EEG、BEAM在急性腔隙性脑梗死患者中的应用研究

目的：用脑电图（EEG）脑电地形图（BEAM）对早期（3天内）腔隙性脑梗死（腔梗）实施检测,观察其敏感性、变化特点以及对临床诊断的指导价值。方法：对65例早期腔梗的患者做EEG、BEAM检测,同期做计算机断层扫描（CT）或磁共振成像（MRI）对照,并与对照组对比分析。结果：腔梗组发病3天内异常率分别为：EEG66％、BEAM89％（P〈0．05）。CT和MRI总异常率为22％（P〈0．001）。EEG、BEAM主要改变为局限性异常,多在额颞、中央区以0频带功率增高为主,部分病变侧颞区较对侧功率降低,a频带功率减弱。与CT比较,BEAM具有较高的敏感性。结论：EEG、BEAM检查早期腔梗优于CT,起到了指导临床诊断及时治疗的作用。     

闭合性脑外伤脑电图变化与脑电地形图结果比较

目的:探讨脑电学检查在闭合性脑外伤中的应用.方法:对123例闭合性脑外伤患者进行EEG和BEAM检查.结果:EEG异常率为56.9%,表现为弥漫性或局部性慢波增多,BEAM异常率为70.7%,表现为θ或δ频带功率呈弥漫性或局限性增高.结论:闭合性脑外伤的损伤程度与EEG的变化有良好的正相关性;闭合性脑外伤EEG和BEAM,两者有显著性差异;多次重复脑电学检查,有重要临床价值.     

急性丘脑卒中的BEAM定位研究

本文报导了30例急性丘脑卒中患者在脑电地形图的定位研究,其中28例出现异常改变。BEAM显示:28例患者表现为病变部位δ频带呈不同程度的功率增高;在定位分析上,丘脑血管病变多累及BEAM的中央区,其次表现为颞区受累。     

脑出血、脑梗塞急性期脑电图、脑电地形图、经颅多普勒与CT对比研究

本文对CI组(29例),CH组(34例),健康人对照组(30例),同时进行了EEG、BEAM、TCD与CT的前瞻性对比研究。结果CI组和CH组EEG、BEAM异常率分别为96.5％和97.1％,而BEAM定侧定位率远远高于EEG。在CI组,BEAM出现异常早于CT,且异常率(96.5％)高于CT(93.1％)。说明脑功能障碍早于形态学改变。(δ+θ)/(α+β)比值,两组无差异。本文提出病、健侧频带功率差的百分比可作为BEAM一项观察指标。CH组病、健侧δ、θ频带功率均值差的百分比分别为48.58％和47.91％,高于CI组(29.05％和26.38％)。TCD异常率CI组(100％)和CH组(97.1％)两组均高,说明在脑卒中急性期TCD对颅内血流动力学改变很敏感,它虽不能定位定性,但通过动态观察,可了解脑血管功能状态、侧枝循环、颅内动脉开放程度等,对治疗前后疗效评价及预后有指导意义。     

事件相关电位及脑电地形图对睡眠呼吸暂停综合征患者认知功能的评价

目的 :探索睡眠呼吸暂停综合征 (SAS)患者认知功能和临床疗效的评价方法。方法 :利用事件相关电位 (ERP)、脑电地形图 (BEAM)检测和简易智力状态试验 (MMSE)观察SAS患者 (分症状轻的SAS—A和症状重的SAS—B两个亚组 )经鼻持续气道内压通气 (CPAP)治疗前后认知功能的变化 ,并与对照组进行比较。结果 :与对照组比较 ,P30 0潜伏期明显延长 (P <0 0 5 ) ,波辐降低 (P <0 0 5 ) ;SAS—B组MMSE测试得分较低 ,SAS—A组近于正常 ,SAS—A组与SAS—B组之间BEAM总异常率及部分异常频带分布无显著差异 (P >0 0 5 )。结论 :ERP—P30 0、BEAM结合MMSE是观察SAS患者认知功能的有效方法     

病毒性脑炎脑电地形图与临床研究

目的:观察病毒性脑炎病人的脑电地形图特点及对临床治疗的指导价值。方法:自1995年2月至1999年3月间对收治资料齐全以儿童为主的53例病毒性脑炎进行BEAM首次描记及追踪观察。结果;53例中轻度异常17例(32％)中度异常24例(45％),重度异常12例(23％)。发病3～5天内阳性率57％,6～8天阳性率88％。BEAM首次描记时间在一周后阳性率及异常程度最高。结论:病毒性脑炎BEAM改变总体表现以广泛不规则高功率θ频带为主,混有部分高功率δ及杂乱波为特征。     

病毒性脑炎脑电地形图与临床研究

目的:观察病毒性脑炎病人的脑地形图特点及临床治疗的指导价值。方法:自2005年2月至2009年3月间对收治资料齐全以儿童为主的53例病毒性脑炎进行BEAM首次描记及追踪观察。结果:53例中轻度异常17例(32%)中度异常24例(45%),重度异常12例(23%)。发病3～5天内阳性率57%,6～8天阳性率88%。BEAM首次描记时间在一周后阳性率及异常程度最高。结论:病毒性脑炎BEAM改变总体表现以广泛不规则高功率θ频带为主,混有部分高功率δ及杂乱波为主。     

脑电地形图在急性脑梗死中的应用研究

目的急性脑梗死治疗的关键在于尽早恢复缺血半暗带(IP)的功能,缩小梗死的体积.脑梗死的早期诊断及治疗前IP功能的判断对治疗措施的选择致关重要.本课题通过研究脑电地形图(BEAM)在脑梗死中的特征,探讨BEAM在急性脑梗死早期诊断、IP功能判断及早期治疗、疗效观察、预后判断中的应用价值.方法选择100例急性脑梗死的住院患者,入院当时均经CT及BEAM检查.并在治疗前以及治疗后不同阶段观察BEAM的变化及其与神经功能恢复的关系.对BEAM在急性脑梗死早期诊断、治疗和预后中的应用价值进行研究.结果(1)脑梗死发病24小时内,BEAM阳性率为100%,高于CT的38.1%.BEAM可判断梗死的侧别,符合率为100%.(2)BEAM在不同程度神经功能缺损的患者表现不同,在轻、中、重度神经功能缺损中有非常显著差异(P＜0.01).(3)BEAM可显示半暗带的范围及损伤程度.在治疗后,IP范围明显缩小,功率值降低,与临床症状体征缓解相平行.(4)BEAM在发病早期异常程度较轻者预后较好.结论(1)BEAM可提高脑梗死超早期诊断率.(2)BEAM可对脑功能作出评价,并为疗效评定和预后评估提供参考.(3)BEAM可对IP功能作出判断,可作为IP功能恢复的指标.(4)BEAM对急性脑梗死早期治疗方案选择有重要意义.     

新生儿缺血缺氧性脑病的脑电地形图观察

目的：观察新生儿缺血缺氧性脑病(HIE)早期脑电地形图(BEAM)的变化及其意义。方法：应用常规脑电地形图对65例HIE进行了检查。结果：63例患(96％)出现BEAM异常，并且BEAM以背景活动异常为主。结论：BEAM为HIE早期观察脑功能变化的敏感指标。     

急性一氧化碳中毒后迟发性脑病患者EEG观察

目的:了解一氧化碳(CO)中毒后迟发性脑病(DEACMP)患者从急性CO中毒到DEAC- MP发病期、临床治愈期整个病程中的脑电图(EEG)改变及其在临床上的意义。方法:对60例DEAC- MP患者分别在急性CO中毒期、假愈期、DEACMP期及临床治愈期动态进行EEG检查,并与EEG检查时患者症状轻重进行对比。结果:急性CO中毒期EEG 68%为轻度异常,21%为中度异常;假愈期EEG 86%为界线及正常;DEACMP期EEG均异常,且54例(90%)为中、重度异常,并与患者临床症状轻重程度一致;临床治愈期EEG 82%已正常。结论:EEG动态观察对了解DEACMP病程中各期的脑功能变化及疗效判断有较大的指导价值。     

Deletion (2) (q37)

We report on a 5-month-old girl with widely spaced nipples, redundant nuchal skin, coarctation of the aorta, anal atresia with distal fistula, postnatal growth retardation, hypotonia, and sparse scalp hair. Initial clinical assessment suggested the diagnosis of Ullrich-Turner syndrome. Chromosome analysis showed a 46,XX,del(2)(q37) karyotype in peripheral lymphocytes. We compare her findings to those of other reported patients with terminal deletions of 2q. © 1994 Wiley-Liss, Inc.     

可溶性gp130对白血病抑制因子和制瘤素的拮抗作用

在研究可溶性ｇｐ１３０（ｓｇｐ１３０）分子对ＩＬ ６／ＩＬ ６Ｒ作用的基础上,继续研究了ｓｇｐ１３０对ＩＬ ６家族细胞因子白血病抑制因子（ＬＩＦ）和制瘤素（ＯＭ）的生物学作用。结果显示,ｓｇｐ１３０对ＬＩＦ和ＯＭ刺激的人多发性骨髓瘤（ＭＭ）细胞株ＸＧ４ ＣＮＴＦ的增殖有抑制作用。此外,ｓｇｐ１３０对ＬＩＦ和ＯＭ刺激表达ＬＩＦ受体的新鲜ＭＭ细胞的增殖也有抑制作用,提示ｓｇｐ１３０也可为ＬＩＦ和ＯＭ的拮抗剂。     

Theta-behaviour of poly(p-tert-butylstyrene)-block-poly(dimethylsiloxane)-block-poly(p-tert-butylstyrene)

The theta-behaviour of poly(p-tert-butylstyrene)-block-poly(dimethylsiloxane)-block-poly(p-tert-butylstyrene) ABA type triblock copolymers containing ca. 28% by weight tert-butylstyrene was studied in the selective solvents 1-nitropropane and 2-butanone using the phase separation method. The theta-temperatures in these solvents were found to be 157°C and 31°C, respectively. The intrinsic viscosities of the copolymers in 2-butanone (MEK) were obtained at different temperatures. The Mark-Houwink-Sakurada exponent α in MEK at 31°C is greater than 0,5, suggesting that the theta-behaviour of block copolymers is different from that of the homopolymers due to the presence of repulsive interactions between incompatible blocks.     

窄手蚋的重新描述（双翅目：蚋科）

窄手蚋 （Simulium （Simulium） omorii）是Takahasi（1942）发表的新种,当时放在短蚋属（Omiadag）,该蚋标本是采自我国黑龙江省.Takahasi 仅描述了两性成虫和蛹,缺幼虫,况前者也不甚详细 1983年,虞以新和安继尧在我国黑龙江省饶河县珍宝岛地区,采到窄手蚋的两性成虫、幼虫和蛹,描述于后供同道者参考.窄手蚋与Rubzov（1956）描述的S. （S.） tenuimanus Enderlein, 1920很近似,不同的是：1. 足色：雌虫,窄手蚋前、中足股节黑色,后足股节基段1/5棕黄色.tenuimanus蚋,前、中、后足股节巧克力棕黑色,仅基部有点黄色.雄虫,窄手蚋后足转节、股节基端部、胫节基端部和中足基节1/2棕黄色,而tenuimanus 除前足基节和后足胫节基部褐色外,余部黑色.2. 窄手蚋中骨圆形或弹头形,前端圆形,后端凹入呈八字形 tenuimanu 中骨箭形,末端尖.标本保存于军事医学科学院医学昆虫标本馆.     

Degradation of poly(lactide-co-glycolide) (PLGA) and poly(L-lactide) (PLLA) by electron beam radiation

This paper seeks to examine the effects of electron beam (e-beam) radiation on biodegradable polymers (PLGA and PLLA), and to understand their radiation-induced degradation mechanisms. PLGA (80:20) and PLLA polymer films were e-beam irradiated at doses from 2.5 to 50 Mrad and the degradation of these films were studied by measuring the changes in their molecular weights, FTIR spectra, thermal and morphological properties. The dominant effect of e-beam irradiation on both PLGA and PLLA is chain scission. Chain scission occurs first through scission of the polymer main chain, followed by hydrogen abstraction. Chain scission, though responsible for the reduction in the average molecular weight, Tc, Tg and Tm of both polymers, encourages crystallization in PLGA. PLLA also undergoes chain scission upon irradiation but to a lesser degree compared to PLGA. The higher crystallinity of PLLA is the key factor in its greater stability to e-beam radiation compared to PLGA. A linear relationship is also established between the decrease in molecular weight with respect to radiation dose.     

(E)TUDE APPLIQ(E)E DE ENC(E)PHALE ATLAS DANS MALADES AVEC INFARCTION C(E)R(E)BRALE

目的:探讨脑电地形图在脑梗死中的应用价值。方法:在43例脑梗死患者中,进行了脑电地形图和脑CT检查,并进行了对比。结果:脑电地形图和脑CT的改变是一致的,但脑电地形图改变早于脑CT。结论:脑电地形图在脑梗死患者中有重要的应用价值。     

(E)TUDE APPLIQU(E) DE ENC(E)PHAL ATLAS DANS MALADIES PSYCHI(Q)UE

目的:探讨脑电地形图在精神性疾病中的应用价值。方法:106例精神性疾病患者进行了脑电地形图检查,并进行了分析。同时,进行了脑CT检查,并进行了对比。结果:精神性疾患者的脑电地形图有明显的改变。结论:脑电地形图在精神性疾病中有重要应用价值。     

肠系膜上动脉闭塞性休克过程中一氧化氮的抗肺损伤用

本实验采用兔肠系膜上动脉闭塞（ＳＭＡＯ）性休ｋｅ模型，测定了休克前后人．出肺血一氧化氮（ＮＯ）的含量，动态观察了ＮＯ合成抑制剂ＬＮＮＡ对休克时平均动脉血（ＭＡＰ）和肺动脉压（ＰＭＰ）及对生存时间的影响，并测定了人、出肺血脂质过氧化代谢产物丙二醛（ＭＤＡ）的含量改变。结果发现，ＳＭＡＯ休克的出肺血ＮＯ显著低下人肺血（Ｐ＜０．００１），而休克后人、出肺血ＮＯ无明显差异，且与休克前相比也无明显差异。注入Ｌ－ＮＮＡ后显著增加了休克后的ＰＭＰ，缩短了存活时间。并使人、出肺皿ＭＤＡ含量明显增加，结果提示：在兔ＳＭＡＯ休ｋｅ中内源性ＮＯ具有重要的抗肺动脉压增高和抗肺损伤的作用。     

Alpha-thalassaemia (Hb-Bart's) in Rajasthan (India)

A total of 1,647 cord blood samples (618 of scheduled tribes, 487 of scheduled castes and 542 of general castes) of newborns from the Banswara, Bhilwara, Chittorgarh, Dungarpur, Sirohi and Udaipur districts of the Aravali hilly region of Rajasthan were investigated electrophoretically for evidence of Hb-Bart's (alpha-thalassaemia). Hb-Bart's was encountered in 31 (1.88%) neonates constituting 1.8 to 12.6% of their total haemoglobin. Of these, 24 (1.46%) were of alpha-thalassaemia 1 and 7 (0.42%) of alpha-thalassaemia 2. The incidence of alpha-thalassaemia genes varied from 3.07% in the scheduled tribes, 1.43% in the scheduled castes to 0.77% in the general castes populations giving an overall incidence of 1.88%. Except Hb-Bart's allele, no other mutant haemoglobins were observed.     

Pendant-type poly(4-vinylpyridine)-Cr(III) and -Co(III) complexes

Pendant-type poly(4-vinylpyridine) (PVP)-Cr(III) complexes ( 1 ) and -Co(III) complexes ( 2 ) with various degrees of coordination (x) were prepared, and the structures and properties of the polymer complexes are discussed. The magnetic susceptibility of 1 showed that 1 is paramagnetic and that the Cr(III) ions do not interact with each other, although they were coordinated along the PVP chain at high concentration. The far-infrared absorption bands, assigned to the stretching of the coordinative bond between Co and the pyridine-unit of PVP shifted to lower wave numbers in 2 , as compared with the corresponding pyridine complex 4 . It is thus considered that the coordinative bond in 2 is weaker than in the monomeric pyridine complex 4 , owing to the steric hindrance of PVP; the Co(III) chelates coordinated at high concentration. This consideration is supported by the ESR parameters of 1 . The dissociation temperature of the coordinative bond between Co and PVP increased with x. It is presumed that the PVP complex 2 has a rigid structure such that more energy is required to break the coordinative bond.