共查询到20条相似文献,搜索用时 31 毫秒
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Schistosoma mansoni and HIV infection in a Ugandan population with high HIV and helminth prevalence
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Margaret Nampijja Victoria Nannozi Prossy Kabuubi Nakawungu Elson Abayo Emily L. Webb Alison M. Elliott the LaVIISWA study team 《Tropical medicine & international health : TM & IH》2015,20(9):1201-1208
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Bianca Martins Santos Felipe Augusto Soares Stefany Laryssa Rosa Denise da Conceio Ferreira Gomes Bruno Csar Miranda Oliveira Alan Zanoni Peixinho Celso Tetsuo Nagase Suzuki Katia Denise Saraiva Bresciani Alexandre Xavier Falco Jancarlo Ferreira Gomes 《Tropical medicine & international health : TM & IH》2019,24(5):586-595
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Hypertension,cardiovascular risk factors and antihypertensive medication utilisation among HIV‐infected individuals in Rakai,Uganda
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Laura D. Sander Kevin Newell Paschal Ssebbowa David Serwadda Thomas C. Quinn Ronald H. Gray Maria J. Wawer George Mondo Steven Reynolds 《Tropical medicine & international health : TM & IH》2015,20(3):391-396
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C. S. Pinheiro A. P. D. Ribeiro F. C. Cardoso V. P. Martins B. C. P. Figueiredo N. R. G. Assis S. B. Morais M. V. Caliari A. Loukas S. C. Oliveira 《Parasite immunology》2014,36(7):303-312
Schistosoma mansoni is a blood fluke parasite responsible for schistosomiasis. The best long‐term strategy to control schistosomiasis is through immunization combined with drug treatment. In this study, we cloned, expressed and purified SmTSP‐2 fused to the N‐ and C‐terminal halves of Sm29 and tested these chimeras as vaccine candidates using an adjuvant approved to be used in humans. The results demonstrated that vaccination with SmTSP‐2 fused to N‐ or C‐terminus of Sm29‐induced reduction in worm burden and liver pathology when compared to control animals. Additionally, we detected high levels of mouse‐specific IgG, IgG1 and IgG2a against both chimeras and significant amounts of IFN‐γ and TNF‐α and no IL‐4. Finally, studies with sera from patients resistant to infection and living in schistosomiasis endemic areas revealed high levels of specific IgG to both chimeras when compared to healthy individuals. In conclusion, SmTSP‐2/Sm29 chimeras tested here induced partial protection against infection and might be a potential vaccine candidate. 相似文献
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Drug resistance mutations after the first 12 months on antiretroviral therapy and determinants of virological failure in Rwanda
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Jean d'Amour Ndahimana David J. Riedel Mutagoma Mwumvaneza Dieudone Sebuhoro Jean Claude Uwimbabazi Marthe Kubwimana Jules Mugabo Augustin Mulindabigwi Catherine Kirk Steve Kanters Jamie I. Forrest Linda L. Jagodzinski Sheila A. Peel Muhayimpundu Ribakare Robert R. Redfield Sabin Nsanzimana 《Tropical medicine & international health : TM & IH》2016,21(7):928-935
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Margaret L. McNairy Jules B. Bashi Hannah Chung Louise Wemin Marie‐Nicole Akpro Lorng Hermann Brou Cyprien Nioble A. Lokossue Kouame Abo Delphine Achi Kiyali Ouattara Daniel Sess Pongathie Adama Sanogo Alexandre Ekra Virginie Ettiegne‐Traore Conombo J. Diabate Elaine J. Abrams Wafaa M. El‐Sadr 《Tropical medicine & international health : TM & IH》2017,22(4):431-441
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Evaluating facility‐based antiretroviral therapy programme effectiveness: a pilot study comparing viral load suppression and retention rates
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Herbert C. Duber D. Allen Roberts Gloria Ikilezi Nancy Fullman Anne Gasasira Emmanuela Gakidou Annie Haakenstad Aubrey J. Levine Jane Achan 《Tropical medicine & international health : TM & IH》2016,21(6):750-758
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Nutritional status is the major factor affecting grip strength of African HIV patients before and during antiretroviral treatment
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S. Filteau G. PrayGod S. L. Woodd H. Friis D. C. Heimburger J. R. Koethe P. Kelly L. Kasonka A. M. Rehman 《Tropical medicine & international health : TM & IH》2017,22(10):1302-1313
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Virological efficacy with first‐line antiretroviral treatment in India: predictors of viral failure and evidence of viral resuppression
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Anita Shet Ujjwal Neogi N. Kumarasamy Ayesha DeCosta Suresh Shastri Bharat Bhushan Rewari 《Tropical medicine & international health : TM & IH》2015,20(11):1462-1472