皮肤基底细胞癌55例临床与病理分析

目的 通过分析基底细胞癌(BCC)临床病理特点,提高BCC的诊断水平,增强群众健康防病意识.方法 对55例BCC患者的临床资料进行综合性分析.结果 BCC患者中男、女比例为1∶1.29,年龄23～90岁,其中 50～79 岁占 81.82 %,农牧民居多(39例).BCC病程长短不一,多发生于头面部.临床表现为多形性,容易误诊,误诊率达 23.64%,各临床类型中以色素型最易误诊.BCC临床上以结节溃疡型(33例)及色素型(11例)为多见.BCC病理分型中以实体型最多见(25例).结论 BCC的发生与慢性长期日光照射密切相关,病理检查对该病的正确诊断、治疗和预后判断起着重要作用.     

皮肤基底细胞癌70例临床病理分析

目的探讨皮肤基底细胞癌(BCC)临床病理特点及诱发因素。方法对70例患者的临床及组织病理资料进行分析。结果按皮肤损害分型,结节溃疡型38例,色素型14例,浅表型6例,硬斑型10例,纤维上皮瘤型2例。97.2%的肿瘤发生于头面部暴露部位。结论紫外线是BCC的重要诱因。采用扩切病变部后植皮术或旋转皮瓣,既达到根治目的,又保持美观。     

皮肤基底细胞癌238例临床与病理回顾性分析

皮肤基底细胞癌(basal cell carcinoma,BCC)是源自表皮或其附属器,尤其是毛囊基底细胞的恶性肿瘤(目前认为BCC是一种毛源性肿瘤),是皮肤科最常见的恶性肿瘤之一,其发病率较高,占所有皮肤恶性肿瘤的65％～75％[1].BCC的发病率随着人口老龄化而持续性升高,虽然本病恶性程度低,但部分可呈侵袭性生长...     

皮肤基底细胞癌和皮肤鳞状细胞癌270例回顾性分析

 目的:总结我院皮肤基底细胞癌(BCC)和皮肤鳞状细胞癌(SCC)临床与组织病理资料,以期提高BCC与SCC的诊断率。方法：回顾性分析2014年1月1日-2018年12月31日间我院皮肤科门诊经组织病理切片确诊的170例BCC与100例SCC患者的临床与病理资料。结果：BCC与SCC年度发病整体均呈逐渐上升趋势。BCC、SCC男女患病比例分别为0.8∶1、1∶1，好发部位均为曝光部位(头面颈部和四肢)，临床诊断与组织病理诊断符合率分别为62.4%与30.0%。临床诊断上，BCC易与脂溢性角化病(SK)、色素痣混淆；SCC易与BCC、鲍温病、光线性角化病(AK)混淆。结论：BCC和SCC为临床常见的非黑素性皮肤肿瘤，但易误诊和漏诊。临床医生对于可疑病灶应尽早行皮损组织病理检查。     

基底细胞癌31例临床及病理分析

基底细胞癌又名基底细胞上皮瘤 ,是一种低度恶性的皮肤肿瘤 ,临床上常单发 ,男女并无差异。现将临床上所遇 31例并经病理证实的基底细胞癌总结分析如下 :1　临床资料1.1　性别与年龄分布 :共 31例 ,其中男性 19例 ,女性 12例 ;年龄 :从 2 9～ 79岁 ,其中 5 0岁以下者 5例 ,5 0岁及以上者 2 6例 ,计 31例 ,平均 5 8.7岁。1.2　病程分布　从 6个月到 30年 ,其中1年以内者 1例 ;1～ 5年者 17例 ;6～ 10年者 11例 ;10年以上者 2例 ;平均病程6 .3年。1.3　肿瘤部位分布　颜面 13例 ;头皮 8例 ;胸 2例 ;腰背 3例 ;上肢 3例 ;下肢 2例。1.4　肿瘤大…     

基底细胞癌75例临床病理分析

目的探讨皮肤基底细胞癌(BCC)组织病理特征及其鉴别诊断,以对治疗方案的选择提供指导。方法分析75例患者的临床及组织病理资料。结果按组织病理分型,实性BCC 33例,色素性BCC 14例,浅表性BCC 8例,硬斑病样BCC 5例,囊性BCC 3例,角化性BCC 4例,腺样BCC 2例,纤维上皮瘤性BCC 2例,实体与其他混合型4例。以上各型易与脂溢性角化病、光线性角化病、色痣、角化棘皮瘤、黑素细胞瘤、Bowen病等鉴别。结论各型皮肤基底细胞癌均具有明确的组织病理学特征,易与其他皮肤疾病鉴别。外科手术仍为首选治疗,Mohs显微外科手术在预防复发和美观方面更具优势,光动力疗法对表浅型BCC疗效较佳。     

41例皮肤基底细胞癌的临床病理及误诊分析

目的：分析总结41例皮肤基底细胞癌的临床病理特点及误诊情况。方法：对41例皮肤基底细胞癌的临床及病理资料进行回顾性分析。结果：41例皮肤基底细胞癌中,发病年龄中位数为59岁（34～82岁）,多发于头面部,共39例,占95．1％,通过组织病理检查,41例均证实为基底细胞癌。其中9例进行免疫组化标记示CK（＋）,S-100（-）。临床诊断为基底细胞癌24例,占58．5％,误诊为脂溢性角化4例,黑素细胞痣3例,鳞状细胞癌、黑素细胞瘤、寻常狼疮各2例,误诊为其他4例。结论：被误诊的皮肤基底细胞癌患者大多数年龄较大,病程缓慢,临床表现不典型。尽早行组织病理检查,并结合免疫组化标记进行识别,可提高皮肤基底细胞癌的诊断准确率。     

基底细胞癌68例临床病理分析

为探讨基底细胞癌(BCC)临床和组织病理学特点,对68例基底细胞癌患者的临床及病理资料进行回顾性分析.结果显示:(1)病理诊断分型有实体型、混合型、色素型、浅表型、腺样型、纤维化型及囊肿型,其中实体型占52.9%(36/68)为最多见.(2)95.6%的肿瘤好发于头面部等曝光部位,从职业分布看,农民的发病率占66.2%,明显高于其他行业.(3)长期过度紫外线照射是BCC的重要诱因.     

62例基底细胞癌临床和病理分析

基底细胞癌又称基底细胞瘤、基底细胞上皮瘤 ,是发生在皮肤任何部位的一种常见的皮肤肿瘤 ,其临床和病理可分多种类型。我们收集 1990～ 1999年临床、病理确诊且资料完整的基底细胞癌共 6 2例 ,分析如下。1　临床资料6 2例中男 2 2例 ,女 40例 ,男女之比1:1.82 ;年龄最小 2 8岁 ,最大 85岁 ,平均年龄 6 3.2 4岁 ;年龄分布 <30岁 1例、30～39岁 3例、40～ 49岁 6例、5 0～ 5 9岁 17例、6 0～ 6 9岁 2 5例、70～ 79岁 7例、>80岁 3例 ;病期最短 2个月 ,最长 14年 ,平均 5 .4年 ,其中 5年以上 32例 ( 5 1.6 1% )。肿瘤部位 :头、面、颈部共 5 5…     

62例基底细胞癌误诊的临床及组织病理分析

目的分析62例基底细胞癌误诊情况,提高诊断水平,避免误诊误治。方法回顾性分析62例基底细胞癌初步误诊病人临床及组织病理资料。结果 62例患者中误诊为脂溢性角化病7例;色素痣6例;鳞状细胞癌4例;恶性黑素瘤3例;Bowen病3例;日光性角化病2例;乳房外paget病3例;化脓性肉芽肿3例;血管瘤2例;寻常疣3例;炎性肉芽肿3例;表皮囊肿3例;毛母细胞瘤3例;皮肤溃疡4例;盘状红斑狼疮1例;增生性瘢痕2例;皮肤纤维瘤2例;蓝痣1例;包块性质待诊7例。结论提高临床水平及皮肤病检水平不仅减少误诊误治,更重要的是为治疗做出更好的选择。     

基底细胞癌72例临床特征分析

目的：探讨皮肤基底细胞癌（ BCC）临床特征及可能诱因。方法：对72例患者的临床资料进行分析。结果：72例BCC中,平均发病年龄（68.03±12.91）岁,病程2个月～60年,平均（67.64±12.98）月。按皮损类型分型,结节溃疡型51例（70.83％）,色素型5例（6.94％）,浅表型9例（12.50％）,硬斑型2例（2.78％）,纤维上皮瘤型5例（6.94％）。头面部 BCC 共60例,占83.33％;肩部 BCC 6例（8.33％）,均为农民或户外工人患者;颈部2例;后背、腋窝、腹部、踝部各1例。结论：BCC好发于头面部等曝光部位,也可以好发于职业相关性紫外线暴露部位。确诊后早期采用手术切除是主要而有效的治疗方法。     

Pulmonary Metastasis of Basal Cell Carcinoma

Although basal cell carcinoma is the most common skin cancer, it rarely metastasizes. Metastatic basal cell carcinoma may, therefore, initially elude diagnosis and management. We describe the case of a patient with a metastatic basal cell carcinoma present in the lungs. The differential diagnosis of suspected metastatic lesions should include metastases from a cutaneous basal cell carcinoma, in addition to those from more commonly metastasizing carcinomas, especially in patients with a history of a large basal cell carcinoma that has involved the head and neck regions, and was refractory to treatment.     

埃兹蛋白在皮肤鳞癌、基底细胞癌中的表达及相关研究

目的 探讨埃兹（Ezrin）蛋白在皮肤基底细胞癌（BCC）和鳞状细胞癌（SCC）中的表达及在肿瘤侵袭转移过程中的作用.方法 采用免疫组化SP法检测Ezrin蛋白在皮肤BCC（30例）、SCC（32例）及正常皮肤对照组（10例）中的表达情况.结果 Ezrin蛋白在BCC、SCC及正常皮肤对照组中阳性表达率分别为60.0％、84.4％和10％.Ezrin蛋白在各组之间表达差异有统计学意义（P＜0.05）.Ezrin蛋白阳性表达与SCC的分化程度和淋巴结转移密切相关,各组间表达差异有统计学意义（P＜0.05）.结论 Ezrin蛋白的检测可能成为预测皮肤恶性肿瘤转移和预后的一项指标.     

Collision Tumor Associated with Sarcomatoid Eccrine Porocarcinoma and Basal Cell Carcinoma

A ‘collision’ tumor refers to the existence of two different neoplasms within the same tumor. Sometimes, the term ‘biphasic tumor’ is also used. However, a ‘collision’ tumor is defined as the occurrence of two neoplasms within proximity of each other yet maintaining distinctly defined, separate boundaries. In contrast, a ‘biphasic’ tumor demonstrates two or more phenotypically distinct neoplastic cell populations merging within the same space. Here, we report a case of collision tumor associated with sarcomatoid eccrine porocarcinoma and basal cell carcinoma arising in a 57-year-old male patient.     

硬斑病样型基底细胞癌2例及其皮肤镜表现

例1女,38岁,因面部皮疹30余年就诊。例2女,70岁,因鼻背皮疹5年,右面部皮疹1年伴糜烂3个月就诊。例1和例2鼻背上皮损均表现为浸润性斑块,皮肤镜检查符合基底细胞癌,皮肤组织病理检查证实为硬斑病样型。例2右面部皮疹经病理证实为结节型基底细胞癌。均采用Mohs显微外科手术治疗。     

Subclinical Infiltration of Basal Cell Carcinoma in Asian Patients: Assessment after Mohs Micrographic Surgery

Background

Several differences in basal cell carcinomas (BCCs) were found, according to the ethnic group; for example, pigmented BCCs was more common in Asian or Hispanic patients. However, there are few reports on the subclinical extension of the BCC in Asian patients.

Objective

The aim of this study was to evaluate the subclinical infiltration of the basal cell carcinoma in Asian patients.

Methods

All patients with BCC who visited the department of dermatology at Korea University Ansan Hospital were treated with Mohs micrographic surgery. In 81 patients, 83 tumors of BCC were completely eradicated by Mohs micrographic surgery (MMS) from April 2001 to August 2008, and were reviewed in this study. Information recorded included the total margin and the number of stages of Mohs micrographic surgery, anatomic location, tumor size, presence of pigmentation, clinical type, and pathological subtype. We divided the clinical types into nodular, ulcerated, and pigmented, and the pathological types into nodular, micronodular, morpheaform, and adenoid. The BCC was of pigmented type if pigmentation covered more than 25% of the tumor, regardless of whether pigmentation was distinct, or if there was apparent pigmentation that covered more than 10% of the tumor.

Results

The nose and cheek were the most common sites requiring more than one stage of surgery. In tumors smaller than 1 cm, 91.7% required only one stage of excision, compared with 60.6% in tumors larger than 1 cm. More than two Mohs stages were required in 25% of non-ulcerated BCCs and in 46.2% of ulcerated BCCs. Sixty eight percent of pigmented BCCs required only one stage of Mohs micrographic surgery. In cases of non-pigmented BCCs, only 45% required one Mohs stage. More than one Mohs stage was required in 19.2% of non-aggressive BCCs and in 42.9% of aggressive BCCs.

Conclusion

Subclinical infiltration differed between the two groups according to the size of the BCC (1 cm threshold) and most of the BCCs were located in the head and neck area. Considering this result, indication for MMS can be extended for BCCs larger than 1 cm in Asian patients. Ulcerated BCCs required more Mohs stages than non-ulcerated BCCs. Pigmented BCCs might show lesser subclinical infiltration than non-pigmented BCCs. Aggressive pathological subtypes showed more subclinical infiltration than the non-aggressive types; however, after evaluation of the border that was excised with MMS, mixed histologic types were found to be more frequent than generally accepted. Therefore, we consider that, when planning surgery, dermatologists should not place too much confidence in the pathologic subtypes identified by biopsy.     

Basal Cell Carcinoma-Mimicking Lesions in Korean Clinical Settings

Background

Basal cell carcinoma (BCC) is the most common form of skin cancer and possesses various clinical features including translucency, ulceration, pigmentation, telangiectasia, and rolled borders. Accordingly, many cutaneous lesions can mimic BCCs and differential diagnosis is difficult.

Objective

To clarify the differences in clinical characteristics between BCCs and BCC-mimicking lesions (BMLs), and to determine which clinical characteristics are helpful for an accurate clinical diagnosis of BCC.

Methods

We performed clinicopathologic analysis of cutaneous lesions that received a clinical diagnosis of BCC. All lesions included in this study showed more than one of the following characteristics of BCCs: translucency, ulceration, flecked pigmentation, black or blue hue, telangiectasia, and rolled borders. We compared six clinical characteristics between the BCC group and the BML group.

Results

Among 48 lesions in the BML group, there were 15 premalignant or malignant lesions and 33 benign lesions. Various dermatoses mimicking BCC that have not been reported in the dermatological literature were identified, including angiosarcoma, vulvar intraepithelial neoplasm, foreign body granuloma, intravascular papillary endothelial hyperplasia, sarcoidosis, and others. Compared to the BML group, the BCC group had a significantly higher frequency of translucency (76.3% vs. 52.1%, p<0.001), ulceration or erosion (44.2% vs. 27.1%, p=0.022), black or blue hue (40.0% vs. 22.9%, p=0.020), and rolled borders (49.5% vs. 14.6%, p<0.001). Cutaneous lesions with two or less clinical features of BCC were significantly more likely to be BMLs.

Conclusion

The results of this study could be helpful for the differential diagnosis of BCCs and BCC-mimicking cutaneous lesions.     

Capecitabine Plus Oxaliplatin Combination Therapy for Basal Cell Carcinoma

No effective systemic chemotherapy is well-established in basal cell carcinoma. We report a case with three simultaneous malignancies: colon cancer, basal cell carcinoma, and smoldering multiple myeloma. The patient was treated with capecitabine and oxaliplatin after surgery for colon cancer. Surprisingly, he achieved a complete response for basal cell carcinoma. This is the first report of this chemotherapy regimen in basal cell carcinoma. This finding suggests that combination capecitabine and oxaliplatin can be a treatment option for patients unable to receive local therapy.