Analysis of MRI findings in minimum invasive treatment for habitual temporomandibular joint dislocation by autologous blood injection around the temporomandibular joint capsule

The aim of this study was to investigate magnetic resonance imaging (MRI) findings following autologous blood injection (ABI) for habitual temporomandibular joint (TMJ) dislocation. MRI was performed one hour and four and twelve weeks after ABI, revealing three types of significant findings. The first type was similar to hematoma and/or joint effusion in the articular capsule of the TMJ (type I). The second showed sporadic and diffuse T2 emphasis around the TMJ capsule (type II). The third involved a decreased range of condyle movement compared to before ABI (type III). Furthermore, we analyzed the three types of significant MRI findings.At one hour after ABI, type I was Grade 0 in 0 of 14 patients, Grade 1 in 8, Grade 2 in 2, and Grade 3 in 4. Type II was seen in 9 of the 14 cases and type III in 8. After twelve weeks, all cases of type I were Grade 0, no type II cases were evident, and type III was seen in 11 cases. Injecting autologous blood into surrounding TMJ tissues is an important factor in ABI. Minimally invasive treatment for habitual TMJ dislocation using ABI around the TMJ capsule appears to represent a very effective and safe treatment.     

Arthrocentesis followed by intra-articular autologous blood injection for the treatment of recurrent temporomandibular joint dislocation

Temporomandibular joint (TMJ) dislocation is an excessive forward movement of the condyle beyond the articular eminence with complete separation of the articular surfaces and fixation in that position. This study was conducted to assess autologous blood injection to the TMJ for the treatment of chronic recurrent TMJ dislocation. Fifteen patients with bilateral chronic recurrent condylar dislocation were included in the study. Bilateral TMJ arthrocentesis was performed on each patient, followed by the injection of 2 ml of autologous blood into the superior joint compartment and 1 ml onto the outer surface of the joint capsule. Preoperative and postoperative assessment included a thorough history and physical examination to determine the maximal mouth opening, presence of pain and sounds, frequency of luxation, recurrence rate, and presence of facial nerve paralysis. Eighty percent of the subjects (12 patients) had a successful outcome with no further episodes of dislocation and required no further treatment at their 1-year follow-up, whereas three patients had recurrent dislocation as early as 2 weeks after treatment. Autologous blood injection is a safe, simple, and cost-effective treatment for chronic recurrent TMJ dislocation.     

自体血注射治疗复发性颞下颌关节脱位的临床观察

对19例复发性颞下颌关节脱位患者行关节腔和囊周组织自体血注射治疗。1年后随诊,16例无关节脱位复发,有效率为84.2%。也没有观察到TMJ骨质破坏和关节强直的现象。自体血注射治疗复发性颞下颌关节脱位是一种简单、安全、经济、有效的微创治疗方法。     

Histological evaluation of the changes in temporomandibular joint capsule and retrodiscal ligaments following autologous blood injection

IntroductionIn recent years injection of autologous blood into the temporomandibular joint (TMJ) has been reintroduced as a treatment of chronic recurrent TMJ dislocation. The effects of this treatment on components of the TMJ is not fully understood. The purpose of this article is to evaluate the effects of autologous blood on TMJ capsule and the retrodiscal ligament.Material and methodsA total of 16 healthy adult country bred pig were used in this study. Autologous blood were injected into the upper joint space (4 ml) and around the capsule of TMJ unilaterally (1 ml). This procedure was then repeated on the opposite side only by using 5 ml of 0.9% saline. TMJ capsules and retrodiscal ligaments were examined four weeks following the injections.ResultsHistological examination of TMJs injected with autologous blood revealed fibrotic changes in 81.25% of the retrodiscal ligaments and 56.25% of the capsular areas. Whilst no changes were seen in the retrodiscal ligaments nor in the capsules of TMJs injected with saline alone.ConclusionThere is little published clinical data on the use of autologous blood injection and as such the mechanism of action is still unclear. The rate of induction of fibrosis within the retrodiscal ligaments in this study were similar to previously reported studies and case series. However, further studies to evaluate the mechanism of this safe and simple technique are needed.     

The Effect of Chronic Temporomandibular Joint Dislocation: Frequency on the Success of Autologous Blood Injection

Autologous blood injection (ABI) is a conservative, non-surgical method of treating chronic temporomandibular joint (TMJ) dislocation. Although many clinicians have reported positive results, procedural success has not been evaluated according to dislocation type. This study investigated the success of ABI on chronic TMJ dislocation with respect to dislocation frequency. ABI was used to treat 27 joints in 17 patients. The patients were divided into two groups based on dislocation frequency: (A) at least twice a week on different days and (B) at least twice a day. The procedure was successful in 13 of the 15 injected joints (86.6 %) in group A and six of the 12 injected joints (50 %) in group B. This difference was statistically significant (p = 0.03814). Autologous blood injection had limited success in patients with very frequent dislocation, while it was useful for treating less frequently dislocated TMJs.     

Investigation of an autologous blood treatment strategy for temporomandibular joint hypermobility in a pig model

Many different surgical and non-surgical techniques are used for the treatment of temporomandibular joint (TMJ) hypermobility. One of these methods is autologous blood injection into the TMJ. The fate of the autologous blood used for treatment of recurring condylar dislocation is still not completely understood. The authors used 12 pigs (Sus scrota f. domestica) as a model species for autologous blood delivery into the TMJ. Blood injection was followed by histopathological analysis at different times after treatment (1 h, 1, 2 and 4 weeks). Samples were examined by magnetic resonance imaging, macroscopic and histological methods. The deposition of the remaining blood was observed in the form of clots in the distal parts of the upper joint cavity 1 h and 1 week after treatment. 2 weeks after treatment, small blood clots were still apparent in the distal part of the upper joint cavity. 4 weeks after surgery, no remnants of blood, changes or adhesions were apparent inside the TMJ. No morphological or histological changes were observed in the TMJ after the injection of autologous blood suggesting another mechanism is involved in the hypermobility treatment.     

Modified dextrose prolotherapy for recurrent temporomandibular joint dislocation

Conservative interventions with simple procedures and predictable benefits are expected by patients with recurrent dislocation of the temporomandibular joint (TMJ). We have introduced a modified technique of prolotherapy that comprises injection of lignocaine and 50% dextrose at a single site in the posterior periarticular tissues. We studied the effects in 45 younger patients (age range 17–59 years) with non-neurogenic recurrent dislocation of the TMJ, and confirmed the therapeutic effect after more than a year's follow-up. There were appreciable improvements in the number of episodes of dislocation and clicking after the injection. The overall success rate, defined as the absence of any further dislocation or subluxation for more than 6 months, was 41/45 (91%). Of the 41 rehabilitated patients, 26 (63%) required a single injection, 11 (27%) had 2 treatments, and 4 (10%) needed a third injection. All patients tolerated the injections well. The modified dextrose prolotherapy is simple, safe, and cost-effective for the treatment of recurrent dislocation of the TMJ.     

45例复发性颞下颌关节前脱位的分类及治疗探讨

目的 介绍一种基于MRI上关节盘与髁突相对位置的颞下颌关节复发性前脱位分类方法,以及针对不同类型采用不同手术方法治疗的经验。方法 选择2003年5月—2016年5月治疗的45例颞下颌关节复发性前脱位患者。依据MRI分为Ⅰ型（关节盘无移位）、Ⅱ型（关节盘移位）、Ⅲ型（骨关节病）及Ⅳ型（存在精神或神经功能障碍）,依据分类选择不同的手术治疗方法。结果 Ⅰ型28例（62.2%）,Ⅱ型12例（26.7%）,Ⅲ型2例（4.4%）,Ⅳ型3例（6.7%）。Ⅰ型患者采用关节结节增高术或关节镜下硬化剂注射术;Ⅱ型患者采用颞下颌关节盘复位固定术（锚固）及关节镜下关节盘复位固定术,辅助关节结节增高术;Ⅲ型患者根据临床症状进行手术;Ⅳ型患者均采用关节结节凿平术。随访期间未发现开口受限、开口疼痛、脱位复发。结论 基于MRI影像学特点对颞下颌关节脱位进行分类,对术者选择合适的治疗方案具有指导意义。     

Short-term results of autologous blood injection for treatment of habitual TMJ luxation

ABSTRACT: Many surgical and nonsurgical methods for the treatment of temporomandibular joint (TMJ) hypermobility have been published. The purpose of this study was to evaluate the results after autologous blood injection in and around the TMJ for the treatment of habitual luxation. Twenty-five patients were diagnosed as having habitual TMJ luxation and treated with autologous blood injection into the upper joint space and around the joint capsule (group A). A control group of 15 patients with the same diagnosis were subjected to physiotherapy with muscular exercise (group B). Patients in group A were reevaluated 3 months after treatment and those in group B were reevaluated after 3 months of physiotherapy. A statistically significant reduction in maximal mouth opening and TMJ sounds was noted only in group A, whereas the reduction for group B was minimal. These measurements show that intraauricular and periauricular autologous blood injection results in remission of signs and symptoms of TMJ luxation in the short term.     

A prospective assessment of outcomes following the use of autologous blood for the management of recurrent temporomandibular joint dislocation

Purpose

The objective of the study was to compare results of treatment for chronic recurrent temporomandibular joint dislocation (CRTMD) by autologous blood injection (ABI) using two different methods of administration (combination intra- and peri-articular, and peri-articular alone).

Materials and methods

Forty patients diagnosed with CRTMD were randomly divided into two groups of 20 each (A and B). Group A were treated by intra- and peri-articular blood injection, group B were treated by peri-articular injection alone. The follow-up was done at 1, 3, 6, and 12 months. The study assessed presence of dislocations, pain (VAS, 0–10), interincisal mouth opening (IMO), and the presence of sound phenomena. The treatment was considered successful in patients without the persistence of CRTMD symptoms, as well as with a VAS of 0–1.

Result

After 12 months, a beneficial therapeutic effect in group B was seen in 11 patients, while 16 patients from group A had a therapeutic effect.

Conclusion

Intra- and peri-articular ABI is more effective than peri-articular blood application alone in the treatment of CRTMD, although the difference was not statistically significant.

     

Temporomandibular joint "open lock" versus condylar dislocation: signs and symptoms, imaging, treatment, and pathogenesis.

PURPOSE: In the temporomandibular joint (TMJ) "open-lock" condition the condyle is entrapped in front of the lagging disc and cannot slide back under the fossa. The aim of this retrospective study was to describe the signs and symptoms and imaging of TMJ "open lock" versus condylar dislocation and clarify its pathogenesis. The study stresses the efficacy of arthrocentesis in restoring the functional capacity of the joint, while obviating the need for surgical intervention. PATIENTS AND METHODS: The study included 5 patients (3 females and 2 males; ages ranging from 11 to 26 years) presenting 6 open-lock joints that did not respond to conservative treatment. The TMJs postarthrocentesis status in 5 joints (follow-up period, 6 to 32 months) was determined by patient self-assessment and clinical examination. RESULTS: Five TMJs had recurrent open lock and were treated by arthrocentesis. They reacted favorably to the treatment and the open-lock events were eliminated. The first case was apparently misdiagnosed as condylar dislocation, and unnecessary surgical intervention was performed. CONCLUSIONS: Arthrocentesis is a safe and rapid procedure that prevents recurrence of open-lock conditions. This disorder should be distinguished from recurrent condylar dislocation, which requires surgical intervention.     

Treatment of recurrent dislocation of the temporomandibular joint with type A botulinum toxin

A case is reported of a 56-year-old woman who suffered from recurrent dislocations of the temporomandibular joint (TMJ) secondary to an exacerbated tetraspastic syndrome of multiple sclerosis. Following chemical denervation of the masseter and pterygoid muscles with injections of type A botulinum toxin, no further dislocations occurred for periods of up to four months. The treatment has been repeated five times. Some of the indications and possible adverse reactions to this therapy are discussed and comparisons made with other, conventional methods for managing recurrent dislocation of the TMJ.     

Insulin-like growth factor-1 suspended in hyaluronan improves cartilage and subchondral cancellous bone repair in osteoarthritis of temporomandibular joint

This study sought to evaluate the effects of intra-articular injection of insulin-like growth factor-1 (IGF-1) suspended in hyaluronan (HA) on the cartilage and subchondral cancellous bone repair in osteoarthritis (OA) of the temporomandibular joint (TMJ). Disc perforation was performed bilaterally in rabbit TMJs to induce OA. Four groups of animals (n = 12) received OA induction only, and either intra-articular HA injection alone, intra-articular IGF-1 injection alone, or a combination of HA and IGF-1 injection. All therapy was begun 4 weeks after OA induction. The animals were killed 12 or 24 weeks after the first injection, for histology and micro-CT examinations. Two additional animals were used as normal controls. Typical cartilage and subchondral cancellous bone lesions were observed in the OA group. No protective effect on cartilage and subchondral cancellous bone was found in the HA or IGF-1 alone groups. Better histological repair and nearly normal micro-architectural properties of the subchondral cancellous bone were observed in the HA + IGF-1 group compared with the HA or IGF-1 alone groups. HA may be used as an effective carrier for intra-articular injection of IGF-1 and the combination of HA/IGF-1 shows promise as a new rational approach to therapy of TMJ OA.     

Functional reversibility of temporomandibular joint mechanoreceptors

Objective

Previous studies have reported that the maturation of temporomandibular joint (TMJ) mechanoreceptors occurs during the early stages of mastication, and indicated that TMJ mechanoreceptors lose their function when masticatory loading is decreased. The purpose of the present study was to investigate whether the resumption of proper TMJ loading during the early growth period could restore TMJ mechanoreceptor function.

Designs

Ninety-nine 2-week-old male Wistar rats were divided into two groups and fed either pellets [control group (n = 33)] or a liquid diet [experimental group (n = 66)]. At 5 weeks of age, the experimental group was split into changing-diet (n = 33) and liquid-diet (n = 33) groups; the former was fed pellets instead of a liquid diet. TMJ mechanoreceptor activities were recorded from the trigeminal ganglion at 5, 7 and 9 weeks. The firing threshold and maximum instantaneous firing frequency of single TMJ units were measured in each group.

Results

In the changing-diet group, the firing properties of TMJ units were recovered at 7 weeks.

Conclusions

Proper TMJ loading during the early growth period can lead to the restoration of TMJ mechanoreceptor function.     

“Management of recurrent temporomandibular dislocation using orthodontic traction screws.”

Temporomandibular joint dislocation is defined as the loss of joint congruency between the mandibular condyle and the glenoid fossa of the temporal bone. Multiple therapeutic options have been proposed for the treatment of recurrent TMJ dislocation. The aim of this paper is to present two recently treated cases with a modification of Wolford's technique, replacing the Mitek anchors with orthodontic screws. Case series: The first case concerns a 36 year-old women with recurrent temporomandibular dislocation, and the second one a 26 year-old patient with the same diagnosis. In both cases, one 8mm orthodontic screw was placed in the lateral pole of mandibular condyle, sutured with PremiCron® 2/0 to a hole made in the root of each zygomatic arch. At twelve-month follow-up (first patient) and at six-month follow-up (second patient), patients had not presented new episodes of mandibular dislocation and mouth opening range remained stable.This technique can be considered as an alternative to Wolford's technique in treating recurrent temporomandibular dislocation when conservative management fails.     

高渗葡萄糖关节上腔注射治疗颞下颌关节囊松弛（半脱位）和复发性脱位的临床应用

目的：探讨高渗葡萄糖硬化治疗颞下颌关节囊松弛（半脱位）和复发性脱位的效果。方法：采用50%葡萄糖注射剂行关节上腔注射治疗6例颞下颌关节半脱位的患者和7例复发性颞下颌关节脱位的患者,观察疗效;并对其治疗前后Fricton颞下颌关节紊乱指数进行评分,评价患者颞下颌关节功能的变化。结果：13例患者临床疗效满意,随访2月至半年无复发,治疗后患者的颞下颌关节紊乱指数明显改善。结论：采用50%葡萄糖注射剂行关节上腔注射治疗颞下颌关节半脱位和复发性脱位具有良好的效果。     

L-单甲基-精氨酸对颞下颌关节骨关节病治疗作用的实验研究

目的　研究一氧化氮合酶抑制剂L 单甲基 精氨酸对山羊实验性颞下颌关节骨关节病的治疗作用及可能机制。方法　通过双侧颞下颌关节上腔内注射胶原酶建立骨关节病模型 ,从注射胶原酶第 4周起 ,在左侧关节上腔内每隔 3d注射 0 5 %L 单甲基 精氨酸 0 5ml,共 7次 ,右侧同期注射生理盐水 0 5ml。注射胶原酶后 1 2周处死所有动物 ,取双侧关节标本作组织学检查并根据改良Mankin骨关节病评价标准评分。结果　评分结果 :L 单甲基 精氨酸侧为 3 83 ,而对照侧为 6 33 ,两者比较差异有高度显著性 (P <0 0 1 )。结论　L 单甲基 精氨酸关节腔内注射对山羊实验性颞下颌关节骨关节病的发展有抑制作用 ,其作用机制可能与L 单甲基 精氨酸抑制一氧化氮合酶在关节局部产生过多的一氧化氮有关     

手法复位在单侧颞下颌关节前脱位复位中的应用

目的:探讨单侧颞下颌关节前脱位手法复位法。方法:对32例单侧颞下颌关节前脱位患者,采用单手法复位。结果:全部病例均复位成功,复位时间短,复位过程中患者配合好,无明显痛苦。结论:单手复位法是单侧颞下颌关节前脱位的有效复位方法。     

A new surgical approach for the treatment of chronic recurrent temporomandibular joint dislocation

Chronic recurrent temporomandibular joint (TMJ) dislocation is defined as the complete loss of articular relationships, during mouth-wide opening, between the articular fossa of the temporal bone and the condyle-disk complex. The most frequent pathogenetic factors involved in chronic recurrent dislocation of the TMJ are supposed to be trauma, abnormal chewing movements, TMJ ligaments, capsule laxity, and masticatory muscles disorders. In fact, TMJ dislocation occurs more frequently in people with general joint laxity and in patients with internal derangement of the TMJ or with occlusal disturbance.Management of TMJ dislocation remains a challenge. Eminectomy, whose validity has been demonstrated by several authors, acts on the bony obstacle, preventing condylar locking, but does not have a therapeutic effect on TMJ ligament and capsular laxity or masticatory muscle incoordination, which seem to be the real cause of TMJ dislocation in most cases.The authors present a mini-invasive modified technique of eminectomy, which aims to act on both the obstacle and the cause with respect and restoration of TMJ biomechanical constraints.     

Surgical managements of subluxation and dislocation of the temporomandibular joint: clinical and experimental studies

Subluxation and dislocation of the temporomandibular joint (TMJ) are very unpleasant and distressing conditions to patients; they are not common diseases, but large groups of people in countries such as Yemen and Somalia are affected owing to daily chewing of Qat for several hours every day, but in Iraq, the conditions are not common. These clinical studies were conducted on 133 patients: 87 men and 36 women; their age ranged between 18 and 72 years (mean, 45 y), and their complains were difficulties of chewing food, speech, laughing, or yawning. Patients were divided into 3 groups: the first group included 65 patients (45.53%) who were treated by surgical reconstruction of the TMJ by using a fingerlike fascial flap from the temporal fascia for reconstruction of a lax capsule and reenforcement and a block of corticocancellous bone graft from the iliac crest squeezed and impacted in a gap in front of the eminence of TMJ; the second group included 15 patients with delayed dislocation of TMJ (12.20%) who were treated by surgical release fusion of the capsule and condyle from the infratemporal fascia with reenforcement of the capsule by reverse L-shaped plication technique and eminectomy; and the last group included 45 patients with acute dislocation of the TMJ (34.96%) who were treated by modified manual reduction, and follow-up of the patients was between 1 and 20 years. An experimental study was done on rabbits to support our clinical study by using a temporal fascial flap for the reconstruction of a rabbit TMJ capsule, and the aim was to show that any pathologic changes might occur in the capsule or the condyle. The result was very optimistic, and there were no cellular changes observed in the condyle or surrounding structures.