光子脱毛的临床疗效与分析

目的为了评价光子（强脉冲光）脱毛技术的疗效，以及疗效与治疗次数、治疗间隔时间、治疗参数、毛发形态的关系。方法使用武汉奇致激光公司生产的DPL系列Princess光子嫩肤仪对57例多毛患者共176个部位（均为治疗2次以上）进行治疗。结果57例患者的176个治疗部位取得了满意的疗效，71％的治疗部位脱毛率达痊愈标准，21％的治疗部位脱毛率达到了有效的标准，最低脱毛率也高于50％以上。总有效率达到了92％以上。治疗期间共有3例5个治疗部位发生热损害。结论光子脱毛技术是一种方便快捷，安全，高效的治疗多毛的办法。     

810nm半导体激光脱毛216例疗效分析

目的观察810nm半导体激光脱毛的安全性和临床疗效。方法应用半导体激光脱毛机对216例患者不同部位进行治疗，波长为810nm，光斑面积12mm×10mm，能量密度6～10J／cm2，脉宽5～400ms，治疗间隔6～8周。结果216例患者经4～6次连续治疗后均达到理想的脱毛效果，治疗后毛发明显减少，再生毛发细小，浅谈。治疗次数达到6次或以上可显著提高疗效。结论半导体激光脱毛安全有效。     

GentleYAG 1064nm激光与强脉冲光脱毛的疗效与安全性比较

目的比较GentleYAG激光脱毛与强脉冲光脱毛的疗效与安全性。方法应用GentleYAG激光与强脉冲光进行脱毛治疗,治疗后分析脱毛效果及不良反应。结果GentleYAG激光脱毛治疗在唇部、发际(有效率均为95.00%)疗效优于强脉冲光(有效率分别为70.00%,65.00%)脱毛治疗,差异有显著性;两种脱毛治疗方法在腋部、四肢(有效率分别为95.00%和90.00%,95.00%和95.00%)部位疗效相当,差异无显著性;GentleYAG激光脱毛治疗后不良反应低于强脉冲光,两者差异有显著性。结论GentleYAG激光脱毛效果在唇部、发际疗效优于强脉冲光,两种脱毛方法在腋部、四肢疗效相当,GentleYAG激光脱毛比强脉冲光脱毛的不良反应更少。     

半导体激光治疗多毛症的疗效观察

目的：观察Lightsheer半导体激光脱毛治疗的疗效。方法：应用半导体激光机治疗90例多毛症患者，波长800nm、脉冲宽度5～100ms、能量密度值10～60J／cm^2，术前脱毛治疗区常规备皮。治疗选择脉宽100ms．能量28～35J／cm^2为宜，一般从低能量开始，治疗间隔依据不同部位毛发的休止期时间，1～3个月左右治疗一次。结果：随访12个月90例患者均获得满意效果，且无1例出现瘢痕、色素沉着等不良反应。结论：与传统方法相比，激光脱毛有其独特的选择性光热作用及周围皮肤组织的非侵人性和操作简便的优势。     

激光脱毛疗效10年随访

目的对我院激光脱毛治疗的效果和安全性进行回顾性总结。方法随访我院357例半导体激光脱毛患者共579个部位,所有患者皆治疗结束10~12年。通过照片比对治疗前后及治疗停止后十年的毛发情况,分析治疗部位、治疗参数和治疗次数对疗效的影响,激光脱毛的不良反应及患者的治疗满意度。结果 10年后357例患者579个部位毛发情况比治疗前有显著改善,脱毛率达84.07%。治疗10年后与治疗结束2个月后比较脱毛率差异无统计学意义。毛发越黑越粗疗效越好,且治疗能量及治疗次数与有效率成正比;深色皮肤不良反应发生率高,易烫伤产生色素沉着或色素减退,但无一例瘢痕形成;患者总满意度达99.1%。结论激光脱毛方便快捷,安全性好,满意度高。     

强脉冲光治疗唇部多毛的疗效观察

目的:评价强脉冲光(IPL)治疗唇部多毛的短期疗效和不良反应。方法:使用IPL设备对28例女性进行上唇部脱毛治疗,共治疗4次,间隔4⁶周。具体参数:640-/695-nm滤波片、双脉冲(脉宽3.56周。具体参数:640-/695-nm滤波片、双脉冲(脉宽3.5⁵.5 ms、脉冲延迟605.5 ms、脉冲延迟60⁸0 ms)、能量密度1680 ms)、能量密度16²2 J/cm2、光斑大小15 mm×35 mm。评价毛发脱减率及患者自我满意度。结果:毛发平均脱减率1次治疗后为62.3%,2次治疗后为72.7%,3次治疗后为74.2%,4次治疗后为77.0%,毛发脱减率随治疗次数增加而增加,差异有统计学意义(F=70.62,P<0.05)。4次治疗后患者的自我满意度评分为2.9,高于2次治疗后的评分2.3(Z=-4.36,P<0.05)。本观察中患者均无严重不良反应。结论:强脉冲光治疗唇部多毛安全有效。     

强脉冲光与红光治疗糖皮质激素依赖性皮炎临床疗效分析

目的 回顾性分析比较强脉冲光与红光治疗糖皮质激素（简称激素）依赖性皮炎的临床疗效及不良反应。方法 应用强脉冲光治疗以面部毛细血管扩张为主要表现的激素依赖性皮炎患者70例,能量密度20 ～ 23 J/cm2,其中脉宽为2.6 ～ 5.0 ms,延迟时间为15 ～ 20 ms,间隔4周治疗1次,平均3.49次。使用波长（633 ± 3） nm红光治疗以面部皮肤敏感为主要表现的激素依赖性皮炎患者197例,能量密度128 J/cm2,每次照射20 min,每周治疗2次,平均4.23次。对每次治疗的疗效及不良反应进行评价。结果 强脉冲光治疗激素依赖性皮炎的总有效率为88.57%;红光治疗的总有效率为83.76%。强脉冲光3脉冲治疗组和2脉冲治疗组的疗效差异有统计学意义（?字2 = 8.14,P ＜ 0.05）。所有患者均未出现严重不良反应。结论 强脉冲光和红光治疗激素依赖性皮炎均有较好疗效。     

皮肤美容及整容

20052716 长脉冲紫翠宝石激光脱毛1386例疗效及安全性评价，20052717 光子脱毛50例患疗效分析，20052718 Relume光子色素再生仪照射治疗皮肤白斑病的临床观察，20052719 高能量脉冲CO2激光修复面部凹陷性痤疮瘢痕的疗效与汽化深度，20052720 Medlite美肤激光治疗眉眼线后遗症的疗效观察。     

强脉冲光治疗面部痤疮临床疗效分析

目的评价强脉冲光治疗面部痤疮的疗效。方法用强脉冲光治疗116例面部痤疮患者，总计治疗5次，治疗间隔3-4周。对患者治疗前后的面部情况进行照相对比评分，并观察不良反应。结果116例患者中治疗有效率为85．4％。痊愈率为41．4％。面部毛发较多的患者中有7例暂时性色素沉着持续时间较长。结论强脉冲光治疗面部痤疮有效。     

强脉冲光脱腋毛疗效观察

随着人们生活水平的提高及审美观的改变，要求脱腋毛的女性越来越多。目前已有多种激光和光子设备成功用于脱毛治疗。我们采用强脉冲光（IPL）对52例女性进行腋部脱毛治疗。取得满意疗效。现报道如下。     

A multicentre trial of the epilation efficacy of a new,large spot size,constant spectrum emission IPL device

This study assesses the efficacy of a new, low fluence, constant spectrum IPL device. In three European centres, 52 females underwent epilation of one arm axilla with the new IPL, the contralateral axilla serving as a treatment control. Satisfied patients at the 1‐month assessment received no further treatments and in the other patients up to five further monthly sessions were given. Clinical photography was taken at the pretreatment baseline and at approximately 1 month later. Side effects and hair attributes were graded. Patient satisfaction was graded. All patients completed the study: 11 required one treatment, with eight, 13, 11 and nine requiring two, three, four and five sessions, respectively. Side effects were minimal. A total of 44 patients were very satisfied with the final result, eight were somewhat satisfied and no patient expressed dissatisfaction, giving an overall satisfaction score of 84.6%. In all cases, hair regrowth in the treated side was finer and lighter. The greatest efficacy was seen in coarse dark hair in darker skin, and least efficacy was noted in fine blonde hair in lighter skin. Epilation with this constant spectrum IPL was safe, effective, well tolerated, and with high patient satisfaction. Repeated sessions were required in some patients with lighter hair and skin.     

A multicentre trial of the epilation efficacy of a new, large spot size, constant spectrum emission IPL device.

This study assesses the efficacy of a new, low fluence, constant spectrum IPL device. In three European centres, 52 females underwent epilation of one arm axilla with the new IPL, the contralateral axilla serving as a treatment control. Satisfied patients at the 1-month assessment received no further treatments and in the other patients up to five further monthly sessions were given. Clinical photography was taken at the pretreatment baseline and at approximately 1 month later. Side effects and hair attributes were graded. Patient satisfaction was graded. All patients completed the study: 11 required one treatment, with eight, 13, 11 and nine requiring two, three, four and five sessions, respectively. Side effects were minimal. A total of 44 patients were very satisfied with the final result, eight were somewhat satisfied and no patient expressed dissatisfaction, giving an overall satisfaction score of 84.6%. In all cases, hair regrowth in the treated side was finer and lighter. The greatest efficacy was seen in coarse dark hair in darker skin, and least efficacy was noted in fine blonde hair in lighter skin. Epilation with this constant spectrum IPL was safe, effective, well tolerated, and with high patient satisfaction. Repeated sessions were required in some patients with lighter hair and skin.     

Comparison of hair reduction with three lasers and light sources: Prospective,blinded and controlled study

Abstract

Objective: The main goal of this study was to compare the hair removal efficacy of three methods: intense pulsed light (IPL), a combination of IPL and radio frequency (RF) and diode laser (810 nm). Methods: Forty participants were treated within three standardized squares on lateral sites on their legs. Each of these squares was treated twice with an interval of 4–6 weeks. The fourth square was left as a control. A blinded physician counted the hairs in each square before the first treatment and 8 months after the second treatment. Immediate and delayed side effects as well as pain scores were recorded. Results: The mean hair count reduction achieved by the diode laser, IPL and IPL+RF was 49.90%, 39.16% and 47.15%, respectively. This study did not show any serious side effects and the number of side effects was minimal. The mean pain scores for the first and second treatments by diode laser, IPL and IPL+RF were 4.65 and 4.58, 2.43 and 2.53, and 3.95 and 4.03, respectively. At the end of the study, a free hair removal treatment for both legs was chosen by patients in the proportion 20 diode laser, 10 IPL and eight IPL+RF. Conclusions: The combination of RF and optical energies proved its safety and efficacy for hair removal, which is comparable with diode lasers and approximately 20% more efficient than ‘pure’ IPL.     

不同类型皮肤和不同部位运用强脉冲光子脱毛的疗效观察

目的探讨强脉冲光子脱毛的疗效与治疗次数和能量之间的关系。方法用强脉冲光子对3种类型皮肤共156例患者进行脱毛治疗。结果Ⅲ型皮肤组脱毛有效率为98.9%,IV型皮肤为95.8%,V型皮肤为86.6%。疗效与治疗次数密切相关;各部位治疗次数及能量均不同。结论强脉冲光子脱毛疗效显著,方便快捷,副反应小。     

Lasers for reduction of unwanted hair in skin of colour: a systematic review and meta-analysis

Light-based therapies are one of the most effective and widely used strategies for removal of undesired hair, with a broadly favourable safety profile. However, subjects with pigmented skin are found to be more prone to laser-related adverse events. While prolonged pulse-width and longer treatment duration were proposed to minimize adverse events, the optimal treatment option among available phototherapy modalities – long-pulsed (Nd:YAG), pulsed diode and alexandrite lasers as well as intense pulsed light (IPL) – remains unclear, particularly for skin of colour. To determine superiority in terms of effectiveness and tolerability, we conducted a systematic review of literature on different types of in-office laser and IPL for hair removal in subjects with Fitzpatrick skin types III–VI. The meta-analysis was performed using Review Manager (RevMan) version 5.3 and included 12 eligible comparative trials (nine randomized controlled trials and three quasi-randomized). In terms of hair count reduction, pooled effect estimates for long-pulsed ND:YAG laser [OR: 0.26, 95% CI (0.1, 0.78)] and diode laser [standardized mean difference (SMD): −0.11, 95% CI (−0.62, 0.39)] were not statistically significant from those of IPL; in contrast, alexandrite laser was found to be superior to IPL in reducing hair count [SMD: −1.7, 95% CI (−2.6, −0.78)]. In terms of adverse events, the pooled effect estimates favoured long-pulsed Nd:YAG laser to IPL with respect to postinflammatory hyperpigmentation [OR: 0.26, 95% CI: (0.1, 0.78)]. However, both pulsed diode and alexandrite lasers exhibited a comparable safety profile to IPL, despite higher pain scores with lasers. In conclusion, this systematic review suggests that treatment outcomes for different in-office laser devices and IPL in subjects with skin type III–VI are broadly similar; nevertheless, we observed a trend towards greater hair reduction following laser therapy compared with IPL.     

Evidence-based review of hair removal using lasers and light sources

BACKGROUND: Unwanted hair growth remains a therapeutic challenge and there is a considerable need for an effective and safe treatment modality. OBJECTIVE: From an evidence-based view to summarize efficacy and adverse effects from hair removal with ruby, alexandrite, diode, and Nd:YAG lasers and intense pulsed light (IPL). METHODS: Original publications of controlled clinical trials were identified in Medline and the Cochrane Library. RESULTS: A total of 9 randomized controlled (RCTs) and 21 controlled trials (CTs) were identified. The best available evidence was found for the alexandrite (three RCTs, eight CTs) and diode (three RCTs, four CTs) lasers, followed by the ruby (two RCTs, six CTs) and Nd:YAG (two RCTs, four CTs) lasers, whereas limited evidence was available for IPL sources (one RCT, one CT). Based on the present best available evidence we conclude that (i) epilation with lasers and light sources induces a partial short-term hair reduction up to 6 months postoperatively, (ii) efficacy is improved when repeated treatments are given, (iii) efficacy is superior to conventional treatments (shaving, wax epilation, electrolysis), (iv) evidence exists for a partial long-term hair removal efficacy beyond 6 months postoperatively after repetitive treatments with alexandrite and diode lasers and probably after treatment with ruby and Nd:YAG lasers, whereas evidence is lacking for long-term hair removal after IPL treatment, (v) today there is no evidence for a complete and persistent hair removal efficacy, (vi) the occurrence of postoperative side-effects is reported low for all the laser systems. CONCLUSION: The evidence from controlled clinical trials favours the use of lasers and light sources for removal of unwanted hair. We recommend that patients are pre-operatively informed of the expected treatment outcome.     

Complete regression of a melanocytic nevus under intense pulsed light therapy for axillary hair removal in a cosmetic center

Intense pulsed light (IPL) therapy using noncoherent broad-spectrum light has been reported to be effective for hair removal, and also for treating superficial pigmented lesions like ephelides and solar lentigines. We report complete regression of a pigmented melanocytic nevus, histologically confirmed, after hair removal treatment with IPL. The use of lasers and IPL is a common procedure used by dermatologists and even other professions for the treatment of cosmetically troubling skin conditions. The main advantage of such treatment is a reduction of surgical scars, thus producing a favorable cosmetic outcome, but a major limitation is that histopathologic diagnosis is not usually obtained prior to treatment. Such devices should be carefully used in patients with potentially dangerous melanocytic lesions. We also review the recent literature regarding inadequate treatment of melanocytic lesions with lasers.     

Split-leg comparison of low fluence diode laser and high fluence intense pulsed light in permanent hair reduction in skin types III to IV

Background/Objectives: All the standard light‐based techniques for permanent hair reduction, like laser and intense pulsed light (IPL) employ the highest tolerable fluence with a single pass. As opposed to standard techniques, a new diode laser technique employs low fluence with multiple passes. Here we evaluate and compare the efficacy, treatment time, comfort and safety of the low fluence multiple pass diode laser with high fluence single pass IPL for permanent hair reduction in Type III to IV Asian patients. Methods: Thirty Asian patients with Type III to IV black hair were enrolled and received three sessions of treatments at 6‐weekly to 8‐weekly intervals. A split‐leg study was performed in which the IPL was applied to one leg of each patient while the laser was applied to the other. The patients were followed up for 12 months. Results: All patients were satisfied with the results of the long‐term hair reduction without long‐term side effects. There was no statistically significant difference in hair reduction and treatment time between the laser (76.85%, 21.39 min) and the IPL (74.53%, 22.17 min) (P > 0.05). The visual analogue scale (VAS) pain score of the IPL (5.96) was higher than that of the laser (3.10) (P < 0.01). Conclusions: A series of high fluence single pass IPL and low fluence multiple pass diode laser treatments were performed with similar efficacy, speed and safety for permanent hair reduction. However, low fluence multiple pass diode laser treatment was less painful than high fluence single pass IPL.     

Hair removal using a combination of conducted radiofrequency and optical energies--an 18-month follow-up.

OBJECTIVE: Multiple lasers and intense pulsed light sources have been shown to provide long-term hair removal; however, the management of all dark skin phenotypes and light-colored hair remains problematic. The present study examined the long-term photoepilatory effect of a combined intense pulsed light (IPL) (680-980 nm)/radiofrequency (RF) (10-30 J/cm3) light source and its efficiency for the treatment of multiple skin phenotypes and varied hair colors. METHODS: Forty adult patients (skin phenotypes II-V) with varied facial and non-facial hair colors were treated with a combined IPL/RF technology. Four treatments were carried out over a period of 9-12 months at 8-12-week intervals. Light energy ranged from 15 to 26 J/cm2, while RF energy varied from 10 to 20 J/cm3. Hair counts and photographic evaluation of skin sites were obtained at baseline, and months 1, 3 and 5 after the final treatment session. H&E biopsies were examined at 1 week in five randomly selected study cohorts. RESULTS: Maximum hair reduction was observed at 6-8 weeks after each treatment. An average clearance of 75% was observed in all body locations at 18 months. No significant adverse sequelae were reported. Results showed no significant dependence on skin color: lighter and darker skin types responded similarly to treatment. Histologic evaluation revealed thermal damage to hair follicles with vacuolar degeneration. CONCLUSION: The combined IPL (680-980 nm)/RF light source with contact cooling is a safe and effective method of long-term hair reduction in patients of diversified skin types and varied hair colors and is associated with excellent patient safety.