共查询到18条相似文献,搜索用时 15 毫秒
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Zewdu Hurissa Samuel Gebre‐Silassie Workagegnehu Hailu Tewodros Tefera David G Lalloo Luis E. Cuevas Asrat Hailu 《Tropical medicine & international health : TM & IH》2010,15(7):848-855
Objectives To describe the clinical presentation of patients with visceral leishmaniasis (VL) with and without human immunodeficiency virus (HIV) co‐infection and factors associated with poor outcome in northwest Ethiopia. Method Retrospective review of 241 patients with VL (92 with and 149 without HIV co‐infection). Results HIV co‐infection was present in 92 (38%) of the patients. Clinical presentation of VL was indistinguishable between patients with and without HIV co‐infection. Co‐infected patients had a poorer outcome i.e. either death or treatment failure (31.5%vs. 5.6%, P < 0.001). The presence of tuberculosis or sepsis syndrome among patients with VL and HIV co‐infected independently predicted death or treatment failure [odds ratio 4.5 (95% CI 1.47–13.92, P = 0.009) and 9.1 (95% CI 2.16–37.97, P = 0.003), respectively]. Despite having similar clinical presentation at the time of diagnosis, VL and HIV co‐infected patients had a higher mortality and treatment failure than immunocompetent patients. Conclusion The frequency of HIV co‐infection among patients with VL is high in the study area, and this co‐infection was associated with death or treatment failure. The clinical management of VL in HIV co‐infected patients is a major challenge that requires new treatment approaches to improve its outcome. 相似文献
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Causes and consequences of higher Leishmania infantum burden in patients with kala‐azar: a study of 625 patients 下载免费PDF全文
Danielle A. Zacarias Nuno Rolão Flaviane A. de Pinho Ingridi Sene Jailthon C. Silva Teresinha C. Pereira Dorcas L. Costa Carlos H. N. Costa 《Tropical medicine & international health : TM & IH》2017,22(6):679-687
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Uptake and performance of prevention of mother‐to‐child transmission and early infant diagnosis in pregnant HIV‐infected women and their exposed infants at seven health centres in Addis Ababa,Ethiopia 下载免费PDF全文
Marshet Girma Rahel Wendaferash Hailu Shibru Yemane Berhane Michael Hoelscher Arne Kroidl 《Tropical medicine & international health : TM & IH》2017,22(6):765-775
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Outcomes among HIV‐infected children initiating HIV care and antiretroviral treatment in Ethiopia 下载免费PDF全文
Zenebe Melaku Sileshi Lulseged Chunhui Wang Matthew R. Lamb Yoseph Gutema Chloe A. Teasdale Solomon Ahmed Tsigereda Gadisa Zelalem Habtamu Abubaker Bedri Ruby Fayorsey Elaine J. Abrams 《Tropical medicine & international health : TM & IH》2017,22(4):474-484
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First molecular epidemiology of Entamoeba histolytica,E. dispar and E. moshkovskii infections in Yemen: different species‐specific associated risk factors 下载免费PDF全文
Mona A. Al‐Areeqi Hany Sady Hesham M. Al‐Mekhlafi Tengku Shahrul Anuar Abdulelah H. Al‐Adhroey Wahib M. Atroosh Salwa Dawaki Fatin Nur Elyana Nabil A. Nasr Init Ithoi Yee‐Ling Lau Johari Surin 《Tropical medicine & international health : TM & IH》2017,22(4):493-504
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Treatment interruption in HIV‐positive patients followed up in Cameroon's antiretroviral treatment programme: individual and health care supply‐related factors (ANRS‐12288 EVOLCam survey) 下载免费PDF全文
Christelle Tong Marie Suzan‐Monti Luis Sagaon‐Teyssier Mohamed Mimi Christian Laurent Gwenaëlle Maradan Marie‐Thérèse Mengue Bruno Spire Christopher Kuaban Laurent Vidal Sylvie Boyer the EVOL Cam group 《Tropical medicine & international health : TM & IH》2018,23(3):315-326
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Flora S. Kano Bruno A. M. Sanchez Tais N. Sousa Michaelis L. Tang Jéssica Saliba Fernando M. Oliveira Paulo A. Nogueira Alessandra Q. Gonçalves Cor J. F. Fontes Irene S. Soares Cristiana F. A. Brito Roberto S. Rocha Luzia H. Carvalho 《Tropical medicine & international health : TM & IH》2012,17(8):989-1000
Objective To investigate risk factors associated with the acquisition of antibodies against Plasmodium vivax Duffy binding protein (PvDBP) – a leading malaria vaccine candidate – in a well‐consolidated agricultural settlement of the Brazilian Amazon Region and to determine the sequence diversity of the PvDBP ligand domain (DBPII) within the local malaria parasite population. Methods Demographic, epidemiological and clinical data were collected from 541 volunteers using a structured questionnaire. Malaria parasites were detected by conventional microscopy and PCR, and blood collection was used for antibody assays and molecular characterisation of DBPII. Results The frequency of malaria infection was 7% (6% for P. vivax and 1% for P. falciparum), with malaria cases clustered near mosquito breeding sites. Nearly 50% of settlers had anti‐PvDBP IgG antibodies, as detected by enzyme‐linked immunosorbent assay (ELISA) with subject’s age being the only strong predictor of seropositivity to PvDBP. Unexpectedly, low levels of DBPII diversity were found within the local malaria parasites, suggesting the existence of low gene flow between P. vivax populations, probably due to the relative isolation of the studied settlement. Conclusion The recognition of PvDBP by a significant proportion of the community, associated with low levels of DBPII diversity among local P. vivax, reinforces the variety of malaria transmission patterns in communities from frontier settlements. Such studies should provide baseline information for antimalarial vaccines now in development. 相似文献
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Prevalence and risk factors of metabolic syndrome in HIV‐infected adults at three urban clinics in a post‐conflict setting,eastern Democratic Republic of the Congo 下载免费PDF全文
Patrick D. M. C. Katoto Friedrich Thienemann André N. H. Bulabula Tonya M. Esterhuizen Aimé B. Murhula Pierre P. M. Lunjwire Dieudonné M. Bihehe Jean B. Nachega 《Tropical medicine & international health : TM & IH》2018,23(7):795-805