N末端B型脑钠肽检测在老年心力衰竭诊断中的应用价值

目的探讨老年慢性心力衰竭患者血清中的N末端B型脑钠肽在检测诊断中的应用价值。方法选取笔者所在医院近年来收治的150例老年慢性心衰患者作为观察组,同期老年健康体检者150例作为对照组,利用ReliaSSJ-2型多功能免疫检测仪对两组患者进行检测,比较血清中BNP以及NT-proBNP浓度与NYHA心功能的分析关系,并作统计学分析。结果与对照组比较,观察组患者血清中的BNP和NT-proBNP水平均显著增高,差异有统计学意义(P<0.05)。血清中NT-proBNP的水平高于BNP,且与BNP存在相关性。结论血清中BNP和NT-proBNP的测定对于老年慢性心力衰竭患者具有一定的诊断价值,而血清中NT-proBNP的表达较BNP更为敏感。     

N末端B型脑钠肽原的检测在慢性心力衰竭诊断中的应用

目的：探讨N末端B型脑钠肽原(NT-proBNP)的检测在慢性心力衰竭诊断中的临床价值。方法75例慢性心力衰竭患者作为实验组,同期75例健康成年人作为对照组。观察对比两组B型脑钠肽原和NT-proBNP差异,同时比较不同心功能分级患者的B型脑钠肽原和NT-proBNP差异。结果实验组患者B型脑钠肽原和NT-proBNP水平明显高于对照组,差异具有统计学意义(P<0.05);不同心功能分级患者B型脑钠肽原和NT-proBNP水平差异具有统计学意义(P<0.05),随着心功能分级增加, B型脑钠肽原和NT-proBNP水平也呈现增加趋势。结论 B型脑钠肽原和NT-proBNP在慢性心力衰竭诊断中具有重要意义,检测具有方法简便、灵敏度和特异性强的特点,临床值得推广应用。     

N末端B型脑钠肽检测在老年心力衰竭诊断中的应用价值

目的 探讨分析老年患者血清中N末端B型脑钠肽在心力衰竭的诊断检测中的临床价值.方法 选取在本院治疗的120例老年慢性心力衰竭患者作为观察组,将在同期在本院行健康体检的健康老年人120名作为对照组,两组患者均采用多功能免疫检测仪对血清中B型脑钠肽以及NT-proBNP进行检测,对两组数据进行对比统计分析.结果 观察组患者血清中的B型脑钠肽和NT-proBNP的水平均明显高于对照组,两组对比差异有统计学意义（P 〈 0.05）.结论 老年血清中的B型脑钠肽和NT-proBNP水平测定对老年慢性心力衰竭诊断具有重要的意义,而血清中NT-proBNP 的表达水平比B型脑钠肽更为敏感.     

脑钠肽在心力衰竭中的临床意义

目的探讨心力衰竭患者血浆脑钠肽(BNP)变化的临床意义。方法选择90例住院心力衰竭患者及门诊选择50例心功能正常者作为研究对象。所有研究对象即刻采集血标本以备血浆检测BNP、血糖、血脂、肝肾功能等,并以超声诊断仪采用辛普森法测定左室射血分数(LVEF)。结果随着心力衰竭程度加重,血浆BNP水平逐渐升高,患者脑钠肽(BNP)与左室射血分数(LVEF)存在良好负相关。结论慢性心力衰竭患者血浆BNP浓度升高,且随心力衰竭程度的增加而显著升高。     

血清脑钠肽和氮端脑钠肽与心力衰竭发病程度的相关性

目的探讨脑钠肽及氮端脑钠肽与心力衰竭者的NYHA心功能分级的相关性,为心力衰竭的诊断防治提供参考。方法心力衰竭患者120例(观察组,Ⅰ级组20例,Ⅱ级组60例,Ⅲ级组30例,Ⅳ级组10例)与健康体检者40例(对照组)分别采集血清检测脑钠肽及氮端脑钠肽值。结果心力衰竭血清脑钠肽及氮端脑钠肽含量水平明显高于对照组,二者之间差异有统计学意义(P<0.01)。在观察组患者中,心功能(NYHA)I级组血清脑钠肽及氮端脑钠肽水平与对照组比较无统计学差异(P>0.05),而Ⅱ级组、Ⅲ级组、IV组的脑钠肽及氮端脑钠肽水平都比较对照组明显升高(P<0.05)。各组间随NYHA分级的增高,血清脑钠肽及氮端脑钠肽水平有明显升高趋势,差异均有统计学意义(P<0.05)。结论血清脑钠肽和氮端脑钠肽水平变化有助于心力衰竭的早期诊断和治疗,与NYHA心功能相结合,更能准确评价其治疗效果和评估预后,值得推广应用。     

脑钠肽检测在心力衰竭患者中的临床价值

目的研究脑钠肽(BNP)检测在心力衰竭患者中的临床价值。方法应用化学发光法检测心力衰竭患者和健康对照组血清BNP水平,并进行比较。结果心力衰竭组患者BNP水平明显高于健康对照者(P<0.05),随着心衰程度的加重,患者血浆BNP浓度逐渐升高(P<0.05)。结论血清BNP的含量与心力衰竭高度相关,对心力衰竭诊断、判断其严重程度及预后都有十分重要的应用价值。     

慢性心力衰竭患者血清嗜铬粒蛋白A、脑钠肽水平及左室质量指数相关性研究

目的 观察慢性心力衰竭(CHF)患者外周血血清嗜铬粒蛋白A(CgA)水平的变化,探讨CgA的价值和临床意义.方法 测定不同程度CHF患者(CHF组,49例)血清cgA、脑钠肽(BNP)水平及左室质量指数(LVMI),与12例正常健康人(对照组)进行对照,分析CHF组血清CgA与BNP水平及LVMI的相关性.结果 CHF组血清CgA、BNP水平及LVMI均显著高于对照组(P<0.01),且随着心力衰竭程度的加重而增加;CgA与BNP、LVMI分别具有良好的相关性(r=0.88,P<0.01;r=0.61,P<0.01).结论 心力衰竭患者CgA水平分别与BNP水平、LVMI、NY-HA功能分级呈明显正相关,检测CgA水平有助于判断CHF病情的严重程度.     

氨基末端脑钠肽前体浓度的影响因素

脑钠肽（BNP）和氨基末端脑钠肽前体（NT—proBNP）监测在21世纪初由国外传人我国,10多年来逐渐广泛应用于临床。2010年《急性心力衰竭诊断治疗指南》推荐BNP和NT—proBNP监测用于诊断和预后的判断。血浆BNP和NT—proBNP作为心力衰竭的诊断和预后指标成为近年来的研究热门。NT—proBNP和BNP在心肌扩张时同时释放人血,但由于NT-proBNP的半衰期比BNP长,因此NT—proBNP检测提供了更高的灵敏度,     

甲状腺激素与B型脑钠肽检测在慢性充血性心力衰竭患者中的临床意义

目的探讨血清甲状腺激素与血浆B型脑钠肽(BNP)检测水平在慢性充血性心力衰竭(CHF)患者的临床意义。方法临床上已确诊为CHF的患者共186例,分为Ⅱ级心力衰竭组58例,Ⅲ级心力衰竭组67例,Ⅳ级心力衰竭组61例,检测血清游离三碘甲状腺原氨酸(FT3)、游离四碘甲状腺原氨酸(FT4)、促甲状腺激素(TSH)及血浆BNP水平。结果血清FT3Ⅳ级心力衰竭组均低于Ⅱ、Ⅲ级心力衰竭组(P<0.05),Ⅲ级心力衰竭组低于Ⅱ级心力衰竭组(P<0.05);血浆BNPⅣ级心力衰竭组高于Ⅱ、Ⅲ级心力衰竭组(P<0.05);Ⅲ级心力衰竭组高于Ⅱ级心力衰竭组(P<0.05);FT4、TSH三组之间无明显差异(P>0.05)。结论 CHF患者中联合测定血清FT3与血浆BNP水平能更好地反映心力衰竭患者的临床严重程度及评估预后。     

脑钠肽水平与冠状动脉狭窄程度的相关性研究

血浆脑钠肽(BNP)水平是反映左室舒张末期压(LVEDP)的生化指标,与慢性充血性心力衰竭(CHF)的严重程度相关,CHF的加重而升高,已经作为诊断左室功能不全的一种特异性手段,广泛应用于临床实际工作中。我们在临床工作中还发现高血浆脑钠肽水平与冠状动脉病变血管狭窄严重程度有一定的关系,通过对脑钠肽水平与冠状动脉病变血管支数及冠状动脉病变血管狭窄程度的相关性研究,认为脑钠肽水平可作为冠状动脉狭窄程度预测因子,准确、及时判断冠心病患者冠状动脉狭窄的严重程度,从而达到准确治疗冠心病、提高冠心病患者生活质量、减轻患者医疗费用和社会负担。     

Degraded and undegraded carrageenans and experimental gastric and duodenal ulceration

The prevention of histamine-induced gastric and duodenal ulceration in the guinea-pig has been examined using a series of undegraded and degraded carrageenans. Undegraded carrageenans were active at lower doses than degraded carrageenans. The high viscosity of the undegraded carrageenans in solution prevented their use in larger doses. Degradation of carrageenan without serious loss of sulphate, gives a product which allows the dose to be increased to an extent that its effect more than offsets the slight loss in activity caused by the degradation. No single feature of carrageenan structure can be related to anti-ulcer activity although degradation, and hence reduction of molecular size, generally reduces activity. Sulphate contents over 30% have little apparent effect on activity; κ-carrageenans were not consistently different in anti-ulcer activity from Λ-carrageenans. This contrasts with the antipeptic activity of carrageenans where κ-carrageenans are less active than their Λ-counter-parts. As with antipeptic activity, the degree of anti-ulcer activity is probably determined by a combination of structural features which includes molecular size and polyanionic properties.     

Affective and Anxiety Disorders and Alcohol and Drug Dependence:

Depression and anxiety frequently coexist in patients with substance use disorders. This clinically-oriented article examiens the relationship between these conditions and emphasizes data showing that substances of abuse can cause signs and symptoms of both depression and anxiety. These substance-related syndromes appear to have a different course and prognosis than uncomplicated, independent anxiety and major depressive disorders, and clinicians should consider the role of alcohol and other drugs in all patients presenting with these complaints. The authors will also outline an approach for diagnosing and managing patients with the combination of a substance use and depressive or anxiety disorder.     

Alcohol and Substance Use and Abuse in Women and Children

No abstract available for this article.     

Glucosidase and fucosidase inhibitors and Advances in nucleosides and nucleotides.

The American Chemical Society Symposium "Glucosidase and fucosidase inhibitors" took place on 1 April 1998 and was organized by Professors Zbigniew J Witczak (UConn, School of Pharmacy, CT, USA), Kuniaki Tatsuta (Waseda University, Tokyo, Japan) and Waldemar Priebe, MD (Anderson Cancer Center, University of Texas, USA). Professor Witczak provided introductory remarks including the status of existing glucosidase inhibitors, and chaired the morning session, which consisted of six lectures. The symposium was well received, and was particularly attractive for those interested in networking, as attendance was about sixty. In addition, some participants and attendees presented posters on the subject during the regular poster session organized by the Division of Carbohydrate Chemistry.