV stroke volume (SV) without shunt or valvular diseases was also correlated well with that of LV when it was calculated using horizontal long axial image. However, SV ratio (LVSV/RVSV) was not necessarily ideal numerical 1. In addition LV wall motion was evaluated by multicontour systolic display and phase analysis in SPECT and gated planar images. The results obtained with SPECT were better correlated with those of LVG than gated planar images. It is concluded that multigated cardiac blood pool SPECT is a clinically useful method for an evaluation of cardiac function and left ventricular regional wall motion.     

利用256iCT对左心室解剖结构和功能定量研究

目的应用256iCT对正常人左心室结构和功能相关指标进行定量研究,分析各指标与年龄和性别的关系。方法搜集506例行256iCT冠状动脉CTA结果正常的患者的影像资料;所有患者近6个月无心血管疾病病史。对原始图像进行多期重组,确定左心室舒张末期及收缩末期,分别对左心室舒张末期和收缩末期的室间隔厚度(septal wall thickness,SWT)、左室后壁厚度(posterior wall thickness,PWT)、左室宽径(LV inner diameter,LVID)、舒张末期容积(end-diastolic volume,EDV)、收缩末期容积(end-systolic volume,ESV)、每搏输出量(stroke volume,SV)和射血分数(ejection fraction,EF)进行测量和计算,并进行相关统计学处理。结果左心室舒张末期SWT、PWT、LVID 95%参考值范围分别为:4.4～12.1 mm,4.0～14.0 mm,28.1～60.8 mm。左心室收缩末期SWT、PWT、LVID 95%参考值分别为:6.2～15.7 mm,7.9～20.8 mm,18.1～46.3 mm。EDV、ESV、SV、EF 95%参考值范围分别为:55.9～165.7 ml,20.9～75.9 ml,25.8～98.6 ml,39.8%～78.3%。收缩期LVID和舒张期LVID值不同年龄组之间差异有统计学差异(P<0.05),并且随着年龄增长有增大趋势。收缩期SWT、舒张期SWT、收缩期PWT、舒张期PWT以及EF值有随着年龄增长而增大的趋势,同时EDV、ESV、SV值随着年龄增长有减小的趋势,但以上各指标在不同年龄组之间的差异均无统计学意义(P>0.05)。不同性别组分析显示除EF值无统计学差异以外,其余各指标均有统计学差异(P<0.05),且男性组各参数均大于女性组。结论初步制定了左心室形态、功能相关参数的正常参考值,为临床诊断、危险评级及预后判断提供有意义信息。     

Assessment of left ventricular volumes and function: intraindividual comparison of multi-slice spiral CT and electron beam CT in an animal model

PURPOSE: To evaluate multi-slice spiral computed tomography (MSCT) for measurements of left ventricular volumes, ejection fraction (EF), and myocardial mass in comparison with electron beam CT (EBCT) as a reference method. MATERIAL AND METHODS: Six minipigs underwent both standardized contrast-enhanced MSCT (effective acquisition time per cardiac cycle 125.7+/-30.1 ms, reconstructed slice thickness 8 mm) and EBCT (acquisition time 50 ms, collimated slice thickness 8 mm). The contrast-to-noise ratio of the left ventricle was measured in each animal, and the contour sharpness of the myocardium was analyzed. Volumes (EDV, ESV, SV) ejection fraction (EF), and muscle mass were calculated by MSCT and by EBCT using the slice summation method. RESULTS: MSCT had a higher contrast-to-noise ratio and delineated the myocardial contours more sharply than EBCT. There was a close linear correlation between both modalities for all parameters (EDV: rP=0.88, ESV: rP=0.91, SV: rP=0.85, EF: rP=0.93; mass: rP=0.90; P<0.05 each). MSCT slightly overestimated ESV and slightly underestimated SV and EF compared with EBCT (P<0.05 each). CONCLUSIONS: Image quality in MSCT is superior to that of EBCT. Functional parameters correlate well between both modalities, but the accuracy of MSCT is limited by its lower temporal resolution.     

Accuracy of different reconstruction intervals to quantify left ventricular function and mass in cardiac computed tomography examinations

PURPOSE: To compare the accuracy of cardiac dual-source CT (DSCT) reconstructions obtained at 5% and 10% of the cardiac cycle and MRI for quantifying global left ventricular (LV) function and mass in heart transplant recipients. MATERIAL AND METHODS: We prospectively included 23 heart transplant recipients (21 male, mean age 60±11.7 years) who underwent cardiac DSCT and MRI examinations. We compared LV parameters on cardiac DSCT reconstructions obtained at 5% (0%-95%) and 10% (0%-90%) intervals of the cardiac cycle and on double-oblique short-axis MR images. We determined ejection fraction (EF), end-diastolic volume (EDV), end-systolic volume (ESV), stroke volume (SV), and myocardial mass using commercially available semiautomated segmentation analysis software for DSCT datasets and conventional manual contour tracing for MR studies. RESULTS: Using different reconstruction intervals to quantify LV parameters at DSCT resulted in non-significant differences (P>.05). Compared to MRI, DSCT slightly overestimated LV-EDV, ESV, and mass when both 5% (11.5±25.1ml, 6.8±10.9ml, and 28.3±21.6g, respectively) and 10% (mean difference 15.3±26.3ml, 7.4±11.5ml, and 29.3±18.7g, respectively) reconstruction intervals were used. DSCT and MRI estimates of EF and SV were not significantly different. CONCLUSION: In heart transplant recipients, DSCT allows reliable quantification of LV function and mass compared with MRI, even using 10% interval reconstructions.