Fine needle aspiration biopsy cytology of superficial lymph nodes: comparative with histopathology

Fine needle aspiration biopsy cytology was done in 215 lymph nodes involving cervical, submandibular, supraclavicular, axillary and inguinal regions. One hundred and forty of these were diagnosed by histopathology after excisional biopsy or surgery, including 46 cases of metastatic tumor, 57 of lymphoma (46 were non-Hodgkin's lymphoma and 11 were Hodgkin's disease), and 37 of benign lymphadenopathy. Diagnosis of metastatic malignancy was easily made by aspiration biopsy cytology with a total sensitivity of 95.7% (44/46). The diagnosis of lymphoma was less satisfactory with a total sensitivity of 82.5% (47/57). The specificity for diagnosis of benign lymphadenopathy was 97.3% (36/37) with one false positive. The concordance of cell type in aspiration biopsy cytology and histopathology was 75% (33/44) in metastatic malignancy, and 73.5% (28/38) in lymphoma. Typical Reed-Sternberg giant cells were detected in 4 of 11 cases of Hodgkin's disease by aspiration cytology. Out of the 37 cases of benign lymphadenopathy diagnosed by aspiration cytology, 7 were cases of tuberculous lymphadenitis, of which typical Langhans' giant cells were found in 2, and acid fast stain bacilli in 3 cases. There was no complication or needle tract spreading throughout the procedure. We concluded that aspiration biopsy cytology is a simple, safe, reliable, and quick diagnostic method.     

Fine needle aspiration biopsy cytology in diagnosis of cervical lymphadenopathies

Four hundred and forty-four patients with cervical lymphadenopathies without any consideration for age and sex were subjected to fine needle aspiration biopsy cytology. The results were compared with those of histological sections. In tuberculous lymphadenitis, pyogenic lymphadenitis, Hodgkin's disease and leukaemic infiltration of lymph nodes 100% correct diagnosis was made; it was 98.4% in metastatic carcinoma, 97% in non-specific lymphadenitis and 92.3% in non-Hodgkin lymphoma. An overall 96.2% correct diagnosis was made by fine needle aspiration biopsy cytology technique.     

Role of fine needle aspiration cytology in diagnosis of breast lumps.

Objective: The aim of this study is to find out the common causes of breast lump and to determine the sensitivity and specificity of FNAC of breast lump. Materials and methods: This is a retrospective study of FNAC of breast done in pathology department of NMCTH from January 2003 to December 2005. FNAC findings were correlated with data from histopathology records to determine the sensitivity and specificity of FNAC. Results: FNAC of breast constituted 16% of all the FNACs. Age group of the patients ranged from 17 to 56 years with mean of 32 years. Fibroadenoma was the most common diagnosis. Malignancy was diagnosed in only 6.6% of the cases. Histological correlation was done in 21 cases. Sensitivity and specificity of FNAC of breast was found to be 83.3% and 100% respectively. Conclusion: FNAC of breast is simple, cost effective and less traumatic method for diagnosis of breast lump. It is highly sensitive and specific also, and can reduce the needs for open biopsies. So FNAC should be used as a routine method for determining the nature of breast lumps. Key words: FNAC, breast lump, neoplasm.     

Fine needle aspiration biopsy cytology in diagnosis of salivary gland tumours

Fine needle aspiration biopsy cytology of salivary gland tumours was performed in 97 patients. Histological confirmation was available in all cases except 9 cases of sialo-adenitis which responded to antibiotics. Accuracy of cytological diagnosis in exact categorisation of benign and malignant tumours was 93.7% and 91.1% respectively. False negative was 4.1%. The overall accuracy was 95.8%. There was no false positive report. Exact classification of tumour was made in 94.1% cases, ie, 80 out of 85 tumours. No complication was encountered in this procedure.     

132例乳腺肿块针吸细胞学诊断与病理组织学诊断对比分析

目的比较乳腺肿块针吸细胞学检查在临床中的应用价值。方法分析132例乳腺肿块针吸细胞学诊断,并与术后病理组织学诊断结果相对比。结果针吸细胞学检查良性病变101例,乳腺癌31例,其中肯定为癌者29例,疑为癌2例,阳性率为93.9%,假阴性诊断2例,占6.1%,无假阳性报告。结论乳腺肿块针吸细胞学在乳腺肿块良恶性病变的鉴别中具有较高的应用价值。     

Fine needle aspiration biopsy in the diagnosis of breast cancer

A prospective study of 176 Fine Needle Aspiration Biopsies (FNAB) in 172 patients was carried out to assess the accuracy of FNAB in diagnosing breast cancer at the University Hospital of the West Indies. The results showed 99 per cent and 97 per cent accuracy and sensitivity rates, respectively. There were no false positives and a one per cent false negative rate. FNAB provides a rapid, safe and cheap method of accurately diagnosing breast cancer.     

Fine needle aspiration cytology in isolated thyroid swellings: a prospective two year evaluation

During 1 September 1981 to August 1982 aspiration cytology was carried out in all isolated thyroid swellings referred to the Aberdeen Thyroid Clinic: cytological findings were not disclosed, did not influence management, and were compared retrospectively with the histological diagnosis. In a total of 70 swellings sensitivity for the detection of neoplasia was 86% and overall accuracy 92%; the positive predictive value was 80% and negative predictive value 96%. During the second year (1 September 1982 to 31 August 1983), when cytological findings were used to influence management, the frequency of operation for isolated thyroid swellings decreased by 25% and the proportion of operations for neoplasia increased from 31% to 50%. In terms of bed occupancy the potentially avoidable surgical workload for benign disease was reduced by 34%. Aspiration cytology, carried out at the first clinic attendance, makes a sound basis for selective surgery and leads to economy in the management of isolated thyroid swellings.     

隆胸术后并发症的针吸细胞学诊断

目的 探讨隆胸术后并发症的针吸细胞学特点、鉴别诊断及其在临床诊断中的意义.方法 收集我院经针吸细胞学检查诊断10例病例,对其临床表现及针吸细胞学特点进行分析、总结.结果 凝胶聚丙烯酰胺水凝胶假体植入者7例,其中有1例于凝胶假体植入术后一年针吸为乳腺癌；3例为自体脂肪注入,均有较特异的形态学特点.结论 针吸细胞学诊断隆胸术后并发症快速、损伤小、操作简便并且准确率高,可以为临床医生选择合理治疗方案提供重要依据.     

Fine needle aspiration biopsy of thyroid nodules

Between April 1982 and December 1988, we performed 611 fine needle aspiration (FNA) biopsies in 502 patients with solitary thyroid nodules. The biopsy results were classified as follows: unsatisfactory, 19%; benign, 53%; suspicious, 23%; and malignant, 5%. Malignant lesions were found at surgery in 24 of 25 patients with malignant cytology and 31 of 68 patients with suspicious cytology. Autonomous nodules, obviating the need for surgery, were detected in 5 of 36 (14%) patients with cytology suspicious for follicular neoplasm. We conclude that FNA biopsy of the thyroid nodule is a safe and accurate diagnostic test. Thyroid scintigraphy remains useful in patients with cytologic results suspicious for follicular neoplasm. A cost-effective strategy for managing thyroid nodules is presented.     

Fine needle aspiration cytology of gastric carcinoma.

Four patients between 58 and 81 years of age undergoing investigation and endoscopic biopsy for gastric carcinoma also were subjected to direct-vision fine needle aspiration cytology of their mucosal lesions which yielded malignant cells. The relevance of this technique is discussed regarding both intrinsic and extrinsic lesions of the gastrointestinal tract.     

1731例乳腺肿块细针穿刺诊断的临床应用分析

目的：探讨乳腺肿块细针穿刺细胞学检查（FNAC）的临床应用价值。方法：对2006～2010年的1 731例乳腺肿块细针穿刺细胞学检查结果进行对比分析。结果：1 731例乳腺细针穿刺病例,2009～2010年的病例及阳性病例明显高于2006～2008年,其中924例做了活检对照,恶性肿瘤敏感性为96.68%（233/241）,假阴性率为3.32%（8/241）,无假阳性。FNAC诊断的总准确率为97.29%（899/924）。结论：乳腺肿块细针穿刺诊断技术,操作简易、快速、安全、可靠、价格低廉,可在基层医院及乳腺癌筛查中大力推广。     

Evaluation of fine needle aspiration and imprint cytology in the early diagnosis of breast lesions with histopathological correlation

Fifty-one breast lumps were studied by fine needle aspiration cytology (FNAC) and scrape imprint cytology. Of the 51 cases, 28 were malignant and included infiltrating duct carcinoma (22), well differentiated adenocarcinoma (2), mucinous, papillary and lobular carcinoma (one each) and malignant lymphoma (one). Benign lesions were mastitis, fibroadenoma and fibrocystic disease. The diagnostic accuracy of FNAC was 90.2% and that of imprint 94.1% with no false negatives. Two imprint smears and one aspirate designated suspicious were proved to be benign. The combination of FNAC and imprint cytodiagnosis gave a diagnostic accuracy of 96% thus proving their value in the rapid diagnosis of breast lesions.