计算机操作引起的尺骨撞击综合征

[目的]探讨键盘鼠标操作引起腕部尺骨撞击综合征的原因.[方法]2004年12月～2007年12月,诊断为尺侧撞击综合征的长期键盘鼠标操作者33例,利用物理检查及影像学检查,分析操作键盘鼠标引起尺骨撞击综合征的原因.[结果]尺骨阳性变异13例(39.3%),10例尺骨中性变异患者在握拳、旋前位能够诱发尺骨动态阳性变异(66.7%);13例(92.9%)出现腕骨MRI信号改变,信号改位于腕骨、尺骨头相对部位;13例(92.9%)出现三角纤维软骨(triangular fibrocartilage,TFC)损伤,部位多在尺侧及中央部(76.9%).[结论]长时间反复键盘鼠标操作,使腕部频繁或高重复性尺偏、旋前,加剧或诱发尺骨动态阳性,导致尺骨头密集地撞击TFC和腕骨,造成尺骨撞击综合征.     

尺骨撞击综合征的特点及早期诊断

目的探讨尺骨撞击综合征的特点及早期诊断方法并提出新的诊断标准。方法对1998年12月～2004年12月治疗的123例腕尺侧疼痛患者进行仔细检查,采用顾玉东等提出的诊断标准,特别结合腕部MRI检查,确诊尺骨撞击综合征48例。总结尺骨憧击综合征的X线及MRI影像学特点,分析腕部临床症状与Chun和Palmer评分及影像学表现的关系。结果本组33例患者存在尺骨阳性变异(68．8%),X线检查发现患者出现腕骨坏死比例为27．1%,其中以月骨坏死为主(64．7%)；MRI检查均发现腕骨不同程度信号改变,腕部骨坏死均位于月骨尺侧部分的近端和三角骨腰部及底部；患者腕部临床症状与Chun和Palmer评分及影像学表现关系密切。结论提高对尺骨撞击综合征的认识水平,以临床症状为基础,充分利用影像学检查,特别是MRI检查,可以明显提高该病征的早期诊断率。     

桡骨远端骨折治疗后腕部尺骨撞击综合征

目的探讨桡骨远端骨折后尺骨撞击综合征与遗留腕部功能受限的关系。方法对桡骨远端骨折后遗留腕尺侧疼痛、握力下降的患者进行仔细检查,结合Tamaino和Cerezal的诊断标准,确诊尺骨撞击综合征52例,并探讨腕关节功能评分(Sarmiento改良方法)与尺骨变异程度的关系。结果尺骨阳性变异38例(73.1%),其中变异超过10mm者31例(59.6%);优、良组的平均尺骨变异为(1.5±0.5)和(4.5±1.8)mm,可、差组的平均尺骨变异为(9.6±3.7)和(16.2±4.8)mm,腕部症状与尺骨变异程度关系密切(P<0.01)。MRI检查发现腕骨及三角纤维软骨复合体(TFCC)不同程度信号改变,腕骨坏死位于月骨尺侧部分的近端和三角骨腰部及底部。结论桡骨远端骨折后治疗不当可导致尺骨撞击综合征,遗留腕尺侧疼痛、握力下降,其病理过程是腕骨及TFCC损伤,而非单纯的软组织损伤。     

尺骨撞击综合征诊疗进展

尺骨撞击综合征是导致腕部尺侧疼痛的重要原因之一,其病因多为尺骨阳性变异,诊断依靠症状、查体、影像学检查及腕关节镜检查。X线检查可观察到尺骨阳性变异,月骨和三角骨硬化、囊变等;MRI检查可以早期发现骨髓及软骨改变如水肿、囊变,以及三角纤维软骨复合体损伤等,灵敏度及特异度较高;腕关节镜可以直接观察到腕关节月骨偏尺侧软骨软化或损伤,发现MRI等影像学检查难以发现的早期细微病变,是诊断尺骨撞击综合征的金标准,同时镜下可进行治疗性操作。尺骨撞击综合征通常保守治疗效果有限,以手术治疗为主,手术方法主要有尺骨短缩截骨术、Wafer术、腕关节镜下清理术、桡骨截骨矫形术等。该文就尺骨撞击综合征诊断及治疗进展进行综述。     

非创伤性尺腕撞击综合征的诊断和治疗

目的 探讨无明确创伤病史且X线片表现不典型的尺腕撞击综合征的特点及诊断标准和治疗方法.方法 回顾性研究2003年10月至2010年10月明确诊断和治疗的55例尺腕撞击综合征患者中没有明确创伤病史且X线片表现不典型的25例,在Kostas诊断标准基础上,观察尺腕压力试验、动态尺骨正向变异、MRI检查的阳性率和腕关节镜检查,分析观察指标对诊断结果的影响和临床意义.治疗采取尺骨短缩手术,截骨方式中16例采用水平截骨(Darrow法),9例采用斜行截骨(Rayhack法),加压钢板螺钉内固定.采用Darrow标准作为疗效评价标准.结果 本组25例患者中尺腕压力试验阳性比率为84％,动态尺骨正向变异的发生比率为52％,MRI检查发现腕骨信号改变的比率为82％,以月骨尺侧部近端和三角骨腰部最为常见,腕关节镜检查三角纤维软骨复合体(TFCC)退变及尺骨头和月骨的软骨退变比率为100％.随访时间4～48个月,平均26个月.25例骨折均愈合,水平截骨的平均愈合时间为4.5个月,斜行截骨的平均愈合时间为2.5个月.优7例,良15例,中2例,差1例;总优良率为88％.术后未发生严重并发症,治疗结果满意.结论 非创伤性尺腕撞击综合征由于缺少明确的创伤病史,尤其当X线片表现不典型时同其他引起腕关节尺侧疼痛的病因较难鉴别,应用尺腕压力试验、动态尺骨正向变异检查和早期MRI检查可早期明确诊断,有效提高诊断率.腕关节镜检查可作为诊断困难和鉴别诊断的补充手段.应用尺骨短缩手术可明显改善症状,斜行截骨是值得推荐的截骨方式.     

桡骨远端骨折腕关节MRI和疗效评估的临床研究

目的 探讨桡骨远端骨折疗效欠佳的原因，及其与骨折伴发的软组织损伤的关系。方法 对65例桡骨远端骨折内固定物取出术后，经平均1．8年随访的患者，选择其中20例（评分为良4例，可11例，差5例）进行腕关节MRI检查，观察关节软骨和腕尺侧三角纤维软骨（triangularfibro cartilage，TFC）的损伤情况。结果 MRI检查发现，9例有明显的TFC损伤（占45％，其中评分为良1例，可3例，差5例）。8例有桡骨远端关节软骨的损伤（40％，评分为可3例，差5例）。结论 TFC损伤和创伤性关节炎可能是影响桡骨远端骨折疗效，造成术后腕部慢性疼痛的主要原因。     

关节镜技术治疗前外侧踝关节撞击综合征

[目的]探讨前外侧踝关节撞击综合征的病因及关节镜治疗效果。[方法]回顾分析踝关节镜技术治疗的22例前外侧踝关节撞击综合征患者。所有患者均行关节镜清理,清除撞击组织,修整损伤的软骨。采用AOFAS评分系统和Meislin标准对疗效进行评估。[结果]22例患者术后均获得随访(随访时间12~24个月,平均16.8个月),镜下发现均存在前外侧踝撞击,撞击物类型:外侧滑膜组织撞击12例,半月板样组织撞击3例,下胫腓前韧带远侧束撕裂撞击3例,距腓前韧带损伤瘢痕组织增生撞击4例。AOFAS评分由术前的(46.27±12.50)分提高到末次随访时的(85.14±10.20)分,手术前后差异具有统计学意义(P<0.05)。采用Meislin标准进行疗效评估,优8例,良10例,可4例,差0例,优良率81.82%。[结论]踝关节前外侧撞击综合征多发生在踝关节反复损伤后,撞击物多为增生瘢痕组织,可合并出现关节软骨损伤。关节镜是诊断和治疗踝关节前外侧软组织撞击综合征的有效手段,具有创伤小、恢复快、疗效好等优点。     

踝关节软组织撞击综合征的诊断和治疗

目的 探讨踝关节软组织撞击综合征的诊断和治疗。方法 1995年3月～2001年5月，我科共收治踝关节软组织撞击综合征36例。其中经MRI检查后行踝关节切开嵌夹软组织切除术14例，关节镜检查及镜下切除嵌夹软组织22例。结果 随访36例，时间6月～7年，平均22月，优9例，良19例，可7例，差1例，优良率77．8％(28／36)。结论 关节镜检查及镜下手术是治疗踝关节软组织撞击综合征有效方法。     

MSCT图像重建技术在尺骨撞击综合征中的应用

目的评价MSCT图像重建技术在尺骨撞击综合征诊断中的应用价值。方法回顾性分析经腕关节镜检查证实的18例尺骨撞击综合征患者MSCT图像重建技术及标准后前位X线平片检查的影像资料,对尺骨变异、月骨及三角骨异常变化进行统计学分析。结果⑴MSCT图像重建技术及标准后前位X线平片检查测量出的尺骨变异差异无统计学意义(t=0.3562,P>0.05);⑵MSCT图像重建显示18例尺骨阳性变异15例,占总例数83.3%,其中阳性变异超过2 mm者11例,占总阳性变异的73.3%;中性及阴性变异3例,占总例数16.7%;⑶MSCT重建技术显示月骨和/或三角骨异常变化14例,占总例数77.8%,其中单纯月骨异常变化8例,月骨及三角骨同时异常变化5例,单纯三角骨异常变化1例。标准后前位X线平片能显示月骨和/或三角骨异常变化10例,占总例数55.6%,其中单纯月骨异常变化6例、月骨及三角骨同时异常变化4例,无单纯三角骨异常变化;⑷MSCT图像重建技术测量尺骨阳性伴月骨及三角骨异常变化14例,占总例数77.8%,尺骨阳性变异不伴月骨及三角骨异常变化1例,占总例数5.6%。阳性变异大于2 mm伴月骨及三角骨异常变化11例,占总例数61.1%,月骨及三角骨异常变化例数的78.6%。无尺骨中性及阴性变异伴月骨及三角骨异常变化。结论MSCT图像重建技术及后前位X线平片测量尺骨变异无统计学差异;尺骨撞击综合征发展过程中尺骨阳性变异呈易感因素;尺骨阳性变异大于2 mm时易引起月骨、三角骨异常变化;MSCT图像重建技术可以很好地显示尺骨变异及月骨、三角骨骨质硬化情况。     

腕关节镜下Wafer术治疗尺骨撞击综合征26例围手术期护理体会

目的探索腕关节镜下尺骨头部分磨除术(Wafe术)治疗尺骨撞击综合征的围手术期护理。方法在26例尺骨撞击综合征患者行腕关节镜下Wafer术治疗期间,实施术前心理疏导、完善准备、术后并发症的预防与观察等护理措施。结果 26例患者均顺利完成手术,术后分别出现1例引流管积血阻塞和1例尺神经浅支损伤,均经对症处理后痊愈,未发生其他严重并发症。术后2个月采用改良Mayo评分评定腕关节功能,本组优良率100.00%(26/26)。术后3个月肌力恢复均至健侧80%以上。未发生腕部疼痛及严重腕关节活动受限等后遗症。结论对尺骨撞击综合征患者实施腕关节镜下Wafer术治疗期间,全面而细致行围术期护理,有助于减少术后并发症,提升手术效果和促进腕关节功能的恢复。     

Vasopressor hormone response following mesenteric traction during major abdominal surgery

Background : We investigated the vasopressor hormone response following mesenteric traction (MT) with hypotension due to prostacyclin (PGI₂) release in patients undergoing abdominal surgery with a combined general and epidural anesthesia. Methods : In a prospective, randomized, placebo-controlled study we administered 400 mg ibuprofen (i.v.) in 42 patients scheduled for abdominal surgery. General anesthesia was combined with epidural anesthesia (T4-L1). Before as well as 5, 15, 30, 45, and 90 min after MT we recorded plasma osmolality, hemodynamics and measured 6-keto-PGFlα (stabile metabolite of PGI₂), TXB₂ (stabile metabolite of thromboxane A₂) active renin, and arginine vasopressin (AVP) plasma concentrations by radioimmunoassay. Catecholamine levels were assessed by high-pressure liquid chromatography (HPLC) with electrochemical detection. Results : Following MT, arterial hypotension occurred along with a substantial PGI₂ release. This was completely abolished by ibuprofen administration. Although plasma levels of 6-keto-PGF_1α (1133 (708) vs. 60 (3) ng/L, median (median absolute deviation), P=0.0001, placebo vs. ibuprofen) remained significantly elevated, blood pressure was restored within 30 min after MT in the placebo group. At the same point in time plasma concentrations of TXB² (164 (87) vs. 58 (1) ng/L, P=0.0001), epinephrine (46 (33) vs. 14 (6) ng/L, P=0.001), AVP (41 ± (18) vs. 12 (7) ng/L, P=0.0004), and active renin (27 (12) vs. 12 (4) ng/L, P = 0.001) were significantly higher in placebo-treated patients. Conclusion : Under combined general and epidural anesthesia arterial hypotension following MT due to endogenous PGI₂ release is associated with enhanced release of AVP, active renin, epinephrine and thromboxane A₂, presumably contributing to hemodynamic stability within 30 min after MT.     

A Teaspoon Pump for Pumping Blood with High Hydraulic Efficiency and Low Hemolysis Potential

Abstract: Virtually all blood pumps contain some kind of rubbing, sliding, closely moving machinery surfaces that are exposed to the blood being pumped. These valves, internal bearings, magnetic bearing position sensors, and shaft seals cause most of the problems with blood pumps. The original teaspoon pump design prevented the rubbing, sliding machinery surfaces from contacting the blood. However, the hydraulic efficiency was low because the blood was able to "slip around" the rotating impeller so that the blood itself never rotated fast enough to develop adequate pressure. An improved teaspoon blood pump has been designed and tested and has shown acceptable hydraulic performance and low hemolysis potential. The new pump uses a nonrotating "swinging" hose as the pump impeller. The fluid enters the pump through the center of the swinging hose; therefore, there can be no fluid slip between the revolving blood and the revolving impeller. The new pump uses an impeller that is comparable to a flexible garden hose. If the free end of the hose were swung around in a circle like half of a jump rope, the fluid inside the hose would rotate and develop pressure even though the hose impeller itself did not "rotate"; therefore, no rotating shaft seal or internal bearings are required.     

Microspheres Based Detoxification System: A New Method in Convective Blood Purification

Abstract: A variety of protein-bound or hydrophobic substances, accumulating as a result of pathologic conditions such as exogenous or endogenous intoxications, are removed poorly by conventional detoxification methods because of low accessibility (hemodialysis), insufficient adsorption capabilities (hemosorption), low efficiency (peritoneal dialysis), or economic limitations (high-volume plasmapheresis). Combining advantages of existing methods with microspheric technology, a module-based system was designed. Major operating parameters of the latter can be modified to allow for adjustment to individual clinical situations. An extracorporeal blood circuit including a plasmafilter is combined with a secondary high-velocity plasma circuit driven by a centrifugal pump. Different microspheric adsorbers can be combined in one circuit or applied in sequence. Thus, a prolonged treatment can be tailored using specially designed selective adsorber materials. Comparing this system with existing methods (high-flux hemodialysis, molecular adsorbent recycling system), results from our in vitro studies and animal experiments demonstrate the superior efficiency of substance removal.     

Tissue perfusion in relation to cardiac output during continuous positive-pressure ventilation and administration of propranolol or verapamil

Background : Our objective was to determine whether administration of propranolol or verapamil modifies the hemodynamic adaptation to continuous positive-pressure ventilation (CPPV), in particular the regional distribution of cardiac output (CO).
Methods : General hemodynamics and regional blood flows assessed by microsphere technique (15 (μm) were recorded in 16 anesthetized pigs during spontaneous breathing (SB) and CPPV with 8 cm H₂O end-expiratory pressure (CPPV8) before and after intravenous administration of propranolol (0.3 mg · kg⁻¹ followed by 0.15 mg · kg⁻¹ · h⁻¹, n=8) or verapamil (0.1 mg · kg⁻¹ followed by 0.3 mg · kg⁻¹ · h⁻¹, n=8).
Results : CPPV8 depressed CO by 25% without shifts in its relative distribution with the exception of a noteworthy increase in adrenal perfusion. Propranolol increased arterial blood pressure, and due to a fall in heart rate, CO dropped by 25%. The kidneys and, to a lesser extent, the splanchic region and central nervous system received increased fractions of the remaining CO at the expense of skeletal muscle flow. Similar patterns were seen during SB and CPPV8 such that the combination of propranolol and CPPV8 depressed CO by 50%. The circulatory effects of verapamil were less evident but myocardial perfusion tended to increase.
Conclusions : The combination of propranolol or verapamil with CPPV does not result in any specific hemodynamic interaction in anesthetized pigs, except that the combined effect of propranolol and CPPV may severely reduce CO.     

Bariatric Surgery in Some "Central and East-European (former Eastern bloc)"Countries - Current Status and Prediction for the Next Millennium

Background: Obesity is increasing globallly, including in the formerly "Eastern Bloc" countries. Methods: A survey was made of obesity and bariatric surgery. Results: In the 8 East and Central European countries studied, with total population 300 million, roughly 43% of the population was overweight (BMI 25-30), 23% obese (BMI > 30), with about 15 million people morbidly obese (BMI > 40). From 0-10 morbidly obese individuals/100,000/year undergo bariatric surgery. Conclusion: Most countries were found to provide inadequate treatment for obesity.The majority of the morbidly obese are not treated effectively. However, health-care awareness of obesity and bariatric surgeons are slowly increasing.     

Volatile anaesthetics reduce adhesion of blood platelets under low-flow conditions in the coronary system of isolated guinea pig hearts

Background : Inhibitory effects of volatile anaesthetics on platelet aggregation have been demonstrated in several studies. However, the influence of volatile anaesthetics on intracoronary platelet adhesion has not been elucidated so far.
Methods : Isolated hearts of guinea pigs were perfused with buffer in the absence or presence of volatile anaesthetics (0.5 and 1 MAC) at constant coronary flow rates of 5 ml/min for 25 min, then 1 ml/min for 30 min and again 5 ml/min for 10 min. Before, during and after low-flow perfusion, a bolus of human platelets was applied into the coronary system. To simulate thrombogenic conditions, 0.3 U/ml human thrombin was infused during low-flow perfusion and reperfusion. The number of platelets sequestered to the endothelium was calculated from the difference between coronary in- and output of platelets. The myocardial production of lactate and consumption of pyruvate and coronary perfusion pressure were also determined.
Results : At a flow rate of 5 ml/min only about 3% of the applied platelets did not emerge from the coronary system, in any group. In contrast, 13.1±1.2% (mean±SEM) of infused platelets became adherent in low-flow perfusion in the control group without anaesthetic. The adherence was reduced with each 1 MAC isoflurane (to 6.2±1.2%), sevoflurane (to 4.4±0.9%) or halothane (to 3.2±1.5%) (each P <0.05 vs. control). Volatile anaesthetic, 0.5 MAC, did not inhibit platelet adhesion to a statistically significant extent in any case. Perfusion pressure and metabolic parameters were not statistically different between the control and the hearts exposed to anaesthetics.
Conclusion : Volatile anaesthetics in a concentration of 1 MAC can reduce the adhesion of platelets in the coronary system under reduced flow conditions. This action does not arise from vasodilation or inhibition of ischaemic stress.     

Synergistic interaction between the effects of propofol and midazolam with fentanyl on phrenic nerve activity in rabbits

Background: It has been shown that the depressive effects of both propofol and midazolam on consciousness are synergistic with opioids, but the nature of their interactions on other physiological systems, e. g. respiration, has not been fully investigated. The present study examined the effect of propofol and midazolam alone and in combination with fentanyl on phrenic nerve activity (PNA) and whether such interactions are additive or synergistic. Methods: PNA was recorded in 27 anaesthetised and artificially ventilated rabbits. In three groups, propofol, fentanyl and midazolam were administered intravenously in incremental doses to construct dose-response curves for the depressant effects of each one on PNA. In another two groups, the effect of pretreatment with either fentanyl 1 μg · kg^?1 i. v. or midazolam 0.05 mg · kg^?1 i. v. on the effects of propofol and fentanyl respectively on PNA were studied. Results: Propofol and fentanyl caused a dose-dependent depression of PNA with complete abolition at the highest total doses of 16 mg · kg^?1 i. v. and 32 μg · kg^?1 i. v., respectively. In contrast, midazolam in incremental doses to a total of 0.8 mg · kg^?1 reduced mean PNA by 63%, but approximately 12% of PNA remained at a total dose as high as 6.4 mg · kg^?1. The mean ED₅₀s, calculated from dose-response curves, were 5.4 mg · kg^?1, 3.9 μg · kg^?1 and 0.4 mg · kg^?1 for propofol, fentanyl and midazolam, respectively. Initial doses of either fentanyl 1 μg · kg^?1 i. v. or midazolam 0.05 mg · kg^?1 i. v. acted synergistically with subsequent doses of either propofol or fentanyl to abolish PNA at total doses of 8 mg · kg^?1 and 8 μg · kg^?1, respectively. Conclusion: Fentanyl has a synergistic interaction with both propofol and midazolam on PNA and hence potentially on respiration.     

Influence of dopexamine hydrochloride on haemodynamics and regulators of circulation in patients undergoing major abdominal surgery

Background: Catecholaminergic support is often used to improve haemodynamics in patients undergoing major abdominal surgery. Dopexamine is a synthetic vasoactive catecholamine with beneficial microcirculatory properties. Methods: The influence of perioperative administration of dopexamine on cardiorespiratory data and important regulators of macro- and microcirculation were studied in 30 patients undergoing Whipple pancreaticduodenectomy. The patients received randomized and blinded either 2 μg · kg^?1 · min^?1 of dopexamine (n=15) or placebo (n=15, control group). The infusion was started after induction of anaesthesia and continued until the morning of the first postoperative day. Endothelin-1 (ET-1), vasopressin, atrial natriuretic peptide (ANP), and catecholamine plasma levels were measured from arterial blood samples. Measurements were carried out after induction of anaesthesia, 2 h after onset of surgery, at the end of surgery, 2 h after surgery, and on the morning of the first postoperative day. Results: Cardiac index (CI) increased significantly in the dopexamine group (from 2.61±0.41 to 4.57±0.78 1 · min^?1 · m^?2) and remained elevated until the morning of the first postoperative day. Oxygen delivery index (DO₂I) and oxygen consumption index (VO₂I) were also significantly increased in the dopexamine group (DO₂I: from 416±91 to 717±110 ml/m² · m²; VO₂I: from 98±25 to 157±22 ml/m² · m²), being significantly higher than in the control group. pHi remained stable only in the dopexamine patients, indicating adequate splanchnic perfusion. Vasopressive regulators of circulation increased significantly only in the untreated control patients (vasopressin: from 4.37±1.1 to 35.9±12.1 pg/ml; ET-1: from 2.88±0.91 to 6.91±1.20 pg/ml). Conclusion: Patients undergoing major abdominal surgery may profit from prophylactic perioperative administration of dopexamine hydrochloride in the form of improved haemodynamics and oxygenation as well as beneficial influence on important regulators of organ blood flow.     

Systemic analgesia adapted to the children's condition

A concept of balanced analgesia using nonsteroidal anti-inflammatory drugs (NSAIDs), paracetamol (acetaminophen), opioids, and corticosteroids can also be used in patients with pre-existing illnesses. NSAIDs are the most effective treatment for acute pain of moderate intensity in children; however, these drugs should be avoided in patients at increased risk for serious side effects, e.g. patients with renal impairment, bleeding tendency, or extreme prematurity. NSAIDs can be given with minimal risks to the younger child with mild to moderate asthma, and, in these patients, the use of steroids can be encouraged; in addition to their antiemetic and analgesic action, a beneficial effect on asthma symptoms can be expected. In the non-intubated child with cerebral trauma, exaggerated sedation caused by opioids and increased bleeding tendency caused by NSAIDs must be avoided. In neonates and small infants, the oral administration of sucrose or glucose is helpful to minimize pain reaction during short uncomfortable interventions.