老年急性脑梗塞患者血液流变学变化分析

目的 研究老年急性脑梗塞患者血脂及血液流变学变化特点，并分析二者的相关性。方法 ７６例老年急性脑梗塞患者，测定全血粘度（ＢＶ）、血浆粘度（ＰＶ）、血小板聚集率（ＰＡｇｔ）、凝血酶时间（ＴＴ）、凝血酶时间（ＰＴ）、白陶土部分凝血活酶时间（ＫＰＴＴ）、总胆固醇（ＴＣ）、甘油三酯（ＴＧ）、高密度脂蛋白胆固醇（ＨＤＬ－Ｃ）、低密度脂蛋白胆固醇（ＬＤＬ－Ｃ）、脂蛋白（ａ）［Ｐ（ａ）］、载脂蛋白（Ａｐｏ）Ａ１     

不同分期肺癌患者血液流变学变化的临床意义

目的探讨不同病期肺癌患者血液流变学变化及其临床意义。方法采用国产血液粘度计，在37C条件下，测定全血粘度、血浆粘度、红细胞压积、红细胞聚集指数、纤维蛋白元，并观察各期肺癌患者的血液流变学特性及参数间的差异。结果Ⅱ、Ⅲ期肺癌的血液流变学各参数，包括全血各粘度，血浆粘度等指标均显著高于正常人，其各个切变率、全血粘度和血浆粘度等指标均明显高于正常人，而Ⅰ、Ⅳ期肺癌各个血液流变学指标接近甚至低于正常。结论肺癌患者在病程的不同阶段，血液流变学有不同的变化，这种变化可能有其特定的临床意义。     

肺癌与血小板参数、血液流变学的临床分析

目的通过对肺癌患者血小板数量、血液流变学的观察，评估血小板升高，血粘度增高对肺癌诊断和预后判断的价值。方法分析106例肺癌患者的血小板数量、血液流变学变化的情况。结果肺癌患者中有35～67％的血小板升高，在血小板增高的46例中有42例是肺癌Ⅲ、Ⅳ期病例，且血粘度均升高，并死亡21例。结论血小板升高、高粘状态可作为肺癌诊断及预后判断的一项有意义的指标，对肺癌具有辅助诊断价值。     

脑梗死患者血液流变学及血小板参数的变化及其临床意义

目的探讨血液流变学指标及血小板参数改变对脑梗死的诊断价值。方法对我院43例脑梗死患者及31例健康对照组行血液流变学指标及血小板参数检测。结果脑梗死患者各项血液流变学指标均高于对照组,突出表现为高黏滞血症和高凝血症;脑梗死患者的血小板分布宽度、血小板平均容积、大血小板比率均明显高于对照组。结论血液流变学指标及血小板参数的改变与脑梗死发生密切相关,有助于脑梗死患者的临床诊断。     

老年冠心病患者血液流变学测定

目前巳公认血液流变学的变化与心血管疾病的发生、发展也有着密切的关系。近年研究也颇受重视。本现对老年前期、老年期冠心病患的血液流变学变化情况作一报告．     

肺癌患者血液流变学指标变化的临床分析

目的分析肺癌患者血液流变学指标的变化及临床意义。方法对98例肺癌患者和50例健康人血液流变学指标进行检测分析。结果肺癌患者全血黏度、血浆黏度、血沉、红细胞压积、红细胞刚性指数、红细胞聚集指数、纤维蛋白原的水平较健康对照组有明显增高,有显著性差异（P〈0.01）;晚期患者各项指标与早期患者比较差异有统计学意义（P〈0.05）;有转移组与无转移组的比较也有统计学意义（P〈0.01）。结论肺癌患者存在明显高凝状态,血液流变学指标变化对肺癌的诊断、治疗观察、转移复发、预后监测有一定的临床价值。     

低分子量肝素钙对老年患者血液流变学和血小板功能的影响

立迈青 (低分子量肝素钙 )是由普通肝素 (UFH)裂解而成的 ,目前广泛用于血栓性疾病的治疗。为提高对低分子量肝素钙治疗作用的认识 ,我们观察了低分子量肝素钙对 5 7例老年患者血液流变学和血小板功能的影响。1　临床资料选择我院老年病科收治的老年患者共 96例 ,男性 91例 ,女性 5例 ,年龄 6 5～ 87岁。其中治疗组 5 7例 ,对照组 39例 ,用药前 1周停用影响血液流变学及血小板功能的抗凝药物。治疗组 :在对症治疗基础上 ,给予低分子量肝素钙 5 0 0 0U皮下注射或静脉滴注 ,每日 1次 ,连续用 10d。对照组 :只给予对症治疗。检测指标 :高切全…     

143例脑梗塞患者血小板聚集率和血液流变学分析

我们测定了143例脑梗塞患者(按1986年第二次全国脑血管病会议标准确诊)的血小板聚集率(PAgt)和血液流变学五项指标,并与对照组比较。结果见表1、表2。 讨论:由表1看出脑梗塞组血小板1分钟、5分钟和最大聚集率均高于正常对照组(P<0.01)。脑梗塞时,由于血管内皮细     

老年血管性痴呆血液流变学与脑血管血液动力学变化

血管性痴呆是我国老年期痴呆最常见的类型之一，本病的诊断主要根据病史、体征及神经心理学检测并结合影像学改变作出综合性判断。为研究老年血管性痴呆的情况，我们应用简易精神状态检查法（ＭＭＳＥ）检查了３５０例脑梗塞患者，对其中老年梗塞１８０例患者（痴呆组５８...     

肺癌患者血栓前状态分子标志物的变化

目的研究肺癌患者血栓前状态(prethmmbotic state PTS)分子标志物变化并探讨其意义。方法采用酶联免疫吸附双抗体夹心法检测82例肺癌患者和50名正常人凝血、抗凝纤溶系统实验室指标,包括血小板α颗粒膜蛋白-140(GMP-140)、凝血酶原片段1+2(F1+2),凝血酶-抗凝血酶复合物(TAT),D-二聚体(D-dimer)。结果肺癌患者体内GMP-140、F1+2、TAT、D-dimer的水平较正常人显著升高(P0.05),上述指标在晚期肺癌组和PS评分2的患者中明显升高(P0.05)。结论肺癌患者出现血小板活化、凝血功能增强、纤溶功能减退,存在明显的血栓前状态。     

Prognostic significance of preoperative platelet count in patients with gallbladder cancer

AIM:To investigate the prognostic value of preoperative platelet count(PLT) in patients with primary gallbladder cancer(GBC).METHODS:The clinical data of 223 GBC patients after surgery was retrospectively reviewed.A receiver operating characteristic(ROC) curve was plotted to verify the optimum cutoff point for PLT.Univariate and multivariate survival analyses were performed to identify the factors associated with the prognosis.RESULTS:The ROC curve showed that the optimum cutoff point for PLT was 178 × 109/L,and the entire cohort was stratified into group A with PLT 178 × 109/L and group B with PLT ≤ 178 × 109/L.Group A had a better survival than group B(P 0.001).There was an obvious difference between the two groups in terms of the differentiation degree,advanced tumor stage,lymph node metastasis(P 0.001) and pathological type(P 0.05).The univariate analysis demonstrated that tumor location,differentiation degree,TNM stage,Nevin stage,lymph node metastasis and PLT were associated with overall survival(P 0.001).In the multivariate analysis,PLT(P = 0.032),lymph node metastasis(P = 0.007),tumor location(P 0.001) and TNM stage(P = 0.005) were independent prognostic factors.CONCLUSION:PLT is closely correlated with GBC prognosis and could be used to identify the population with a poorer prognosis after surgery.     

非瓣膜病心房颤动患者血小板活化状态的研究

目的了解非瓣膜病心房颤动(房颤)患者血小板的活化状态。方法观察92例非瓣膜病持续性房颤患者(房颤组)与60例窦性心律者(对照组)血小板功能状态的分子标记物水平,用酶联免疫吸附双抗体夹心法测定血浆血小板α颗粒膜糖蛋白-140(GMP-140)水平,用放射免疫分析法测定血栓素B2(TXB2)和6-酮-前列腺素F1α(6-k-PGF1α)水平。结果房颤组GMP-140和TXB2水平显著高于对照组,6-k-PGF1α水平显著低于对照组,TXB2/6-k-PGF1α比值也显著高于对照组。调整其他影响因素后,房颤组GMP-140和TXB2水平仍显著高于对照组,6-k-PGF1α水平仍显著低于对照组。GMP-140水平在合并糖尿病和合并高甘油三酯血症的房颤患者进一步升高。结论非瓣膜病房颤患者处于血小板激活状态。     

肺癌多发转移患者凝血特征及临床护理要点

随着全球恶性肿瘤逐年上升,其发病率、病死率已超过心血管疾病.在我国,肺癌的病死率在所有恶性肿瘤中居第1位.肺癌患者最常见凝血及纤溶系统功能异常,并与肿瘤的生长、浸润、转移密切相关.本研究通过分析肺癌患者血小板计数及血浆纤维蛋白原的指标、评价特征及其变化,指导临床诊治与护理.     

晚期非小细胞肺癌患者血小板及血浆纤维蛋白原水平的临床意义

目的探讨血小板(PLT)计数及血浆纤维蛋白原(Fm)与晚期非小细胞肺癌之间的关系及其临床意义。方法收集2011年住院的80例晚期非小细胞肺癌患者(肺癌组)和30名健康体检者(对照组)PLT计数及FIB并对两组指标进行对比分析。结果肺癌组PLT计数及FIB均高于对照组(P0.05),肺癌组中血细胞计数和FIB水平在病理类型上差异无统计学意义,分期上存在统计学差异,Ⅳ期的PLT计数高于Ⅲ期(P均0.05)。结论对肺癌患者或者临床怀疑肺癌患者,行PLT计数及FIB检查对临床诊断和治疗预后判断有重要的意义。     

终末期肝病并发自发性腹膜炎患者血小板计数的变化及其临床意义

目的：探讨终末期肝病并发自发性腹膜炎患者血小板计数的变化及其临床意义。方法：对266例并发自发性腹膜炎的终末期肝病患者进行回顾性分析,研究对象分为失代偿期肝硬化组、慢性重型肝炎组。观察两组患者血小板计数在腹膜炎发作前、腹膜炎发生时、腹膜炎治愈后的变化,以同组中未并发自发性腹膜炎的患者为对照。结果：失代偿期肝硬化和慢性重型肝炎并发自发性腹膜炎患者血小板计数在腹膜炎发生时下降,腹膜炎治愈后回升（P均〈0.01）。结论：血小板计数变化可作为失代偿期肝硬化和慢性重型肝炎并发自发性腹膜炎诊断和治疗的一项辅助参考指标。     

Elevated platelet count is a strong predictor of poor prognosis in stage I non-small cell lung cancer patients

Stage I non-small cell lung cancer (NSCLC) show a highly variable biological behavior which cannot be accurately predicted by the current available prognostic markers. Platelet plays a significant role in cancer cell growth, progression and metastasis. This study aimed to investigate whether preoperative platelet count correlate with clinical prognosis in localized NSCLC. A retrospective clinical analysis was designed for a total of 234 stage I NSCLC patients in our hospital between October 2006 and December 2009. Pre-operative platelet count was measured. The association of platelet count with clinical pathological factors and patient outcome was evaluated. A significant correlation was detected between platelet count and tumor cell differentiation and T stage. Patients with elevated platelet count had an elevated risk of disease progression and death compared to patients with normal platelet count. The hazard ratio was 5.314 (95% confidence interval [CI] 2.750–10.269) for disease progression and 3.139 (95% CI 1.227–8.034) for death. The trend linking increasing platelet count with risk was also statistically significant for both the outcomes (p?<?0.05). These finding demonstrate that preoperative platelet count is a useful predictor of high risk progression and poor prognosis in stage I NSCLC patients.     

Changes in platelet count in uncomplicated and severe falciparum malaria

This study investigated alterations in platelet counts pre- and post-treatment with artemisinin derivatives in uncomplicated and severe falciparum malaria. Serial platelet counts were taken over 4 weeks for 110 uncomplicated and 110 severe falciparum malaria patients admitted to the Hospital for Tropical Diseases during 2005-2008. On admission, prior to treatment, thrombocytopenia was found in 73.6% of uncomplicated falciparum malaria patients and 90.9% of severe falciparum malaria cases. Platelet levels significantly lower in severe malaria cases. Although initial platelet counts were lower than normal in both study groups, they slowly increased significantly over time, and approached normal levels by several weeks post-treatment. No bleeding was evident during treatment, and none of the patients required a platelet transfusion. Platelet transfusions are not required for malaria patients with thrombocytopenia who have no bleeding.