尖锐湿疣患者合并解脲支原体沙眼衣原体和淋球菌感染的结果 …

对６５例确诊的尖锐湿疣患者，用ＰＣＲ法检测其泌尿生殖道的淋球菌、沙眼衣原体、解脲支原体。结果显示６５例患者中，有３５例合并淋球菌和（或）沙眼前原体、解脲支原体感染、合并单一病原体感染者２５列，合并两种病原体混合感染者１０例。３５例合并感染者中，男１２例，女２３例。提示ＳＴＤ患者易合并（两种或两种以上）病原体感染、ＳＴＤ患者应进行全面的病原菌检查，以尽早发现隐慝性感染，及时进行针对性治疗。     

PCR检测164例STD患者5种常见病原体结果

ＰＣＲ检测１６４例ＳＴＤ患者５种常见病原体结果黄干军近年来我们用聚合酶链反应（ＰＣＲ）对１６４例性传播疾病（ＳＴＤ）患者进行了淋球菌（ＧＣ）、沙眼衣原体（ＣＴ）、解脲支原体（ＵＵ）、人类乳头瘤病毒（ＨＰＶ）和单纯疱疹病毒（ＨＳＶ）的ＤＮＡ检测，现报告...     

287例男性泌尿生殖道感染病原体分析

为进一步了解目前我国男性泌悄生殖道感染的病因，利用细菌培养、解脲支原体培养、免疫荧光检测沙眼衣原体等方法，对２８７例男性泌尿生殖道感染患者进行病原体检测。结果２８２例检出病原体，其中淋球菌７８例（２７．６５％），解脲支原体４９例（１７．３７％），沙眼衣原体４５例（１５．９５％），较国内其它报道少；而非特异性细菌感染物别是在慢性前列腺炎中增加，尤以金黄色葡萄球菌为甚，共９８例，占病例总数的３４．７５     

323例泌尿生殖道衣原体感染合并淋菌及支原体分析

沙眼衣原体(CT)是引起非淋菌性尿道炎(NGU)及女性生殖系统感染的主要病原体。为了解沙眼衣原体合并淋球菌、支原体感染情况，我们于1997年6月～2002年9月，对于确诊为沙眼衣原体感染患者同时进行淋球菌(NG)、解脲支原体(UU)、人型支原体(MH)的检测，有完整资料共323例，结果报告如下：     

阿奇霉素治疗无并发症泌尿生殖道衣原体及支原体感染

我们用阿奇霉素（Ａｚｉｔｈｒｏｍｙｃｉｎ）治疗泌尿生殖道的沙眼衣原体（ＣＴ）、解脲支原体（ＵＵ）感染的非淋菌性尿道炎（ＮＧＵ）,并与美满霉素作为对照,现将结果报告如下：１病例选择：选择沙眼衣原体荧光抗体检测阳性,解脲支原体培养阳性,未合并其他ＳＴＤ...     

尖锐湿疣合并其他性病病原体感染临床分析

为了探讨尖锐湿疣（CA）患者合并感染其他性病病原体的情况，2001年6月～2003年6月，我们对99例临床资料完整，并且经5％醋酸白试验确诊为CA的患者，同时进行了淋球菌（NG）、沙眼衣原体（Ct）和解脲支原体（Uu）的检测，现将其合并感染其他病原体的检测结果报道如下。     

上海地区非淋菌性尿道炎宫颈炎的病原学调查研究

对上海地区１１２４例性病门诊患者进行沙眼衣原体、解脲支原体及淋球菌的检测，证实其中４９１例有６２３株不同病原微生物引起的感染。病原中沙眼衣原体、解脲支原体和淋球菌分别占患者总数的１５．７％（１７７／１１２４）、２７％（３０４／１１２４）和１２．６％（１４２／１１２４）。约９０％的病原阳性患者为２１～４０岁。淋病患者中５０％为２种以上病原的混合感染。本文就病原检出的有关因素等问题进行了探讨。     

男性泌尿生殖道淋球菌,沙眼衣原体和解脲支原体混合感染的临床分析

对１９９３年￣１９９６年间的２１９７例男性由性病引起的尿道炎患者进行淋球菌、沙眼衣原体和解脲支原体检测，并对混合感染情况进行分析。结果表明：２１９７例患者总的混合感染率为２１．８％（４７８／２１７９），其中，淋球菌混合感染率为４４．２％，沙眼衣原体为４４．７％，解脲支原体为５８．８％；混合感染特别是解脲支原体的混合感染，在近１￣２年增长迅速，而且９０．３％发生在２０￣４０岁年龄组。提示对性病引起的     

老年妇女性传播疾病病原体检测分析

目的了解老年妇女性传播疾病病原体感染情况。方法对患者分别进行淋球菌、沙眼衣原体、解脲脲原体、人型支原体、滴虫和念珠菌检测。结果386例患者共检出淋球菌3例(0.78%)、沙眼衣原体6例(1.55%)、解脲脲原体107例(27.72%)、人型支原体4例(1.04%)、滴虫19例(4.92%)、念珠菌63例(16.32%),其中解脲脲原体和念珠菌阳性率均明显高于健康对照组,经χ2检验,差异具有显著性(P<0.01)。结论老年妇女性传播疾病病原体以解脲脲原体为主,念珠菌亦是常见的主要病原体之一。     

1063例STD门诊患者解脲支原体、沙眼衣原体与淋球菌感染情况分析

目的了解本地区STD门诊患者的解脲支原体、沙眼衣原体和淋球菌的感染情况。指导临床诊断、用药。方法采集女性宫颈口分泌物、男性尿道口分泌物分别做淋球菌培养、沙眼衣原体抗原检测和解脲支原体培养。结果1063例STD门诊患者中查出单一淋球菌感染208例,单一衣原体感染172例,单一解脲支原体感染358例,支原体、衣原体混合感染53例,淋球菌、支原体混合感染68例,淋球菌、衣原体感染60例,淋球菌、衣原体、支原体三重感染5例。结论混合感染率比较高,混合感染女性明显高于男性,支原体感染女性明显高于男性。     

性病患者中输血传播病毒的检测及其传播途径

目的 探讨输血传播病毒(transfusion transmitted virus,TTV)在性病(STD)患者中的感染状况及经性传播的可能性。方法 调查性病患者的性行为相关因素及应用巢式聚合酶链反应(nested-PCR)检测237例STD患者和80例健康体检正常人的血清TTVDNA。结果 ①STD患者和正常人的血清TTVDNA阳性率分别为19.41%(46/237)和2.5%(2/80),前者TTVDNA的阳性率明显高于后者(P<0.005)。②STD患者男性与女性TTVDNA的阳性率分别为20.59%和17.82%,两者之间差异无显著性(P>0.05)。③不同STD病种患者中以梅毒、生殖器疱疹以及梅毒合并非淋球菌性尿道炎(NGU)和尖锐湿疣(CA)、生殖器疱疹合并NGU患者的TTVDNA的阳性率较高,分别为29.41%、30.43%、33.33%、42.86%、33.33%,而NGU患者的TTVDNA阳性率(10.87%)较低。④28对(56例)STD患者配偶TTVDNA阳性率为28.57%(16/56),11对(22例)正常人配偶TTVDNA的阳性率为4.55%(1/22),两者之间差异有显著性(P<0.05)。⑤TTVDNA阳性组和阴性组的STD患者嫖娼大于半年以上者的人数分别为21例和9例(P<0.005),性伴平均人数分别为17.12和7.86(P<0.001)。结论 STD患者中存在严重的TTV感染;嫖娼的时间越长,性伴数越多,感染TTV可能性越大,提示性传播可能是TTV感染途径之一。     

性病与HIV感染者中HSV2、HBsAg和HCV的检测

目的 比较性病患者和HIV感染者血清中单纯疱疹病毒(HSV)、乙型肝炎病毒(HBV)及丙型肝炎病毒(HCV)的感染情况,为采取综合性的防治方案提供参考依据。方法 对经蛋白印迹法确证的HIV(+)/AIDS库存血清标本和梅毒、淋病及衣原体感染患者血清标本,用ELISA方法同时检测HSV2-IgG、HSV2-IgM、HBsAg和HCV-IgG4项指标,并对2组标本的检测结果进行比较。结果 在76份性病样品中,检出HSV2-IgG24例占31.58%;HSV2-IgM1例占1.32%;HBsAg8例占10.53%和HCV1例占1.32%。在另外分组的14例HIV阳性标本中,检出HSV2-IgG7例占50.00%;HSV2-IgM5例占35.71%;HBsAg8例占57.14%和HCV3例占21.43%。在总共90份标本中,有6例标本同时检测到HSV和HBV;2例标本同时检出HSV-IgM和HBV;2例同时检出上述4项指标。统计分析发现,HIV(+)/AIDS组中HSV、HBV和HCV的检出率明显高于性病组(P<0.05)。结论 HIV(+)/AIDS患者中合并HSV、HBV及HCV的感染率明显高于其他性病患者。     

性病门诊人乳头瘤病毒感染的流行病学调查

目的：了解性病门诊就诊者中人乳头瘤病毒（human papillomavirus,HPV）及其它性传播疾病（sexuallytransmitted disease,STD）病原体混合感染的流行情况。方法：对90例临床样本采用聚合酶链反应（polymerase chain reac-tion,PCR）技术检测尿道或宫颈拭子HPV DNA,同时检测其它STD病原体。结果：在90例就诊者中,HPV DNA阳性13例（14.4%）,女性、混合感染数多者及教育程度低者HPV感染率高（P〈0.05）,HPV感染者至少同时伴有1种其它STD病原体感染。结论：HPV在性病门诊就诊者中存在一定的感染率,HPV感染与性别、混合感染数、教育程度等相关,HPV与其它STD病原体的混合感染多见。     

性传播疾病病原检测方法的比较研究

目的回顾总结本科性病门诊的性传播疾病的流行病学资料,比较万倍显微镜与C learview快速诊断试剂盒检测、分离培养及染色涂片检测的检出符合率。方法回顾性调查本科性病门诊自应用万倍显微镜以来的所有病例,分别选取30例患者与C learview快速诊断试剂盒检测、分离培养及染色涂片检测结果进行比较。结果单发性病中以非淋菌性尿道炎菌性尿道炎、淋病、梅毒为主,其发病率分别为38.49%,16.17%和11.83%,其中男性分别为38.00%,16.96%和11.43%;女性分别为39.78%,14.36%和12.64%。复合感染中以淋病合并非淋菌性尿道炎菌性尿道炎为多(1 0.4 4%),其次是非淋菌性尿道炎菌性尿道炎合并梅毒(4.3 9%),非淋菌性尿道炎菌性尿道炎合并生殖器疱疹(2.17%)。万倍显微镜与C learview快速诊断试剂盒检测、分离培养及染色涂片检测的检出符合率达90%以上。结论万倍显微镜具有操作简单,监测范围广、检出率高、费用低等优点,适用于性病门诊对性传播疾病的快速准确诊断。     

HIV感染者53例皮肤黏膜疾病和性传播疾病的临床分布

目的探讨贺州市53例HIV感染者皮肤黏膜疾病及性传播疾病的病种分布、临床表现以及经性途径感染艾滋病变化的特点。方法回顾分析53例HIV感染者在门诊就诊期间皮肤黏膜及性传播疾病的种类、特征及实验室检查资料。结果 HIV感染者传播途径以性传播者占84.91%;皮肤黏膜损害复杂,以真菌、病毒感染等为主;疾病种类依次为性病、带状疱疹、湿疹、银屑病、泛发体癣等8种;有2种以上皮肤黏膜疾病者8例(15.09%);性传播疾病以早期梅毒为主13例(24.53%)。结论 HIV感染者皮肤黏膜损害以真菌、感染最多,性传播途径是HIV感染的主要途径之一,泛发的皮肤黏膜病变和合并性病感染可作为诊断HIV感染的依据之一。     

Serological study for sexually transmitted diseases in patients attending STD clinics in Calcutta

Total 457 patients attending different STD clinics of Calcutta were studied for serological tests for STD. TPHA positivity was maximum (18.60%), followed by chlamydia infection (15.97%), VDRL reactivity (8.98%), HIV infection (6.35%), and HBs Ag (3.72%). Total 37.20% samples were positive for one or more infection. Out of these, one, two, three and four tests positivity was seen in 65.29%, 25.88%, 8.24% and 0.59% respectively. The age group which had maximum infection (20.13%) was 15-30 years.     

珠海市皮肤性病专科门诊就诊人群7种性传播疾病感染分析

目的了解珠海市皮肤性病专科门诊就诊人群性传播疾病(STD)的感染情况,为临床性病的防治提供实验室依据。方法选取珠海市慢性病防治中心2015年至2017年皮肤科、性病科和妇科诊治患者,对沙眼衣原体(CT)、解脲支原体(UU)、人型支原体(MH)、梅毒(TP)、念珠菌(CA)、淋病奈瑟菌(NG)和人类免疫缺陷病毒(HIV)7种病原体(抗体)阳性率情况进行分析,统计分析剔除阳性复诊患者,同时统计分析混合感染和反复感染情况。结果3年共有6862人进行STD不同项目检查,7种病原体检测共有14828项,阳性1963项(13.2%),CT、NG、TP、HIV、UU、MH和CA病原体阳性率分别为14.2%、23.6%、11.1%、2.9%、31.9%、4.8%和17.3%,3年间STD病原体阳性率差异无统计学意义(P>0.05)。不同科室中,妇科送检病原体阳性率最高,为19.2%;不同性别中,女性患者的病原体总阳性率为19.3%,男性为9.8%,两者差异具有统计学意义(P<0.05),但男性CT、NG和HIV阳性率高于女性。患者混合感染率为2.5%,男性混合感染比女性高,但女性反复感染率高于男性。结论专科门诊就诊者7种病原体阳性率较高,女性病原体总阳性率高于男性,女性支原体、念珠菌反复感染现象较普遍,男性泌尿生殖道支原体和念珠菌感染应受到重视。加强对该类人群的性传播疾病的健康教育,引导就诊者进行STD联合筛查,对性传播疾病的防控具有重要意义。     

Sentinel surveillance of human immunodeficiency virus infection in sexually transmitted disease clinics in the United States.

From April 1988 through December 1989, sera obtained for syphilis testing from consecutive patients attending 98 sexually transmitted disease (STD) clinics in 37 metropolitan areas were tested for antibodies to human immunodeficiency virus (HIV) in an unlinked (blinded) survey. HIV seroprevalence in STD clinics ranged from 0 to 38.5% (median, 2.3%), with the highest rates found in the Mid-Atlantic states, Florida, and Puerto Rico. The highest median rates were found in men who have sex with men (36.1%) and heterosexual intravenous (IV) drug users (4.1%). For heterosexual persons who do not report IV drug use, median rates were highest in the 35- to 39-year-old age group for men (6.4%) and the 30- to 34-year-old age group for women (0.9%). Among persons who do not report risk behaviors for HIV infection, men had substantially higher median rates of HIV infection than women (P less than 0.001, Wilcoxon Signed Rank test), and rates were positively correlated with HIV infection rates in IV drug users in the same clinic (Pearson correlation coefficient [r] = 0.8; P less than 0.001). Among heterosexual STD clinic patients who do not report IV drug use, the median HIV infection rate for blacks (1.8%) was at least 2 times higher than the median infection rates for hispanics (0.9%) and whites (0.7%). The results of this study show that HIV infection in STD clinic patients varies by geographic area, sex, race and ethnic group, and risk behavior.(ABSTRACT TRUNCATED AT 250 WORDS)     

Epidemiologic characteristics of two different populations of women with Chlamydia trachomatis infection and their male partners.

Two groups of women under the age of 26 with chlamydial infection (A-asymptomatic women from a screening program, B-traditional STD clinic patients) and their partners were compared with respect to history of STD, sexual behavior, contraception, and indices for income and social welfare expense. The mean number of partners was 1.3 in group A and 1.8 in group B. Women in group B, in spite of more frequent condom use, demonstrated greater risk behavior both with respect to STD and to unwanted pregnancy and also had higher indices for social welfare expense. More group A partners than group B partners were asymptomatic and chlamydia negative. Group B partners also more often had low income as well as high social welfare expense indices. In both groups, complicated chains of transmission were found, and the need for expert contact tracing in both types of patient groups is stressed.     

Papillomavirus infection among abortion applicants and patients at a sexually transmitted disease clinic.

The base-line prevalence of human papillomavirus (HPV) infection among applicants for first trimester induced abortion and among a sexually transmitted disease (STD) clinic population with macroscopically visible condyloma is investigated. Cervical cells were collected from 505 women applying for induced abortion. Cell scrapes were obtained from the surface of the warts from 81 female and 32 male STD patients. HPV DNA 6/11, 16/18, and 31/33/35 were detected by a dot blot technique (ViraPap and ViraType, Life Technologies, Gaithersburg, MD). Of the 505 abortion applicants, 31 (6.1%) had HPV DNA. In the STD population, 64 (79.0%) patients had positive test results for HPV DNA from cervical, introital cell scrapes, or both. Of the 32 male STD patients from whom preputial, urethral samples, or both were taken, 24 (75%) had HPV DNA. After typing, the relative proportion of HPV 6/11 was 9.7% in abortion applicants, 72.2% in female STD patients, and 91.3% in male STD patients. The relative proportion of high-risk HPV types, such as 16/18 and 31/33/35, was 89.7% among abortion applicants, 38.9% among female STD patients and 13.0% among male STD patients. The majority of abortion applicants infected with HPV were thus infected with a potentially oncogenic HPV type, and the prevalence of HPV type 16/18 and 31/33/35 was also high among female STD patients.