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目的开发一种具有抗菌和供能作用且适应糖尿病、高血压和肥胖病患者的替硝唑木糖醇注射液,建立该制剂的含量测定方法并对其稳定性进行初步考察。方法拟定处方组成与制备工艺;并进行性状、鉴别、杂质和有关物质检查等质量研究,采用紫外分光光度法测定替硝唑含量,容量法测定木糖醇含量;影响因素试验考察其稳定性。结果替硝唑的含量可于317nm波长处直接测定,平均回收率为99.07%,RSD=0.63%(n=9);本品在光照、低温及高温条件下5d及10d的样品与0d比较,其外观性状、pH值、澄明度、有关物质及含量等均无明显变化。结论该制剂处方合理,制备工艺可行,含量测定方法准确,稳定性良好。 相似文献
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目的研发可抗茵和补充能量,且适用于糖尿病、高血脂和肥胖病患者的帕珠沙星木糖醇注射液。方法拟订处方组成与制备工艺,并进行其性状、鉴别、杂质和有关物质检查等质量研究,用反相高效液相色谱法测定甲磺酸帕殊沙星含量,用容量法测定木糖醇含量;通过影响因素试验考察制剂稳定性。结果甲磺酸帕殊沙星的含量可于239nm波长处直接测定,平均回收率为100.85%,RSD=0.33%;在低温及高温条件下,放置5d及10d的样品与0d的比较,外观性状、pH值、澄明度、有关物质及含量等均无明显变化。结论该制剂处方合理,制备工艺可行,含量测定方法简单、快捷、准确。 相似文献
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目的 制备氟尿嘧啶氯化钠注射液 ,建立该制剂的质量控制方法并对其稳定性进行初步探讨。方法 拟定处方组成与制备工艺 ;采用紫外分光光度法中的吸收系数法测定氟尿嘧啶含量 ,容量法测定氯化钠含量 ;影响因素试验考察其稳定性。结果 该制剂质量可控 ;影响因素试验系取该注射液在光照、低温及高温条件下 5 d及 10 d的样品与 0 d比较 ,该注射液的外观性状、p H值、澄明度及氟尿嘧啶和氯化钠含量等均无明显变化。结论 该制剂处方合理 ,制备工艺可行 ,含量测定方法准确 ,稳定性良好 相似文献
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盐酸左氧氟沙星凝胶剂的制备与质量控制 总被引:2,自引:0,他引:2
目的制备盐酸左氧氟沙星凝胶,并建立其质量控制方法.方法以0.5%卡波姆940为凝胶基质,采用高效液相色谱法测定制剂中盐酸左氧氟沙星的含量,并进行稳定性考察和皮肤刺激性试验.结果盐酸左氧氟沙星浓度在12.5~200 mg·L-1范围内线性关系良好,平均回收率为99.9%,RSD为0.02;制剂稳定性良好,对皮肤无刺激性.结论该制剂处方合理,制备工艺简便,质量控制方法简单、准确. 相似文献
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目的:配制氧氟沙星漱口液,并考察其稳定性。方法:通过参考有关资料,确定处方和制备方法,并采用紫外分光光度法测定氧氟沙星含量,进行稳定性研究。结果:初均速法考察稳定性,线性关系良好,预测其室温有效期为t0.9=310d,氧氟沙星平均回收率为99.46%,RSD=1.92%(n=5)。结论:该制剂稳定性良好,可作为临床辅助治疗药物。 相似文献
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目的:制备左氧氟沙星凝胶剂并建立其含量测定方法,观察其疗效.方法:以卡波姆940为辅料,制备左氧氟沙星凝胶剂;以紫外分光光度法测定其含量, 测定波长为293 nm.考察该制剂对脓疱病或毛囊炎的疗效.结果:平均回收率为101.7%,RSD=0.5%.该制剂对50例脓疱病或毛囊炎的治愈率为94.0%.结论:本制剂工艺简单,质量稳定、可控,疗效确切,使用方便. 相似文献
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《Journal of addictive diseases》2013,32(3):73-87
Depression and anxiety frequently coexist in patients with substance use disorders. This clinically-oriented article examiens the relationship between these conditions and emphasizes data showing that substances of abuse can cause signs and symptoms of both depression and anxiety. These substance-related syndromes appear to have a different course and prognosis than uncomplicated, independent anxiety and major depressive disorders, and clinicians should consider the role of alcohol and other drugs in all patients presenting with these complaints. The authors will also outline an approach for diagnosing and managing patients with the combination of a substance use and depressive or anxiety disorder. 相似文献
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The synthesis of gaultherin (1) and its analogs was carried out to provide 11 glycosides under phase-transfer catalytic conditions. The activities of all synthesized compounds were evaluated by nitric oxide production inhibitory assay in vitro. Methyl 2-O-(4-O-β-d-galactopyranosyl)-β-d-glucopyranosylbenzoate (5f) showed significantly anti-nociceptive and anti-inflammatory effects by the evaluation in vivo. Structure–activity relationships within these compounds were discussed. 相似文献
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Nestorov I 《Toxicology letters》2001,120(1-3):411-420
Two important methodological issues within the framework of the variability and uncertainty analysis of toxicokinetic and pharmacokinetic systems are discussed: (i) modelling and simulation of the existing physiologic variability in a population; and (ii) modelling and simulation of variability and uncertainty when there is insufficient or not well defined (e.g. small sample, semiquantitative, qualitative and vague) information available. Physiologically based pharmacokinetic models are especially suited for separating and characterising the physiologic variability from the overall variability and uncertainty in the system. Monte Carlo sampling should draw from multivariate distributions, which reflect all levels of existing dependencies in the intact organism. The population characteristics should be taken into account. A fuzzy simulation approach is proposed to model variability and uncertainty when there is semiquantitative, qualitative and vague information about the model parameters and their statistical distributions cannot be defined reliably. 相似文献
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The effects of the d and l isomers of amphetamine on self-stimulation responding were tested following acute and chronic administration. Tolerance and post-drug depression of responding occurred in tests with both isomers, indicating no role for p-hydroxynorephedrine (PHN) which is one of the metabolites of d-amphetamine. In the second experiment, d-amphetamine, methylphenidate and cocaine all produced quantitatively and qualitatively similar effects on self-stimulation responding following acute administration. Following chronic administration of d-amphetamine, animals showed tolerance to all three drugs, indicating cross-tolerance among them. These data are consistent with an hypothesis that tolerance and post-drug depression following chronic amphetamine treatment are the result of decreases in postsynaptic receptor sensitivity, which would lead to a decreased effectiveness of all three drugs, regardless of their pre-synaptic mechanisms. 相似文献
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Rationale Two pharmacotherapies are approved for treating alcohol craving (acamprosate and naltrexone), but both have shown mixed findings
in animals and humans.
Objectives The present experiments utilized a “reinforcer blocking” approach (i.e., rats were able to consume ethanol during treatment)
to better understand the efficacy of these treatments for ethanol seeking and drinking using ethanol-dependent and nondependent
rats.
Materials and methods In “nondependent” experiments, drugs (acamprosate 50, 100, and 200 mg/kg; naltrexone 0.1, 0.3, and 1.0 mg/kg) were administered
over 3-week periods prior to operant sessions with a low response requirement to gain access to reinforcers for 20 min. For
“dependent” experiments, rats were made dependent in vapor/inhalation chambers.
Results Acamprosate and naltrexone had similar effects on intake in nondependent and dependent rats; neither drug was selective for
ethanol over sucrose drinking. In nondependent animals, naltrexone was more efficacious at more doses than acamprosate, and
acamprosate’s effects were limited to a dose that also had adverse effects on body weight. Both pharmacotherapies showed more
selectivity when examining reinforcer seeking. In nondependent rats, acamprosate and naltrexone had response-attenuating effects
in ethanol, but not sucrose, groups. In dependent animals, acamprosate had selective effects limited to a decrease in sucrose
seeking. Naltrexone, however, selectively decreased ethanol-seeking in nondependent rats.
Conclusions The naltrexone-induced decreases in seeking suggested a change in incentive motivation which was selective for ethanol in
nondependent rats. The “nondependent” paradigm may model early stages of “problem drinking” in humans, and the findings suggest
that naltrexone could be a good intervention for this level of alcohol abuse and relapse prevention. 相似文献
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Schierholz JM Yücel N Rump AF Beuth J Pulverer G 《International journal of antimicrobial agents》2002,19(6):81-516
Catheters, urethral and ureteral stents and other urological implants are frequently affected by encrustration and infection due to their permanent contact with urine. Indwelling urinary catheters provide a haven for microorganisms and thus require extensive monitoring. Several surface modification techniques have been proposed to improve the performance of devices including the immobilization of biomolecules, the incorporation of hydrophilic grafts to reduce protein adsorption, the creation of hydrophobic surfaces, the creation of microdomains to regulate cellular and protein adhesion, new polymers and antimicrobial coatings. Physico-chemical explanation to elucidate the mechanism of such encrustation or infection inhibiting materials is still not available. Our series of experiments showed a marked decrease of silver-activity in biological fluids which corresponds with the controversial clinical results obtained with silver coated urinary catheters. Rifampicin/minocycline coated catheters had very low activity against Gram-negative rods, enterococci and Candida spp., the main causing organisms of urinary catheter infection. Surface engineered materials and antimicrobial drug delivery systems will be the next generation of sophisticated urinary catheters and stents, if both efficacy as well as efficiency has been proved clinically. 相似文献
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Summary The effects of alprazolam 0.5 mg and lorazepam 2 mg on cognitive and psychomotor skills were assessed in twelve normal volunteer subjects in a randomised, double-blind, crossover design. Single and multiple dose effects were monitored using a battery of tests comprising critical flicker fusion threshold (CFFT), choice reaction time (CRT), simulated car tracking, and subjective ratings of perceived sedation (LARS) and of sleep behaviour (LSEQ). Compared with placebo baseline scores, treatment with lorazepam 2 mg (both single and multiple doses) resulted in a widespread impairment of CRT, tracking accuracy, and CFFT. Single doses of alprazolam 0.5 mg reduced CFFT with respect to the placebo baseline. Single and multiple dose treatment with both drugs resulted in subjective reports of sedation, a reduction of sleep onset latency, and improved sleep quality. Only lorazepam 2 mg significantly disrupted the integrity of behaviour on waking from sleep. These results suggest important pharmacodynamic differences between the two drugs in the doses used. 相似文献