西帕依固龈液治疗青春期牙龈炎的临床疗效评价

目的 评价西帕依固龈液体防治青春期牙龈炎的临床疗效.方法 将80例青春期牙龈炎患者随机分成实验组30例、对照组30例及空白组20例,分别使用西帕依固龈液、复方氯己定含漱液及生理盐水,嘱患者含漱5ml/次,3 min/次,3次/d,使用2周.观察患者的牙龈指数(gingival index,GI),龈沟出血指数(sulcus bleeding index,SBI),菌斑指数(plaque index,PLI).结果 2周后实验组和对照组患者的GI,SBI,PLI均有明显改善(P＜0.05),空白组无显著变化.对照组的不良反应发生率为16.7％,实验组和空白组无不良反应.结论 西帕依固龈液能降低GI,SBI,PLI指数,改善牙龈症状,且不良反应发生率低,对青春期牙龈炎有一定的治疗效果.     

西帕依固龈含漱液治疗慢性牙龈炎的临床效果观察

目的：观察西帕依固龈含漱液治疗慢性牙龈炎的临床疗效.方法：选取慢性牙龈炎患者150例作为研究对象,随机分研究组和对照组.研究组使用西帕依固龈含漱液,对照组使用朵贝氏液含漱.对比两组病例牙龈充血水肿改善情况,龈沟出血指数以及菌斑指数的变化情况.结果：研究组治疗后牙龈指数临床总有效率92％,龈沟出血有效率88％,菌斑指数有效率80％,均优于对照组的80％、72％和64％,两组比较差异具有统计学意义（P＜0.05）.结论：西帕依固龈含漱液治疗牙龈炎疗效较好、较安全,有较好的临床应用前景.     

西帕依固龈液治疗牙龈炎引起的牙龈出血的疗效观察

目的观察西帕依固龈液治疗因牙龈炎引起牙龈出血的效果,为临床治疗提供参考。方法选取2008年6月～2009年3月因刷牙出血来我科就诊的患者,诊断为牙龈炎者125例,男72例,女53例,年龄18～60岁。主要症状为牙龈炎症,探诊出血,牙周袋≤3mm,无附着丧失。将患者随机分成2组,实验组64例,使用西帕依固龈液含漱,对照组61例,使用口泰含漱液;使用方法均为每日3～5次,每次3～5ml,含漱1min,漱后均不再用清水漱口,漱口0.5h内勿饮水和进食;使用4周复查,记录龈沟出血指数情况。评定疗效。采用卡方检验进行统计学分析。结果实验组64例,有效56例,无效8例,有效率为87.5%;对照组61例,有效46例,无效15例,有效率为75.4%。组间有效率差异无统计学意义（P〉0.05）。结论西帕依固龈液对治疗因牙龈炎引起的牙龈出血有一定的疗效,具有较好的临床推广价值。     

西帕依固龈液治疗慢性牙周炎的疗效观察

西帕依固龈液由没食子制成,主治牙周疾病引起的牙齿酸软,咀嚼无力,松动移位,牙龈出血等[1]。本试验通过对92例分别使用西帕依固龈液和口泰的慢性牙周炎病人的牙周状况检查,旨在了解西帕依固龈的临床疗效。     

西帕依固龈液治疗急性放射性口炎疗效观察

目的观察西帕依固龈液治疗急性放射性口炎的临床疗效。方法选取口腔及鼻咽癌患者放疗过程中出现急性放射性口炎患者70例,随机平均分为2组。实验组使用西帕依固龈液,对照组使用稀释后的复方硼砂液含漱治疗,含漱时间为晨起、3餐后清洁口腔后及临睡前,每次5～10ml,含漱2～3min,共使用2周;对2种药物的治疗效果进行比较。结果使用西帕依固龈液治疗急性放射性口炎35例,有效30例,有效率85.71%;使用复方硼砂液治疗35例,有效15例,有效率为42.86%;西帕依固龈液疗效明显优于复方硼砂液（P〈0.001）。结论西帕依固龈液对治疗急性放射性口炎具有较好的临床效果。     

西帕依固龈液用于治疗口腔疾病中的研究现状

口腔是一个复杂的环境,其中的多种细菌及其代谢产物可以原发或继发引起多种口腔疾病。西帕依固龈液在药理及临床实验中均表明有明显的抗菌、消炎、镇痛及抑制自由基等作用,并具有清洁口腔和除臭之功效,可应用于多种口腔疾病的辅助治疗。该文就西帕依固龈液用于治疗口腔疾病的研究现状作一综述。     

西帕依固龈液治疗复发性口腔溃疡的疗效观察

复发性口腔溃疡(ROU)治疗方法虽多,但疗效均不太理想。我科用西帕依固龈液治疗160例ROU患者,并对其临床疗效进行统计学分析,观察其对局部疼痛的缓解情况及对受损黏膜的修复促进作用。1资料和方法1.1一般资料收集我科门诊确诊为ROU的患者160例,年龄16～60周岁,男70例,女90例。纳     

西帕依固龈液治疗口臭随机对照试验的Meta分析

目的:系统评价西帕依固龈液治疗口臭的临床疗效.方法:计算机检索美国图书馆PubMed/MEDLINE、CNKI中国知网(总库)、维普期刊资源整合服务平台相关文献.根据Jadad量表对纳入文献进行质量评价.采用Cochrane协作网提供的RevMan 5.3分析软件进行Meta分析.结果:共纳入8项临床随机对照研究(RCT)、608例有口臭症状患者.依据Meta分析结果,西帕依固龈液与安慰剂比较治疗口臭的评分(organoleptic score,OS)[WMD=-0.43,95％ CI(-0.57,-0.29)]、菌斑指数(plaque index,PLI) [WMD=-1.59,95％ CI(-1.67,-1.51)]均显示有显著差异;西帕依固龈液与西药比较治疗口臭OS[WMD =0.16,95％ CI(0.05,0.28)]效果略差且降低PLI[WMD=0.10,95％ CI(0.03,0.18)]的抑菌效果也略差.西帕依固龈液与生理盐水治疗口臭临床总有效率差异有统计学意义[RR:1.64,95％CI(1.11,2.42)].结论:西帕依固龈液治疗口臭疗效优于安慰剂,可有效降低口臭值和菌斑指数,与西药相比降低口臭值、抑菌方面稍显欠缺.     

西帕依固龈液合剂治疗复发性阿弗他溃疡的疗效研究

按照阿弗他溃疡诊断标准选取病例100 例,随机分为试验组和对照组各50 例,试验组用西帕依固龈液合剂,对照组用复方氯已定含漱液治疗,疗程7 d.结果表明西帕依固龈液合剂治疗轻型阿弗他溃疡有效率高于复方氯已定.     

西帕依固龈液和没食子体外抗白色念珠菌的活性测定

目的：体外观察西帕依固龈液和没食子对白色念珠菌的作用,并对二者的抑菌和杀菌效果进行评价。方法：采用常量肉汤稀释法,检测西帕依固龈液和没食子的抑菌和杀菌效果。结果：西帕依固龈液对白色念珠菌的最低抑菌浓度（MIC）为5mg/ml,最低杀菌浓度（MBC）为10mg/ml;没食子提取液对白色念珠菌的最低抑菌浓度（MIC）为25mg/ml,杀菌浓度（MBC）为50mg/ml。结论：没食子提取液和西帕依固龈液在体外均具有一定的抗白色念珠菌活性。     

A three-year prospective study of adult subjects with gingivitis. I: clinical periodontal parameters

AIM: The objective of this study was to monitor prospectively clinical parameters in subjects without signs of destructive periodontal disease who were involved in a primary prevention programme, and to determine the changes that occurred between yearly examinations over a 3-year period. MATERIAL AND METHODS: One hundred and twenty-six subjects aged at least 20 years with a maximum of two tooth sites with probing pocket depth (PPD)>4 mm and no proximal sites with clinical attachment loss participated in the study. Primary prevention was provided at baseline of the study and then every 6 months. Plaque, bleeding on probing (BoP) and PPD were scored at baseline, 1, 2 and 3 years. RESULTS: There were no significant changes in the plaque score over the 3 years. After year 1, the BoP score was significantly improved with 5.6%, while no further improvement in BoP was found at years 2 and 3. The mean PPD decreased from 2.3 to 2.1 mm over the 3 years (p<0.05). CONCLUSION: Although some individuals exhibiting minor signs of periodontal pathology may have benefited from the primary prevention, the overall clinical improvement was limited for such subjects in the present 3-year study.     

A controlled 6-month clinical trial to study the effects of a stannous fluoride dentifrice on gingivitis

OBJECTIVES: This study was conducted to assess anti-plaque and anti-gingivitis benefits of a stabilized stannous fluoride (SnF(2))/sodium hexametaphosphate (SHMP) dentifrice versus a negative control. MATERIAL AND METHODS: This was a randomized, 6-month, stratified, single-centre, double-blind, parallel group, clinical study conducted in harmony with the guidelines for evaluating chemotherapeutic products for the control of gingivitis outlined by the American Dental Association. A stabilized 0.454% SnF(2)/SHMP dentifrice was tested against a commercially available negative control dentifrice. Following baseline measurements, subjects received a dental prophylaxis. Subjects were instructed to brush twice daily for 60 s using their assigned product. Efficacy measurements were obtained at baseline, 3 and 6 months post treatment using the Modified Gingival Index, Gingival Bleeding Index and the Turesky Modified Quigley-Hein Plaque Index. Oral tissue examinations were performed at all visits. Results: A total of 140 subjects were enroled and 128 completed the study. RESULTS after 6 months showed the SnF(2) dentifrice delivered a 16.9% reduction in gingivitis (p<0.001), a 40.8% reduction (p<0.001) in gingival bleeding, and an 8.5% reduction in plaque (p=0.001) versus the negative control. Both treatments were well tolerated. CONCLUSIONS: Twice daily use of the SnF(2)/SHMP dentifrice over 6 months provided statistically significant anti-plaque and anti-gingivitis benefits relative to a negative control.     

Some effects of mouthrinses containing salifluor on de novo plaque formation and developing gingivitis

Abstract Three clinical trials were carried out to evaluate the effects of mouth-rinses containing 5n-oetanoyl-3’trifluormethylsalieylanilide (salifluor) on plaque and gingivitis. Each trial was performed as a double-blind, randomised and cross-over designed study (studies 1. 2 and 3). In each study, 10 young individuals with healthy gingiva abolished all means of mechanical plaque control during the course of the experimental period including 6 × 4 days (study 1), 3 × 18 days (study1) and 3 × 14 days (study 2). They rinsed, 2 × daily, with various mouthwash preparations for 4 days (study 1), for the last 4 days of a 18 day period (study 2) or for 14 days (study 3), 6 (control, vehicle control, 0.08%. 0.12% and 0.2% salifluor and 0.12% chlorhexidine), 3 (control, 0.12% salifluor and 0.12% chlorhexidine) and 3 (control, 0.12% salifluor and 0.12% chlorhexidine) mouthwash preparations were tested in studies 1, 2 and 3 respectively. The findings of study 1 indicated that (i) mouthrinses containing salifluor were significantly more effective than control rinses and that (ii) the salifluor mouthrinses were equally effective as the 0.12% chlorhexidine mouthrinse, in retarding 4-day de novo plaque formation. The findings of study 2 indicated that (i) the mouthrinse containing 0.12% salifluor retarded de novo plaque formation to the same extent as the 0.12% chlorhexidine mouthrinse at healthy as well as at inflamed sites but that (ii) the anti-plaque effects of the salifluor and chlorhexidine mouthrinses were significantly smaller at sites with inflamed than with healthy gingiva. In study 3, it was observed that there was no significant difference between the 0.12% salifiuor and 0.12% chlorhexidine mouthrinses in retarding de novo plaque formation and the development of gingivitis during a 14-day period of no mechanical plaque control. Thus, the results of the 3 clinical trials demonstrated the potential of salifluor as an effective anti-plaque and anti-inflammatory agent.     

Some thoughts on the measurement of gingivitis

The selection of a method for measurement is of critical importance in the planning of a study. Despite the great strides afforded by research of gingivitis, a "gold standard" for its measurement has yet to be clearly established. Traditional clinical indices continue to serve as "gold standards" in many investigations. There is a need for some caution and tentativity in interpreting the results of such studies. Additionally, those studies which yield data on an ordinal scale should make more use of statistical methodologies specifically geared toward the analysis of such data.     

Comparative effects of 2 mouthrinses on the development of supragingival dental plaque and gingivitis

A 6-month double-blind, controlled clinical study was completed with 124 healthy adult subjects to determine the efficacy of 2 mouthrinses, Listerine (LA) and Peridex (PX), used as supplements to regular oral hygiene measures in reducing supragingival dental plaque and gingivitis. Following screening examinations for entry levels of existing gingivitis and plaque, baseline gingival and plaque area indices, extrinsic tooth stain, supragingival calculus, bleeding and soft tissue condition were recorded. All subjects then received a complete dental prophylaxis to remove plaque, calculus and extrinsic stain. Subjects were randomly assigned to 1 of 3 groups and performed supervised rinses twice daily for 30 s in addition to their normal oral hygiene, for 6 months. All indices were again evaluated at 3 and 6 months. After 6 months, LA and PX significantly (p less than 0.001) inhibited development of plaque by 36.1% and 50.3%, respectively, and the development of gingivitis by 35.9% and 30.5%, respectively, compared to a hydroalcohol control. PX was more effective in inhibiting plaque and both mouthrinses appeared to be equally effective in inhibiting gingivitis. LA patients did not develop significant levels of stain or supragingival calculus at 6 months, compared to baseline or control. PX patients developed significant levels of extrinsic stain and supragingival calculus compared to baseline and control. Though PX was more effective than LA in the control of plaque, this study indicates that both LA and PX were effective agents in a regimen for the control of plaque and gingivitis.     

活性银离子抗菌液治疗青春期龈炎的临床效果观察

目的观察活性银离子抗菌液治疗青春期龈炎的临床效果。方法选择78例青春期龈炎患者,随机分成两组,试验组使用活性银离子抗菌液配合洁治术,对照组单纯使用洁治术,分别在治疗前后检测牙龈指数(GI)、菌斑指数(PLI)、龈沟出血指数(SBI),并作统计学处理。结果通过临床对两组患者进行比较发现,使用活性银离子抗菌液含漱后试验组和对照组的GI、PLI差异有统计学意义(P<0.05),使用活性银离子抗菌液含漱后试验组和对照组的SBI差异无统计学意义(P>0.05)。结论用活性银离子抗菌液配合洁治术是治疗青春期龈炎的有效方法。     

A modification to the experimental gingivitis protocol to compare the antiplaque properties of two toothpastes

BACKGROUND AND AIMS: Randomised, blind, controlled experimental gingivitis and home-use study protocols are used to evaluate the efficacy of oral hygiene products. The present methodological study combined the two clinical trial designs to compare the preventive and therapeutic potentials of two toothpastes. MATERIAL AND METHODS: The study was a parallel group, randomised, double-blind design, initially involving 73 healthy dentate subjects. A 21-day experimental gingivitis protocol was combined with a 6-week (42 days) home-use protocol. At baseline, modified gingival index (MGI), gingival index (GI) and gingival bleeding (GB) were recorded. A dental prophylaxis was then performed. Subjects were allocated to either control fluoride or stannous fluoride toothpaste based on gender and GI. During the first 21-day period, subjects applied the allocated toothpaste, for 1 min twice a day, to a group of teeth in a plastic shield and brushed the remaining teeth with the same paste. From day 21 the shield was not placed, and subjects brushed all teeth with the toothpaste for 1 min twice per day up to day 42. MGI, GB and a plaque index (PI) were recorded on days 21 and 42. RESULTS: Sixty-nine and 67 subjects completed to days 21 and 42, respectively. For shielded teeth, PI, MGI and GB increased to day 21 and then after ceasing the use of the shield decreased to day 42. At day 21, PI favoured the stannous fluoride toothpaste, but differences did not achieve statistical significance for any parameter at days 21 or 42. For unshielded teeth, there were no significant differences between the toothpastes for any parameter at either time point. CONCLUSION: : The feasibility of combining two gingivitis clinical trial methodologies appears proven, and data on both the preventive and therapeutic chemical and mechanical efficacy of toothpastes can be obtained through such protocols. Specifically from the present study and consistent with some other reports, the plaque inhibitory properties of the stannous fluoride product are limited and do not always translate into an antiplaque/antigingivitis effect.     

电动牙刷对牙龈炎作用的研究

目的 :评估两种电动牙刷 (佳洁士SpinBrushTM和佳洁士SpinBrushProTM)在为期 1个月的使用后 ,受试者牙龈炎较基线减少的程度。方法 :实验采用随机、对照、检查者单盲的平行设计。在实验初 (第 1天 )及实验末 (第 30天 )记录所有受检者的L e -Silness牙龈指数GI值 ,牙刷功效表示为 1月后的GI值较基线时发生的变化。结果 :共有 87名受试者完成本实验。佳洁士电动牙刷SpinBrush和SpinBrushPro组一月后的GI值与基线比显著降低 6 0 % (P <0 .0 0 1) ;牙龈出血点一月后也显著减少 6 0 % (P <0 .0 0 1)。结论 :佳洁士电动牙刷SpinBrush和SpinBrushPro对减少牙龈炎有明显作用。     

Clinical index systems used to assess the efficacy of mouth-rinses on plaque and gingivitis

Abstract The American Dental Association's Council on Dental Therapeutics has adopted Guidelines for acceptance of hemo therapeutic products for the control of supragingival dental plaque and gingivitis. The most widely used plaque indices are the plaque index (PI) and the Turesky index. Gingivitis has usually been assessed by the Loe and Silness method, although the modified gingival index of Lobene and a bleeding index reported by Caton and Poison have also been used. To date. 2 products have been accepted by the Council as being effective in helping control supragingival plaque and gingivitis. These products were evaluated using clinical indices described in this review. The indices were selected from the many in the literature as being valid, reliable, and easily learned. Suggestions are made for criteria to be used in comparability studies.     

Effect of oxybenzone on PGE2-production in vitro and on plaque and gingivitis in vivo

OBJECTIVES: To study the effect of oxybenzone on prostaglandin E2 (PGE2) production in cell culture and to evaluate the effect of an oxybenzone-containing dentifrice on plaque and gingivitis in a 6-week clinical trial. MATERIAL AND METHODS: Human embryo palatal mesenchyme (HEPM) cells were used for testing the inhibition of IL-1beta-stimulated PGE2-production in vitro by different concentrations of oxybenzone. For the in vivo study, a total of 66 individuals with a Quigley & Hein plaque index of at least 1.5 and an Ainamo & Bay gingival index of at least 0.2 were included in a double-blind clinical trial with two cells and a parallel design. Two compositions of fluoride dentifrice were used, one with the addition of 0.5% oxybenzone, and one without. Plaque and gingival index were obtained at three time points: (1) at baseline, (2) after 3 weeks, and (3) after 6 weeks. RESULTS: A dose-dependent inhibition of PGE2-production was found in the HEPM cell culture following oxybenzone exposure. In the clinical trial, a 25% reduction of gingival index was observed in the oxybenzone group (p<0.001) after 6 weeks as compared with 2% for the placebo group. CONCLUSIONS: These findings indicate that PGE2-production is reduced by oxybenzone in vitro and that the use of oxybenzone in a dentifrice reduces gingivitis in vivo.