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膜荚黄芪叶黄酮类成分的研究 总被引:1,自引:0,他引:1
《中成药》2017,(8)
目的研究膜荚黄芪Astragalus membranaceus(Fish.)Bge.叶黄酮类成分。方法膜荚黄芪叶75%乙醇提取物的乙酸乙酯、正丁醇部位采用硅胶、ODS、制备型HPLC柱进行分离纯化,根据波谱数据鉴定所得化合物的结构。结果从中分离鉴定出13个化合物,分别为槲皮素(1)、槲皮素-3-O-β-D-葡萄糖苷(2)、鼠李柠檬素-3-O-β-D-葡萄糖苷(3)、rhamnocitrin-3-O-β-neohesperidoside(4)、rhamnocitrin-3-O-β-D-glucopyranoside(1→2″)-β-D-apiofuranosyl(5)、沙苑子苷(6)、黄豆黄素(7)、4',7-二羟基-3'-甲氧基异黄酮(8)、染料木素(9)、芒柄花素-7-O-β-D-葡萄糖苷(10)、染料木苷(11)、黄豆黄苷(12)、银椴苷(13)。结论化合物5、8、13为首次在黄芪属植物中分离得到,化合物2为首次在该植物中分离得到。 相似文献
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《中成药》2017,(4)
目的研究药桑Morus nigra L.叶的黄酮类成分。方法采用大孔吸附树脂和HPLC制备柱,对药桑叶80%乙醇提取物的正丁醇部位进行分离纯化,通过波谱数据鉴定所得化合物的结构。结果从中分得11个化合物,分别鉴定为槲皮素(1)、淫羊藿次苷Ⅱ(2)、德钦红景天苷(3)、草质素-7-O-(3″-β-D-葡萄糖基)-α-L-鼠李糖苷(4)、槲皮素-3-O-β-(2″-O-乙酰基)吡喃半乳糖苷-7-O-α-吡喃阿拉伯糖苷(5)、红景天苷(6)、山柰酚-3-O-β-(2″-O-α-L-吡喃鼠李糖基)-葡萄醛酸苷(7)、槲皮素-3-O-α-吡喃鼠李糖基(1→2)-β-吡喃葡萄醛酸苷(8)、鼠李素-3-O-半乳糖苷(9)、槲皮素-3'-O-β-D-葡萄糖苷(10)、槲皮素-3-O-β-D-吡喃葡萄糖苷(11)。结论化合物1~10为首次从该植物中分离得到。 相似文献
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目的 研究淡竹叶Lophatherum gracile Brongn.黄酮类成分。方法 淡竹叶提取物采用ODS、MCI、Sephadex LH-20进行分离纯化,根据理化性质及波谱数据鉴定所得化合物的结构。结果 从中分离得到20个化合物,分别鉴定为芦丁(1)、槲皮素(2)、槲皮素-3-O-β-D-葡萄糖苷(3)、槲皮素-7-O-α-L-鼠李糖-3-O-β-D-芸香糖苷(4)、槲皮素-3-O-β-D-葡萄糖-(1-6)-O-α-L-鼠李糖-(1-2)-O-β-D-木糖糖苷(5)、槲皮素-3-O-β-D-葡萄糖-(1-2)-O-α-L-鼠李糖-(1-6)-O-β-D-葡萄糖-(1-2)-O-α-L-鼠李糖糖苷(6)、山柰酚(7)、山柰酚-3-O-β-D-芸香糖苷(8)、异鼠李素(9)、异鼠李素-3-O-β-D-芸香糖苷(10)、异鼠李素-3-O-β-D-芸香糖-(2-1)-O-β-D-葡萄糖苷(11)、异鼠李素-7-O-α-L-吡喃鼠李糖-3-O-β-D-芸香糖苷(12)、异鼠李素-3-O-β-D-葡萄糖苷(13)、异鼠李素-3-O-β-D-葡萄糖苷-1-烯-4-羰基-十二烷基(14)... 相似文献
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目的:对大叶醉鱼草化学成分进行研究。方法:利用硅胶柱色谱、聚酰胺柱色谱、大孔吸附树脂进行分离纯化,并运用现代波谱技术进行结构鉴定。结果:从大叶醉鱼草地上部分分离得到7个黄酮类化合物,分别鉴定为:洋芹素(1)、洋芹素-7-O-β-D-葡萄糖苷(2)、金合欢素(3)、金合欢素-7-O-β-D-葡萄糖苷(4)、金合欢素-7-O-α-L-鼠李糖(1-6)-β-D-葡萄糖苷(5)、木犀草素(6)、木犀草素-7-O-β-D-葡萄糖苷(7)。结论:所有化合物均为首次从该植物中分离得到。 相似文献
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采用多种色谱技术,从大叶冬青的叶中分离得到9 个化合物,通过IR,UV,MS,NMR 等波谱学方法鉴定了化合物的结构,分别为5-羟基-6,7,8,4’-四甲氧基黄酮(1),橘红素(2),川陈皮素(3),5-羟基-6,7,8,3’,4’-五甲氧基黄酮(4),5,6,7,8,4’-五甲氧基黄酮醇(5),5,6,7,8,3’,4’-六甲氧基黄酮醇(6),5-羟基-3’,4’,7-三甲氧基二氢黄酮(7),大豆脑苷Ⅰ(8)和大豆脑苷Ⅱ(9)。化合物 1~9 为首次从大叶冬青中分离得到。 相似文献
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目的 研究五裂茶薦子Ribesmeyeri Maxim.叶中黄酮类成分.方法 五裂茶薦子叶80%乙醇提取物采用大孔树脂、硅胶、DAC-50制备色谱进行分离纯化,根据理化性质及波谱数据鉴定所得化合物的结构.结果 从中分离得到15个化合物,分别鉴定为小麦黄素(1)、小麦黄素-7-O-β-D-吡喃葡萄糖苷(2)、山柰酚-3-... 相似文献
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《中成药》2016,(7)
目的研究栲Castanopsis fargesii Franch.树叶的多酚类成分。方法应用MCI、Sephadex LH-20、ODS C18和Diaion HP20SS柱对栲树叶80%乙醇提取物进行分离纯化,根据波谱数据鉴定所得化合物结构。结果从中分离得到10个化合物,分别鉴定为莽草酸(1)、原儿茶酸(2)、咖啡酸(3)、没食子酸(4)、没食子酸甲酯(5)、没食子酸乙酯(6)、5-O-galloylquinic acid(7)、5-O-caffeoylquinic acid(8)、5-O-galloyl-(-)-shikimic acid(9)、5-O-galloylhamamelose(10)。结论除化合物2、9外,其余均为首次从该植物中分离得到。 相似文献
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紫珠叶黄酮类化合物的研究 总被引:12,自引:2,他引:10
目的 :研究紫珠叶的化学成分。方法 :柱色谱色谱法分离 ,理化性质和光谱确定结构。结果 :分得 7个化合物 ,5-羟基 3,6 ,7,4′-四甲氧基黄酮 (Ⅰ) ,3′ ,4′ ,5-三羟基黄酮-7-O-葡萄糖苷 (Ⅱ) ,3′,5 ,7-三羟基黄酮-4′-O-葡萄糖苷 (Ⅲ ) ,5 ,7-二羟基 3′-甲氧基黄酮-4′-O-葡萄糖苷 (Ⅳ) ,β-谷甾醇 (Ⅴ) ,熊果酸 (Ⅵ )和白桦脂酸 (Ⅶ )。 结论 :均为首次从该植物中得到 ,化合物Ⅰ ,Ⅲ ,Ⅳ为首次从该属植物中得到。 相似文献
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目的:研究枸骨Ilex cornuta Lindl.ex Paxt.叶的黄酮类成分。方法:利用硅胶柱色谱和半制备高效液相色谱对枸骨的叶进行分离纯化, 利用光谱学手段结合理化性质鉴定其结构。结果:分离鉴定了9个黄酮类化合物, 分别为:山柰酚-3-O-β-D-吡喃葡萄糖(1→2)-α-L-吡喃阿拉伯糖苷(1),槲皮素-3-O-β-D-吡喃葡萄糖(1→2)-α-L-吡喃阿拉伯糖苷(2),异鼠李素-3-O-β-D-吡喃葡萄糖苷(3),金丝桃苷(4),3’-甲氧基大豆苷(5),异鼠李素(6),芒柄花素(7),山柰酚(8),槲皮素(9).结论:化合物1为新的黄酮类成分。 相似文献
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柔毛淫羊藿叶黄酮类成分研究 总被引:4,自引:1,他引:3
对柔毛淫羊藿Epimedium pubescens叶的化学成分进行研究.采用硅胶,Sephadex LH-20,MCI柱色谱及制备、半制备HPLC等方法进行分离和纯化,根据理化性质和波谱数据鉴定化合物结构.从柔毛淫羊藿叶的70%乙醇提取物中分离得到11个化合物,分别鉴定为脱水淫羊藿素(1),淫羊藿次苷Ⅱ(2),2'-O-鼠李糖基淫羊藿次苷Ⅱ(3),去甲基脱水淫羊藿素(4),宝藿苷Ⅱ(5),朝霍素B(6),粗毛淫羊藿苷(7),苜蓿素(8),山柰酚(9),大豆素(10),对羟基苯甲酸乙酯(11).其中化合物 11 为首次从淫羊藿属植物中分离得到,其余10个化合物为首次从该植物中分离得到. 相似文献
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Lee SY Min BS Kim JH Lee J Kim TJ Kim CS Kim YH Lee HK 《Phytotherapy research : PTR》2005,19(4):273-276
Four flavonoids, epicatechin (1), afzelin (2), quercitrin (3), and tiliroside (4), were isolated from the leaves of Litsea japonica (Thunb.) Jussieu (Lauraceae). The structures of compounds were identified by comparing their chemical and spectral data with those previously reported. The flavonoids (1-4) were tested for their anti-complement activity against classical pathway of complement system. Compounds 2-4 showed inhibitory activity against complement system with IC50 values of 258, 440, and 101 microm, respectively, whereas 1 was inactive. For the evaluation of the structure-activity relationship of 5,7-dihydroxyflavones, myricitrin (5) from Juglans mandshurica also tested for it's anti-complement activity and is inactive in this assay system. Furthermore, compounds 2, 3, and 5 were hydrolyzed with naringinase to give kaempferol (2a), quercetin (3a), and myricetin (5a), and these were also tested for their activity. Of the three aglycones, 2a exhibited anti-complement activity with an IC50 value of 730 microM, while 3a and 5a were inactive. The inhibitory potencies of 2, 2a, 3, 3a, 5, and 5a against complement activity increased in inverse proportion to number of free hydroxyls on B-ring of 5,7-dihydroxyflavone. Of the compounds tested, 4 showed the most potent inhibitory activity against the complement system. 相似文献
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Cistus laurifolius flower buds are used traditionally in folk medicine against gastric ailments. In a prior study we showed that the chloroform extract of Cistus laurifolius had a potent anti-ulcer activity. It has been known that there is a causal relationship between peptic ulcer and Helicobacter pylori infection. Then in a previous study, we demonstrated that chloroform extract of Cistus laurifolius possessed a significant anti-Helicobacter pylori activity. We designed this study to isolate and define the active component(s) involved in the anti-Helicobacter pylori activity of the extract through activity-guided fractionation procedures. The chloroform extract was fractionated by using various chromatography techniques, i.e., Sephadex LH-20 column chromatography and preparative thin layer chromatography and six compounds were isolated (1-6). Each of these six compounds' anti-Helicobacter pylori activity was tested in vitro and was measured as minimum inhibition concentration (MIC) values by using agar dilution method. The compound 2 had the highest activity against Helicobacter pylori (MIC 3.9 microg/mL). Its chemical structure was elucidated as quercetin 3-methyl ether (isorhamnetin) by various spectroscopic techniques. We believe that the therapeutic effect of Cistus laurifolius in ulcer is at least partially related to its effect on Helicobacter pylori. We hope that the isolated flavonoid having anti-Helicobacter pylori activity ultimately can be utilized as an alternative or additive agent to the current therapy. 相似文献
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Sannomiya M Fonseca VB da Silva MA Rocha LR Dos Santos LC Hiruma-Lima CA Souza Brito AR Vilegas W 《Journal of ethnopharmacology》2005,97(1):1-6
Byrsonima crassa Niedenzu (IK) (Malpighiaceae) is used in Brazilian folk medicine for the treatment of diseases related mainly to gastric ulcers. In this study, we evaluated the potential antiulcerogenic effect of three different extracts obtained from the leaves of Byrsonima crassa namely hydromethanolic (80% MeOH), methanolic (MeOH) and chloroformic extracts (CHCl(3)). The oral administration (250, 500 and 1000 mg/kg) of all the extracts reduced the formation of lesions associated with HCl/ethanol administration in mice. The 80% MeOH extract significantly reduced the incidence of gastric lesions by 74, 78 and 92% at doses of 250, 500 and 1000 mg/kg, respectively (P<0.01). The MeOH extract reduced the ulceration by 93 and 99% only at the doses of 500 and 1000 mg/kg (P<0.01). The lower gastroprotective action (69%) was observed when animals were treated with CHCl(3) extract at the dose of 1000 mg/kg (P<0.01). Phytochemical investigation of Byrsonima crassa afforded five known substances: quercetin-3-O-beta-d-galactopyranoside, quercetin-3-O-alpha-l-arabinopyranoside, the biflavonoid amentoflavone, (+)-catechin and (-)-epicatechin. The presence of these phenolic compounds may probably explain the antiulcerogenic effect of the extracts of Byrsonima crassa leaves. 相似文献
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云南傣族药物灯台叶中黄酮类成分 总被引:1,自引:0,他引:1
目的:研究云南傣族传统药物灯台叶Alstonia scholaris中黄酮类化学成分.方法:用色谱分离,用理化性质和波谱鉴定化学结构.结果:分离鉴定了山柰酚(1),槲皮素(2),异鼠李素(3),山柰酚-3-O-β-D-半乳糖苷(4),槲皮素_3-O-β-D-半乳糖苷(5),异鼠李素-3-O-β-D-半乳糖苷(6),山柰酚-3-O-β-D-半乳糖-(2→1)-O-β-D-木糖苷(7),槲皮素-3-O-β-D-半乳糖-(2→1)-O-β-D-木糖苷(8)共8个黄酮类成分.结论:化合物1-7为首次从傣药灯台叶分离得到. 相似文献