共查询到19条相似文献,搜索用时 62 毫秒
1.
海洋生药尖海龙的抗疲劳作用研究 总被引:1,自引:1,他引:0
研究海洋生药尖海龙的抗疲劳作用,分析了尖海龙的营养成分;用尖海龙提取的总脂肪和酶水解液进行抗疲劳动物实验。结果表明,尖海龙总脂肪、酶水解液都能显著延长小鼠游泳时间(较空白对照P<0.05),减少运动引起的血乳酸增加和加速运动后血乳酸含量的降低(P<0.05),增加小鼠肌糖原和肝糖原的储备(P<0.05)。证明尖海龙的总脂肪和酶水解液都具有抗疲劳作用。实验结果同时证实,尖海龙整体生药的抗疲劳作用更为有效(较空白对照,P<0.01)。 相似文献
2.
3.
4.
5.
新型异黄酮及甾体类化合物抗辐射作用的实验研究 总被引:1,自引:0,他引:1
目的对进行改构的两种异黄酮类化合物F12、F2及一种甾体类化合物ZE1进行体外、体内实验,寻找一种新型的抗辐射药物。方法以Genistein和雌二醇为阳性对照,应用MTT法对比研究三种化合物在不同的浓度对IEC-6、巨核细胞系-Dami细胞株细胞增殖活性的影响;并观察其对8Gy和12Gy60Co-γ射线照射小鼠肠道及造血辐射防护效果。结果F2、F12、ZE1在不同浓度对IEC-6及Dami细胞均有不同的辐射防护作用,效果显著优于Genistein和雌二醇(P〈0.01)。动物实验结果显示F2使辐射损伤小鼠的骨髓和脾脏有核细胞数量增加,肠上皮细胞绒毛高度增加,隐窝变长,效果与雌二醇相当,而未观察到明显的毒副反应。结论经过特定结构修饰的异黄酮类化合物F2,有较好的辐射保护作用,同时无明显的雌激素样作用,提示可能是较为理想的辐射防护剂候选药物。 相似文献
6.
目的:研究甾体甲基化转移酶。方法:从γ-oryzaniol提取的cycloartenol和24(28)-methylenecycloartenol为初始原料合成目标化合物。结果:成功地合成了11个甾体衍生物。结论:目标化合物均经HPLC纯化;结构均经NMR和GC/MS确证,方法简便易行。 相似文献
7.
8.
10.
11.
Ge葱中含硫化合物对培养心肌细胞的作用 总被引:2,自引:0,他引:2
目的:考察Ge葱中的5种化合物对小鼠培养心肌细胞的作用方法:制备小鼠的培养心肌细胞,利用微机控制的图像分析监视系统,考察Ge葱中分离出的5种挥发性成分对培养心肌细胞的心率及振幅的作用。结果:其中二甲基二硫、甲基烯丙基三硫、甲基烯丙基硫醚和二烯丙基二硫对培养心肌细胞的心率和振幅均有明显的增强作用,并对Ca^2+-ATp酶有明显的抑制作用,而不含硫的2-戊酮对心Na、K_A 相似文献
12.
目的:考察 葱(Allium victorialis L.)中的5种化合物对小鼠培养心肌细胞的作用。 方法:制备小鼠的培养心肌细胞,利用微机控制的图像分析监视系统,考察 葱中分离出的5种挥发性成分对培养心肌细胞的心率及振幅的作用。 结果:其中二甲基二硫、甲基烯丙基三硫、甲基烯丙基硫醚和二烯丙基二硫对培养心肌细胞的心率和振幅均有明显的增强作用,并对Ca2+-ATP酶有明显的抑制作用,而不含硫的2-戊酮对心率、振幅、Na+,K+-ATP酶及Ca2+-ATP酶均无影响。 结论:含硫化合物引起的正性肌力作用可能与它的酶抑制作用有关。 相似文献
13.
14.
The effects of polymyxin B (PXB) on action potential of the mice right ventricular myocardial cell were studied by means of intracellular capillary glass electrode. The action potential amplitude (APA) and maximal depolarization rate of phase O (Vmax) of action potential were lowered after administering PXB for 5 min. APA was lowered from 104.0±4.2 mV to 100.7±5.1mV, decreasing 3.2% (P<0.01); Vmax was lowered from 691.5±114.1 v/s to 515.15±71.5 v/s, decreasing 25.5% (P<0.001). Practically, the resting potential remained unchanged. With the continued administration of PXB, the functional refractory period was significantly prolonged. APA90 was temporarily shortened and then prolonged. The results suggest that PXB inactivate or block the fast sodium channel in myocardial cell membrane, which may relate to the antiarrhythmic effect in animal experiment. 相似文献
15.
G. Baccelli R. Valentini L. Gregorini G. Cellina G. Mancia J. Ludbrook A. Zanchetti 《Clinical and experimental pharmacology & physiology》1978,5(6):607-615
1. Cardiac performance in response to 30% maximal isometric handgrip exercise was studied in fourteen patients convalescing uneventfully from a first myocardial infarction. In each patient, heart rate, mean arterial blood pressure and cardiac index were measured, and total peripheral resistance was calculated. The covariance of changes in the mean arterial blood pressure and cardiac index in these patients was matched against tolerance limits calculated from published data for normal subjects. 2. All patients had normal haemodynamic values at rest, and showed the usual rise of heart rate and mean arterial pressure during handgrip exercise. However, in six patients (group 1) the rise in mean arterial pressure was, as in normal subjects, accounted for mainly by a rise in cardiac index, with no consistent change in peripheral resistance. In eight patients (group 2), the mean arterial pressure rose to the same level as in group 1, but with a consistent increase in peripheral resistance and a smaller rise in the cardiac index. 3. It is suggested that in a substantial proportion of patients who are making a seemingly uncomplicated recovery from myocardial infarction, it may be possible to unmask an impairment of left ventricular function by means of isometric handgrip exercise. 相似文献
16.
牛磺酸对家兔心肌肌膜和磷脂脂质体脂质过氧化的影响 总被引:2,自引:0,他引:2
《中国药理学通报》1991,(5)
在家兔心肌肌膜和人工生物膜脂质体上,牛磺酸显著抑制氧自由基发生系统(FeCl_3和抗坏血酸)所引起的脂质过氧化物丙二醛的增加,其抑制作用呈剂量依赖和时间依赖关系。本结果证实牛磺酸具有抗氧化作用,在膜水平上直接起到自由基清除剂作用。 相似文献
17.
P. Roberts-Thomson R. J. McRitchie J. P. Chalmers 《Clinical and experimental pharmacology & physiology》1991,18(5):315-318
1. We studied the effects of an intravenous bolus of endothelin-1 on arterial pressure and myocardial contractility in the conscious rabbit. 2. Endothelin produced an initial fall in arterial pressure accompanied by an increase in heart rate. This was followed by a dose-dependent increase in arterial pressure, peaking about 7 min after injection, accompanied by a reciprocal fall in heart rate. 3. Left ventricular rate of change of pressure (LV dP dt) increased with endothelin except at higher doses (0.8 and 1.6 nmol/kg), where in some animals it decreased. 相似文献
18.
不同年龄组急性心肌梗塞溶栓治疗的对比研究 总被引:2,自引:0,他引:2
47例急性心肌梗塞(AMI)患者按发病年龄随机分成三组,进行尿激酶(UK)溶栓疗效的对比研究。结果表明,12小时内溶栓的47例AMI患者再通率、死亡率和并发症发生率分别为55.3%、14.9%和8.5%。6小时内溶栓再通率老年组(50%)明显低于青年组(80%)和老年前期组(70%)。老年组住院病死率为25.9%,且有出血并发症发生,而青年组和老年前期组无一例死亡且无一例出血并发症发生。提示UK溶栓疗效与患者年龄有关,老年人溶栓疗效较差,病死率和出血并发症发生率较高。 相似文献
19.
蝙蝠葛碱对动物耐缺氧及实验性心肌缺血和梗塞的影响 总被引:3,自引:0,他引:3
本文报道蝙蝠葛碱(Dau)对小白鼠耐缺氧和大鼠实验性心肌缺血及梗塞的影响。异丙肾上腺素(Iso)诱发耗氧量增加后,Dau,维拉帕米(Ver)和普萘洛尔(Pro)均能提高小鼠常压耐缺氧能力、延长存活时间、降低耗氧速率.Dau和Ver延长存活时间与其降低耗氧速率有关,而Pro的这一作用可能与降低耗氧速率和提高对氧的利用能力有关。 Dau明显降低iv垂体后叶素(Pit)所致的大白鼠心电图L—Ⅱ的J点和T波抬高幅度,降低大鼠冠脉结扎所致的心电图L—Ⅱ的J点抬高幅度和病理性Q波的出现率,明显缩小结扎24小时后心肌梗塞范围,提示Dau对实验性心肌缺血和梗塞具有保护作用。 相似文献