肿瘤患者主观睡眠质量与心身状况相关分析

目的了解肿瘤患者的睡眠质量与焦虑、抑郁情绪等心身状况以及它们之间的关系.方法采用匹茨堡睡眠质量指数量表(PSQI)、焦虑自评量表(SAS)、抑郁自评量表(SDS)、状态-特质焦虑问卷(STAI)和症状自评量表(SCL-90)调查88名肿瘤住院患者主观睡眠质量与心身状况.结果患者在PSQI量表调查中总均分为(6.88±4.08)分,男、女患者分别为(6.47±4.08)分和(7.61±3.97)分,性别间差异无显著性(P＞0.05),PSQI≥8分者占32.4%;SAS与SDS得分分别为(43.5±9.5)分,(44.5±10.8)分.而PSQI得分与SAS、SDS、SCL-90总分间存在显著的相关性(r分别为0.544与0.399,0.493;P＜0.01).结论肿瘤患者的主观睡眠较差,并存在着焦虑及抑郁情绪.睡眠质量与焦虑、抑郁情绪密切相关,PSQI值越高,抑郁及焦虑越严重.     

孕妇的主观睡眠质量及心身状况的对照研究

目的 了解孕妇在妊娠期的主观睡眠质量及心身状况。方法 采用匹兹堡睡眠质量指数量表（PSQI）、焦虑自评量表（SAS）、状态－特质焦虑量表（STAI）、抑郁自评量表（SDS）及症状自评量表（SCL－90）评定孕妇组与对照组的睡眠及心身状况。结果 与对照组相比,孕妇组PSQI主观睡眠质量、睡眠紊乱因子分高,睡眠时间、白天功能紊乱因子分低（P＜0．05）;SAS总分、STAI总分、状态焦虑因子分高,非状态焦虑因子分低（P＜0．05）;SDS躯体化障碍因子分高,精神情感症状因子分低（P＜0．05）;SCL－90躯体化因子分高,人际关系因子分低（P＜0．05）。结论 孕妇在妊娠期有明显的睡眠紊乱、焦虑及躯体化症状。     

彝族2型糖尿病患者睡眠质量与焦虑抑郁情绪的相关性研究

目的了解彝族2型糖尿病患者睡眠质量,焦虑抑郁情绪以及之间的关系。方法对168例确诊的2型糖尿病患者同时进行匹兹堡睡眠质量指数(PSQI),焦虑自评量表(SAS)和抑郁自评量表(SDS)评定。结果 PSQI(7.97±3.08)分,SAS(39.23±7.61)分,SDS(42.97±7.09)分,SAS与SDS存在显著的正相关(P<0.01)。PSQI总分与焦虑和抑郁情绪均呈显著正相关。结论糖尿病患者除饮食运动及药物治疗外,改善睡眠,控制负性情绪可增强治疗效果及提高患者生活质量。     

孕妇的主观睡眠质量及心身状况的对照研究

目的了解孕妇在妊娠期的主观睡眠质量及心身状况.方法采用匹兹堡睡眠质量指数量表(PSQI)、焦虑自评量表(SAS)、状态-特质焦虑量表(STAI)、抑郁自评量表(SDS)及症状自评量表(SCL-90)评定孕妇组与对照组的睡眠及心身状况.结果与对照组相比,孕妇组PSQI主观睡眠质量、睡眠紊乱因子分高,睡眠时间、白天功能紊乱因子分低(P＜0.05)SAS总分、STAI总分、状态焦虑因子分高,非状态焦虑因子分低(P＜0.05);SDS躯体化障碍因子分高,精神情感症状因子分低(P＜0.05);SCL-90躯体化因子分高,人际关系因子分低(P＜0.05).结论孕妇在妊娠期有明显的睡眠紊乱、焦虑及躯体化症状.     

公共场所从业人员睡眠质量及心理健康状况的相关性研究

目的了解不同场所从业人员的睡眠质量和心理健康状况及其相关性。方法随机抽取从事客房、餐厅、舞厅、商场服务的人员528名，以匹兹堡睡眠质量指数、焦虑和抑郁自评量表为工具，对其睡眠质量及心理状况进行测量，并作相关性分析。结果睡眠质量问题、焦虑及抑郁症状的发生率分别为10.06%、10.23%和41.10%；PSQI、SAS、SDS得分分别为4.31±2.56、39.49±7.87和47.22±9.03。各场所间的PSQI、SAS、SDS均有显著性的差异(P＜0.01)，PSQI与SAS和SDS间呈显著性的相关关系(P＜0.05)。结论舞厅从业人员的睡眠质量和心理健康状况均比其他场所的差。     

消化性溃疡患者主观睡眠质量及其与心理因素相关分析

目的: 探讨消化性溃疡患者的主观睡眠质量与心理因素以及二者之间的相关性.方法:采用匹茨堡睡眠质量指数量表(PSQI)、焦虑自评量表(SAS)、抑郁自评量表(SDS)和症状自评量表(SCL-90),对本院消化内科60例消化性溃疡患者及60例正常对照组进行调查,并通过相关分析探讨消化性溃疡患者主观睡眠质量和心理因素之间的关系.结果:患者组与对照组PSQI、 SAS、SDS及SCL-90各量表分的差异均有统计学意义( P< 0.05).消化性溃疡患者的PSQI总分与SAS、SDS、SCL-90总分之间呈正相关关系 (r分 别为0.356、0.440、0.341; P<0.05).结论:消化性溃疡患者主观睡眠质量较差,并存在与精神症状相关的睡眠障碍.     

彝族2型糖尿病患者睡眠质量与焦虑抑郁情绪的相关性研究

目的 了解彝族2型糖尿病患者睡眠质量,焦虑抑郁情绪以及之间的关系.方法 对168例确诊的2型糖尿病患者同时进行匹兹堡睡眠质量指数（PSQI）,焦虑自评量表（SAS）和抑郁自评量表（SDS）评定.结果 PSQI（7.97±3.08）分,SAS（39.23±7.61）分,SDS（42.97±7.09）分,SAS与SDS存在显著的正相关（P〈0.01）.PSQI总分与焦虑和抑郁情绪均呈显著正相关.结论 糖尿病患者除饮食运动及药物治疗外,改善睡眠,控制负性情绪可增强治疗效果及提高患者生活质量.     

针对性护理干预改善甲状腺手术患者焦虑抑郁心理的实效性研究

目的 探究针对性护理干预对甲状腺手术患者焦虑抑郁心理的改善作用。 方法 杭州市第一人民医院在2015年4月—2016年3月期间对54例接受甲状腺手术治疗的患者围手术期实施针对性护理干预,作为干预组;选取此前1年在围手术期仅接受常规护理干预的54例患者作为对照组。护理前后利用抑郁自评量表(self-rating depression scale,SDS)、焦虑自评量表(self-rating anxiety scale,SAS)和匹兹堡睡眠质量指数量表(pittsburgh sleep quality index scale,PSQI)对2组患者的抑郁、焦虑和睡眠质量进行评估,并利用日常生活能力评分(BI评分)和生活质量量表(SQLS)评分对患者的生活质量进行评价,利用SPSS 19.0统计软件对结果进行分析。 结果 2组护理前SDS、SAS、PSQI、BI评分和SQLS评分相比,差异不具有统计学意义(P＞0.05);护理后,干预组SDS、SAS和PSQI分别为(31.2±9.5)分、(33.5±10.8)分和(37.9±6.2)分,对照组为(47.9±11.6)分、(53.1±5.8)分和(48.3±9.4)分,干预组SDS、SAS和PSQI明显低于对照组(P＜0.05);护理后,干预组BI评分和SQLS评分均明显高于对照组(P＜0.05)。 结论 针对性护理干预模式的实施对于改善甲状腺手术患者的精神状况及睡眠质量具有显著效果,有助于生存质量的改善。      

消化性溃疡患者主观睡眠质量及其与心理因素相关分析

目的：探讨消化性溃疡患者的主观睡眠质量与心理因素以及二者之间的相关性。方法：采用匹茨堡睡眠质量指数量表（PSQI）、焦虑自评量表（SAS）、抑郁自评量表（SDS）和症状自评量表（SCL-90）,对本院消化内科60例消化性溃疡患者及60例正常对照组进行调查,并通过相关分析探讨消化性溃疡患者主观睡眠质量和心理因素之间的关系。结果：患者组与对照组PSQI、SAS、SDS及SCL-90各量表分的差异均有统计学意义（P〈0.05）。消化性溃疡患者的PSQI总分与SAS、SDS、SCL-90总分之间呈正相关关系（r分别为0.356、0.440、0.341;P〈0.05）。结论：消化性溃疡患者主观睡眠质量较差,并存在与精神症状相关的睡眠障碍。     

原发性青光眼患者睡眠和视觉相关生活质量

目的 研究原发性青光眼患者的睡眠和视觉相关生活质量状况,为临床干预提供循证医学依据。方法 选取2019年8月~2020年12月在西北大学附属第一医院和西安交通大学第二附属医院住院部收治的原发性青光眼患者共116人作为研究对象,采用匹兹堡睡眠质量指数量表（PSQI）、焦虑自评量表（SAS）、抑郁自评量表（SDS）和美国国立眼科研究所视功能调查问卷（NEI-VFQ-25）进行问卷调查,并分析各量表得分之间的相关性;分析性别、年龄、文化程度、居住地及经济收入对患者睡眠、心里健康及生活治疗的影响。结果 原发性青光眼患者PSQI得分为10.59±3.69,SAS、SDS得分分别为53.05±7.64和56.31±9.07,NEI-VFQ-25得分为65.30±11.61。青光眼患者的PSQI得分与SAS得分正相关（r=0.34, P＜0.01）,SAS得分与SDS得分正相关（r=0.40, P＜0.01）,PSQI得分与SDS得分不相关（P＞0.05）,NEI-VFQ-25得分与SAS得分负相关（r=-0.37, P＜0.01）,NEI-VFQ-25得分与PSQI得分、SDS得分不相关（P＞0.05）。开角型青光眼患者和闭角型青光眼患者的焦虑症患病率差异具有统计学意义（P＜0.05）,各年龄段患者的焦虑症患病率差异和失眠症患病率差异均具有统计学意义（P＜0.05）;经济收入不同的青光眼患者焦虑症及失眠症患病率差异均具有统计学意义（P＜0.05）;不同性别、年龄、生活环境及文化程度青光眼患者的抑郁症患病率差异具有统计学意义（P＜0.05）。结论 青光眼患者中焦虑、抑郁的发生率较高,睡眠质量和生活质量较差,原发性青光眼患者焦虑、抑郁、失眠状态及生活质量与性别、年龄、文化程度、生活环境、经济收入等因素相关,临床中工作中应实施个体化的心理疏导和健康教育。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.