细辛与其同属植物A.kooyanum Makino var.nipponicum Kitamura和A.hexalobum F.Maekawa根的水溶性成分

中药细辛自古以来用作镇咳、祛痰、镇痛与发汗药。最近发现其挥发油成分2,3,4-三甲氧基-1-丙烯基苯具有催眠与降血压作用。欧细辛A.europaeum L.中尚有反式-乌头酸,体外试验表明具有抗肿瘤活性,并对大鼠肾皮质与肝碎片有呼吸抑制作用。最近并发现细辛中所含甲基丁香油酚(Methyleugenol)对支气管平滑肌有松弛作用,还报道了另一种辛味成分Isobutyldodesatetraen-amide。本文报告中药细辛的同属植物A.kooy-anum Makino var.nipponicum Kitamura(Ⅰ)与A.hexalobum F.Maekawa(Ⅱ)根的水溶性成分及其镇咳成分的检定。作者报道了产于日本的二种细辛属植物(Ⅰ)、(Ⅱ)根中含有丰富的蔗糖,(Ⅰ)的含量为5.4％,而(Ⅱ)中则含有5.3％。用豚鼠二氧化硫引咳法     

A Review of: “Analysis of Clinical Trials Using SAS: A Practical Guide,by A. Dmitrienko,G. Molenberghs,C. Chuang-Stein,and W. Offen”

A testing procedure is proposed to assess the consistency of noninferiority from a collection of trials based on simultaneous t lower confidence bounds or Scheffé's lower confidence bounds. Methods for simultaneous inferences on pairwise or many-to-one comparisons among multiple noninferiority trials are also discussed. To avoid bias due to subjective trial exclusion a tuning parameter k is embedded into the testing procedure to provide flexibility to quantify the “consistency of noninferiority” when the total number of trials is large. The size and power of the proposed test are discussed. The method is illustrated using simulations and real data analysis.