无后囊的后房型人工晶体缝线固定术

目的：评价后房型人工晶体（ＩＯＬ）缝线固定术的疗效。方法：４０例（４１只眼）无后囊膜的无晶体眼，外伤性白内障或白内障囊外摘除后囊膜破损＞５ｍｍ、晶体半脱位，施行后房型ＩＯＬ缝线固定术。结果：本组４１只眼手术均获成功，术后随访４～１８月。裸眼视力≥０．４者３５眼，占８５．３７％；≥０．１者６眼，占１４．６３％。术后３６眼ＩＯＬ居中，１眼轻度偏心，４眼轻度倾斜。结论：无后囊的后房型ＩＯＬ缝线固定术，是一种安全理想的方法。     

白内障超声乳化吸除及后房型人工晶体植入术探讨

探讨并总结超声乳化技术及超声乳化仪各项机械参数的合理运用。方法对３９例（４４只眼）老年性、并发性、先天性和外伤性白内障行超声乳化摘除。结果术后１天裸眼或矫正视力≥０．５者占４５．４５％，术后１周、１个月和３个月视力≥０．５者分别占６８．１８％、７９．５４％和８６．３６％。角膜散光术后１周≤１．５Ｄ占６４％，术后１月≤１．５Ｄ占７５％。结论超声乳化白内障吸除术，术后散光小，视力恢复快，值得在临床推广应用。但也是一种极其复杂的手术，需要手术者充分了解超声乳化仪的原理及性能才能获得满意的手术效果。     

170眼白内障囊外摘除并植入人工晶体临床分析

对１３８例患者１７０眼施行白内障囊外摘除并植入人工晶体，其中老年性白内障１３２眼，并发性白内障２５眼，外伤性白内障１３眼，患者年龄８￣８５岁，术后随访半月至１９个月，视力≤０．４者１８眼，占１０．６％≥０．５者１５２眼，占８９．４％。     

外伤性白内障人工晶体植入手术的探讨

对６２例（６２只眼）外伤性白内障施行白内障摘除及人工晶体植入手术。随访３～３８个月，术后矫正视力≥０５者占５１６％，≥１０者占２０９％。对外伤性白内障人工晶体植入的时机、手术操作、术后并发症及前房型人工晶体的植入进行了探讨。认为正确选择手术时机，处理好术中并发症，选择合适的晶体，可以减轻术后并发症，使病人恢复更好视力。     

人工晶体植入术治疗外伤性白内障28例

外伤性白内障２８例行人工晶体植入术。空孔伤２３例，其中空孔伤合并球内异物３眼；钝挫伤５眼。伤后至手术时间为３天￣２年。２８眼均植入后房型人工晶体。出院时敌正视力≥０．８者１６例（５７．１％），随访时间４月￣１４个月。随访时矫正视力≥０．５者１３例（６５．０％），对外伤性白内障的特点、手术时间和手术操作的关键作了讨论和分析。     

角膜穿通修补联合后房型人工晶体植入

对１０例角膜穿通并外伤性白内障患者在修复角膜伤口同时摘出白内障联合后房型人工晶体植入。随访时间３～１３个月，矫正视力０．４者２例，≥０．５者６例，≥１．０者２例。着重对手术时机、适应证、并发症等进行了讨论     

白内障超声乳化吸出及囊袋内人工晶体植入术

为观察和评价超声乳化白内障吸出术的临床效果、特点、并发病及防治措施，对４１　眼白内障施行超声乳化吸出术及小切口（６ｍｍ）囊袋内人工晶体植入术，并以同期的白内障患者４１眼行现代囊外摘除及后房型人工晶体植入做对照。结果：术后６个月，视力≥１．０者占４３．９％＞０．８者占７０．７≥０．５者占９２．７％，均明显高于对照组（Ｐ＜０．００１），术后平均散光为１．０４±０．８１，１，低于对照组（Ｐ＜０．０１）。白内障超声乳化吸出并囊袋内人工晶体植入术的复明效果优于囊外摘除并后房型人工晶体植入术。     

角膜穿透修补联合后房型人工晶体植入

对１０例角膜穿通并外伤性白内障患者在修复角膜伤口同时摘出白内障联合后房型人工晶体植入。随访时间３－１３个月，矫正视力０．４者２例，≥０．５者６例，≥１．０者２例。着重对手术时机，适应证，并发症等进行了讨论。     

白内障超声乳化吸出术及后房型人工晶体植入术临床观察（附250例分析）

为开展白内障超声乳化吸出术，探索提高成功率的方法，笔者对２５０例（２６０只眼）各类型白内障施超声乳化吸出术后及后房型人工晶状体植入术，结果：术后一周裸眼或矫正视力≥０．５者占９０．８％，一个月者占９４．０％，三个月者占９７．９％，平均散光术后一周为１．１５±０．５４Ｄ，一个月为１．０４±０．６１Ｄ，三个月为０．９４±０．６２Ｄ，分别小于１２ｍｍ大切口对照组（Ｐ〈０．０５），认为超声乳化后效果明显优     

外伤性白内障人工晶体植入手术的探讨

对６２例外伤性白内障施行白内障摘除及人工晶体植入手术。随记３－３８个月，术后矫正视力〉０．５才占５１．６％，〉１．０者占２０．９％，对外伤性白内障人工晶体植入的时机，手术操作，术后并发症及前房型人工晶体的植入进行了探讨，认为正确选择手术时机，处理好术并发症，选择合适的晶体，可以减轻术后并发症，使病人恢复更好视力     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.