睫状肌麻痹对成人散光的影响

目的 通过比较睫状肌麻痹前后散光度数及其矢量成分的变化,探讨睫状肌麻痹对散光的影响。方法横断面研究。随机选取2018年5月至2020年1月在惠州市第三人民医院视光专科就诊并同意参加本研究的成人近视患者261例(18～48岁),对其进行眼轴、小瞳综合验光、睫状肌麻痹下(复方托吡卡胺滴眼液)综合验光仪主觉验光检查。收集被检者年龄、性别、眼轴、睫状肌麻痹前后屈光度数,并采用配对t检验对睫状肌麻痹前后散光度数及各矢量变化进行分析。每例均取右眼进行统计分析。结果 所有被检的261例均完成本研究。睫状肌麻痹后,等效球镜度数减少了(0.37±0.47) D(P <0.05)。在本研究中睫状肌麻痹前后柱镜度数≥0.25 D的人数为243例,占93.1%。散光类型以顺规散光为主,其后依次为斜轴散光、逆规散光。睫状肌麻痹后高度散光比例稍有增加,从37.13%增加到40.33%,同时高度散光组中顺规散光比例从71.13%增加到了77.55%。但是睫状肌麻痹前后,散光度数及各矢量成分的变化均无统计学意义。结论 对成人近视患者而言,散光检出率高,且以顺规散光为主。睫状肌麻痹可降低等效球镜度数,但对散光度数...     

不同睫状肌麻痹剂对儿童调节力及屈光状态的影响

Objective To find out the longest effective duration of Mydrin P and Romi eyedrop on cycloplegia,compare the residual accommodation after cycloplegia by Mydrin P eyedrop, 1% Atropine paste and Romi eyedrop, analyze their effect on ametropia. To provide some experimental basis for using cycloplegia adeptly in clinic. Methods Seventy-five children (147eyes) were checked, 4～16 years old with, mean age of 10.12 years old. There are no systemic diseases. The patients were divided into 3 groups: A, 1% Atropine group; B,Romi eyedrop group and C,Mydrin P group. Before and after administration of these eyedrops,ob-jective refraction was checked in hand-hold auto refractor; subjective refraction was checked in phoropter,and retinoscopy refraction was finished. Phoropter was used to check the accommodation response and the residual accommodation respectively by "pushup" method. Results (1)In Romi eyedrop group,the time of maxi-mum cycloplegia was 60 minutes,the patients can read in the next day; in Mydrin P group,the time was 30 minutes, can read next day. (2) Average residual accommodation at the maximum cycloplegia: A, 1% Atropine group (2.0440±0.95484D),B,Romi eyedrop group (2.2214±0.6952D),C,Mydrin P group (2.6656±0.9999D). The residual accommodation in Romi eyedrop and Atropine groups had no significant difference, In-dependent-samples t Test P 0.05.The residual accommodation in Mydrin P group was stronger than the other two groups,more significant in myopia eyes. (3) The residual accommodation of three groups had no relation-ship with age and refractive status. (4) The results were same in cycloplegic refraction with hand-hold auto re-fractor and phoropter of each group of A, 1% Atropine group,B,Romi eye, drop group and C,Mydrin P group (P 0.05). The difference was 0.33D in autorefraction and phoropter,autorefraction negative. Conelusions (1) The time of maximum cycloplegia effective of Romi eye-drop was 60 minutes, of Mydrin P was 30 min-utes. (2) The residual accommodation in Romi eyedrop and Atropine groups was almost same, the residual ac-commodation in Mydrin-P group was stronger than the other two groups,more significant in myopia eyes. (3)Residual accommodation. Three groups have no relationship with age and refiaction. (4) Romi eyedrop and,Mydrin-P eyedrop can be used in the cycloplegic refraction for children in myopia and hyperopia.     

两种睫状肌麻痹剂对像差影响的对照研究

目的评价环喷托酯和托吡卡胺散瞳前后对像差测量的影响。方法选取准分子激光原位角膜磨镶术患者随机分为环喷托酯组15例(30眼)和托吡卡胺组15例(29眼)。两组患者测量像差后,分别给予1%环喷托酯及0.5%托吡卡胺,散瞳后再次测量像差,并比较两组散瞳前后像差球镜值(6mm)和高阶像差的均方根(MRS)值。结果两组暗室瞳孔下像差球镜值均小于综合验光值和散瞳后像差测量值,差异有统计学意义(P<0.05)。两组在暗室下或是散瞳后,随着分析瞳孔的增大,三阶(RMS3)、四阶(RMS4)、五阶(RMS5)、总高阶像差(RMSh)和球差C12逐渐增大,差异有统计学意义(P<0.05),而慧差C7、C8差异无统计学意义(P>0.05)。而在同一分析瞳孔直径下,散瞳前后各阶高阶像差和RMSh、C7、C8差异无统计学意义,散瞳后C12增大,与暗室下C12比较,差异有统计学意义(P<0.05)。在同一瞳孔直径下,环喷托酯组球差值与托吡卡胺组相比,差异无统计学意义(P>0.05)。结论睫状肌麻痹剂影响像差的测量,使球差值增大。     

不同睫状肌麻痹剂对儿童调节力及屈光状态的影响

Objective To find out the longest effective duration of Mydrin P and Romi eyedrop on cycloplegia,compare the residual accommodation after cycloplegia by Mydrin P eyedrop, 1% Atropine paste and Romi eyedrop, analyze their effect on ametropia. To provide some experimental basis for using cycloplegia adeptly in clinic. Methods Seventy-five children (147eyes) were checked, 4～16 years old with, mean age of 10.12 years old. There are no systemic diseases. The patients were divided into 3 groups: A, 1% Atropine group; B,Romi eyedrop group and C,Mydrin P group. Before and after administration of these eyedrops,ob-jective refraction was checked in hand-hold auto refractor; subjective refraction was checked in phoropter,and retinoscopy refraction was finished. Phoropter was used to check the accommodation response and the residual accommodation respectively by "pushup" method. Results (1)In Romi eyedrop group,the time of maxi-mum cycloplegia was 60 minutes,the patients can read in the next day; in Mydrin P group,the time was 30 minutes, can read next day. (2) Average residual accommodation at the maximum cycloplegia: A, 1% Atropine group (2.0440±0.95484D),B,Romi eyedrop group (2.2214±0.6952D),C,Mydrin P group (2.6656±0.9999D). The residual accommodation in Romi eyedrop and Atropine groups had no significant difference, In-dependent-samples t Test P 0.05.The residual accommodation in Mydrin P group was stronger than the other two groups,more significant in myopia eyes. (3) The residual accommodation of three groups had no relation-ship with age and refractive status. (4) The results were same in cycloplegic refraction with hand-hold auto re-fractor and phoropter of each group of A, 1% Atropine group,B,Romi eye, drop group and C,Mydrin P group (P 0.05). The difference was 0.33D in autorefraction and phoropter,autorefraction negative. Conelusions (1) The time of maximum cycloplegia effective of Romi eye-drop was 60 minutes, of Mydrin P was 30 min-utes. (2) The residual accommodation in Romi eyedrop and Atropine groups was almost same, the residual ac-commodation in Mydrin-P group was stronger than the other two groups,more significant in myopia eyes. (3)Residual accommodation. Three groups have no relationship with age and refiaction. (4) Romi eyedrop and,Mydrin-P eyedrop can be used in the cycloplegic refraction for children in myopia and hyperopia.     

不同睫状肌麻痹剂对儿童调节力及屈光状态的影响

Objective To find out the longest effective duration of Mydrin P and Romi eyedrop on cycloplegia,compare the residual accommodation after cycloplegia by Mydrin P eyedrop, 1% Atropine paste and Romi eyedrop, analyze their effect on ametropia. To provide some experimental basis for using cycloplegia adeptly in clinic. Methods Seventy-five children (147eyes) were checked, 4～16 years old with, mean age of 10.12 years old. There are no systemic diseases. The patients were divided into 3 groups: A, 1% Atropine group; B,Romi eyedrop group and C,Mydrin P group. Before and after administration of these eyedrops,ob-jective refraction was checked in hand-hold auto refractor; subjective refraction was checked in phoropter,and retinoscopy refraction was finished. Phoropter was used to check the accommodation response and the residual accommodation respectively by "pushup" method. Results (1)In Romi eyedrop group,the time of maxi-mum cycloplegia was 60 minutes,the patients can read in the next day; in Mydrin P group,the time was 30 minutes, can read next day. (2) Average residual accommodation at the maximum cycloplegia: A, 1% Atropine group (2.0440±0.95484D),B,Romi eyedrop group (2.2214±0.6952D),C,Mydrin P group (2.6656±0.9999D). The residual accommodation in Romi eyedrop and Atropine groups had no significant difference, In-dependent-samples t Test P 0.05.The residual accommodation in Mydrin P group was stronger than the other two groups,more significant in myopia eyes. (3) The residual accommodation of three groups had no relation-ship with age and refractive status. (4) The results were same in cycloplegic refraction with hand-hold auto re-fractor and phoropter of each group of A, 1% Atropine group,B,Romi eye, drop group and C,Mydrin P group (P 0.05). The difference was 0.33D in autorefraction and phoropter,autorefraction negative. Conelusions (1) The time of maximum cycloplegia effective of Romi eye-drop was 60 minutes, of Mydrin P was 30 min-utes. (2) The residual accommodation in Romi eyedrop and Atropine groups was almost same, the residual ac-commodation in Mydrin-P group was stronger than the other two groups,more significant in myopia eyes. (3)Residual accommodation. Three groups have no relationship with age and refiaction. (4) Romi eyedrop and,Mydrin-P eyedrop can be used in the cycloplegic refraction for children in myopia and hyperopia.     

不同睫状肌麻痹剂对儿童调节力及屈光状态的影响

Objective To find out the longest effective duration of Mydrin P and Romi eyedrop on cycloplegia,compare the residual accommodation after cycloplegia by Mydrin P eyedrop, 1% Atropine paste and Romi eyedrop, analyze their effect on ametropia. To provide some experimental basis for using cycloplegia adeptly in clinic. Methods Seventy-five children (147eyes) were checked, 4～16 years old with, mean age of 10.12 years old. There are no systemic diseases. The patients were divided into 3 groups: A, 1% Atropine group; B,Romi eyedrop group and C,Mydrin P group. Before and after administration of these eyedrops,ob-jective refraction was checked in hand-hold auto refractor; subjective refraction was checked in phoropter,and retinoscopy refraction was finished. Phoropter was used to check the accommodation response and the residual accommodation respectively by "pushup" method. Results (1)In Romi eyedrop group,the time of maxi-mum cycloplegia was 60 minutes,the patients can read in the next day; in Mydrin P group,the time was 30 minutes, can read next day. (2) Average residual accommodation at the maximum cycloplegia: A, 1% Atropine group (2.0440±0.95484D),B,Romi eyedrop group (2.2214±0.6952D),C,Mydrin P group (2.6656±0.9999D). The residual accommodation in Romi eyedrop and Atropine groups had no significant difference, In-dependent-samples t Test P 0.05.The residual accommodation in Mydrin P group was stronger than the other two groups,more significant in myopia eyes. (3) The residual accommodation of three groups had no relation-ship with age and refractive status. (4) The results were same in cycloplegic refraction with hand-hold auto re-fractor and phoropter of each group of A, 1% Atropine group,B,Romi eye, drop group and C,Mydrin P group (P 0.05). The difference was 0.33D in autorefraction and phoropter,autorefraction negative. Conelusions (1) The time of maximum cycloplegia effective of Romi eye-drop was 60 minutes, of Mydrin P was 30 min-utes. (2) The residual accommodation in Romi eyedrop and Atropine groups was almost same, the residual ac-commodation in Mydrin-P group was stronger than the other two groups,more significant in myopia eyes. (3)Residual accommodation. Three groups have no relationship with age and refiaction. (4) Romi eyedrop and,Mydrin-P eyedrop can be used in the cycloplegic refraction for children in myopia and hyperopia.     

不同睫状肌麻痹剂对儿童调节力及屈光状态的影响

Objective To find out the longest effective duration of Mydrin P and Romi eyedrop on cycloplegia,compare the residual accommodation after cycloplegia by Mydrin P eyedrop, 1% Atropine paste and Romi eyedrop, analyze their effect on ametropia. To provide some experimental basis for using cycloplegia adeptly in clinic. Methods Seventy-five children (147eyes) were checked, 4～16 years old with, mean age of 10.12 years old. There are no systemic diseases. The patients were divided into 3 groups: A, 1% Atropine group; B,Romi eyedrop group and C,Mydrin P group. Before and after administration of these eyedrops,ob-jective refraction was checked in hand-hold auto refractor; subjective refraction was checked in phoropter,and retinoscopy refraction was finished. Phoropter was used to check the accommodation response and the residual accommodation respectively by "pushup" method. Results (1)In Romi eyedrop group,the time of maxi-mum cycloplegia was 60 minutes,the patients can read in the next day; in Mydrin P group,the time was 30 minutes, can read next day. (2) Average residual accommodation at the maximum cycloplegia: A, 1% Atropine group (2.0440±0.95484D),B,Romi eyedrop group (2.2214±0.6952D),C,Mydrin P group (2.6656±0.9999D). The residual accommodation in Romi eyedrop and Atropine groups had no significant difference, In-dependent-samples t Test P 0.05.The residual accommodation in Mydrin P group was stronger than the other two groups,more significant in myopia eyes. (3) The residual accommodation of three groups had no relation-ship with age and refractive status. (4) The results were same in cycloplegic refraction with hand-hold auto re-fractor and phoropter of each group of A, 1% Atropine group,B,Romi eye, drop group and C,Mydrin P group (P 0.05). The difference was 0.33D in autorefraction and phoropter,autorefraction negative. Conelusions (1) The time of maximum cycloplegia effective of Romi eye-drop was 60 minutes, of Mydrin P was 30 min-utes. (2) The residual accommodation in Romi eyedrop and Atropine groups was almost same, the residual ac-commodation in Mydrin-P group was stronger than the other two groups,more significant in myopia eyes. (3)Residual accommodation. Three groups have no relationship with age and refiaction. (4) Romi eyedrop and,Mydrin-P eyedrop can be used in the cycloplegic refraction for children in myopia and hyperopia.     

不同睫状肌麻痹剂对儿童调节力及屈光状态的影响

Objective To find out the longest effective duration of Mydrin P and Romi eyedrop on cycloplegia,compare the residual accommodation after cycloplegia by Mydrin P eyedrop, 1% Atropine paste and Romi eyedrop, analyze their effect on ametropia. To provide some experimental basis for using cycloplegia adeptly in clinic. Methods Seventy-five children (147eyes) were checked, 4～16 years old with, mean age of 10.12 years old. There are no systemic diseases. The patients were divided into 3 groups: A, 1% Atropine group; B,Romi eyedrop group and C,Mydrin P group. Before and after administration of these eyedrops,ob-jective refraction was checked in hand-hold auto refractor; subjective refraction was checked in phoropter,and retinoscopy refraction was finished. Phoropter was used to check the accommodation response and the residual accommodation respectively by "pushup" method. Results (1)In Romi eyedrop group,the time of maxi-mum cycloplegia was 60 minutes,the patients can read in the next day; in Mydrin P group,the time was 30 minutes, can read next day. (2) Average residual accommodation at the maximum cycloplegia: A, 1% Atropine group (2.0440±0.95484D),B,Romi eyedrop group (2.2214±0.6952D),C,Mydrin P group (2.6656±0.9999D). The residual accommodation in Romi eyedrop and Atropine groups had no significant difference, In-dependent-samples t Test P 0.05.The residual accommodation in Mydrin P group was stronger than the other two groups,more significant in myopia eyes. (3) The residual accommodation of three groups had no relation-ship with age and refractive status. (4) The results were same in cycloplegic refraction with hand-hold auto re-fractor and phoropter of each group of A, 1% Atropine group,B,Romi eye, drop group and C,Mydrin P group (P 0.05). The difference was 0.33D in autorefraction and phoropter,autorefraction negative. Conelusions (1) The time of maximum cycloplegia effective of Romi eye-drop was 60 minutes, of Mydrin P was 30 min-utes. (2) The residual accommodation in Romi eyedrop and Atropine groups was almost same, the residual ac-commodation in Mydrin-P group was stronger than the other two groups,more significant in myopia eyes. (3)Residual accommodation. Three groups have no relationship with age and refiaction. (4) Romi eyedrop and,Mydrin-P eyedrop can be used in the cycloplegic refraction for children in myopia and hyperopia.     

不同睫状肌麻痹剂对儿童调节力及屈光状态的影响

目的 找出美多丽P滴眼液、罗米滴眼液最大睫状肌麻痹时间,对比美多丽P滴眼液、罗米滴眼液、1%阿托品眼膏最大睫状肌麻痹时的剩余调节力,并分析3种药物对屈光不正检测的影响.为眼科临床上合理应用睫状肌麻痹剂提供一定的实验依据.方法 对4～16岁儿童75例、147只眼进行检查,均未曾配戴眼镜,未曾屈光治疗,其裸眼或矫正视力均可达1.0,并除外其他眼病及影响调节的全身病.按3种药物分3组,对其睫状肌麻痹前后不同时间点分别进行手持自动电脑验光仪客观验光,视网膜检影验光,在综合验光仪上主观验光,在其上用移近法测量调节力及剩余调节力.结果 (1)最大睫状肌麻痹时间罗米为60min,美多丽P为30min,次日均可以正常阅读.(2)最大睫状肌麻痹时平均剩余调节力:1%阿托品组(2.0440±0.95484)D,罗米组(2.2214±0.6952)D,美多丽P组(2.6656±0.9999)D.两独立样本t检验前两组无显著差异,美多丽P组与前两组差异显著,尤其近视时剩余调节力偏大.(3)三组剩余调节力均与屈光状态及年龄无关.(4)1%阿托品、罗米、美多丽P三组中每组药物最大睫状肌麻痹后,综合验光仪验光、视网膜检影结果无差别,都能达到主、客观验光结果的一致性.结论 罗米滴眼液、美多丽P滴眼液在临床上可以作为近视及远视验光的有效睫状肌麻痹剂.     

不同睫状肌麻痹剂对儿童调节力及屈光状态的影响

Objective To find out the longest effective duration of Mydrin P and Romi eyedrop on cycloplegia,compare the residual accommodation after cycloplegia by Mydrin P eyedrop, 1% Atropine paste and Romi eyedrop, analyze their effect on ametropia. To provide some experimental basis for using cycloplegia adeptly in clinic. Methods Seventy-five children (147eyes) were checked, 4～16 years old with, mean age of 10.12 years old. There are no systemic diseases. The patients were divided into 3 groups: A, 1% Atropine group; B,Romi eyedrop group and C,Mydrin P group. Before and after administration of these eyedrops,ob-jective refraction was checked in hand-hold auto refractor; subjective refraction was checked in phoropter,and retinoscopy refraction was finished. Phoropter was used to check the accommodation response and the residual accommodation respectively by "pushup" method. Results (1)In Romi eyedrop group,the time of maxi-mum cycloplegia was 60 minutes,the patients can read in the next day; in Mydrin P group,the time was 30 minutes, can read next day. (2) Average residual accommodation at the maximum cycloplegia: A, 1% Atropine group (2.0440±0.95484D),B,Romi eyedrop group (2.2214±0.6952D),C,Mydrin P group (2.6656±0.9999D). The residual accommodation in Romi eyedrop and Atropine groups had no significant difference, In-dependent-samples t Test P 0.05.The residual accommodation in Mydrin P group was stronger than the other two groups,more significant in myopia eyes. (3) The residual accommodation of three groups had no relation-ship with age and refractive status. (4) The results were same in cycloplegic refraction with hand-hold auto re-fractor and phoropter of each group of A, 1% Atropine group,B,Romi eye, drop group and C,Mydrin P group (P 0.05). The difference was 0.33D in autorefraction and phoropter,autorefraction negative. Conelusions (1) The time of maximum cycloplegia effective of Romi eye-drop was 60 minutes, of Mydrin P was 30 min-utes. (2) The residual accommodation in Romi eyedrop and Atropine groups was almost same, the residual ac-commodation in Mydrin-P group was stronger than the other two groups,more significant in myopia eyes. (3)Residual accommodation. Three groups have no relationship with age and refiaction. (4) Romi eyedrop and,Mydrin-P eyedrop can be used in the cycloplegic refraction for children in myopia and hyperopia.     

Effect of ifenprodil on ocular tissue circulation in rabbits.

Ifenprodil tartrate has long been employed as a cerebral vasodilator with alpha and N-methyl-D-aspartate (NMDA) receptor antagonistic activities. The purpose of this study was to evaluate the effects of ifenprodil on ocular circulation in rabbits. Experiments were performed during the dark phase in Dutch rabbits conditioned to a schedule of alternating 12-hr periods of light and dark. Effects on ocular tissue blood velocity were estimated using the laser speckle method in the iris, posterior choroid, and optic nerve head (ONH). Measurements of tissue blood velocity were performed both after intravenous injection of ifenprodil at a dose of 0.2 mg/kg, 0.1 mg/kg, and the same volume of the vehicle, and after topical instillation of 0.5% ifenprodil (50 microl) twice daily for 1, 3 and 20 days unilaterally in a masked manner. Intraocular pressure (IOP) was also measured during the experimental period. Intravenous administration of ifenprodil caused a significant increase in blood velocity in the ONH, choroid, and iris, but ONH circulation was affected at a lower dose than uveal circulation. In the topical instillation experiment, IOP in the ifenprodil-treated eye was significantly lower, by approximately 2 mmHg, than that in the contralateral eye when the laser speckle measurement was performed. Twice-daily, unilateral 0.5% ifenprodil instillation significantly increased blood velocity in the iris after 3 days and that in the ONH and posterior choroid after 20 days in the treated eye. Topical 0.5% ifenprodil increased blood velocity in the iris, posterior choroid, and ONH after multiple dosings. After systemic administration, ONH circulation appeared to be influenced at a lower dose than was uveal circulation.     

The pharmacology of cycloplegics

A brief review of the pharmacological action of cycloplegic drugs is followed by a specification of the doses and actions of five commonly used cycloplegics. Some criterion for selecting a cycloplegic are presented.     

The effect of interleukin-1 on ocular inflammation in rabbit ocular tissue

IL-1 (Interleukin-1) has attracted attention not only as a mediator of the immunological response but as a substance involved in acute and chronic inflammatory responses. The author induced endophthalmitis by intravitreous injection of IL-1 into rabbit eyes. The inflammation model was characterized by the indicators of aqueous humor protein and PGE2 levels, and IL-1 and PAF were investigated as possible mediators of inflammation in IL-1 induced endophthalmitis. A prostaglandin (PG) synthetase inhibitor suppressed both the protein level and PGE2 level, while a PAF antagonist acted to inhibit the increase in the protein level in aqueous humor but did not inhibit the rise in PGE2. Combined administration of the PAF antagonist and the PG synthetase inhibitor further reduced both the protein and PGE2 levels. These findings suggest that PAF may be a mediator of endophthalmitis due to IL-1, and that IL-1 induced endophthalmitis is also modified by other factors in addition to PAF.     

新型医用黏合剂治疗角膜穿通伤对眼前节的影响

目的探讨医用组织黏合剂治疗角膜穿通伤对眼前节的刺激反应,及对角膜内皮细胞和血-房水屏障功能的影响。方法 20只日本大耳白兔建立角膜穿通伤模型,右眼采用医用胶黏合、左眼采用缝线缝合术,术后大体观察兔眼前节情况;角膜共聚焦显微镜观察角膜内皮细胞形态和密度变化,抽兔眼房水行房水蛋白含量测定,透射电镜观察内皮细胞超微组织结构变化。结果术中和术后各时间点医用胶组和缝线组角膜伤口均密闭。两组术后不同时间点角膜共聚焦显微镜观察角膜穿通伤口周边内皮细胞形态和密度无明显差异。房水蛋白含量在术后7d均为最高,医用胶组和缝线组分别为(0.561±0.284)g·L-1、(0.523±0.303)g·L-1,随伤口愈合术后90d恢复正常,各观察时间点两组间差异均无统计学意义(均为P>0.05)。透射电镜观察角膜内皮细胞示:术后14d细胞超微结构基本正常,两组均可见细胞内少量粗面内质网扩张,空泡稍增多,线粒体肿胀;术后30d均恢复正常。结论医用组织黏合剂治疗角膜穿通伤口组织相容性好,对眼前节无明显刺激反应和异物反应。     

曲安奈德注射剂对眼组织的毒性作用

曲安奈德用于玻璃体腔注射治疗眼底病，体外细胞培养实验发现常规治疗剂量的商用曲安奈德注射剂对人视网膜色素上皮细胞具有抑制作用，而去除载体后抑制作用明显下降。动物实验显示使用4mg以上的曲安奈德会出现剂量依赖性的外层视网膜改变。曲安奈德的毒性作用呈现局灶性。除视网膜外，曲安奈德注射剂对晶状体、小梁网和角膜内皮细胞也有不同程度的影响。但亦有部分研究认为曲安奈德对眼组织无毒性作用。实验动物、曲安奈德注射剂量及半衰期、防腐剂来源等因素的不同可能是造成结论相悖的原因。