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IntroductionCognitive disorders such as deficit of attention and executive and visuoconstructive dysfunctions occur in Parkinson's disease dementia (PDD). Memory impairment is not an early feature and statement not well delimited.Case reportA 78-year-old man with PDD underwent neuropsychological assessment and moreover demonstrated memory decline. After death, pathology examination of the brain and immunohistochemy analysis confirmed PD and showed Lewy body pathology (LBP) in the insula, limbic and especially in CA3 hippocampus areas. Hippocampus and gyrus parahippocampic also exhibited neurofibrillary tangles. Lack of senile plaque and lack of beta A4 amyloid deposition were noticeable in the whole brain examination.ConclusionSevere executive dysfunctions are probably related to LBP and dysfunction in memory process may be related to DNF lesions in medial temporal area. 相似文献
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J.-P. Brandel D. Salomon I. Capek V. Vaillant A. Alpérovitch 《Revue neurologique》2009,165(8-9):684-693
IntroductionTransmissible spongiform encephalopathies (TSE) have been under epidemiological surveillance in France and in Europe since the early 1990s. The observation of iatrogenic Creutzfeldt-Jakob disease (CJD), the outbreak of bovine spongiform encephalopathy (ESB) and its probable transmission to many species gave rise to the surveillance which remains warranted by the emergence of a variant of CJD (vCJD), in 1996.State of artIn France, epidemiological surveillance is coordinated by the InVS which receives input from cases notifications addressed to INSERM Unit 708 directly by clinicians or more often following requests for 14-3-3 detection in CSF. All suspected cases are followed up until a final diagnosis is established. Thanks to the effectiveness of the French network of neuropathology, autopsies are performed in more than half of patients who die with a diagnosis of suspected CJD. Diagnostic criteria allow comparison of the incidence of the different forms of the disease in all countries with a system of surveillance. Sporadic CJD is the most frequent form of the disease with more than 80% of the cases. Its origin remains unknown. To date, cases of iatrogenic CJD referred to the French surveillance network have been caused by dura mater grafts or human growth hormone treatments administrated in the 1980s. Ten percent of TSE are of genetic origin with an autosomic dominant transmission of a mutation or an insertion located on the PRNP gene. The most recent form of the disease is vCJD which is a new form, first described in the United Kingdom in 1994.Prospect and conclusionActive epidemiological surveillance remains a timely issue, particularly in France, because of the development of new cases of iatrogenic CJD after human growth hormone treatment. It is of importance in France and worldwide because of the emergence of post-transfusional cases of vCJD and the possible appearance of vCJD in persons with valine-valine or methionine-valine genotypes at codon 129. 相似文献
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Jean-Luc Rinaudo 《L'évolution Psychiatrique》2018,83(3):427-434
Objectives
The aim of this paper was to analyze the experiences of students to whom a telepresence robot was made available in periods during which they were prevented from attending university courses.Methods
This research uses a psychopathological approach to everyday virtual life. At the end of the period of use of the robot, non-directive research interviews were conducted with the students.Results
The analysis shows that the device can be experienced by these students as a potential space of subjectivation because it appears to help avoid a possible collapse and thus facilitates the mobilization of psychic elements that were not previously elaborated.Discussion
The robot is experienced as the possibility of an augmented body, and, beyond, of an augmented subject into which the students project a part of themselves, enabling a subjective appropriation of the self via a mirror effect. Finally, it is important to recall that this device is used within an educational program. Any educational or learning process upsets references, as for an adolescent experiencing the changes that affect him. The role of peers is important in sustaining a sense of permanence of identity.Conclusion
There is thus the possibility of a space of intersubjectivation enabling the construction of the link on three levels: the subjectivation of the absent subject represented by the avatar-robot; the subjectivation of the subject's peers; the internal links of the group. 相似文献18.
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Prof. Dr. Ch. Kayser 《Journal of neural transmission (Vienna, Austria : 1996)》1962,24(1-4):457-491
Sans résuméAvec 21 FiguresNo type of sensation is understood by physiologists or psychologists. If the study of feeding is postponed until the nature of sensation is clarified, we shall have long time to wait, indeed. (J. R. Brobeck, 1957) 相似文献