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This study measured plaque accumulation on anterior teeth after topical or mouth rinse application of 0.2% chlorhexidine gluconate. Compared with water plaque scores were highly significantly reduced. There was no significant difference in plaque scores between topical application or mouth rinsing. The importance of locally adsorbed chlorhexidine is emphasised and the relevance of an oral reservoir effect questioned.  相似文献   

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Twenty strains of streptococci were isolated from dental plaque obtained from 4 students rinsing twice a day with a 0.2 per cent solution of chlorhexidine gluconate. The predominant streptococci in all plaque samples had characteristics similar to Streptococcus sanguis.  相似文献   

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Delmopinol is a new surface active anti-plaque agent that has demonstrated a low antimicrobial effect in vitro. By use of a vitality staining technique, the antimicrobial effect on bacteria in plaque samples was tested after rinsing with delmopinol or chlorhexidine. 6 healthy male subjects volunteered to rinse for 4 days using a double-blind cross-over study design with a wash-out period between the rinsing regimens. No oral hygiene measures were allowed during the test periods and each test period started with a professional tooth cleaning procedure 2 days before the start of rinsing to allow for plaque formation. Rinsing was performed with 0.2% delmopinol hydrochloride or 0.2% chlorhexidine digluconate 2 x a day. Small samples of plaque were collected from the buccal surfaces of premolars and 1st molars before the first rinse on day 1 and then before and 1, 2, 4, 7, and 24 h after the last rinse on the 4th day. The plaque samples were immediately stained with propidium iodide and fluorescein diacetate to visualize dead and vital microorganisms respectively. The vitality of the microflora was evaluated using a fluorescence microscope. The baseline vitality values were 91% for chlorhexidine and 86% for delmopinol. At day 4, the plaque vitality for chlorhexidine was approximately 40% up to 4 h and 50% at 7 h and 60% at 24 h after the last rinse. Corresponding values for plaque vitality after delmopinol rinsing were between 70 and 80% on all sampling occasions.(ABSTRACT TRUNCATED AT 250 WORDS)  相似文献   

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AIM: This study assessed the plaque inhibiting effect of a 0.2% chlorhexidine (CHX) solution (Corsodyl) with three different rinsing times following a 72 h non-brushing period. MATERIAL AND METHODS: The clinical investigation was a single-blind, randomised study involving 90 volunteer students (40 male and 50 female, mean age 23.2 years). Subjects were randomly allocated to one of three groups for which the protocol only differed with respect to the duration of rinsing. At the start of the trial, all participants received a dental prophylaxis to remove all plaque deposits. Subjects refrained from all mechanical oral hygiene procedures, but rinsed two times per day for the allocated duration with CHX mouth rinse over a period of 72 h. The chlorhexidine preparation was of 0.2% concentration used at a dose of 10 ml for either 15, 30 or 60 s. After 72 h, the Quigley & Hein plaque index (PI) from all volunteers was recorded at six sites per tooth. All participants received a questionnaire to evaluate their perception of rinsing duration. RESULTS: After 72 h, the mean whole-mouth PI was 1.33, 1.18 and 1.24, respectively, for the 15, 30 and 60 s rinsing group. The difference in plaque scores between the three groups was not statistically significant. Results from the questionnaire showed a significant difference between the groups for their perception of rinsing duration. CONCLUSIONS: No significant difference was observed in the level of plaque after 72 h of non-brushing whether the subjects rinsed for 15, 30 or 60 s with 0.2% chlorhexidine.  相似文献   

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Two groups of children, ages 12 to 15, rinsed daily for 28 mo with aqueous fluoride solutions, one group using 0.05% sodium fluoride (NaF) and the other group using 0.1% stannous fluoride (SnF2). The SnF2 group had less plaque accumulation after four mo, but no difference was apparent at 16 and 28 mo. Gingivitis was less severe in the SnF2 group throughout the study, although the difference did not reach statistical significance. The 0.1% SnF2 solution, used daily as a mouthrinse, inhibits plaque formation, although this inhibitory effect is not apparent after 16 mo of rinsing.  相似文献   

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The aim of this study was to investigate a possible dose-response effect of delmopinol hydrochloride, on the development of plaque and on the healing of gingivitis. 64 healthy male volunteers, aged 18-40 years with healthy gingivae and clean teeth, participated. During a 2-week period, the participants refrained from all oral hygiene and rinsed 2x daily with a placebo solution. On day 14 of the study, they received professional toothcleaning, and were randomly assigned to 4 groups. For the following 2 weeks, they rinsed 2x daily for 1 min with 10 ml of 0.05% (15 subjects), 0.1% (17) or 0.2% (16) delmopinol, respectively. 16 subjects rinsed with 0.2% chlorhexidine. No oral hygiene procedures were performed during the test period. On days 0, 14 and 28, gingival bleeding index and the presence of stainable plaque were determined. Periodic identical photographs were used for planimetric determination of buccal plaque extension. No significant difference for the reduction in gingival bleeding index was found between 0.2% delmopinol and chlorhexidine rinsing. The mean plaque index showed its most significant reduction on lingual surfaces of both upper and lower jaws when rinsing with 0.2% delmopinol. Mean plaque extension was reduced by 23% for 0.05%, 39% for 0.1% and 55% for 0.2% delmopinol. A significant dose-response effect for 0.05%, 0.1% and 0.2% delmopinol was found for gingival bleeding index, plaque index and plaque extension. The results show that delmopinol favors the healing of gingivitis and reduces plaque formation.  相似文献   

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The effect of chlorhexidine dihydrochloride (chlorhex HCl) in lozenges on plaque growth was assessed on 21 subjects with fresh plaque of 7 days duration. The lozenges, which contained 5 mg chlorhex HCl, were sucked three times daily after meals, for 2 weeks. The study was a single-blind crossover. Placebo lozenges had all the ingredients except chlorhex HCl. These were used as a control. Results indicated that lozenges containing chlorhex HCl were a potent plaque inhibitor. The mean plaque score was reduced by 62.8% from an initial mean plaque score (DO) of 2.38 +/- 0.48 to (D7) 0.89 +/- 0.26 (p less than 0.0001), after 1 wk of usage. A further reduction to plaque score (D14) of 0.56 +/- 0.27 (p less than 0.0001) was recorded by the end of the 2nd wk. Usage of the placebo during the same time period did not show significant differences in the plaque score (DO = 2.38; D7 = 2.33; D14 = 2.42). Inhibition of plaque formation to the 1104 test surfaces revealed a total elimination of the higher levels of plaque (scores 4 and 5), a considerable reduction of the middle levels (scores 2 and 3) and a significant increase (44.7%) of low level plaque (score 1). Total elimination of plaque (score 0) was observed in 50.3% of the test group surfaces. Lozenges containing 5 mg chlorhexidine dihydrochloride, taken three times daily, were an efficient, comfortable and potent agent for reducing and inhibiting plaque formation. These lozenges are a more convenient alternative to chlorhexidine mouthrinses and may prove to be superior to these.  相似文献   

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The experimental gingivitis model was used to compare the anti-plaque, anti-gingivitis and anti-microbial efficacies of a phenolic compound (Listerine) and an amine/stannous fluoride mouthwash (Meridol), using a placebo preparation as negative control and a chlorhexidine solution as positive control in a double-blind study. After professional toothcleaning, 36 volunteers performed optimal oral hygiene for a period of 2 weeks. They then ceased all oral hygiene procedures for 21 days during which they rinsed twice daily with 1 of the 4 mouthrinses. After 3 weeks of rinsing, plaque indices remained the lowest in the chlorhexidine group, while subjects using Listerine or Meridol harbored similar indices significantly lower than that of individuals rinsing with the placebo solution. Up to that time, the gingival index scores were equal in all groups except for the chlorhexidine group in which the values only amounted to half of these encountered in the other groups. The plaque vitality scores showed a bactericidal effect in vivo of chlorhexidine during the entire time of experimental gingivitis. In contrast, the data gave no evidence of an antibacterial effect in vivo of Listerine. The efficacy of Meridol to kill micro-organisms was similar to chlorhexidine during the early stages of plaque accumulation and, with time, became insignificant. This study has demonstrated that chlorhexidine was superior to Listerine and Meridol in its ability to maintain low plaque scores and gingival health during this 3-week period of no mechanical oral hygiene. Moreover, it was also shown that Meridol was as effective as Listerine in reducing plaque accumulation and, in contrast to Listerine, possessed a remarkable but transient antibacterial effect in vivo.  相似文献   

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Selection of teeth representative of the whole dentition has been used in clinical and epidemiological investigations. The present study was carried out to assess the relationship between 3 different subsets of teeth and the whole dentition for the plaque index, gingival index and probing depth. The selections were: the subset described by Ramfjord (16, 21, 24, 36, 41, 44), the CPITN Alternative I subset (17, 16, 11, 26, 27, 37, 36, 31, 46, 47) and the CPITN Alternative II subset (16, 11, 26, 36, 31, 46). The comparisons were performed on data obtained for 15-year-old adolescents. A strong correlation was observed between the whole dentition and each of the subsets for all assessments. The distribution of scores of the Ramfjord selection and the whole dentition was not statistically different. Corresponding comparisons showed that the distribution of scores of the CPITN selections and the whole dentition was statistically different. Plaque and gingival index scores of these selections underestimated 0 scores and overestimated 2 + 3 scores. Probing depths less than or equal to 2 mm were underestimated and probing depths greater than or equal to 4 mm overestimated. The bias associated with the CPITN Alt I was more pronounced than that of the CPITN Alt II subset of teeth in the adolescents examined.  相似文献   

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Three methods for the recording of gingivitis, plaque and supra- and subgingival calculus in detail, by examining only a part of the mouth were compared with results obtained from whole mouth examinations in the same individuals. The three methods assessed were anterior segment examination only; left side alternating with right side of the mouth and the examination of 4/14 /41/6as being representative of the whole mouth. Gingivitis was recorded by a modification of the PMA system of scoring. Calculus was recorded using the calculus surface index and plaque by a numerical system based on the area of plaque covering the clinical crown. All three methods of partial mouth recording gave results which were not statistically different from the results of full mouth examinations in the 400 adults investigated, with certain provisos in the case of two of the methods. The examination of the anterior segment must include both the labial and lingual gingivae and should not be restricted to the upper jaw only. The left side should be alternated with the right side in consecutive subjects, since the gingival scores obtained for the right side were consistently higher than those obtained for the left side of the mouth.  相似文献   

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All teeth except the lower right canine, premolars and molars, in each of 4 adult male macaque monkeys with heavy plaque deposits and severe gingivitis, were scaled and polished daily for 5 days, followed by daily topical applications of 2% aqueous chlorhexidine gluconate. Minimal amounts of simple plaque containing epithelial cells and Gram positive cocci formed on the treated teeth whereas the untreated teeth retained heavy deposits of complex plaque. In chlorhexidine treated areras the clinical level of gingivitis appeared to subside to a minimum after 15-20 days. Histomorphometric assessments of gingivitis after 42 or 52 days treatment were made on decalcified paraffin sections, by measuring the total area of gingival connective tissue and the area containing inflammatory cells and calculating the proportion of gingival tissue affected. A total of 21 teeth were assessed. Untreated teeth had from 16-40% of the gingivba inflamed, treated teeth only 0-6%. Thus daily topical application of chlorhexidine significantly inhibits plaque accumulation and maintains a significant reduction in gingivitis in these animals. No differences in the nature or degree of keratinization could be detected between treated and untreated areas, nor were there any visible side effects of the use of chlorhexidine for this period.  相似文献   

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ABSTRACT The purpose of the investigation was to determine the effect of chlorhexidine mouthrinses as a supplement to toothbrushing in the plaque control of mentally retarded children. Fifty-four mentally subnormal children 7–14 years of age took part in the investigation. During the first period, half of the children rinsed their mouths with 0.2 % chlorhexidine gluconate solution twice a day. The rest of the children used a placebo mouth-rinse. After an 8-week interval a “cross-over” experiment was carried out during which a 0.1 % chlorhexidine solution was used. Plaque and gingival indices were scored at the beginning of each period, after 3 weeks, and at the termination after 6 weeks. The results revealed that mouthrinses with 0.1 % as well as 0.2 % chlorhexidine gluconate reduced plaque and gingivitis in mentally retarded children. The results were statistically significant (P < 0.05) for both concentrations. Furthermore, the investigation confirmed the occurrence of certain side effects such as discoloration of teeth and tongues.  相似文献   

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Solutions containing 0.2% of a bis-biguanide, chlorhexidine (positive control), and four bis-amidinourea antimicrobial agents were tested in beagle dogs in a 12-week study. The five agents significantly reduced clinical plaque and gingivitis scores, and gingival fluid volumes in treated dogs, compared with water. All compounds reduced the stain area scores compared to water controls. Stain intensity scores were higher for chlorhexidine than for the four new antimicrobial agents and the water controls. There were no overt behavioral changes. Histological examination of oral tissues revealed no irritation.  相似文献   

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ABSTRACT The prevalence of plaque and gingivitis in 154 children 11–13 years of age was assessed at intervals of 2 and 6 months after an initial examination. The children were divided into four groups, each receiving weekly mouth rinses with fluoride or a placebo solution. Two of the groups carried out supervised toothbrushing immediately before the rinses. Judged from 48 Pl I and G I scores in each child, the baseline data indicated no sex differences, but slight differences in moderate gingivitis, i.e. score 2, between the groups. Paired comparisons of the score 2 frequencies during the experiment indicated no effect on the incidence of gingivitis caused by the fluoride treatments or the supervised toothbrushing. Thus, the weekly fluoride rinses commonly used in the school dental service do not appear to have a detrimental effect on the gingiva of children. The weekly supervised brushing instruction used in the present program was not able to improve significantly the level of oral hygiene in succeeding periods.  相似文献   

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