鼻咽癌放疗后突发感音神经性聋14例临床分析

目的 探讨鼻咽癌放射治疗后突发感音神经性聋患者的临床特点及疗效,以利临床诊治。方法 回顾性分析14例（15耳）鼻咽癌放疗后突发感音神经性聋患者的临床特点及疗效。结果 鼻咽癌放射治疗后突发感音神经性聋的患者中男10例、女4例,左耳10耳、右耳5耳,平均发生时间为放疗后6.6年,突聋前多存在听力损失。250、500、1000、2000、4000 Hz的平均听阈（听力级）：突聋耳为(78.5±24.7) dB,非突聋耳为(57.0±32.4) dB。突聋耳73.33％ (11/15)为感音神经性聋,26.67％为混合性聋(4/15)。12例合并放疗后并发症,至少1例存在后循环障碍。治疗总有效率为26.67％ (4/15),其中4例复发且再治疗无效。结论 鼻咽癌放疗后患者发生突发感音神经性聋的程度较重,疗效较差,易复发。其发病机制可能与放疗所致后循环障碍有关。     

小儿突发性聋临床特征分析

目的探讨小儿突发性聋(突聋)的临床特点、疗效以及预后影响因素,指导临床治疗。方法回顾分析21例(24耳)儿童突聋患者临床资料,并与同期37例(39耳)成人突聋患者进行对比分析。结果小儿组7例有明确上呼吸道感染史,发病时伴耳鸣17耳(70.8%),伴眩晕9耳(37.5%),初诊时0.25~4kHz平均听力损失重度聋以上者23耳,占95.8%;治疗后痊愈5耳(20.8%),总有效率29.2%。成人组有上呼吸道感染史5例,占13.5%,初诊时0.25~4kHz平均听力损失重度聋以上23耳(59%),治疗后痊愈6耳(15.4%),总有效率41%。结论小儿突发性聋听力损失较成人重,预后较成人差。病毒感染可能是小儿突发性聋主要病因,初诊时听力损失水平、初诊时间与预后相关。     

鼻咽癌放疗后长期存活者的听力观察

目的了解鼻咽癌放疗后长期存活者的听力情况。方法对126例(252耳)鼻咽癌放疗后存活5年以上的患者进行纯音听阈、声导抗测试,耳、鼻咽部CT及耳内窥镜检查,对结果进行分析。结果 126例中,放疗后有听力损失87例172耳,占69.05%,其中感音神经性聋26例51耳,占29.89%(26/87),传导性聋5例9耳,占5.75%(5/87),混合性聋56例112耳,占64.37%(56/87);CT示中耳乳突炎121耳(70.35%,121/172);耳内窥镜检查所有鼓膜均浑浊内陷,无穿孔。结论鼻咽癌放疗后长期存活者听力损失的发生率高,以混合性听力损失发生率最高,感音神经性次之,传导性最低。     

鼻咽癌放疗后突发性聋患者的临床特征及预后

目的 探讨鼻咽癌(nasopharyngeal carcinoma,NPC)放疗后突发性聋(突聋)患者的临床特征及预后.方法 收集2010年1月到2019年12月住院治疗的25例NPC放疗后单侧突聋患者的临床资料(NPC组),并选择同期住院治疗的401例不伴N PC的突聋患者(非N PC组)作为对照组,对比分析两组患者...     

突发性聋合并类风湿性关节炎患者的特征及疗效分析

目的:探讨突发性聋(突聋)合并类风湿性关节炎(RA)患者的临床特征及疗效,并分析RA病程对突聋听力预后的影响.方法:收集43例(46耳)合并RA的突聋患者(RA组)的临床资料,并选择同时期住院治疗的386例(400耳)未合并RA的突聋患者(非RA组)作为对照组,比较两组的临床特征及预后;同时根据RA病程长短将RA组患者...     

关于预测突发性聋预后的研究

为确定影响突发性聋听力恢复的主要因素、探求预测突聋预后的方法,作者们对1972～1980年间于发病后2周内就诊的600例(604耳)突发性聋患者进行了综合分析。将从发病日起的整个     

儿童突发性聋患者的临床特征及预后分析

目的 分析儿童突发性聋(简称突聋)患者的临床特征及预后,为该病的临床诊治提供参考.方法 回顾性分析2008年1月～2016年10月确诊并治疗的23例(25耳)儿童突聋患者的临床资料,对所有患者的年龄、性别、耳别、就诊时间、病毒感染史、就诊时言语频率气导纯音听阈及听阈曲线类型、是否伴有耳鸣、眩晕、耳闷及治疗效果进行统计分析,并与同期住院治疗的202例(219耳)成人突聋患者进行对比.结果 本组儿童突聋患者占同期所有突聋患者的10.2％(23/225);儿童突聋患者就诊时平均听阈(87.7±16.1 dB HL)、全聋型比例(72.0％)、眩晕伴发率(52.2％)及病毒感染率(17.4％)均高于成人(分别为72.5±24.7 dB HL、44.7％、29.2％、3.5％),差异均有统计学意义(均为P＜0.05).治疗后儿童突聋患者与成人患者的总有效率分别为52.0％、46.6％,痊愈率分别为4.0％、14.2％,差异均无统计学意义(P＞0.05).结论 本组儿童突聋患者就诊时听力损失较重且常伴有耳鸣及眩晕,其听阈曲线以全聋型为主;疗效与成人突聋患者相当.     

双侧突发性耳聋患者临床特征与预后分析

目的 分析双侧突发性耳聋患者的临床特征及预后效果,了解与该病发生及影响预后的相关因素.方法 对12例双侧突发性耳聋患者的临床资料进行系统性分析,包括临床表现、听力学检查、血液学、影像学检查、治疗方法和疗效评估等,分析致病和影响预后的危险因素,总结该病发生发展及转归的特点.结果 12例患者痊愈2耳,有效1耳,总有效率为12.5%.患者双耳同时发病7例,相继发病5例.可明确突聋诱因的6例,首发症状为听力下降21耳、耳鸣17耳,眩晕8耳.12耳既往有听力损失和耳鸣病史,发病后≤7天治疗者20耳,>7天4耳.12例患者听力损失呈下降型听力曲线15耳,治疗有效1例;全聋型5耳,切迹型2耳,治疗无效;山型1耳,平坦型1耳,痊愈.白细胞计数异常8例,在听力损失程度、耳鸣评价方面,外周血白细胞计数异常与正常患者间差异有统计学意义(P<0.05).免疫抗体检查异常3例;IgE异常增高3例;血清促甲状腺激素测定异常增高1例;葡萄糖增高3例、血清脂质和脂蛋白异常7例,脂类代谢功能异常4例.结论 双侧突发性聋的病情复杂,预后较差.详细分析病史、临床表现和特异性的血液及免疫学系统检查,有助于制定个性化诊疗方案.     

影响突发性聋疗效的相关因素分析

目的 探讨影响突聋疗效预后的相关因素.方法 收集本科突聋病例102例(107耳),建立数据库,进行年龄等相关因素的单因素统计分析.结果 突聋的预后与患者年龄、听力曲线、听力损失程度等有统计学意义;其预后与性别、是否伴有耳鸣、是否伴有眩晕及是否1周内就诊无统计学相关性.结论 患者年龄、听力损失程度与突聋预后呈负相关,低频及平坦型的听力曲线预后好于高频或全聋.     

青少年突发性聋的临床特征(附34例报告)

目的：探讨青少年突发性聋（突聋）的临床特点、疗效及影响预后的因素。方法：对３４例（４２耳）１８岁以下青少年突聋患者进行临床观察。结果：①男女患者构成比约为４：１。约１／３患者发病前有较明确的病毒感染史。发病时伴眩晕、耳鸣者分别占４１．２％及７０．６％。初诊时０．２５￣４ＫＨｚ平均听力损失中重度（≥５６ｄＢ）占８４．７％ 间听力曲线全聋型占５４．８％、下降型占２１．４％。②总体疗效为痊愈率４．８％,     

儿童突发性聋的临床特征及预后相关因素分析

目的 分析儿童突发性聋的临床特征、疗效及影响预后的相关因素,为临床治疗及预后评估提供依据。 方法 收集2010年1月至2017年10月就诊的67例突发性聋患儿临床资料,对其临床特征及治疗效果进行回顾性分析,同时根据疗效将患者分为总体有效组(36例)及无效组(31例),采用单因素及多因素分析的方法分析患者的性别、年龄、病程、初诊听阈、是否伴发耳鸣、眩晕、病毒感染史、发病季节和听力曲线类型对预后的影响。 结果 儿童突聋患者中64.18%在春冬季发病,其就诊时听阈为(76.62±25.97)dB HL,耳鸣及眩晕伴发率分别为70.15%和61.19%,病毒感染率为19.40%,听力曲线中10.44%为低频下降型、2.99%为高频下降型、34.33%为平坦型及52.24%为全聋型。经治疗后,患者听阈为(60.41±31.52)dB HL,总体有效率为53.73%,其中痊愈率、显效率及有效率分别为20.90%、16.42%和16.42%。多因素分析结果显示,初诊听阈越高及听力曲线为全聋型,预后越差(P均<0.05);伴有病毒感染的非全聋型患者预后较好(P<0.05)。 结论 儿童突发性聋患者病毒感染率较高且大部分在春冬季发病,就诊时听力损失较重并常伴有耳鸣及眩晕,其听力曲线以平坦型及全聋型为主。就诊时听力损伤程度轻、伴有病毒感染的非全聋型患者预后较好。     

急性低频感音神经性聋的临床研究

目的探讨急性低频感音神经性聋（acute low-frequency sensorineural hearing loss,ALHL）的临床特征和疗效,提高对该疾病的认识和鉴别能力。方法回顾性分析42例（42耳）ALHL的临床表现、听力学检测结果和2～5年的随访情况,总结ALHL的临床发病特征。结果本组42例（42耳）ALHL呈急性发病,年龄27～44岁。男16例（38.10%）,女26例（61.90%）。20例（20耳）伴低调耳鸣,17例（17耳）伴耳部堵闷,11例（11耳）伴听觉过敏现象,6例（6耳）伴有头昏。0.125～1kHz平均听阈为（38.74&#177;4.62）dBHL,2～8kHz平均听阈为（13.52&#177;3.86）dBHL,治疗后上述平均听阈分别为（21.05&#177;9.74）dBHL和（19.85&#177;9.44）dBHL。所有病人的听性脑干反应（auditory brainstem response,ABR）各波潜伏期及波间期正常。畸变产物耳声发射（distortion product otoacoustic emissions,DPOAE）在低频区引出率为16.67%,高频区引出率为85.71%。结论ALHL以单侧发病为主,常伴低调耳鸣、耳部堵闷及胀满感。该病多见于青年女性。纯音听阈以低频听阈升高为特征,ABR正常。病变可能位于耳蜗顶周。     

尿毒症合并突发性聋患者的临床特征及预后

目的 分析尿毒症合并突发性聋(突聋)患者的临床特征及预后.方法 收集2015年1月-2019年12月在会理县人民医院治疗的尿毒症合并突聋患者29例(30耳),平均初诊听阈值为(62.33±13.68)dB HL;17耳(56.67％)伴耳鸣,8耳(26.67％)伴眩晕;9耳(30.00％)为平坦型,13耳(43.33％...     

Is BPPV a Prognostic Factor in Idiopathic Sudden Sensory Hearing Loss?

Objectives

The prognostic significance of vertigo in patients with idiopathic sudden sensorineural hearing loss (SSNHL) remains a matter of debate because vertigo is associated with many different vestibular disorders. The purpose of this study is to determine the role of benign paroxysmal positional vertigo (BPPV) as a prognostic factor in patients with SSNHL.

Methods

We conducted a retrospective study of 298 patients with SSNHL. Hearing outcomes were evaluated by assessments of pre-treatment hearing and hearing gain. Comparative multivariate analyses between prognostic factors and hearing outcome were conducted.

Results

Thirty-eight (12.7%) SSNHL patients were found to also have BPPV. BPPV showed significant negative prognostic factors in hearing outcome on multivariate analysis (odds ratio, 0.15). In comparison to average pure tone audiometry (PTA), patients diagnosed with SSNHL with BPPV exhibited poorer hearing in pre- and post-treatment PTA compared to SSNHL without BPPV. Old age (>60 years), pre-treatment hearing, and canal paresis were significant outcome predictors.

Conclusion

BPPV in SSNHL patients, representing definitive vestibular damage, was closely related to poor prognosis.     

Sudden sensorineural hearing loss during pregnancy: clinical characteristics,management and outcome

Background: Sudden sensorineural hearing loss (SSNHL) may occur during pregnancy with a rare prevalence, and little is known about it.

Aims: To retrospectively analyze cases of SSNHL during pregnancy and investigate their clinical characteristics, management and outcome.

Material and methods: Records of 30 SSNHL patients during pregnancy were reviewed, including age, localization, duration from onset to treatment, gestation period, accompanying symptoms, initial hearing threshold, final hearing threshold, audiogram, treatment and outcome.

Results: Twenty-four patients (80.0%) suffered SSNHL in the second trimester or the last trimester with a high rate of tinnitus (70.0%). The initial hearing threshold was 63.4?±?25.1?dB, and most audiograms were flat and profound. The overall recovery rate was 60.0%, including complete recovery (33.3%) and partial recovery (26.7%). Further, 16 patients received adjuvant intratympanic steroid showed a better audiologic outcome (improvement 27.1?±?16.4 vs. 15.7?±?12.0?dB, p?=?.042) than those who had not.

Conclusions and significance: SSNHL during pregnancy often occurred in the second trimester or the last trimester with a severe hearing loss, the most audiogram configurations are flat and profound. Dextran-40 is a safe and beneficial therapy for SSNHL patients during pregnancy and adjuvant intratympanic steroid increase the probability of hearing recovery.     

妊娠期突发性聋的临床特点及预后

目的分析妊娠期突发性聋的临床特点及预后,并探讨其治疗方案,提高临床医师对该病的认识。方法收集2013年1月~2017年1月在南华大学附属第一医院诊断并住院治疗的16例妊娠期突发性聋患者的一般临床资料。16例患者均为单侧发病,左侧8耳,右侧8耳;3例妊娠早期发病,7例妊娠中期发病,6例妊娠晚期发病;10例伴有耳鸣,4例伴有眩晕,患者入院平均听阈为（64.45±27.83 ）dBHL,所有患者入院后均予低分子右旋糖酐静脉滴注及鼓室内注射地塞米松治疗。结果治疗后平均听阈为（46.48±29.81）dBHL,平均听阈改善值为（17.34±15.70） dBHL,与治疗前比较差异具有统计学意义（P<0.05）。痊愈5耳,显效2耳,有效6耳,无效3耳。结论妊娠期突发性聋常发病于妊娠中晚期,听力损失较重且常伴有耳鸣,听力曲线以全聋型和平坦型为主;给予鼓室内注射地塞米松联合低分子右旋糖酐静脉滴注治疗安全有效。     

Sudden sensorineural hearing loss: a review of diagnosis, treatment, and prognosis

Sudden sensorineural hearing loss (SSNHL) is commonly encountered in audiologic and otolaryngologic practice. SSNHL is most commonly defined as sensorineural hearing loss of 30 dB or greater over at least three contiguous audiometric frequencies occurring within a 72-hr period. Although the differential for SSNHL is vast, for the majority of patients an etiologic factor is not identified. Treatment for SSNHL of known etiology is directed toward that agent, with poor hearing outcomes characteristic for discoverable etiologies that cause inner ear hair cell loss. Steroid therapy is the current mainstay of treatment of idiopathic SSNHL in the United States. The prognosis for hearing recovery for idiopathic SSNHL is dependent on a number of factors including the severity of hearing loss, age, presence of vertigo, and shape of the audiogram.     

Different prognoses in patients with profound sudden sensorineural hearing loss

Background: Inner ear hemorrhage is increasingly recognized as a cochlear lesion that can cause profound sudden sensorineural hearing loss (SSNHL).

Objectives: To investigate changes of cochlear and vestibular function and to compare therapeutic recovery from profound SSNHL induced by different etiologies.

Material and methods: Eighty patients with profound SSNHL (≥90?dB) were divided into an inner ear hemorrhage group and a non-inner ear hemorrhage group by MRI. Statistical analysis was performed to compare the therapeutic effects from vertigo and hearing loss and the outcomes of follow-up in the two groups.

Results: There were significant differences between the two groups in terms of the overall 14-day therapeutic response rate (20 vs. 48%), the incidence of imbalance (26.7 vs. 6%), the incidence of semicircular canal dysfunction on the affected side (60 vs. 20%), the incidence of abnormal C-VEMP and O-VEMP on the affected side (63.3 vs. 38%; and 60 vs. 30%, respectively), the average hearing threshold (74.2?±?10.7 vs. 53.6?±?11.4?dB), and the word recognition score (65.5?±?21.7 vs. 83.5?±?24.5%) at a 12-month follow-up.

Conclusions and significance: A higher percentage of patients with profound SSNHL induced by inner ear hemorrhage were associated with vertigo and had a poor prognosis.     

振动声桥植入二例

目的 探讨振动声桥(Vibrant Soundbridge,VSB)植入的手术效果.方法 根据VSB植入的手术适应证,分别对1例感音神经性聋患者和1例传导性聋(先天性小耳畸形)患者进行VSB植入.感音神经性聋患者术前纯音测听(0.5、1、2、4 kHz)平均听阈(听力级)为56 dB,小耳畸形患者的平均气导听阈为61 dB.术后7周开机调试.结果 2例患者术后听力均获改善,声场助听听阈(0.5、1、2、4 kHz):感音神经性聋患者为32 dB,获益24 dB;传导性聋(小耳畸形)患者为40 dB,获益21 dB.2例患者术后均无面神经麻痹、眩晕及耳鸣.结论 VSB植入对于感音神经性聋和传导性聋均有效.

Abstract：

Objective To investigate the effect of Vibrant Soundbridge ( VSB) implantation.Methods In accordance with the indications for VSB implantation,surgeries were done for two patients who suffered from either a sensorineural or conductive hearing loss ( microtia).Their preoperative auditory thresholds(0.5,1,2 and 4 kHz) were 56 dB HL and 61 dB HL.The VSB was turned on and adjusted seven weeks after surgery.Results Postoperative auditory thresholds of the two patients were improved.Their pure tone thresholds were 32 dB HL and 40 dB HL,and the respective improvement was 24 dB HL and 21 dB HL.There was no facial paralysis,vertigo and tinnitus.Conclusion Patients with a sensorineural or conductive hearing loss may benefit from VSB implantation.