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1.
女性建党型痤疮患者黄体期八项性激素和皮质醇水平的检测 总被引:18,自引:0,他引:18
目的 探讨女性寻常型痤疮患者体内性激素和皮质醇水平的改变及与临床的关系。方法 采用放射免疫分析法,对54例女性寻常型痤疮患者黄体期血清中8种性激素及皮质醇水平进行了测定,并以30例正常女性作为对照。结果 患者组睾酮、雄烯二酮、硫酸脱氢表雄酮均显著高于对照组(P〈0.01);雌二醇、孕酮、泌乳素、卵泡刺激素和黄体生成素无明显变化(P〉0.05);皮质醇水平明显降低(P〈0.05);月经前加重组雌二醇 相似文献
2.
女性痤疮血清性激素及胰岛素样生长因子-1的研究 总被引:4,自引:2,他引:2
目的:探讨性激素和生长激素在痤疮发病中的作用。方法:采用放射免疫法检测了30例女性痤疮患者血清睾酮(T)游离睾酮(FT)、二氢睾酮(DHT)、脱氢表雄酮(DHEA)、雌二醇(E2)、孕酮(Pr)、泌乳素(PRL)和胰岛素样生长因子-1(IGF-1)水平。结果:女性痤疮患者血清DHT、DHEA、IGF-1明显高于正常对照(P〈0.05),其余指标无显著差异;轻、中、重型痤疮的激素水平无显著差异;IGF-1与性激素水平无显著相关(P〉0.05)。结论:性激素尤其雄激素和生长激素在痤疮的发病中起了一定的作用。 相似文献
3.
伴多囊卵巢综合征的痤疮性激素水平变化及相关分析 总被引:5,自引:0,他引:5
为探讨成年女性痤疮患者血清性激素水平的变化及与多囊卵巢综合征(PCOS)的相关性,对60例成年女性痤疮患者进行血清性激素水平测定和妇科B超检查,其中24例伴PCOS痤疮患者行腹腔镜下微波治疗。结果发现患者组血清睾酮(T),黄体生成素(LH)高于对照组(P<0.05),微波术后其T,LH值明显下降(P<0.05),该手术对痤疮治愈率和总有效率分别为58.3%和91.7%,提示成年女性痊痤疮与PCOS有相关性,高雄激素血症可能是引起女性痤疮的主要因素之一。 相似文献
4.
青春期后女性痤疮患者血清性激素水平的研究 总被引:11,自引:2,他引:9
目的:检测青春期后女性痤疮患者体内性激素的水平。方法:采用放射免疫法对25岁以上的34例女性痤疮患者血清睾酮(T)、雌二醇(E2)、泌尿素(PRL)、黄体生成素(LH)和卵泡刺激素(FSH)进行了测定,并以32例正常女性作为对照。结果:患者组T显著高于对照组(P<0.001);E2和LH显著低于对照组(P<0.001);PRL和FSH无明显变化(P>0.05)。结论:性激素异常可能是女性痤疮迟发和持久不退的主要原因。 相似文献
5.
复方蛇草汤治疗寻常痤疮的临床与实验研究 总被引:37,自引:0,他引:37
应用复方蛇草汤治疗寻常痤疮42例,总有效率76.2%,对照组28例服用异维A酸,总有效率82.1%,两组疗效经统计学处理无显著性差异(P〉0.05),治疗前、后分别测定治疗组患者血清睾酮、雌二醇水平,进行皮损表皮分层剥离扫描电镜观察;测定痤疮丙酸杆菌对复方蛇草汤的敏感性,实验结果显示:复方蛇草汤可有效升高男性患者血清中降低的雌二醇水平(P〈0.05),对女性患者血清中升高的睾酮水平降低不明显(P〉 相似文献
6.
女性痤疮与多囊卵巢综合征的相关性研究 总被引:7,自引:0,他引:7
目的 检测成年女性痤疮患者体内性激素水平的变化,探讨其与多囊卵巢综合征(PCOS)的相关性。方法 采用放射免疫分析法,对50例痤疮患者进行血清性激素水平测定和妇科经阴道超声检查。以30例正常成年女性为对照。结果 痤疮组睾酮、二氢睾酮、脱氢表雄酮及黄体生成素水平增高,与正常对照组比较差异有高度显著性(P<0.001或P<0.01);雌二醇、卵泡刺激素、孕酮水平变化不明显(P均>0.05)。50例中有28例患PCOS。对其中10例应用达英-35治疗,可降低血清雄激素水平。结论 高雄激素血症和PCOS与成年女性痤疮有关,且是其长期不愈的重要原因。达英-35对此类痤疮有较好疗效。 相似文献
7.
目的:分析女性寻常型痤疮与体内性激素水平的关系.方法:采用放射免疫法对38例女性寻常型痤疮患者进行了6项性激素水平测定,并以36名正常女性作为对照.结果:病例组的血清睾酮(T)水平明显高于对照组(P〈0.01).结论:女性痤疮的发生与雄激素水平升高或相对升高有密切关系. 相似文献
8.
性激素与尖锐湿疣人乳头瘤病毒的相关性研究 总被引:10,自引:0,他引:10
为了探讨尖锐湿疣人乳头瘤病毒感染与性激素的关系,采用斑点杂交、免疫组化和放免测定等技术,检测了重庆地区47例女性尖锐湿疣(CA)患者病变组织中HPVDNA、雌激素受体(ER)以及血清中雌二醇(E2)、孕酮(P)和睾酮(T)。结果提示:妊娠期HPVDNA含量、ER表达量均明显高于对照组和其余各组(P<0.001),健康组中无ER表达;HPVDNA含量与ER表达量之间呈正相关(P<0.001),与血清E2、P也呈正相关(P<0.001),与T无明显相关(P>0.05)。我们认为性激素特别是雌激素、孕激素在HPV感染中可能有协同作用 相似文献
9.
66例痤疮患者血清睾酮及雌二醇水平研究 总被引:30,自引:1,他引:30
对66例痤疮患者和20名正常人的血清睾酮及雌二醇水平进行检测。结果显示:伴有多毛现象女性患者的血清睾酮水平和男性患者的雌二醇水平明显高于正常对照组(P〈0.05),提示痤疮发生与性激素水平改变有关。 相似文献
10.
目的:了解女性痤疮患者甲状腺功能的状况及性激素与甲状腺激素的关系。方法:采用放射免疫分析方法,对54例女性座疮患者和30例正常对照者血清中甲状腺激素及8项性激素进行测定。结果:所有痤疮患者及正常对照者血清T3、T4、TSH水平均在所用试剂盒所列正常范围内。但通过患者组与对照组比较发现,患者组T4水平高于正常对照组,差异有高度显著性(P<0.01),而T3及TSH无明显变化;相关分析结果表明,T4与各项性激素间均无明显相关(P>0.05)。结论:与正常对照组相比,女性痤疮患者血清T4水平存在有整体差别;在痤疮的发病中,甲状腺激素可能是在毛囊水平发挥作用。 相似文献
11.
Androgens are an essential prerequisite for the development of acne. The present study was undertaken to characterize the androgen status of women with late onset and persistent acne only and, using the dexamethasone (dex) suppression test, to identify the source(s) of the androgen excess. We measured serum levels of total testosterone (T), free testosterone (FT), androstenedione (
4A), dihydrotestosterone (DHT), dehydroepiandrosterone sulphate (DHEA-S) and sex hormone binding globulin (SHBG) in 34 healthy control subjects, in 34 women with mild acne and in 29 women with moderate or severe acne. Serum FT, DHT and DHEA-S levels in patients of both acne groups were significantly higher than those in the control subjects. The other hormone levels showed no significant differences between patients and control subjects, and there were no significant differences between the two acne groups in any of the androgen levels. In order to evaluate the ovarian and adrenal contributions to serum androgens in the acne patients, the serum levels of
4A, T, DHT and DHEA-S were measured prior to and following 2 weeks of dex therapy. Following the dex test, the DHT and T of adrenal origin were significantly higher in the acne patients than in the control subjects. These results suggest that, in acne patients, hyperandrogenaemia is likely to develop as a result of adrenal androgen excess. In addition, since abnormally high androgen levels are frequently seen in late onset and persistent acne, it seems that this condition is likely to be a sign of hyperandrogenism. 相似文献
12.
C.R. DARLEY J.W. MOORE G.M. BESSER D.D. MUNRO C.R.W. EDWARDS L.H. REES J.D. KIRBY 《Clinical and experimental dermatology》1984,9(1):28-35
The androgen status of fifty women with persistent or late onset acne vulgaris has been investigated. Abnormalities of serum androgens and sex hormone binding globulin (SHBG) alone or in combination were present in 52% of the patients. Elevated serum testosterone and low SHBG were the commonest abnormalities found (46%). Raised levels of serum dehydroepiandrosterone (DHA) and DHA sulphate were present in 16% and 12% of patients respectively, but elevation of one or other of these androgens was the sole abnormality in only 6% of patients. Serum prolactin was raised in 18% of patients but there was no correlation between prolactin and androgen levels. There was also no correlation between the androgen levels and the severity, distribution or pattern of acne or the presence of hirsuties or irregular periods. The hormonal abnormalities found in this group of patients with acne are similar to those seen in females with the polycystic ovary syndrome and idiopathic hirsuties. 相似文献
13.
目的:探讨妊娠期痤疮患者体内性激素水平的改变。方法:采用化学发光酶免疫分析法测定50例妊娠患者血清中的黄体生成素(LH)、卵泡刺激素(FSH)和睾酮(T)的水平,并以50例正常孕妇做对照。结果:患者组LH和FSH显著高于对照组(P<0.05),T略高于对照组,差异无显著性(P>0.05)。结论:在妊娠期痤疮患者中雄激素水平不是发病的决定性因素。 相似文献
14.
C.R. DARLEY J.W. MOORE G.M. BESSER D.D. MUNRO J.D. KIRBY 《The British journal of dermatology》1983,108(3):345-353
Women with persistent or late onset acne vulgaris were divided into two treatment groups. The first received continuous low dose prednisolone to suppress ACTH-dependent androgen secretion and the second was treated with cyclical oestrogens with medroxyprogesterone to elevate sex hormone binding globulin (SHBG). In both groups there was a significant improvement in the severity of the acne after 4 months’treatment. Although pre-existing hormonal abnormalities were corrected, the improvement in the acne did not correlate with the baseline hormone levels. However, suitable oestrogen-progesterone combinations or low dose prednisolone may be given, alone or in combination, to suppress free circulating androgens in these patients with a high probability of improving their acne. 相似文献
15.
女性痤疮患者卵泡期血清六项性激素水平的测定 总被引:1,自引:0,他引:1
目的探讨女性寻常痤疮患者体内性激素水平的改变。方法采用电化学发光免疫分析法对30例青春期女性痤疮患者及20例迟发性女性痤疮患者卵泡期血清六项性激素水平进行检测,并分别与相应年龄段的正常女性各15人作对照。结果女性青春期痤疮患者血清雌二醇水平明显低于同龄正常对照组(P<0.05);睾酮/雌二醇比值明显高于正常对照组(P<0.01);促卵泡素明显高于正常对照组(P<0.05);女性迟发性痤疮患者血清睾酮水平较相应年龄的正常对照组显著升高(P<0.05)。结论青春期女性痤疮发病的主要原因可能是由于雌激素分泌不足,使血清内睾酮水平相对增多所致。女性迟发性痤疮发病的主要原因则可能与雄激素分泌增多有关。 相似文献
16.
Seirafi H Farnaghi F Vasheghani-Farahani A Alirezaie NS Esfahanian F Firooz A Ghodsi SZ 《International journal of dermatology》2007,46(11):1188-1191
BACKGROUND: Acne is generally recognized as a disorder of young adults; however, the referral of patients aged over 25 years with acne is increasing. Disturbed androgen production in the ovaries or adrenal gland and impaired plasma transport of androgens in women with adult-onset acne or acne associated with hirsutism have been described. METHODS: Thirty-five white women with adult-onset acne (onset after the age of 25 years) and hirsutism (A + H), 35 white women with adult acne without hirsutism (A - H), and 35 age-matched white female controls were recruited in this case-control study. Serum levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), total testosterone, dihydroepiandrosterone sulfate (DHEA-S), and sex hormone binding globulin (SHBG) were determined in all patients and compared. RESULTS: The mean SHBG, free androgen index (FAI), and DHEA-S were significantly different between A + H and control subjects. The only significant difference between A - H and control subjects was observed for DHEA-S. CONCLUSION: DHEA-S plays a key role in the pathogenesis of adult-onset acne. Measurement of circulating androgens, including DHEA-S, especially in patients presenting with adult-onset acne and hirsutism, is helpful, and patients with elevated levels can benefit from hormonal therapy. 相似文献