Lupus erythematosus simulating syphilis II

We report on a false reactive 19 S (IgM) FTA-Abs test in a case of lupus erythematosus discoides. We are not aware of any similar case described in the literature so far.     

Gravitational erythema

We report a case demonstrating an extremely unusual erythema on the lower limbs induced by standing. This phenomenon has never come to our attention before and we can find only one previous report of a similar case in the literature. We propose the name‘gravitational erythemal for this entity.     

Spitz nevus: a case report.

The case of a 2-mm Spitz nevus is reported. We comment on the case and describe the skin-surface microscopy features.     

Cutaneous T-lymphocyte lymphoma in association with multiple myeloma

We report a case of cutaneous T-lymphocyte lymphoma in which multiple myeloma, a B-lymphocyte neoplasm, developed. We also review the emerging evidence on the immunoregulatory capacity of neoplastic T lymphocytes. Our case clinically supports the notion that neoplastic T lymphocytes may sometimes express helper activity for a specific B-lymphocyte clone (idiotype-specific helper function).     

Pruritic urticarial papules and plaques of pregnancy (polymorphic eruption of pregnancy): two unusual cases

Summary We report two unusually florid cases of polymorphic eruption of pregnancy (PEP) or pruritic urticarial papules and plaques of pregnancy, the first occurring in a triplet pregnancy, and the second with some clinical features more suggestive of pemphigoid gestationis (PG). The first case responded to treatment with moderately potent topical steroids while the second case required a short course of systemic steroids. Our first case is the only reported case of PEP occurring during a triplet pregnancy. We discuss the effect of multiple pregnancy on PEP and some distinguishing factors between PEP and PG.     

Multiple Milia Localized to the Vulva

Milia are most commonly observed on the cheeks and eyelids. We studied a case of multiple milia localized to the vulva in a 64-year-old female. A review of English and Japanese literature for the last 20 years failed to uncover any reports of milia limited to this area. We describe this case in detail and provide a short review of the literature on cysts of the genitalia.     

Vibrio vulnificus septicemia presenting as purpura fulminans

We present a case of Vibrio vulnificus septicemia presenting as purpura fulminans, which can often result in a catastrophic course. This case had a fortunate outcome due to immediate and intensive empirical antibiotic treatment and the relatively healthy condition of the patient. We focused on the prognostic factors for the relatively good outcome in this patient.     

Benign persistent papular acantholytic and dyskeratotic eruption: a case report and review of the literature

We report a case of a 35-year-old female with a persistent pruritic acantholytic and dyskeratotic eruption on the chest and vulva. The light and electron microscopic studies showed suprabasal epidermal clefting with acantholysis and dyskeratotic cells. We suggest that the most appropriate term for this case is that of benign persistent papular acantholytic and dyskeratotic eruption.     

Cutaneous infarction. Manifestation of disseminated mucormycosis.

We describe the second reported case of cutaneous infarction as a manifestation of disseminated mucormycosis. The lesion, which closely resembled ecthyma gangrenosum, occurred in a leukemic patient who was on a regimen of broad-spectrum antibiotics. In this case as in the only other reported case, Mucor pusillus was the cause.     

Purpuric drug eruption and alopecia induced by erlotinib

We herein report a case of diffuse alopecia with pustules on the scalp and purpuric lesions on the lower legs in a Japanese man after treatment with erlotinib. This is a unique case in which rare skin eruptions simultaneously occurred. We discuss herein a combination of skin eruptions as an adverse reaction of epidermal growth factor-receptor (EGF-R) tyrosine kinase inhibitor. It is indispensable to be aware of rare skin reactions when applying molecular targeting therapies.     

Oral isotretinoin and haemophilia A

The effects of oral isotretinoin on the coagulation system are still not well known: some case reports describe thrombocytopenia or thrombocytosis, others present different effects on fibrinolysis. We report a case of severe acne treated with oral isotretinoin in a patient affected with haemophilia A. In this case, which differs from the only other case reported in the literature, oral isotretinoin did not appear to influence the haemophilic patient's need of factor VIII.     

Porphyria cutanea tarda and chronic lymphatic leukemia

We report on a case of porphyria cutanea tarda going with CLL. A review on 21 similar cases in literature warrants our assumption that in our case, too, porphyria cutanea tarda has been triggered by CLL.     

Leucocytoclastic vasculitis following nodular scabies

We describe the case of an 80-year-old man who came to our observation with a widespread form of nodular scabies. During therapy purpuric dermatitis developed and was diagnosed as leucocytoclastic vasculitis based on histological findings. Blood chemistry revealed raised levels of circulating immunocomplexes. We report this case because of the association of an unusual form of scabies with a complication only rarely associated with this disease.     

Plaque form of warty dyskeratoma - acantholytic dyskeratotic acanthoma

We report the case of a 64-year-old man with a plaque-like lesion on the lower back. Clinically, squamous cell carcinoma was suspected, but the histological features resembled those of isolated Darier's disease or pemphigus vegetans. The lesion was removed with the final diagnosis of acantholytic dyskeratotic acanthoma. We discuss this case with special regard to the differential diagnosis of other isolated acantholytic acanthomas.     

Linear scleroderma with prominent multiple lymphadenopathy followed by the development of polymyositis: A case report and review of published work

Localized scleroderma is an inflammatory disorder affecting the skin and underlying tissues, a certain subset of which develops other autoimmune diseases on the basis of a prominent autoimmune background. We here report a unique case of linear scleroderma presenting with a sclerotic plaque on the left thigh, multiple lymphadenopathy in bilateral inguinal and para‐aortic lymph nodes, and hepatosplenomegaly, who later developed polymyositis. We describe the detailed disease course of our case and discuss the clinical significance of multiple lymphadenopathy in localized scleroderma based on a review of published work.     

Erythema nodosum associated with Yersinia enterocolitica infection

We report a 74-year-old woman who presented to hospital with fever, vomiting, diarrhea, and 2 weeks later developed erythema nodosum (EN) on the legs, and was diagnosed with Yersinia enterocolitica infection based on her clinical course and microbiological examination of the stool. She also had a complication of pancreatitis, which made the diagnosis challenging. We should suspect infection by Y. enterocolitica when diagnosing cases of EN with gastrointestinal symptoms. We assume EN is likely to appear 2 weeks after the onset of gastrointestinal symptoms from our case and other case reports.     

Acantholytic dyskeratotic epidermal nevus with eccrine differentiation: a case report and review of literature

Terminology regarding classification of benign lesions with prominent eccrine differentiation can be confusing as these lesions can have overlapping clinical and histologic characteristics. In this report, we examine a case and review of the literature to suggest that these entities may be better classified as a spectrum of benign lesions with overlapping features rather than distinct entities. We describe a case of an acantholytic dyskeratotic epidermal nevus with eccrine differentiation on the back of a 2-year-old patient. We then discuss the classic clinical and histologic presentations of eccrine nevi and epidermal nevi with eccrine differentiation as they relate to each other and to our case.     

Localized Pemphigus Foliaceus with Unilateral Facial Involvement

Pemphigus foliaceus is a superficial vesiculobullous disease that typically presents with widespread lesions. Localized presentations are less frequent, and they typically occur in middle-aged patients, following exposure to topical medications, and later on, become more disseminated. We present a case of a 19-year-old female with a localized presentation of pemphigus foliaceus unrelated to previous topical medications, that was a diagnostic and therapeutically challenging case. We also discuss the literature on localized cases, differences in presentations and responses to various treatment modalities.     

A Case of Bullous Pemphigoid in a Patient on Hemodialysis

We describe a case of bullous pemphigoid (BP) in a patient with chronic renal failure maintained on hemodialysis. We diagnosed BP by histopathological and immunofluorescence studies. The relationship between BP and chronic renal failure and/or hemodialysis is not clear, but we believe that immune disarrangement due to chronic renal failure and/or hemodialysis may have influenced the pathogenesis of BP in our case.     

A recent case of erythromelanosis follicularis faciei et colli in a female

We report on a new case of erythromelanosis follicularis faciei et colli (EFF) in a female patient. This case as well as 5 others similar cases of female patients we recently published suggest that EFF is a dermatosis also affecting women.