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<正> 强啡肽(Dynorphin)是1979年Goldstain等发现的一种内源性阿片肽,它在离体豚鼠回肠标本上具有强烈的阿片样活性。近年来,对于它在体内不同中枢部位的痛觉调制作用以及在电针镇痛中所起的作用日益引起人们的兴趣。在脊髓内,已有资 相似文献
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针刺镇痛频率特异性的进一步证明 总被引:45,自引:3,他引:45
我们以往的工作证明 ,不同频率的电针会引起中枢不同种类的神经肽释放 ,产生不同的生理作用和治疗效果 ,近年来又有一些新的资料进一步证明并扩展了这一假说。1 .2Hz电针引起中枢内吗啡肽 (EM)释放 ,1 0 0Hz无效EM是近年新发现的一种阿片肽 ,还不清楚何种频率的电针可促进其释放。①将EM抗体注入大鼠脊髓蛛网膜下腔可阻断 2Hz电针镇痛 ,而不影响 1 0 0Hz电针镇痛 (Han ,etal.NeuroscLett,1 999,2 74:75) ;②将EM抗体或μ受体拮抗剂CTOP注入小鼠脑室 ,阻断 2Hz电针镇痛而不影响 1 0 0Hz电针镇痛 (… 相似文献
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The mechanism of acupuncture analgesia (AA) has been widely explored since the 1970s. Early studies investigated the relationship between acupuncture and endogenous opiates (beta-endorphin, enkephalin, endomorphin and dynorphin). Before the 1990s, most experts agreed on the concept that in normal animal models, lower frequency electroacupuncture (EA) stimulates the release of beta-endorphin, enkephalin and endomorphin, which in turn activates the mu- and delta-opioid receptors, and that higher frequency EA stimulates dynorphin which activates the kappa-opioid receptor. Besides endogenous opiates, our studies have focused on serotonin. The serotoninergic descending inhibitory pathway is suggested to be an important mechanism of acupuncture analgesic, collaborating with endogenous opiates. Many efforts have been made to clarify these mechanisms, but to date no satisfactory consensus has been reached. In the late 1990s, researchers began to focus on the different analgesic effects of EA between normal and hyperalgesic animal models. Published data from these studies imply that normal and hyperalgesic animals respond differently to EA. Results from experiments on the anti-hyperalgesia effect of EA have raised a new issue about the influences of EA on receptors to excitatory amino acid in the spinal cord level. Results from various studies have shown that these receptors play a role in the mechanism of AA. Recently, research on the autonomic nervous system (ANS) seem to indicate its connection with acupuncture. The inflammatory reflex (via the ANS) might be a crucial part of anti-hyperalgesia elicited by acupuncture, and this reflex, which regulates the immune system in the organism, can elucidate not only the mechanism of AA but also the mechanism of acupuncture applied to other inflammatory conditions. Innovation of functional image study enables us to analyze the responses of cortex on living human body to acupuncture. However, results of these experiments are still controversial. After 30 years of acupuncture research, there are still many puzzles left to be solved regarding the mechanism of AA. 相似文献
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中脑导水管周围灰质内催产素在电针镇痛中的作用及机制的实验研究 总被引:4,自引:1,他引:3
我们以往的工作表明 ,侧脑室和脊髓蛛网膜下腔内注射催产素 (OT)能明显提高大鼠电针镇痛效应 ,注射抗催产素血清 (AOTS)则能显著降低电针镇痛效应。提示 ,中枢神经系统内的催产素在电针镇痛的复杂过程中发挥着一定作用。中脑导水管周围灰质 (PAG)是电针镇痛的关键部位 ,其内含有丰富的OT、OT神经末梢及OT受体 ,但中枢OT在电针镇痛中的作用是否与之有关 ,作用机制怎样 ?是一个引人关注的问题。本工作以钾离子透入法 ,以甩尾法作为疼痛指标 ,测定大鼠痛阈 ,观察PAG注射OT、AOTS、纳洛酮 (Nx)、抗 β 内啡肽血清 (… 相似文献
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This study examined whether or not the antinociceptive effect of 2- or 100-Hz electroacupuncture (EA) depends on the integrity of the retrosplenial cortex (RSC). Rats were taken for determination of tail-flick latency before and after injection of saline or 2% lidocaine (0.25 μl) into the retrosplenial cortex (RSC) bilaterally. Five minutes later, they were submitted to a 20-minute period of 2 Hz, 100 Hz, or sham EA at the Zusanli and Sanyinjiao acupoints bilaterally, and tail-flick latency was measured within 30 seconds after the end of stimulation and at 5-minute intervals for up to 30 minutes. EA at a frequency of either 2 or 100 Hz induced a strong and long-lasting inhibition of the tail-flick reflex in rats treated with saline (0.25 μl) injected into the RSC. The analgesia produced by 2-Hz EA lasted for a shorter time in lidocaine-treated rats. By contrast, RSC impairment did not change the analgesic effect of 100 Hz EA. The integrity of the RSC is implicated in the duration of analgesia induced by low-frequency EA but is not essential for the analgesic effects evoked by high-frequency EA. 相似文献
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<正> 本世纪七十年代初,Simon,Pert和 Terenius 三个实验室分别独立地确定在体内特别是中枢神经系统内存在着特异的阿片受体。随后,Hughes 等成功地从猪脑中分离提取出两种具有阿片活性的五肽—甲硫-脑啡肽和亮-脑啡肽。在此以后,人们又从垂体中发现了阿片活性更强的β-内啡肽和强啡肽。这些内源性阿片样物质(OLS)的发现,为疼痛生理之研究打开了新的突破口.1975年,Mayer 等首次报告了静脉内注射特异的阿片受体阻断剂纳络酮可以翻转针刺的镇痛作用.这就提示在针刺镇痛的机制中可能有 OLS 参与,但尚不能明确在OLS 这一族化合物中哪一个具体组分在发挥作用. 相似文献