食管心房调搏对室上性心动过速诊断的准确性评价

评价食管电生理检查对室上性心动过速诊断的准确性。方法 比较102例室上性心动过速经心内和食管电生理检查的结果。结果 102例室上性心动过速101例分型诊断一致：房室折返性心运过速（AVRT）58例,房室结折返性心运过速（AVNRT）37例,房内折返性心动过速（IART）5例,窦房结折返性心动过速（SART）1例,房性自律性心动过速（AAT）1例。6例房性心动过速（IART5例,AAT1例）起源于右房还是左房和57例房室折返性心动过速的旁路位于右侧还是左侧,两种检查结果完全一致。结论 食管心房调搏对室上性心动过速的分型诊断和初步定位诊断具有很高的准确性,这对选择射频消融术病例和简化消融术程序具有重要意义。     

食管心房调搏检查对窄QRS波群心动过速的诊断意义

目的 探讨食管电生理检查对窄QRS波群心动过速诊断的临床意义。方法 比较98例窄QRS波群心动过速食管和心内电生理检查的结果。结果 98例窄QRS波群心动过速97例分型诊断一致：房室折返性心动过速52例，房室结内折返性心动过速32例，心房内折返性心动过速和心房扑动各5例，房性自律性心动过速、窦房折返性心动过速和室性心动过速各1例。6例房性心动过速与54例房室折返性心动过速起源两种检查结果完全一致。结论 食管心房调搏对窄QRS波群心动过速的分型诊断和初步定位诊断具有很高的准确性，故可作为必要检查，有助筛选射频导管消融病例。     

食管心房调搏揭示室上性心动过速的探讨

食管心房调搏揭示室上性心动过速的探讨罗莹郑竹虚蔡力周晓芳黄启华陶建虹（四川省人民医院心血管病研究室成都６１００７２）关键词心动过速，室上性；食管；电刺激食管心房调搏可无创性揭示室上性心动过速（ＳＶＴ）的发生机理，可鉴别房室结折返性心动过速（ＡＶＮＲＴ...     

食管心房调搏揭示室上性心动过速的探讨

食管心房调搏揭示室上性心动过速的探讨罗莹郑竹虚蔡力周晓芳黄启华陶建虹（四川省人民医院心血管病研究室成都６１００７２）关键词心动过速，室上性；食管；电刺激食管心房调搏可无创性揭示室上性心动过速（ＳＶＴ）的发生机理，可鉴别房室结折返性心动过速(ＡＶＮＲＴ...     

应用食管心房调搏术检测评价硫氮酮对阵发性室上性心动过速的作用(摘要)

本研究通过食管心房调搏方法，对20例阵发性室上性心动过速（PSVT）频繁发作的患者，静脉注射硫氮书酮，观察其前后电生理效应，探讨其作用机理及临床意义。1．材料和方法：20例中男8例，女12例，年龄平均44．6（13～71岁）。根据电生理诊断标准。房室结折返性心动过速（AVNRT）7例；房室折返性心动过速（AVRT）12例，（顺向型10例、逆向型2例）；房内折返性心动过速（PAT）l例。检查前停用抗心律失常药物至少5个半衰期。应用食管心房调搏方法在窦性心律下，对心房作分组递增起搏及程控期前刺激法（SI～S。），步长10ms进行正反扫描…     

经食道心房调搏术诊治心律失常1159例的分析

目的：探讨经食道心房调搏（TEAP）对心律失常的诊断价值。方法：对1159例患者的食道与心内电生理检查（EPS）结果进行分析。结果：1159例检出房室结双径路299例（25．8％）,房室结多径路伴房室结折返性心动过速（AVNRT）3例,旁道伴房室折返性心动过速（AVRT）120例（占10．3％）．房性心动过速23例（2．0％）．窦房结折返性心动过速2例,迷走神经张力增高性过缓性心律失常152例（13．1％）,病态窦房结综合征11例（1．0％）;检查结果正常者414例（35．7％）。以超速抑制法终止阵发性室上性心动过速发作,成功144例（99．3％）,失败1例。结论：TEAP是一种简便、易行和高效、安全的心律失常诊治方法,值得临床广泛应用。     

食管心房调搏诊断室上性心动过速的临床研究

为探讨食管心房调搏揭示室上性心动过速发生机制的价值和局限性,回顾性分析成功射频导管消融的１３８例隐匿性单房室旁道参与的顺向型房室折返性心动过速和１００例单一类型房室结折返性心动过速的食管心房调搏结果。结果显示：前１３８例中,３例前间隔旁道引起者食管心房调搏均诊断为房室结折返性心动过速余为左右侧其它部位的旁道,诊断正确。后１００例中,５例为慢－慢型,２例为快－慢型,食管心房调搏均诊断为房室折返性心动     

食管心房调搏对顺向型房室折返性心动过速旁道定位的作用

食管心房调搏安全、简便、可靠，对快速心律失常的诊断、鉴别诊断与定位有着重要的临床价值。本文通过对食道调搏时被诊断为顺向型房室折返性心动过速(OAVRT)的58例患者，进行旁道定位与心内电生理检查结果的对比，评价食管心房调搏对OAVRT旁道定位的作用。     

应用食管心房调搏术检测评价硫氮酮对阵发性室上性心动过速的作用

本研究通过食管心房调搏方法，对20例阵发性室上性心动过速（PSVT）频繁发作的患者，静推硫氮革酮观察其前后电生理效应，探讨其作用机理及临床意义。1．材料和方法：20例中男8例，女12例，年龄平均44．6（13～17）岁。根据电生理诊断标准。房室结折返性心动过速（AVNRT）7例（慢快型）；房室折返性心动过速（AVRT）12例，倾向型10例，逆向型2例；房内折返性心动过速1例。其中1例患高心病，心功能Ⅱ级，1例患二尖瓣脱垂，其它无器质性疾病。检查前停用抗心律失常药物至少5个半衰期。应用食管心房调搏在窦性心律下对心房作分组递增起搏…     

窦房结折返性心动过速的诊断与鉴别诊断（附三例分析）

报道３例较少见的窦房结折返性心动过速，其中２例经食管心房调搏诱发。其特点为适当的房性、室性期前收缩可诱发或终止，发作时心房活动顺序、Ｐ波形态与窦性心律时完全相同。另１例为左侧隐匿性房室旁道行射频消融后心房内程序刺激诱发，心内电生理记录其发作前后的心房激动顺序完全一样。本文描述窦房结折返性心动过速的常规心电图及食管心电图特征，并对其发生机理、诊断及鉴别诊断进行讨论。     

Age-dependent changes of protein structure II. Conformational differences of aldolase of young and old rabbits

Conformational differences between aldolase from old and young rabbit muscle are revealed and described by means of UV difference spectroscopy, thermal perturbation difference spectra, and UV fluorescence. These two objects differ in thermal stability of protein conformation, but similar conformational transitions are observed on substrate binding.     

The effect of hormones on the haemodynamics in animals of different age groups

The investigation was undertaken to study to effect of varying doses of epinephrine, vasopressin, insulin, thyroxin, estradiol-dipropionate on the haemodynamics and contractility of the myocardium of rats in different age groups, as well as the effect of epinephrine and vasopressin on coronary blood circulation in dogs of various age groups. The age group peculiarities of reactions to the hormones were compared with changes in their content in the blood of animals of different age groups.Upon administering small concentrations of the hormones in this study, more pronounced changes in haemodynamics and contractility of the myocardium were observed in senile animals. The administration of larger doses led to more pronounced changes in mature animals. During the process of aging, there is a decrease in the range of the reactions of the cardiovascular system to the action of hormones.In case of long term (14 days) administration of thyroxin, it was found that in senile animals the contractility of the heart was lower than that in short term (4 days) administration. In long term administration of thyroxin, it was found that in mature animals the index for the myocardium's contracting ability was more pronounced than in short term administration.Irregular changes in the concentrations of different hormones in the blood, changes in sensitivity and ability of the myocardium to respond to their action lead to changes in the hormonal regulation of the heart, and to the development of aging metabolic and functional changes.     

Effects of HIV Infection on Pulmonary Artery Pressure in Children

BackgroundPulmonary hypertension may complicate human immunodeficiency virus (HIV) infection and result in right ventricular (RV) failure and premature death. There are limited data of the effects of childhood HIV infection or antiretroviral therapy (ART) on pulmonary artery pressure (PAP).ObjectivesTo establish if there is an association between childhood HIV infection or its treatment and pulmonary artery pressure.MethodsThe study conducted a cross-sectional study of 102 HIV-infected (48 ART-naïve, 54 ART-exposed) and 51 HIV-uninfected children in Jakarta, Indonesia, to estimate PAP using echocardiography parameters: tricuspid regurgitation peak velocity (TRV), left ventricular systolic index and diastolic eccentricity index (EI), and RV systolic function, assessed by tricuspid annulus plane systolic excursion. The association between either ART-naive or ART-exposed HIV and PAP was explored using general linear modelling adjusted for potential confounders.ResultsART-exposed HIV-infected children had higher TRV (adjusted difference: 0.36 m/s; 95% confidence interval [CI]: 0.12 to 0.60; p = 0.003) and diastolic EI (adjusted difference 0.06; 95% CI: 0.01 to 0.11; p = 0.02) than did uninfected children. The EI in ART-exposed children was significantly higher than normal. ART-naive HIV-infected children had a lower tricuspid annulus plane systolic excursion (adjusted difference: –2.2 mm; 95% CI: –3.73 to –0.71; p = 0.004), despite no difference in TRV (adjusted difference: 0.18 m/s; 95% CI: –0.06 to 0.43 m/s; p = 0.14). Seven (13%) ART-exposed and 4 (8.3%) ART-naïve HIV-infected children had pulmonary hypertension. Within-HIV group comparisons showed that accounting for lower respiratory tract infections attenuated the lower RV systolic function in ART-naïve children but not in ART-exposed children (difference: –1.1 mm; 95% CI:–2.8 to 0.7 mm; p = 0.22), but not the higher left ventricular eccentricity indexes in the ART-exposed children (systolic difference: 0.07; 95% CI: 0.02 to 0.12; p = 0.007; diastolic difference: 0.08; 95% CI: 0.02 to 0.14; p = 0.006).ConclusionsART-exposed HIV infection is associated with higher estimated PAP. Reduced RV systolic function is seen in ART-naïve HIV infection. Lower respiratory tract infection partly explains lower systolic RV function in ART-naïve relative to ART-exposed HIV infection.     

Biological age and its estimation. II. Assessment of biological age of albino rats by multiple regression analysis

Multiple regression model of biological age (BA) theoretically gives agreement with the main concept of BA. When assessment of BA is based on the model, the age being in regression center, the method provides satisfactory results, whereas BA estimates of individuals in extreme age groups are erroneous. Investigation of male and female Wistar rats of age 5–29 months showed the BA estimates calculated from 4–10 physiological indices in young (5–7 mo) animals are overestimated, and in old (24–28 mo) animals are underestimated. Coincidence of average BA in one-age group of animals with its chronological age served as a criterion for the correspondence of the estimate to “real” BA. The paper also examines the following questions: the necessary and sufficient number of physiological indices; the sample size from the intact animal population to establish normal aging standard; the relationship between BA and animal weight.     

Age-dependent changes of protein structure. I. Tissue-specific, electrophoretic and catalytical properties of muscle aldolase of old rabbits

The comparative study of highly purified muscle aldolase from young (6–8 months) and old (52–70 months) rabbits has been performed by the methods of affinity and ion-exchange chromatography, gel electrophoresis under different conditions and enzyme kinetics. The old muscle aldolase is A-type aldolase consisting of equal amounts of α- and β-subunits within a tetramer and does not differ in these properties from the “young” enzyme. The lower specific activity of the “old” enzyme has been observed and the determination of Km and V_max showed the decrease of these parameters with age. The age-dependent change of protein conformation has been suggested.     

抗血小板药物在心脑血管疾病中的临床应用

抗血小板治疗是冠心病、缺血性脑卒中、心房颤动等心脑血管疾病的重要治疗措施之一。近年来,随着抗栓领域基础及临床研究的逐步深入,出现了许多新型的抗血小板药物。本文通过对各种抗血小板药物的临床应用进行综述,以期为血栓栓塞性疾病,尤其是心脑血管疾病提供规范化、个体化的抗血小板治疗。     

Regression of atherosclerotic stenosing lesions of the renal arteries and spontaneous cure of systemic hypertension through control of hyperlipidemia

We describe a 49 year old woman with impressive regression of renal artery stenosing atherosclerotic lesions in response to sustained excellent control of hyperlipidemia.Initially, she had high blood pressure necessitating combined drug therapy with chlorothiazide, methyldopa and propranolol, with only moderately satisfactory control. Renal arteriography revealed a 90 per cent stenosing lesion of the right renal artery and 75 per cent narrowing of the left renal artery. Peripheral vein plasma renin was markedly increased at 32 ng/ml. With a combination of cholestyramine and clofibrate, serum lipids were maintained at normal values for several years. Increased blood pressure diminished spontaneously, and the patient has maintained normal blood pressures after discontinuation of antihypertensive therapy. Repeat renal arteriograms showed almost complete regression of the right renal artery lesion and a possible decrease in left renal artery disease. Peripheral vein plasma renin became normal at 3 ng/ml.This case illustrates that sustained control of hyperlipidemia could lead to regression of atherosclerotic nodules and impressive clinical improvement in certain patients.     

The effects of proteins upon the filtration coefficient of individually perfused frog mesenteric capillaries.

The filtration coefficients (L_p) of the walls of individually perfused frog mesenteric capillaries have been measured using the methods described by Michel et al. (1974). When a vessel was perfused with frog Ringer solution containing no protein, L_p was four to five times greater than its value for the same capillary perfused with frog plasma. The increase of L_p seen on perfusion with protein-free solutions was readily reversible and could be prevented by adding to the Ringer perfusate bovine serum albumin, bovine γ-globulin and human haemoglobin. The addition of whale myoglobin (0.5 g 100 ml^?1) to the Ringer perfusate did not prevent an increase in L_p. Ringer solutions containing 0.1 g of bovine serum albumin 100 ml^?1 were as effective as those containing higher concentrations of albumin in preventing the increase in L_p, but the L_p of capillaries perfused with solutions containing 0.01 g of albumin 100 ml^?1 did not differ from the values for the same capillaries perfused with protein-free solutions. It was shown that in any given capillary, L_p was independent of the direction of fluid flow across the vessel wall and was the same when the capillary was perfused with 9.0 g of bovine albumin 100 ml^?1 and 3 g of bovine γ-globulin 100 ml^?1. Whereas the effects of L_p are seen within 1 min of removing the protein from the perfusate, no changes in L_p were observed during the first 20 min of perfusion and superfusion of capillaries with solutions free of Ca²⁺ and Mg²⁺. L_p also appeared to be unaffected after 20 min perfusion with neuraminidase. It is suggested that plasma proteins are adsorbed onto capillary walls and greatly modify capillary permeability.